Abraham E, Rigo G, Szekely G, Nagy R, Koncz C, Szabados L. Light-dependent induction of proline biosynthesis by abscisic acid and salt stress is inhibited by brassinosteroid in Arabidopsis. Plant Mol. Biol. 51: 363-372 (2003).

Ambikapathy J, Marshall JS, Hocart CH, Hardham AR. The role of proline in osmoregulation in Phytophthora nicotianae. Fungal Genet. Biol. 35: 287-299 (2002).

Ankri S, Serebrijski I, Reyes O, Leblon G. Mutations in the Corynebacterium glutamicum proline biosynthetic pathway: a natural bypass of th proA step. J. Bacteriol. 178: 4412-4419 (1996).

Aral B, Schlenzig JS, Liu G, Kamoun P. Database cloning human delta1-pyrroline-5-carboxylate synthetase (P5CS) cDNA: a bifunctional enzyme catalyzing the first 2 steps in proline biosynthesis. C. R. Acad. Sci. III 319: 171-178 (1996).

Armengaud P, Thiery L, Buhot N, Grenier-De March G, Savoure A. Transcriptional regulation of proline biosynthesis in Medicago truncatula reveals developmental and environmental specific features. Physiol. Plant. 120: 442-450 (2004).

Ayliffe MA, Mitchell HJ, Deuschle K, Pryor AJ. Comparative analysis in cereals of a key proline catabolism gene. Mol. Genet. Genomics 274: 494-505 (2005).

Ayliffe MA, Roberts JK, Mitchell HJ, Zhang R, Lawrence GJ, Ellis JG, Pryor TJ. A plant gene up-regulated at rust infection sites. Plant Physiol. 129: 169-180 (2002).

Baumgartner MR, Hu CA, Steel J, Kamoun P, Saudubray JM, Valle D. A mutation of delta1-pyrroline-5-carboxylate synthase (P5CS) associated with hyperammonemia, hypocitrullinemia, hypoornithinemia and hypoprolinemia. Pediatr. Res. 47: 1404 (2000).

Baumgartner MR, Hu CAA, Almashanu S, Steel G, Obie C, Aral B, Rabier D, Kamoun P, Saudubray JM, Valle D. Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta1-pyrroline-5-carboxylate synthase. Hum. Mol. Genet. 9: 2853-2858 (2000).

Bearne SL, Hekmat O, Macdonnell JE. Inhibition of Escherichia coli CTP synthase by glutamate gamma-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis. Biochem. J. 356: 223-232 (2001).

Bearne SL, Wolfenden R. Glutamate gamma-semialdehyde as a natural transition state analogue inhibitor of Escherichia coli glucosamine-6-phosphate synthase. Biochemistry 34: 11515-11520 (1995).

Becker DF, Thomas EA. Redox properties of the PutA protein from Escherichia coli and the influence of the flavin redox state on PutA-DNA interactions. Biochemistry 40: 4714-4721 (2001).

Belitsky BR, Brill J, Bremer E, Sonenshein AL. Multiple genes for the last step of proline biosynthesis in Bacillus subtilis. J. Bacteriol. 183: 4389-4392 (2001).

Berteli F, Corrales E, Guerrero C, Ariza MJ, Pliego F, Valpuesta V. Salt stress increases ferredoxin-dependent glutamate synthase activity and protein level in the leaves of tomato. Physiol. Plant. 93: 259-264 (1995).

Bertolo RF, Burrin DG. Comparative aspects of tissue glutamine and proline metabolism. J. Nutr. 138: 2032S-2039S (2008).

Bicknell LS, Pitt J, Aftimos S, Ramadas R, Maw MA, Robertson SP. A missense mutation in ALDH18A1, encoding Delta(1)-pyrroline-5-carboxylate synthase (P5CS), causes an autosomal recessive neurocutaneous syndrome. Eur. J. Hum. Genet. 16: 1176-1186 (2008).

Black DS, Edwards GL, Evans RH, Keller PA, Laaman SM. Synthesis and reactivity of 1-pyrroline-5-carboxylate ester 1-oxides. Tetrahedron 56: 1889-1897 (2000).

Boer P, Sperling O. Stimulation of ribose-5-phosphate and 5-phosphoribosyl-1-pyrophosphate generation by pyrroline-5-carboxylate in mouse liver in vivo: evidence for a regulatory role of ribose-5-phosphate availability in nucleotide synthesis. Biochem. Med. Metab. Biol. 46: 28-32 (1991).

Brandriss MC. Isolation and preliminary characterization of Saccharomyces cerevisiae proline auxotrophs. J. Bacteriol. 138: 816-822 (1979).

Brandriss MC, Falvey DA. Proline biosynthesis in Saccharomyces cerevisiae: analysis of the PRO3 gene, which encodes delta1-pyrroline-5-carboxylate reductase. J. Bacteriol. 174: 3782-3788 (1992).

Brandriss MC, Magasanik B. Subcellular compartmentation in control of converging pathways for proline and arginine metabolism in Saccharomyces cerevisiae. J. Bacteriol. 145: 1359-1364 (1981).

Brandriss MC, Magasanik B. Genetics and physiology of proline utilization in Saccharomyces cerevisiae: enzyme induction by proline. J. Bacteriol. 140: 498-503 (1979).

Brandriss MC, Magasanik B. Proline: an essential intermediate in arginine degradation in Saccharomyces cerevisiae. J. Bacteriol. 143: 1403-1410 (1980).

Brandriss MC, Magasanik B. Genetics and physiology of proline utilization in Saccharomyces cerevisiae: mutation causing constitutive enzyme expression. J. Bacteriol. 140: 504-507 (1979).

Brown ED, Wood JM. Redesigned purification yields a fully functional PutA protein dimer from Escherichia coli. J. Biol. Chem. 267: 13086-13092 (1992).

Brown ED, Wood JM. Conformational change and membrane association of the PutA protein are coincident with reduction of its FAD cofactor by proline. J. Biol. Chem. 268: 8972-8979 (1993).

Buentello JA, Gatlin DM. Plasma citrulline and arginine kinetics in juvenile channel catfish, Ictalurus punctatus, given oral gabaculine. Fish Physiol. Biochem. 24: 105-112 (2001).

Camacho Barron M, Gonzalez de Mejia E. Comparative study of enzymes related to proline metabolism in tepary bean (Phaseolus acutifolius) and common bean (Phaseolus vulgaris) under drought and irrigated conditions, and various urea concentrations. Plant Foods Hum. Nutr. 52: 119-132 (1998).

Chang YC, Lee TM. High temperature-induced free proline accumulation in Gracilaria tenuistipitata (Rhodophyta). Bot. Bul. Acad. Sin. 40: 289-294 (1999).

Charlton S, Moir AJG, Baillie L, Moir A. Characterization of the exosporium of Bacillus cereus. J. Appl. Microbiol. 87: 241-245 (1999).

Chen CT, Chen LM, Lin CC, Kao CH. Regulation of proline accumulation in detached rice leaves exposed to excess copper. Plant Sci. 160: 283-290 (2001).

Chen JB, Wang SM, Jing RL, Mao XG. Cloning the PvP5CS gene from common bean (Phaseolus vulgaris) and its expression patterns under abiotic stresses. J. Plant Physiol. 166: 12-19 (2009).

Chen TH, Murata N. Enhancement of tolerance of abiotic stress by metabolic engineering of betaines and other compatible solutes. Curr. Opin. Plant Biol. 5: 250-257 (2002).

Chen Z, Hong X, Zhang H, Wang Y, Li X, Zhu JK, Gong Z. Disruption of the cellulose synthase gene, AtCesA8/IRX1, enhances drought and osmotic stress tolerance in Arabidopsis. Plant J. 43: 273-283 (2005).

