Alexander RW. Teasing apart the Taxol pathway. Trends Biochem. Sci. 26: 152-153 (2001).

Baluska F, Hauskrecht M, Barlow PW, Sievers A. Gravitropism of the primary root of maize: a complex pattern of differential cellular growth in the cortex independent of the microtubular cytoskeleton. Planta 198: 310-318 (1996).

Blagosklonny MV, Fojo T. Molecular effects of paclitaxel: myths and reality (a critical review). Int. J. Cancer 83: 151-156 (1999).

Brincat MC, Gibson DM, Shuler ML. Alterations in Taxol production in plant cell culture via manipulation of the phenylalanine ammonia lyase pathway. Biotechnol. Prog. 18: 1149-1156 (2002).

Collings DA, Asada T, Allen NS, Shibaoka H. Plasma membrane-associated actin in bright yellow 2 tobacco cells. Evidence for interaction with microtubules. Plant Physiol. 118: 917-928 (1998).

de Almeida Engler J, Van Poucke K, Karimi M, De Groodt R, Gheysen G, Engler G, Gheysen G. Dynamic cytoskeleton rearrangements in giant cells and syncytia of nematode-infected roots. Plant J. 38: 12-26 (2004).

Dhonukshe P, Laxalt AM, Goedhart J, Gadella TW, Munnik T. Phospholipase D activation correlates with microtubule reorganization in living plant cells. Plant Cell 15: 2666-2679 (2003).

Eisenreich W, Menhard B, Hylands PJ, Zenk MH, Bacher A. Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin. Proc. Natl. Acad. Sci. U.S.A. 93: 6431-6436 (1996).

Ellis DD, Zeldin EL, Brodhagen M, Russin WA, McCown BH. Taxol production in nodule cultures of Taxus. J. Nat. Prod. 59: 246-250 (1996).

Engels B, Dahm P, Jennewein S. Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production. Metab. Eng. 10: 201-206 (2008).

Fett-Neto AG, DiCosmo F, Reynolds WF, Sakata K. Cell culture of Taxus as a source of the antineoplastic drug taxol and related taxanes. Biotechnology (N.Y.) 10: 1572-1575 (1992).

Fett-Neto AG, Melanson SJ, Sakata K, DiCosmo F. Improved growth and taxol yield in developing calli of Taxus cuspidata by medium composition modification. Biotechnology (N.Y.) 11: 731-734 (1993).

Fisher DD, Cyr RJ. Calcium levels affect the ability to immunolocalize calmodulin to cortical microtubules. Plant Physiol. 103: 543-551 (1993).

Gardiner JC, Harper JD, Weerakoon ND, Collings DA, Ritchie S, Gilroy S, Cyr RJ, Marc J. A 90-kD phospholipase D from tobacco binds to microtubules and the plasma membrane. Plant Cell 13: 2143-2158 (2001).

Georg GI, Cheruvallath ZS, Himes RH, Mejillano MR, Burke CT. Synthesis of biologically active taxol analogues with modified phenylisoserine side chains. J. Med. Chem. 35: 4230-4237 (1992).

Glass-Marmor L, Beitner R. Taxol (paclitaxel) induces a detachment of phosphofructokinase from cytoskeleton of melanoma cells and decreases the levels of glucose 1,6-bisphosphate, fructose 1,6-bisphosphate and ATP. Eur. J. Pharmacol. 370: 195-199 (1999).

Hamberger B, Bohlmann J. Cytochrome P450 mono-oxygenases in conifer genomes: discovery of members of the terpenoid oxygenase superfamily in spruce and pine. Biochem. Soc. Trans. 34: 1209-1214 (2006).

Hause G, Lischewski S, Wessjohann LA, Hause B. Epothilone D affects cell cycle and microtubular pattern in plant cells. J. Exp. Bot. 56: 2131-2137 (2005).

Hefner J, Ketchum RE, Croteau R. Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase from Taxus canadensis and assessment of the role of this prenyltransferase in cells induced for taxol production. Arch. Biochem. Biophys. 360: 62-74 (1998).

Hefner J, Rubenstein SM, Ketchum RE, Gibson DM, Williams RM, Croteau R. Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis. Chem. Biol. 3: 479-489 (1996).

Hezari M, Croteau R. Taxol biosynthesis: an update. Planta Med. 63: 291-295 (1997).

Hezari M, Ketchum RE, Gibson DM, Croteau R. Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures. Arch. Biochem. Biophys. 337: 185-190 (1997).

Hezari M, Lewis NG, Croteau R. Purification and characterization of taxa-4(5),11(12)-diene synthase from Pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis. Arch. Biochem. Biophys. 322: 437-444 (1995).