Chilson OP, Kelly-Chilson AE, Siegel NR. Pyrroline-5-carboxylate reductase in soybean nodules: isolation/partial primary structure/evidence for isozymes. Arch. Biochem. Biophys. 288: 350-357 (1991).

Choudhary NL, Sairam RK, Tyagi A. Expression of delta1-pyrroline-5-carboxylate synthetase gene during drought in rice (Oryza sativa L ). Indian J. Biochem. Biophys. 42: 366-370 (2005).

Covic L, Silva NF, Lew RR. Functional characterization of ARAKIN (ATMEKK1): a possible mediator in an osmotic stress response pathway in higher plants. Biochim. Biophys. Acta 1451: 242-254 (1999).

Davis CR, McPeek MA, McClung CR. Molecular characterization of the proline-1 (pro-1) locus of Neurospora crassa, which encodes delta 1-pyrroline-5-carboxylate reductase. Mol. Gen. Genet. 248: 341-350 (1995).

de La Fuente JL, Rumbero A, Martin JF, Liras P. Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes. Biochem. J. 327: 59-64 (1997).

De Ronde JA, Cress WA, Kruger GH, Strasser RJ, Van Staden J. Photosynthetic response of transgenic soybean plants, containing an Arabidopsis P5CR gene, during heat and drought stress. J. Plant Physiol. 161: 1211-1224 (2004).

de Ronde JA, Spreeth MH, Cress WA. Effect of antisense L-delta1-pyrroline-5-carboxylate reductase transgenic soybean plants subjected to osmotic and drought stress. Plant Growth Regul. 32: 13-26 (2000).

Dekaney CM, Wu G, Jaeger LA. Ornithine aminotransferase messenger RNA expression and enzymatic activity in fetal porcine intestine. Pediatr. Res. 50: 104-109 (2001).

Delauney AJ, Hu CA, Kishor PB, Verma DP. Cloning of ornithine delta-aminotransferase cDNA from Vigna aconitifolia by trans-complementation in Escherichia coli and regulation of proline biosynthesis. J. Biol. Chem. 268: 18673-18678 (1993).

Delauney AJ, Verma DPS. Proline biosynthesis and osmoregulation in plants. Plant J. 4: 215-223 (1993).

Delvecchio VG, Connolly JP, Alefantis TG, Walz A, Quan MA, Patra G, Ashton JM, Whittington JT, Chafin RD, Liang X, Grewal P, Khan AS, Mujer CV. Proteomic profiling and identification of immunodominant spore antigens of Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis. Appl. Environ. Microbiol. 72: 6355-6363 (2006).

Deuschle K, Funck D, Forlani G, Stransky H, Biehl A, Leister D, van der Graaff E, Kunze R, Frommer WB. The role of [delta]1-pyrroline-5-carboxylate dehydrogenase in proline degradation. Plant Cell 16: 3413-3425 (2004).

Deuschle K, Funck D, Hellmann H, Daschner K, Binder S, Frommer WB. A nuclear gene encoding mitochondrial delta-pyrroline-5-carboxylate dehydrogenase and its potential role in protection from proline toxicity. Plant J. 27: 345-356 (2001).

Deutch CE, Klarstrom JL, Link CL, Ricciardi DL. Oxidation of L-thiazolidine-4-carboxylate by delta1-pyrroline-5-carboxylate reductase in Escherichia coli. Curr. Microbiol. 42: 442-446 (2001).

Deutch CE, O'Brien JM Jr, VanNieuwenhze MS. Identification of a trans-dominant mutation affecting proline dehydrogenase in Escherichia coli. Can. J. Microbiol. 31: 988-993 (1985).

Dluzniewska P, Gessler A, Dietrich H, Schnitzler JP, Teuber M, Rennenberg H. Nitrogen uptake and metabolism in Populus x canescens as affected by salinity. New Phytol. 173: 279-293 (2007).

Dombrowski JE, Baldwin JC, Martin RC. Cloning and characterization of a salt stress-inducible small GTPase gene from the model grass species Lolium temulentum. J. Plant Physiol. 165: 651-661 (2008).

Donald SP, Sun XY, Hu CA, Yu J, Mei JM, Valle D, Phang JM. Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species. Cancer Res. 61: 1810-1815 (2001).

Dougherty K, Hu CA, Obie C, Valle D. Molecular cloning, characterization and functional expression of a second mammalian delta1-pyrroline-5-carboxylate reductase. Am. J. Hum. Genet. 65: 493 (1999).

Dougherty KM, Brandriss MC, Valle D. Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae. J. Biol. Chem. 267: 871-875 (1992).

Facklam TJ, Marzluf GA. Nitrogen regulation of amino acid catabolism in Neurospora crassa. Biochem. Genet. 16: 343-354 (1978).

Fahmy AS, Mohamed SA, Girgis RB, Abdel-Ghaffar FA. Enzymes of delta 1-pyrroline-5-carboxylate metabolism in the camel tick Hyalomma dromedarii during embryogenesis. Purification and characterization of delta 1-pyrroline-5-carboxylate dehydrogenases. Comp. Biochem. Physiol. [B.] 118: 229-237 (1997).

Farmer JL, Bradshaw WS, Smith CS 3d. Characteristics of delta 1-pyrroline-5-carboxylate reductase from Drosophila melanogaster. Comp. Biochem. Physiol. B. 62: 143-146 (1979).

Fedina IS, Georgieva K, Grigorova I. Light-dark changes in proline content of barley leaves under salt stress. Biol. Plant. 45: 59-63 (2002).

Fleming GA, Hagedorn CH, Granger AS, Phang JM. Pyrroline-5-carboxylate in human plasma. Metabolism 33: 739-742 (1984).

Fleming GA, Steel G, Valle D, Granger AS, Phang JM. The aqueous humor of rabbit contains high concentrations of pyrroline-5-carboxylate. Metabolism 35: 933-937 (1986).

Fons M, Cami B, Chippaux M. Possible involvement of a L-delta 1-pyrroline-5-carboxylate (P5C) reductase in the synthesis of proline in Desulfovibrio desulfuricans Norway. Biochem. Biophys. Res. Commun. 179: 1088-1094 (1991).

Forlani G, Giberti S, Berlicki L, Petrollino D, Kafarski P. Plant P5C reductase as a new target for aminomethylenebisphosphonates. J. Agric. Food Chem. 55: 4340-4347 (2007).

Forlani G, Mangiagalli A, Pinter C, Nielsen E. Expression of delta(1)-pyrroline-5-carboxylate dehydrogenase and proline/arginine homeostasis in Solanum tuberosum. Physiol. Plant. 110: 22-27 (2000).

Forlani G, Occhipinti A, Berlicki L, Dziedziola G, Wieczorek A, Kafarski P. Tailoring the structure of aminobisphosphonates to target plant P5C reductase. J. Agric. Food Chem. 56: 3193-3199 (2008).

Forlani G, Scainelli D, Nielsen E. Delta(1)-pyrroline-5-carboxylate dehydrogenase from cultured cells of potato: purification and properties. Plant Physiol. 113: 1413-1418 (1997).

Forlani G, Scainelli D, Nielsen E. Two delta(1)-pyrroline-5-carboxylate dehydrogenase isoforms are expressed in cultured Nicotiana plumbaginifolia cells and are differentially modulated during the culture growth cycle. Planta 202: 242-248 (1997).

Franco OL, Melo FR. Osmoprotectants - A plant strategy in response to osmotic stress. Russ. J. Plant Physiol. 47: 137-144 (2000).

Fujii T, Mukaihara M, Agematu H, Tsunekawa H. Biotransformation of L-lysine to L-pipecolic acid catalyzed by L-lysine 6-aminotransferase and pyrroline-5-carboxylate reductase. Biosci. Biotechnol. Biochem. 66: 622-627 (2002).

Fujita T, Maggio A, Garcia-Rios M, Bressan RA, Csonka LN. Comparative analysis of the regulation of expression and structures of two evolutionarily divergent genes for delta1-pyrroline-5-carboxylate synthetase from tomato. Plant Physiol. 118: 661-674 (1998).

Funck D, Stadelhofer B, Koch W. Ornithine-delta-aminotransferase is essential for arginine catabolism but not for proline biosynthesis. BMC Plant Biol. 8: 40 (2008).

Geraghty MT, Vaughn D, Nicholson AJ, Lin WW, Jimenez-Sanchez G, Obie C, Flynn MP, Valle D, Hu CA. Mutations in the delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia. Hum. Mol. Genet. 7: 1411-1415 (1998).

Gilmour SJ, Sebolt AM, Salazar MP, Everard JD, Thomashow MF. Overexpression of the Arabidopsis CBF3 transcriptional activator mimics multiple biochemical changes associated with cold acclimation. Plant Physiol. 124: 1854-1865 (2000).

Ginzberg I, Stein H, Kapulnik Y, Szabados L, Strizhov N, Schell J, Koncz C, Zilberstein A. Isolation and characterization of two different cDNAs of delta1-pyrroline-5-carboxylate synthase in alfalfa, transcriptionally induced upon salt stress. Plant Mol. Biol. 38: 755-764 (1998).

Goyer A, Johnson TL, Olsen LJ, Collakova E, Shachar-Hill Y, Rhodes D, Hanson AD. Characterization and metabolic function of a peroxisomal sarcosine and pipecolate oxidase from Arabidopsis. J. Biol. Chem. 279: 16947-16953 (2004).

Hagedorn CH. Demonstration of a NADPH-linked delta 1-pyrroline-5-carboxylate-proline shuttle in a cell-free rat liver system. Biochim. Biophys. Acta 884: 11-17 (1986).

Hagedorn CH, Phang JM. Catalytic transfer of hydride ions from NADPH to oxygen by the interconversions of proline and delta 1-pyrroline-5-carboxylate. Arch. Biochem. Biophys. 248: 166-174 (1986).

Hagedorn CH, Phang JM. Transfer of reducing equivalents into mitochondria by the interconversions of proline and delta 1-pyrroline-5-carboxylate. Arch. Biochem. Biophys. 225: 95-101 (1983).

Hagedorn CH, Yeh GC, Phang JM. Transfer of 1-pyrroline-5-carboxylate as oxidizing potential from hepatocytes to erythrocytes. Biochem. J. 202: 31-39 (1982).

Hao B, Gong WM, Ferguson TK, James CM, Krzycki JA, Chan MK. A new UAG-encoded residue in the structure of a methanogen methyltransferase. Science 296: 1462-1466 (2002).

Hare PD, Cress WA. Metabolic implications of stress-induced proline accumulation in plants. Plant Growth Regulation 21: 79-102 (1997).

Hare PD, Cress WA, van Staden J. Proline synthesis and degradation: a model system for elucidating stress-related signal transduction. J. Exp. Bot. 50: 413-434 (1999).

Haslett MR, Brosnan ME. Assay and subcellular localization of delta1-pyrroline-5 carboxylate dehydrogenase in rat liver. FASEB J. 16: A918-A918 (2002).

Hayashi F, Ichino T, Osanai M, Wada K. Oscillation and regulation of proline content by P5CS and ProDH gene expressions in the light/dark cycles in Arabidopsis thaliana L. Plant Cell Physiol. 41: 1096-1101 (2000).

Hayzer DJ, Leisinger T. The gene-enzyme relationships of proline biosynthesis in Escherichia coli. J. Gen. Microbiol. 118: 287-293 (1980).

Hayzer DJ, Moses V. Proline biosynthesis by cell-free extracts of Escherichia coli and potential errors arising from the use of a bioradiological assay procedure. Biochem. J. 173: 207-217 (1978).

Hellmann H, Funck D, Rentsch D, Frommer WB. Hypersensitivity of an Arabidopsis sugar signaling mutant toward exogenous proline application. Plant Physiol. 122: 357-368 (2000).

Hellmann H, Funck D, Rentsch D, Frommer WB. Hypersensitivity of an Arabidopsis sugar signaling mutant toward exogenous proline application. Plant Physiol. 123: 779-790 (2000).

Henslee JG, Wakabayashi Y, Small C, Jones ME. Factors influencing pyrroline 5-carboxylate synthesis from glutamate by rat intestinal mucosa mitochondria. Arch. Biochem. Biophys. 226: 693-703 (1983).

Herzfeld A, Mezl VA, Knox WE. Enzymes metabolizing delta1-pyrroline-5-carboxylate in rat tissues. Biochem. J. 166: 95-103 (1977).

Hmida-Sayari A, Gargouri-Bouzid R, Bidani A, Jaoua L, Savoure A, Jaoua S. Overexpression of Delta(1)-pyrroline-5-carboxylate synthetase increases proline production and confers salt tolerance in transgenic potato plants. Plant Sci. 169: 746-752 (2005).

Hong Z, Lakkineni K, Zhang Z, Verma DP. Removal of feedback inhibition of delta(1)-pyrroline-5-carboxylate synthetase results in increased proline accumulation and protection of plants from osmotic stress. Plant Physiol. 122: 1129-1136 (2000).

Hoshino T, Kosuge T, Hidaka Y, Tabata K, Nakahara T. Molecular cloning and sequence analysis of the proC gene encoding delta 1-pyrroline-5-carboxylate reductase from an extremely thermophilic eubacterium Thermus thermophilus. Biochem. Biophys. Res. Commun. 199: 410-417 (1994).

Hu CA, Bart Williams D, Zhaorigetu S, Khalil S, Wan G, Valle D. Functional genomics and SNP analysis of human genes encoding proline metabolic enzymes. Amino Acids 35: 655-664 (2008).

Hu CA, Delauney AJ, Verma DP. A bifunctional enzyme (delta 1-pyrroline-5-carboxylate synthetase) catalyzes the first two steps in proline biosynthesis in plants. Proc. Natl. Acad. Sci. U.S.A. 89: 9354-9358 (1992).

Hu CA, Khalil S, Zhaorigetu S, Liu Z, Tyler M, Wan G, Valle D. Human Delta1-pyrroline-5-carboxylate synthase: function and regulation. Amino Acids 35: 665-672 (2008).

Hu CA, Lin WW, Obie C, Valle D. Molecular enzymology of mammalian delta1-pyrroline-5-carboxylate synthase. Alternative splice donor utilization generates isoforms with different sensitivity to ornithine inhibition. J. Biol. Chem. 274: 6754-6762 (1999).

Hu CA, Lin WW, Valle D. Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase. J. Biol. Chem. 271: 9795-9800 (1996).

Hua X, van de Cotte B, Van Montagu M, Verbruggen N. A 69 bp fragment in the pyrroline-5-carboxylate reductase promoter of Arabidopsis thaliana activates minimal CaMV 35S promoter in a tissue-specific manner. FEBS Lett. 458: 193-196 (1999).

Hua XJ, van de Cotte B, Van Montagu M, Verbruggen N. Developmental regulation of pyrroline-5-carboxylate reductase gene expression in Arabidopsis. Plant Physiol. 114: 1215-1224 (1997).

Hua XJ, Van De Cotte B, Van Montagu M, Verbruggen N. The 5' untranslated region of the At-P5R gene is involved in both transcriptional and post-transcriptional regulation. Plant J. 26: 157-169 (2001).

Hughes V, Smith S, Garcia-Sanchez A, Sales J, Stevenson K. Proteomic comparison of Mycobacterium avium subspecies paratuberculosis grown in vitro and isolated from clinical cases of ovine paratuberculosis. Microbiology 153: 196-205 (2007).

Humbertclaude V, Rivier F, Roubertie A, Echenne B, Bellet H, Vallat C, Morin D. Is hyperprolinemia type I actually a benign trait? Report of a case with severe neurologic involvement and vigabatrin intolerance. J. Child Neurol. 16: 622-623 (2001).