Huang KX, Huang QL, Wildung MR, Croteau R, Scott AI. Overproduction, in Escherichia coli, of soluble taxadiene synthase, a key enzyme in the Taxol biosynthetic pathway. Protein Expr. Purif. 13: 90-96 (1998).

Huang S, Jin L, Du J, Li H, Zhao Q, Ou G, Ao G, Yuan M. SB401, a pollen-specific protein from Solanum berthaultii, binds to and bundles microtubules and F-actin. Plant J. 51: 406-418 (2007).

Hugdahl JD, Morejohn LC. Rapid and reversible high-affinity binding of the dinitroaniline herbicide oryzalin to tubulin from Zea mays L. Plant Physiol. 102: 725-740 (1993).

Jha S, Sanyal D, Ghosh B, Jha TB. Improved taxol yield in cell suspension culture of Taxus wallichiana. Planta Med. 64: 270-272 (1998).

Ketchum RE, Gibson DM, Croteau RB, Shuler ML. The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate. Biotechnol. Bioeng. 62: 97-105 (1999).

Ketchum RE, Rithner CD, Qiu D, Kim YS, Williams RM, Croteau RB. Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures. Phytochemistry 62: 901-909 (2003).

Kim BJ, Gibson DM, Shuler ML. Effect of the plant peptide regulator, phytosulfokine-alpha, on the growth and Taxol production from Taxus sp. suspension cultures. Biotechnol. Bioeng. 95: 8-14 (2006).

Koepp AE, Hezari M, Zajicek J, Vogel BS, LaFever RE, Lewis NG, Croteau R. Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew. J. Biol. Chem. 270: 8686-8690 (1995).

Korolev AV, Chan J, Naldrett MJ, Doonan JH, Lloyd CW. Identification of a novel family of 70 kDa microtubule-associated proteins in Arabidopsis cells. Plant J. 42: 547-555 (2005).

Kovacs K, Zhang L, Linforth RS, Whittaker B, Hayes CJ, Fray RG. Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit. Transgenic Res. 16: 121-126 (2007).

Lin X, Hezari M, Koepp AE, Floss HG, Croteau R. Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew. Biochemistry 35: 2968-2977 (1996).

Mathur J, Chua NH. Microtubule stabilization leads to growth reorientation in Arabidopsis trichomes. Plant Cell 12: 465-478 (2000).

McChesney JD, Venkataraman SK, Henri JT. Plant natural products: back to the future or into extinction? Phytochemistry 68: 2015-2022 (2007).

Milanesio M, Ugliengo P, Viterbo D, Appendino G. Ab initio conformational study of the phenylisoserine side chain of paclitaxel. J. Med. Chem. 42: 291-299 (1999).

Mirjalili N, Linden JC. Methyl jasmonate induced production of taxol in suspension cultures of Taxus cuspidata: ethylene interaction and induction models. Biotechnol. Prog. 12: 110-118 (1996).

Morant M, Bak S, Moller BL, Werck-Reichhart D. Plant cytochromes P450: tools for pharmacology, plant protection and phytoremediation. Curr. Opin. Biotechnol. 14: 151-162 (2003).

Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF, Renaud J, Couladouros EA, Paulvannan K, et al. Total synthesis of taxol. Nature 367: 630-634 (1994).

Nims E, Dubois CP, Roberts SC, Walker EL. Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering. Metab. Eng. 8: 385-394 (2006).

Ojima I, Lin S, Wang T. Recent advances in the medicinal chemistry of taxoids with novel beta-amino acid side chains. Curr. Med. Chem. 6: 927-954 (1999).

Patel RN. Tour de paclitaxel: biocatalysis for semisynthesis. Annu. Rev. Microbiol. 52: 361-395 (1998).

Pestchanker LJ, Roberts SC, Shuler ML. Kinetics of taxol production and nutrient use in suspension cultures of Taxus cuspidata in shake flasks and a Wilson-type bioreactor. Enzyme Microb. Technol. 19: 256-260 (1996).

Potocky M, Elias M, Profotova B, Novotna Z, Valentova O, Zarsky V V. Phosphatidic acid produced by phospholipase D is required for tobacco pollen tube growth. Planta 217: 122-130 (2003).

Rajangam AS, Kumar M, Aspeborg H, Guerriero G, Arvestad L, Pansri P, Brown CJ, Hober S, Blomqvist K, Divne C, Ezcurra I, Mellerowicz E, Sundberg B, Bulone V, Teeri TT. MAP20, a microtubule-associated protein in the secondary cell walls of Populus tremula L. x tremuloides Michx is a target of the cellulose synthesis inhibitor, 2,6-dichlorobenzonitrile. Plant Physiol. 148: 1283-1294 (2008).

Rao KV. Taxol and related taxanes. I. Taxanes of Taxus brevifolia bark. Pharm. Res. 10: 521-524 (1993).