Igarashi Y, Yoshiba Y, Sanada Y, Yamaguchi-Shinozaki K, Wada K, Shinozaki K. Characterization of the gene for delta1-pyrroline-5-carboxylate synthetase and correlation between the expression of the gene and salt tolerance in Oryza sativa L. Plant Mol. Biol. 33: 857-865 (1997).

Igarashi Y, Yoshiba Y, Takeshita T, Nomura S, Otomo J, Yamaguchi-Shinozaki K, Shinozaki K. Molecular cloning and characterization of a cDNA encoding proline transporter in rice. Plant Cell Physiol. 41: 750-756 (2000).

Inagaki E, Ohshima N, Sakamoto K, Babayeva ND, Kato H, Yokoyama S, Tahirov TH. New insights into the binding mode of coenzymes: structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase complexed with NADP+. Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 63: 462-465 (2007).

Inagaki E, Ohshima N, Takahashi H, Kuroishi C, Yokoyama S, Tahirov T. Crystal structure of Thermus thermophilus Delta(1)-pyrroline-5-carboxylate dehydrogenase. J. Mol. Biol. 362: 490-501 (2006).

Iyer S, Caplan A. Products of proline catabolism can induce osmotically regulated genes in rice. Plant Physiol. 116: 203-211 (1998).

Jimenez-Zurdo JI, Garcia-Rodriguez FM, Toro N. The Rhizobium meliloti putA gene: its role in the establishment of the symbiotic interaction with alfalfa. Mol. Microbiol. 23: 85-93 (1997).

Jones ME. Conversion of glutamate to ornithine and proline: pyrroline-5-carboxylate, a possible modulator of arginine requirements. J. Nutr. 115: 509-515 (1985).

Kamoun P, Aral B, Saudubray JM. A new inherited metabolic disease: delta1-pyrroline 5-carboxylate synthetase deficiency. Bull. Acad. Natl. Med. 182: 131-137 (1998).

Kelly R, Register E. Isolation and sequence analysis of the cDNA encoding delta 1-pyrroline-5-carboxylate reductase from Zalerion arboricola. Gene 172: 149-153 (1996).

Kenklies J, Ziehn R, Fritsche K, Pich A, Andreesen JR. Proline biosynthesis from L-ornithine in Clostridium sticklandii: purification of delta1-pyrroline-5-carboxylate reductase, and sequence and expression of the encoding gene, proC. Microbiology 145: 819-826 (1999).

Keuntje B, Masepohl B, Klipp W. Expression of the putA gene encoding proline dehydrogenase from Rhodobacter capsulatus is independent of NtrC regulation but requires an Lrp-like activator protein. J. Bacteriol. 177: 6432-6439 (1995).

Kim DW, Shibato J, Agrawal GK, Fujihara S, Iwahashi H, Kim du H, Shim IeS, Rakwal R. Gene transcription in the leaves of rice undergoing salt-induced morphological changes (Oryza sativa L.). Mol. Cells 24: 45-59 (2007).

Kim HR, Rho HW, Park JW, Park BH, Kim JS, Lee MW. Assay of ornithine aminotransferase with ninhydrin. Anal. Biochem. 223: 205-207 (1994).

Kishor PBK, Hong Z, Miao G-H, Hu C-AA, Verma DPS. Overexpression of delta1-pyrroline-5-carboxylate synthetase increases proline production and confers osmotolerance in transgenic plants. Plant Physiol. 108: 1387-1394 (1995).

Knight H, Trewavas AJ, Knight MR. Calcium signalling in Arabidopsis thaliana responding to drought and salinity. Plant J. 12: 1067-1078 (1997).

Kocsy G, Laurie R, Szalai G, Szilagyi V, Simon-Sarkadi L, Galiba G, de Ronde JA. Genetic manipulation of proline levels affects antioxidants in soybean subjected to simultaneous drought and heat stresses. Physiol. Plant. 124: 227-235 (2005).

Kohl DH, Schubert KR, Carter MB, Hagedorn CH, Shearer G. Proline metabolism in N2-fixing root nodules: energy transfer and regulation of purine synthesis. Proc. Natl. Acad. Sci. U.S.A. 85: 2036-2040 (1988).

Krishna RV, Beilstein P, Leisinger T. Biosynthesis of proline in Pseudomonas aeruginosa: Properties of gamma-glutamyl phosphate reductase and 1-pyrroline-5-carboxylate reductase. Biochem. J. 181: 223-230 (1979).

Krishnan N, Dickman MB, Becker DF. Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress. Free Radic. Biol. Med. 44: 671-681 (2008).

Krueger R, Jager H-J, Hintz M, Pahlich E. Purification to homogeneity of pyrroline-5-carboxylate reductase of barley. Plant Physiol. 80: 142-144 (1986).

Kukreja N, Singh BP, Arora N, Gaur SN, Sridhara S. Identification of Epicoccum purpurascens allergens by two-dimensional immunoblotting and mass spectrometry. Immunobiology 213: 65-73 (2008).

Kumar SG, Reddy AM, Sudhakar C. NaCl effects on proline metabolism in two high yielding genotypes of mulberry (Morus alba L.) with contrasting salt tolerance. Plant Sci. 165: 1245-1251 (2003).

LaRosa PC, Rhodes D, Rhodes JC, Bressan RA, Csonka LN. Elevated accumulation of proline in NaCl-adapted tobacco cells is not due to altered delta1-pyrroline-5-carboxylate reductase. Plant Physiol. 96: 245-250 (1991).

Limauro D, Falciatore A, Basso AL, Forlani G, DeFelice M. Proline biosynthesis in Streptococcus thermophilus: Characterization of the proBA operon and its products. Microbiology 142: 3275-3282 (1996).

Lin CC, Kao CH. Regulation of ammonium-induced proline accumulation in detached rice leaves. Plant Growth Regul. 35: 69-74 (2001).

Ling M, Allen SW, Wood JM. Sequence analysis identifies the proline dehydrogenase and delta 1-pyrroline-5-carboxylate dehydrogenase domains of the multifunctional Escherichia coli PutA protein. J. Mol. Biol. 243: 950-956 (1994).

Lodato RF, Smith RJ, Valle D, Phang JM, Aoki TT. Regulation of proline biosynthesis: the inhibition of pyrroline-5-carboxylate synthase activity by ornithine. Metabolism 30: 908-913 (1981).

Lodato RF, Smith RJ, Valle DL, Crane K. Mutant cell lines resistant to azetidine-2-carboxylic acid: alterations in the synthesis of proline from glutamic acid. J. Cell Physiol. 119: 137-143 (1984).

Maggio A, Miyazaki S, Veronese P, Fujita T, Ibeas JI, Damsz B, Narasimhan ML, Hasegawa PM, Joly RJ, Bressan RA. Does proline accumulation play an active role in stress-induced growth reduction? Plant J. 31: 699-712 (2002).

Mani S, Van de Cotte B, Van Montagu M, Verbruggen N. Altered levels of proline dehydrogenase cause hypersensitivity to proline and its analogs in Arabidopsis. Plant Physiol. 128: 73-83 (2002).

Marczak JE, Brandriss MC. Isolation of constitutive mutations affecting the proline utilization pathway in Saccharomyces cerevisiae and molecular analysis of the PUT3 transcriptional activator. Mol. Cell Biol. 9: 4696-4705 (1989).

Matsuzawa T. Purification and characterization of pyrroline-5-carboxylate reductase from bovine retina. Biochim. Biophys. Acta 717: 215-219 (1982).

Matsuzawa T. Disease of the ornithine-proline pathway: delta 1-pyrroline-5-carboxylate reductase deficiency in the retina of retinal degeneration mice. Metab. Pediatr. Syst. Ophthalmol. 6: 123-128 (1982).

Matsuzawa T, Ishiguro I. Delta 1-pyrroline-5-carboxylate reductase from baker's yeast: further purification by affinity chromatography with 5' AMP-Sepharose 4B. Biochim. Biophys. Acta 616: 381-383 (1980).

Matsuzawa T, Ishiguro I. Delta 1-pyrroline-5-carboxylate reductase from baker's yeast. Purification, properties and its application in the assays of L-delta 1-pyrroline-5-carboxylate and L-ornithine in tissue. Biochim. Biophys. Acta 613: 318-323 (1980).

Mattana M, Biazzi E, Consonni R, Locatelli F, Vannini C, Provera S, Coraggio I. Overexpression of Osmyb4 enhances compatible solute accumulation and increases stress tolerance of Arabidopsis thaliana. Physiol. Plant. 125: 212-223 (2005).

Maxwell SA, Davis GE. Differential gene expression in p53-mediated apoptosis- resistant vs. apoptosis-sensitive tumor cell lines. Proc. Natl. Acad. Sci. U.S.A. 97: 13009-13014 (2000).

McKnight JA, Hird FJ. The oxidation of proline by mitochondrial preparations. Comp. Biochem. Physiol. [B.] 85: 289-294 (1986).

Meile L, Leisinger T. Purification and properties of the bifunctional proline dehydrogenase/1-pyrroline-5-carboxylate dehydrogenase from Pseudomonas aeruginosa. Eur. J. Biochem. 129: 67-75 (1982).

Meile L, Soldati L, Leisinger T. Regulation of proline catabolism in Pseudomonas aeruginosa PAO. Arch. Microbiol. 132: 189-193 (1982).

Meng Z, Lou Z, Liu Z, Li M, Zhao X, Bartlam M, Rao Z. Crystal structure of human pyrroline-5-carboxylate reductase. J. Mol. Biol. 359: 1364-1377 (2006).

Merrill MJ, Yeh GC, Phang JM. Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. J. Biol. Chem. 264: 9352-9358 (1989).

Miller G, Honig A, Stein H, Suzuki N, Mittler R, Zilberstein A. Unraveling delta1-pyrroline-5-carboxylate-proline cycle in plants by uncoupled expression of proline oxidation enzymes. J. Biol. Chem. 284: 26482-26492 (2009).

Miller G, Stein H, Honig A, Kapulnik Y, Zilberstein A. Responsive modes of Medicago sativa proline dehydrogenase genes during salt stress and recovery dictate free proline accumulation. Planta 222: 70-79 (2005).

Milner JL, McClellan DJ, Wood JM. Factors reducing and promoting the effectiveness of proline as an osmoprotectant in Escherichia coli K12. J. Gen. Microbiol. 133: 1851-1860 (1987).

Miltyk W, Palka JA. Potential role of pyrroline 5-carboxylate in regulation of collagen biosynthesis in cultured human skin fibroblasts. Comp. Biochem. Physiol. [A] 125: 265-271 (2000).

Misener SR, Chen C, Walker VK. Cold tolerance and proline metabolic gene expression in Drosophila melanogaster. J. Insect Physiol. 47: 393-400 (2001).

Misener SR, Walker VK. Extraordinarily high density of unrelated genes showing overlapping and intraintronic transcription units. Biochim. Biophys. Acta 1492: 269-270 (2000).

Misener SR, Walker VK. Complementation cloning and characterization of the pyrroline 5-carboxylate reductase gene from Drosophila melanogaster. Biochem. Genet. 39: 15-31 (2001).

Misra N, Gupta AK. Effect of salt stress on proline metabolism in two high yielding genotypes of green gram. Plant Sci. 169: 331-339 (2005).

Mitchell HJ, Ayliffe MA, Rashid KY, Pryor AJ. A rust-inducible gene from flax (fis1) is involved in proline catabolism. Planta 223: 213-222 (2006).

Mixson AJ, Phang JM. Structural analogues of pyrroline 5-carboxylate specifically inhibit its uptake into cells. J. Membr. Biol. 121: 269-277 (1991).

Mixson AJ, Phang JM. The uptake of pyrroline 5-carboxylate. Group translocation mediating the transfer of reducing-oxidizing potential. J. Biol. Chem. 263: 10720-10724 (1988).

Mohamed SA, Mohamed TM, Fahmy AS, El-Badry MO, Abdel-Gany SS. Fasciola gigantica: enzymes of the ornithine-proline-glutamate pathway - characterization of delta1-pyrroline-5-carboxylate dehydrogenase. Exp. Parasitol. 118: 47-53 (2008).

Morris JG. Nutritional and metabolic responses to arginine deficiency in carnivores. J. Nutr. 115: 524-531 (1985).

Murahama M, Yoshida T, Hayashi F, Ichino T, Sanada Y, Wada K. Purification and characterization of delta1-pyrroline-5- carboxylate reductase isoenzymes, indicating differential distribution in spinach (Spinacia oleracea L.) leaves. Plant Cell Physiol. 42: 742-750 (2001).

Muro-Pastor AM, Maloy S. Proline dehydrogenase activity of the transcriptional repressor PutA is required for induction of the put operon by proline. J. Biol. Chem. 270: 9819-9827 (1995).

Nadaraia S, Lee YH, Becker DF, Tanner JJ. Crystallization and preliminary crystallographic analysis of the proline dehydrogenase domain of the multifunctional PutA flavoprotein from Escherichia coli. Acta Crystallogr. Sect. D-Biol. Crystallogr. 57: 1925-1927 (2001).

Nanjo T, Kobayashi M, Yoshiba Y, Sanada Y, Wada K, Tsukaya H, Kakubari Y, Yamaguchi-Shinozaki K, Shinozaki K. Biological functions of proline in morphogenesis and osmotolerance revealed in antisense transgenic Arabidopsis thaliana. Plant J. 18: 185-193 (1999).

Nocek B, Chang C, Li H, Lezondra L, Holzle D, Collart F, Joachimiak A. Crystal structures of delta1-pyrroline-5-carboxylate reductase from human pathogens Neisseria meningitides and Streptococcus pyogenes. J. Mol. Biol. 354: 91-106 (2005).

Nomura M, Takagi H. Role of the yeast acetyltransferase Mpr1 in oxidative stress: regulation of oxygen reactive species caused by a toxic proline catabolism intermediate. Proc. Natl. Acad. Sci. U.S.A. 101: 12616-12621 (2004).

O'Quinn PR, Knabe DA, Wu G. Arginine catabolism in lactating porcine mammary tissue. J. Anim. Sci. 80: 467-474 (2002).

Obungu VH, Kiaira JK, Njogu RM, Olembo NK. Catabolism of proline by procyclic culture forms of Trypanosoma congolense. Comp. Biochem. Physiol. [B] 123: 59-65 (1999).

Parre E, Ghars MA, Leprince AS, Thiery L, Lefebvre D, Bordenave M, Richard L, Mazars C, Abdelly C, Savoure A. Calcium signaling via phospholipase C is essential for proline accumulation upon ionic but not nonionic hyperosmotic stresses in Arabidopsis. Plant Physiol. 144: 503-512 (2007).

Parvanova D, Ivanov S, Konstantinova T, Karanov E, Atanassov A, Tsvetkov T, Alexieva V, Djilianov D. Transgenic tobacco plants accumulating osmolytes show reduced oxidative damage under freezing stress. Plant Physiol. Biochem. 42: 57-63 (2004).

Peng Z, Lu Q, Verma DP. Reciprocal regulation of delta1-pyrroline-5-carboxylate synthetase and proline dehydrogenase genes controls proline levels during and after osmotic stress in plants. Mol. Gen. Genet. 253: 334-341 (1996).

Perozich J, Nicholas H, Lindahl R, Hempel J. The big book of aldehyde dehydrogenase sequences - An overview of the extended family. Adv.Exp.Med.Biol. 463: 1-7 (1999).