Sainsbury F, Collings DA, Mackun K, Gardiner J, Harper JD, Marc J. Developmental reorientation of transverse cortical microtubules to longitudinal directions: a role for actomyosin-based streaming and partial microtubule-membrane detachment. Plant J. 56: 116-131 (2008).

Shen YC, Chen CY, Chen YJ. Taxumairol M: a new bicyclic taxoid from seeds of Taxus mairei. Planta Med. 65: 582-584 (1999).

Shoji T, Narita NN, Hayashi K, Asada J, Hamada T, Sonobe S, Nakajima K, Hashimoto T. Plant-specific microtubule-associated protein SPIRAL2 is required for anisotropic growth in Arabidopsis. Plant Physiol. 136: 3933-3944 (2004).

Shuler ML. Bioreactor engineering as an enabling technology to tap biodiversity. The case of taxol. Ann. N.Y. Acad. Sci. 745: 455-461 (1994).

Sieberer BJ, Timmers AC, Lhuissier FG, Emons AM. Endoplasmic microtubules configure the subapical cytoplasm and are required for fast growth of Medicago truncatula root hairs. Plant Physiol. 130: 977-988 (2002).

Srinivasan V, Ciddi V, Bringi V, Shuler ML. Metabolic inhibitors, elicitors, and precursors as tools for probing yield limitation in taxane production by Taxus chinensis cell cultures. Biotechnol. Prog. 12: 457-465 (1996).

Sun J, Blaskovich MA, Knowles D, Qian Y, Ohkanda J, Bailey RD, Hamilton AD, Sebti SM. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res. 59: 4919-4926 (1999).

Vanek T, Mala J, Saman D, Silhava I. Production of taxanes in a bioreactor by Taxus baccata cells. Planta Med. 65: 275-277 (1999).

Walker K, Croteau R. Taxol biosynthetic genes. Phytochemistry 58: 1-7 (2001).

Walker K, Croteau R. Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 97: 13591-13596 (2000).

Walker K, Croteau R. Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 97: 583-587 (2000).

Walker K, Ketchum RE, Hezari M, Gatfield D, Goleniowski M, Barthol A, Croteau R. Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis. Arch. Biochem. Biophys. 364: 273-279 (1999).

Walker K, Long R, Croteau R. The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus. Proc. Natl. Acad. Sci. U.S.A. 99: 9166-9171 (2002).

Wang JW, Zheng LP, Wu JY, Tan RX. Involvement of nitric oxide in oxidative burst, phenylalanine ammonia-lyase activation and Taxol production induced by low-energy ultrasound in Taxus yunnanensis cell suspension cultures. Nitric Oxide 15: 351-358 (2006).

Wang YD, Wu JC, Yuan YJ. Salicylic acid-induced taxol production and isopentenyl pyrophosphate biosynthesis in suspension cultures of Taxus chinensis var. mairei. Cell Biol. Int. 31: 1179-1183 (2007).

Weerasinghe RR, Collings DA, Johannes E, Allen NS. The distributional changes and role of microtubules in Nod factor-challenged Medicago sativa root hairs. Planta 218: 276-287 (2003).

Wendt KU, Schulz GE. Isoprenoid biosynthesis: manifold chemistry catalyzed by similar enzymes. Structure 6: 127-133 (1998).

Wheeler NC, Jech K, Masters S, Brobst SW, Alvarado AB, Hoover AJ, Snader KM. Effects of genetic, epigenetic, and environmental factors on taxol content in Taxus brevifolia and related species. J. Nat. Prod. 55: 432-440 (1992).

Wildung MR, Croteau R. A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis. J. Biol. Chem. 271: 9201-9204 (1996).

Yeung TK, Germond C, Chen X, Wang Z. The mode of action of taxol: apoptosis at low concentration and necrosis at high concentration. Biochem. Biophys. Res. Commun. 263: 398-404 (1999).

Yoneda A, Higaki T, Kutsuna N, Kondo Y, Osada H, Hasezawa S, Matsui M. Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils. Plant Cell Physiol. 48: 1393-1403 (2007).

Yukimune Y, Tabata H, Higashi Y, Hara Y. Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures. Nat. Biotechnol. 14: 1129-1132 (1996).

Zamir LO, Zhang J, Wu J, Sauriol F, Mamer O. Five novel taxanes from Taxus canadensis. J. Nat. Prod. 62: 1268-1273 (1999).

Zocher R, Weckwerth W, Hacker C, Kammer B, Hornbogen T, Ewald D. Biosynthesis of taxol: enzymatic acetylation of 10-deacetylbaccatin-III to baccatin-III in crude extracts from roots of Taxus baccata. Biochem. Biophys. Res. Commun. 229: 16-20 (1996).

Number of references = 71