Phang JM, Downing SJ, Valle D. A radioisotopic assay for delta1-pyrroline-5-carboxylate reductase. Anal. Biochem. 55: 266-271 (1973).

Phang JM, Downing SJ, Valle DL, Kowaloff EM. A radioisotopic assay for proline oxidase activity. J. Lab. Clin. Med. 85: 312-317 (1975).

Phang JM, Downing SJ, Yeh GC, Smith RJ, Williams JA, Hagedorn CH. Stimulation of the hexosemonophosphate-pentose pathway by pyrroline-5-carboxylate in cultured cells. J. Cell Physiol. 110: 255-261 (1982).

Phutela A, Jain V, Dhawan K, Nainawatee HS. Proline metabolism under water stress in the leaves and roots of Brassica juncea cultivars differing in drought tolerance. J. Plant Biochem. Biotechnol. 9: 35-39 (2000).

Pileggi M, Pereiara AAM, Silva JD, Pileggi SAV, Verma DPS. An improved method for transformation of lettuce by Agrobacterium tumefaciens with a gene that confers freezing resistance. Braz. Arch. Biol. Technol. 44: 191-196 (2001).

Popova YG, Padkina MV, Sambuk EV. Effect of mutations in genes PH085 and PH04 on proline utilization in yeast Saccharomyces cerevisiae. Russ. J. Genet. 36: 1364-1369 (2000).

Quintero MJ, Muro-Pastor AM, Herrero A, Flores E. Arginine catabolism in the cyanobacterium Synechocystis sp. strain PCC 6803 involves the urea cycle and arginase pathway. J. Bacteriol. 182: 1008-1015 (2000).

Ramanjulu S, Sudhakar C. Proline metabolism during dehydration in two mulberry genotypes with contrasting drought tolerance. J. Plant Physiol. 157: 81-85 (2000).

Rayapati PJ, Stewart CR, Hack E. Pyrroline-5-carboxylate reductase is in pea (Pisum sativum L.) leaf chloroplasts. Plant Physiol. 91: 581-586 (1989).

Raymond MJ, Smirnoff N. Proline metabolism and transport in maize seedlings at low water potential. Ann. Bot. (Lond.) 89: 813-823 (2002).

Rivero RM, Ruiz JM, Romero LM. Importance of N source on heat stress tolerance due to the accumulation of proline and quaternary ammonium compounds in tomato plants. Plant Biol. (Stuttg.) 6: 702-707 (2004).

Roosens NH, Al Bitar F, Loenders K, Angenon G, Jacobs M. Overexpression of ornithine-delta-aminotransferase increases proline biosynthesis and confers osmotolerance in transgenic plants. Mol. Breed. 9: 73-80 (2002).

Roosens NH, Thu TT, Iskandar HM, Jacobs M. Isolation of the ornithine-delta-aminotransferase cDNA and effect of salt stress on its expression in Arabidopsis thaliana. Plant Physiol. 117: 263-271 (1998).

Roosens NH, Willem R, Li Y, Verbruggen I, Biesemans M, Jacobs M. Proline metabolism in the wild-type and in a salt-tolerant mutant of Nicotiana plumbaginifolia studied by 13C-nuclear magnetic resonance imaging. Plant Physiol. 121: 1281-1290 (1999).

Rossi JJ, Vender J, Berg CM, Coleman WH. Partial purification and some properties of delta1-pyrroline-5-carboxylate reductase from Escherichia coli. J. Bacteriol. 129: 108-114 (1977).

Sakuraba H, Takamatsu Y, Satomura T, Kawakami R, Ohshima T. Purification, characterization, and application of a novel dye- linked L-proline dehydrogenase from a hyperthermophilic archaeon, Thermococcus profundus. Appl. Environ. Microbiol. 67: 1470-1475 (2001).

Samuels SE, Acton KS, Ball RO. Pyrroline-5-carboxylate reductase and proline oxidase activity in the neonatal pig. J. Nutr. 119: 1999-2004 (1989).

Sanchez E, Lopez-Lefebre LR, Garcia PC, Rivero RM, Ruiz JM, Romero L. Proline metabolism in response to highest nitrogen dosages in green bean plants (Phaseolus vulgaris L. cv. Strike). J. Plant Physiol. 158: 593-598 (2001).

Sanchez E, Ruiz JM, Romero L. Proline metabolism in response to nitrogen toxicity in fruit of French Bean plants (Phaseolus vulgaris L. cv Strike). Sci. Hortic. 93: 225-233 (2002).

Sanchez E, Ruiz JM, Romero L. The response of proline metabolism to nitrogen deficiency in pods and seeds of French bean (Phaseolus vulgaris L cv Strike) plants. J. Sci. Food Agric. 81: 1471-1475 (2001).

Santos CV, Falcao IP, Pinto GC, Oliveira H, Loureiro J. Nutrient responses and glutamate and proline metabolism in sunflower plants and calli under Na2SO4 stress. J. Plant Nutr. Soil Sci.-Z. Pflanzenernahr. Bodenkd. 165: 366-372 (2002).

Saum SH, Muller V. Salinity-dependent switching of osmolyte strategies in a moderately halophilic bacterium: glutamate induces proline biosynthesis in Halobacillus halophilus. J. Bacteriol. 189: 6968-6975 (2007).

Savioz A, Jeenes DJ, Kocher HP, Haas D. Comparison of proC and other housekeeping genes of Pseudomonas aeruginosa with their counterparts in Escherichia coli. Gene 86: 107-111 (1990).

Savoure A, Jaoua S, Hua XJ, Ardiles W, Van Montagu M, Verbruggen N. Isolation, characterization, and chromosomal location of a gene encoding the delta 1-pyrroline-5-carboxylate synthetase in Arabidopsis thaliana. FEBS Lett. 372: 13-19 (1995).

Sawahel WA, Hassan AH. Generation of transgenic wheat plants producing high levels of the osmoprotectant proline. Biotechnol. Lett. 24: 721-725 (2002).

Scaraffia PY, Isoe J, Murillo A, Wells MA. Ammonia metabolism in Aedes aegypti. Insect Biochem. Mol. Biol. 35: 491-503 (2005).

Schulke N, Sepuri NBV, Gordon DM, Saxena S, Dancis A, Pain D. A multisubunit complex of outer and inner mitochondrial membrane protein translocases stabilized in vivo by translocation intermediates. J. Biol. Chem. 274: 22847-22854 (1999).

Seddon AP, Zhao KY, Meister A. Activation of glutamate by gamma-glutamate kinase: formation of gamma-cis-cycloglutamyl phosphate, an analog of gamma-glutamyl phosphate. J. Biol. Chem. 264: 11326-11335 (1989).

Sekhar PN, Amrutha RN, Sangam S, Verma DP, Kishor PB. Biochemical characterization, homology modeling and docking studies of ornithine delta-aminotransferase--an important enzyme in proline biosynthesis of plants. J. Mol. Graph Model. 26: 709-719 (2007).

Shaw BP, Rout NP. Hg and Cd induced changes in proline content and activities of proline biosynthesizing enzymes in Phaseolus aureus and Triticum aestivum. Biol. Plant. 45: 267-271 (2002).

Shearer G, Jones JR, Kohl DH. The consequences of the isotope effect on proline dehydrogenation rates estimated by the tritium loss method. Anal. Biochem. 203: 191-200 (1992).

Shen BW, Hennig M, Hohenester E, Jansonius JN, Schirmer T. Crystal structure of human recombinant ornithine aminotransferase. J. Mol. Biol. 277: 81-102 (1998).

Shiono T, Kador PF, Kinoshita JH. Stimulation of the hexose monophosphate pathway by pyrroline-5-carboxylate reductase in the lens. Exp. Eye Res. 41: 767-775 (1985).

Shiono T, Kador PF, Kinoshita JJ. Purification and characterization of rat lens pyrroline-5-carboxylate reductase. Biochim. Biophys. Acta 881: 72-78 (1986).

Silva-Ortega CO, Ochoa-Alfaro AE, Reyes-Aguero JA, Aguado-Santacruz GA, Jimenez-Bremont JF. Salt stress increases the expression of P5CS gene and induces proline accumulation in cactus pear. Plant Physiol. Biochem. 46: 82-92 (2008).

Siripornadulsil S, Traina S, Verma DP, Sayre RT. Molecular mechanisms of proline-mediated tolerance to toxic heavy metals in transgenic microalgae. Plant Cell 14: 2837-2847 (2002).

Sleator RD, Gahan CGM, Hill C. Mutations in the listerial proB gene leading to proline overproduction: Effects on salt tolerance and murine infection. Appl. Environ. Microbiol. 67: 4560-4565 (2001).

Small C, Jones ME. A specific radiochemical assay for pyrroline-5-carboxylate dehydrogenase. Anal. Biochem. 161: 380-386 (1987).

Small WC, Jones ME. A quantitative colorimetric assay for semialdehydes. Anal. Biochem. 185: 156-159 (1990).

Small WC, Jones ME. Pyrroline 5-carboxylate dehydrogenase of the mitochondrial matrix of rat liver. Purification, physical and kinetic characteristics. J. Biol. Chem. 265: 18668-18672 (1990).

Smith DD, Wood NJ, Hodgson DA. Interaction between primary and secondary metabolism in Streptomyces coelicolor A3(2): role of pyrroline-5-carboxylate dehydrogenase. Microbiology 141: 1739-1744 (1995).

Smith RJ. A radioisotopic assay for delta 1-pyrroline-5-carboxylate synthase activity. Enzyme 31: 115-121 (1984).

Smith RJ, Downing SJ, Phang JM, Lodato RF, Aoki TT. Pyrroline-5-carboxylate synthase activity in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 77: 5221-5225 (1980).

Stines AP, Naylor DJ, Hoj PB, van Heeswijck R. Proline accumulation in developing grapevine fruit occurs independently of changes in the levels of delta1-pyrroline-5-carboxylate synthetase mRNA or protein. Plant Physiol. 120: 923-931 (1999).

Straub PF, Reynolds PH, Althomsons S, Mett V, Zhu Y, Shearer G, Kohl DH. Isolation, DNA sequence analysis, and mutagenesis of a proline dehydrogenase gene (putA) from Bradyrhizobium japonicum. Appl. Environ. Microbiol. 62: 221-229 (1996).

Strizhov N, Abraham E, Okresz L, Blickling S, Zilberstein A, Schell J, Koncz C, Szabados L. Differential expression of two P5CS genes controlling proline accumulation during salt-stress requires ABA and is regulated by ABA1, ABI1 and AXR2 in Arabidopsis. Plant J. 12: 557-569 (1997).

Sudhakar C, Reddy PS, Veeranjaneyuluk. Effect of salt stress on the enzymes of proline synthesis and oxidation in greengram (Phaseolus aureus Roxb) seedlings. J. Plant Physiol. 141: 621-623 (1993).

Surber MW, Maloy S. The PutA protein of Salmonella typhimurium catalyzes the two steps of proline degradation via a leaky channel. Arch. Biochem. Biophys. 354: 281-287 (1998).

Szekely G, Abraham E, Cseplo A, Rigo G, Zsigmond L, Csiszar J, Ayaydin F, Strizhov N, Jasik J, Schmelzer E, Koncz C, Szabados L. Duplicated P5CS genes of Arabidopsis play distinct roles in stress regulation and developmental control of proline biosynthesis. Plant J. 53: 11-28 (2008).

Szoke A, Miao G-H, Hong Z, Verma DPS. Subcellular location of delta1-pyrroline-5-carboxylate reductase in root/nodule and leaf of soybean. Plant Physiol. 99: 1642-1649 (1992).

Tanner JJ. Structural biology of proline catabolism. Amino Acids 35: 719-730 (2008).

Tateishi Y, Nakagawa T, Esaka M. Osmotolerance and growth stimulation of transgenic tobacco cells accumulating free proline by silencing proline dehydrogenase expression with double-stranded RNA interference technique. Physiol. Plant. 125: 224-234 (2005).

Thiery L, Leprince AS, Lefebvre D, Ali Ghars M, Debarbieux E, Savoure A. Phospholipase D is a negative regulator of proline biosynthesis in Arabidopsis thaliana. J. Biol. Chem. 279: 14812-14818 (2004).

Thompson SG, Wong PT, Leong SF, McGeer EG. Regional distribution in rat brain of 1-pyrroline-5-carboxylate dehydrogenase and its localization to specific glial cells. J. Neurochem. 45: 1791-1796 (1985).

Tizzano M, Sbarbati A. Is rat LRRP Ba1-651 a Delta-1-pyrroline-5-carboxylate dehydrogenase activated by changes in the concentration of sweet molecules? Med. Hypotheses 68: 864-867 (2007).

Tomenchok DM, Brandriss MC. Gene-enzyme relationships in the proline biosynthetic pathway of Saccharomyces cerevisiae. J. Bacteriol. 169: 5364-5672 (1987).

Townsend DE, Kaenjak A, Jayaswal RK, Wilkinson BJ. Proline is biosynthesized from arginine in Staphylococcus aureus. Microbiology 142: 1491-1497 (1996).

Trotel-Aziz P, Niogret MF, Larher F. Proline level is partly under the control of abscisic acid in canola leaf discs during recovery from hyper-osmotic stress. Physiol. Plant. 110: 376-383 (2000).

Ueda A, Kathiresan A, Inada M, Narita Y, Nakamura T, Shi W, Takabe T, Bennett J. Osmotic stress in barley regulates expression of a different set of genes than salt stress does. J. Exp. Bot. 55: 2213-2218 (2004).

Ueda A, Shi WM, Sanmiya K, Shono M, Takabe T. Functional analysis of salt-inducible proline transporter of barley roots. Plant Cell Physiol. 42: 1282-1289 (2001).

Usami M, Mitsunaga K, Nakazawa K, Doi O. Proteomic analysis of selenium embryotoxicity in cultured postimplantation rat embryos. Birth Defects Res. B. Dev. Reprod. Toxicol. 83: 80-96 (2008).

Valle D, Goodman SI, Harris SC, Phang JM. Genetic evidence for a common enzyme catalyzing the second step in the degradation of proline and hydroxyproline. J. Clin. Invest. 64: 1365-1370 (1979).

Vaubourdolle M, Jardel A, Coudray-Lucas C, Ekindjian OG, Agneray J, Cynober L. Fate of enterally administered ornithine in healthy animals: interactions with alpha-ketoglutarate. Nutrition 5: 183-187 (1989).

Vendruscolo EC, Schuster I, Pileggi M, Scapim CA, Molinari HB, Marur CJ, Vieira LG. Stress-induced synthesis of proline confers tolerance to water deficit in transgenic wheat. J. Plant Physiol. 164: 1367-1376 (2007).

Verbruggen N, Villarroel R, Van Montagu M. Osmoregulation of a pyrroline-5-carboxylate reductase gene in Arabidopsis thaliana. Plant Physiol. 103: 771-781 (1993).

Verdoy D, Coba DE LA Pena T, Redondo FJ, Lucas MM, Pueyo JJ. Transgenic Medicago truncatula plants that accumulate proline display nitrogen-fixing activity with enhanced tolerance to osmotic stress. Plant Cell Environ. 29: 1913-1923 (2006).

Verslues PE, Kim YS, Zhu JK. Altered ABA, proline and hydrogen peroxide in an Arabidopsis glutamate:glyoxylate aminotransferase mutant. Plant Mol. Biol. 64: 205-217 (2007).

Vilchez S, Molina L, Ramos C, Ramos JL. Proline catabolism by Pseudomonas putida: cloning, characterization, and expression of the put genes in the presence of root exudates. J. Bacteriol. 182: 91-99 (2000).

Vinod MP, Bellur P, Becker DF. Electrochemical and functional characterization of the proline dehydrogenase domain of the PutA flavoprotein from Escherichia coli. Biochemistry 41: 6525-6532 (2002).

Wagemaker MJ, Eastwood DC, Welagen J, van der Drift C, Jetten MS, Burton K, Van Griensven LJ, Op den Camp HJ. The role of ornithine aminotransferase in fruiting body formation of the mushroom Agaricus bisporus. Mycol. Res. 111: 909-918 (2007).

Wakabayashi Y. Tissue-selective expression of enzymes of arginine synthesis. Curr. Opin. Clin. Nutr. Metab. Care 1: 335-339 (1998).

Wakabayashi Y, Henslee JG, Jones ME. Pyrroline-5-carboxylate synthesis from glutamate by rat intestinal mucosa. Subcellular localization and temperature stability. J. Biol. Chem. 258: 3873-3882 (1983).

Wakabayashi Y, Jones ME. Pyrroline-5-carboxylate synthesis from glutamate by rat intestinal mucosa. J. Biol. Chem. 258: 3865-3872 (1983).

Wakabayashi Y, Yamada R, Iwashima A. Temperature- and time-dependent inactivation of pyrroline-5-carboxylate synthase: suggestive evidence for an allosteric regulation of the enzyme. Arch. Biochem. Biophys. 238: 469-475 (1985).

Wakabayashi Y, Yamada R, Iwashima A. Factors stabilizing pyrroline-5-carboxylate synthase of rat intestine mucosa at a physiological temperature. Arch. Biochem. Biophys. 238: 464-468 (1985).

Wakabayashi Y, Yamada R, Iwashima A. A one-step assay for pyrroline-5-carboxylate synthase using a short AG1-X8 column. J. Biochem. Biophys. Methods 9: 185-192 (1984).

Walker V, Mills GA, Peters SA, Merton WL. Fits, pyridoxine, and hyperprolinaemia type II. Arch. Dis. Child. 82: 236-237 (2000).

Wang ZQ, Yuan YZ, Ou JQ, Lin QH, Zhang CF. Glutamine synthetase and glutamate dehydrogenase contribute differentially to proline accumulation in leaves of wheat (Triticum aestivum) seedlings exposed to different salinity. J. Plant Physiol. 164: 695-701 (2007).

Watford M. Glutamine metabolism and function in relation to proline synthesis and the safety of glutamine and proline supplementation. J. Nutr. 138: 2003S-2007S (2008).

White TA, Johnson WH Jr, Whitman CP, Tanner JJ. Structural basis for the inactivation of Thermus thermophilus proline dehydrogenase by N-propargylglycine. Biochemistry 47: 5573-5580 (2008).

White TA, Krishnan N, Becker DF, Tanner JJ.. Structure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilus J. Biol. Chem. 282: 14316-14327 (2007).

Williamson CL, Slocum RD. Molecular cloning and evidence for osmoregulation of the delta1-pyrroline-5-carboxylate reductase (proC) gene in pea (Pisum sativum L.). Plant Physiol. 100: 1464-1470 (1992).

Winkler HH, Daugherty RM. Proline transport and metabolism in Rickettsia prowazekii. J. Bacteriol. 158: 460-463 (1984).

Wood JM, Zadworny D. Amplification of the put genes and identification of the put gene products in Escherichia coli K12. Can. J. Biochem. 58: 787-796 (1980).

Wright DA, Voytas DF. Potential retroviruses in plants: Tat1 is related to a group of Arabidopsis thaliana Ty3/gypsy retrotransposons that encode envelope-like proteins. Genetics 149: 703-715 (1998).

Wu G, Haynes TE, Li H, Meininger CJ. Glutamine metabolism in endothelial cells: ornithine synthesis from glutamine via pyrroline-5-carboxylate synthase. Comp. Biochem. Physiol. [A] 126: 115-123 (2000).

Wu GY, Meininger CJ, Kelly K, Watford M, Morris M. A cortisol surge mediates the enhanced expression of pig intestinal pyrroline-5-carboxylate synthase during weaning. J. Nutr. 130: 1914-1919 (2000).

Yamada E, Wakabayashi Y. Development of pyrroline-5-carboxylate synthase and N-acetylglutamate synthase and their changes in lactation and aging. Arch. Biochem. Biophys. 291: 15-23 (1991).

Yamada M, Morishita H, Urano K, Shiozaki N, Yamaguchi-Shinozaki K, Shinozaki K, Yoshiba Y. Effects of free proline accumulation in petunias under drought stress. J. Exp. Bot. 56: 1975-1981 (2005).

Yeh GC, Harris SC, Phang JM. Pyrroline-5-carboxylate reductase in human erythrocytes. J. Clin. Invest. 67: 1042-1046 (1981).

Yeh GC, Phang JM. Pyrroline-5-carboxylate stimulates the conversion of purine antimetabolites to their nucleotide forms by a redox-dependent mechanism. J. Biol. Chem. 258: 9774-9779 (1983).

Yeh GC, Phang JM. Stimulation of phosphoribosyl pyrophosphate and purine nucleotide production by pyrroline 5-carboxylate in human erythrocytes. J. Biol. Chem. 263: 13083-13089 (1988).

Yeh GC, Roth EF Jr, Phang JM, Harris SC, Nagel RL, Rinaldi A. The effect of pyrroline-5-carboxylic acid on nucleotide metabolism in erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient subjects. J. Biol. Chem. 259: 5454-5458 (1984).

Yoshiba Y, Aoki C, Iuchi S, Nanjo T, Seki M, Sekiguchi F, Yamaguchi-Shinozaki K, Shinozaki K. Characterization of four extensin genes in Arabidopsis thaliana by differential gene expression under stress and non-stress conditions. DNA Res. 8: 115-122 (2001).

Yoshiba Y, Kiyosue T, Katagiri T, Ueda H, Mizoguchi T, Yamaguchi-Shinozaki K, Wada K, Harada Y, Shinozaki K. Correlation between the induction of a gene for delta 1-pyrroline-5-carboxylate synthetase and the accumulation of proline in Arabidopsis thaliana under osmotic stress. Plant J. 7: 751-760 (1995).

Yoshiba Y, Kiyosue T, Nakashima K, Yamaguchi-Shinozaki K, Shinozaki K. Regulation of levels of proline as an osmolyte in plants under water stress. Plant Cell Physiol. 38: 1095-1102 (1997).

Yoshiba Y, Nanjo T, Miura S, Yamaguchi-Shinozaki K, Shinozaki K. Stress-responsive and developmental regulation of delta1- pyrroline-5-carboxylate synthetase 1 (P5CS1) gene expression in Arabidopsis thaliana. Biochem. Biophys. Res. Commun. 261: 766-772 (1999).

Zhang CS, Lu Q, Verma DP. Removal of feedback inhibition of delta1-pyrroline-5-carboxylate synthetase, a bifunctional enzyme catalyzing the first two steps of proline biosynthesis in plants. J. Biol. Chem. 270: 20491-20496 (1995).

Zhang LP, Mehta SK, Liu ZP, Yang ZM. Copper-induced proline synthesis is associated with nitric oxide generation in Chlamydomonas reinhardtii. Plant Cell Physiol. 49: 411-419 (2008).

Zhou Y, Zhu W, Bellur PS, Rewinkel D, Becker DF. Direct linking of metabolism and gene expression in the proline utilization A protein from Escherichia coli. Amino Acids 35: 711-718 (2008).

Zhu XY, Jing Y, Chen GC, Wang SM, Zhang CL. Solute levels and osmoregulatory enzyme activities in reed plants adapted to drought and saline habitats. Plant Growth Regul. 41: 165-172 (2003).

Number of references = 270