Abbasi AR, Hajirezaei M, Hofius D, Sonnewald U, Voll LM. Specific roles of alpha- and gamma-tocopherol in abiotic stress responses of transgenic tobacco. Plant Physiol. 143: 1720-1738 (2007).

Agrawal S, Kumar A, Srivastava V, Mishra BN. Cloning, expression, activity and folding studies of serine hydroxymethyltransferase: a target enzyme for cancer chemotherapy. J. Mol. Microbiol. Biotechnol. 6: 67-75 (2003).

Aina R, Sgorbati S, Santagostino A, Labra M, Ghiani A, Citterio S. Specific hypomethylation of DNA is induced by heavy metals in white clover and industrial hemp. Physiol. Plant. 121: 472-480 (2004).

Akashi T, Vanetten HD, Sawada Y, Wasmann CC, Uchiyama H, Ayabe SI. Catalytic specificity of pea O-methyltransferases suggests gene duplication for (+)-pisatin biosynthesis. Phytochemistry 67: 2525-2530 (2006).

Aktas M, Narberhaus F. In vitro characterization of the enzyme properties of the phospholipid N-methyltransferase PmtA from Agrobacterium tumefaciens. J. Bacteriol. 191: 2033-2041 (2009).

Alawady A, Reski R, Yaronskaya E, Grimm B. Cloning and expression of the tobacco CHLM sequence encoding Mg protoporphyrin IX methyltransferase and its interaction with Mg chelatase. Plant Mol. Biol. 57: 679-691 (2005).

Alawady AE, Grimm B. Tobacco Mg protoporphyrin IX methyltransferase is involved in inverse activation of Mg porphyrin and protoheme synthesis. Plant J. 41: 282-290 (2005).

Alexander FW, Sandmeier E, Mehta PK, Christen P. Evolutionary relationships among pyridoxal-5'-phosphate-dependent enzymes. Regio-specific alpha, beta and gamma families. Eur. J. Biochem. 219: 953-960 (1994).

Alfadhli S, Rathod PK. Gene organization of a Plasmodium falciparum serine hydroxymethyltransferase and its functional expression in Escherichia coli. Mol. Biochem. Parasitol. 110: 283-291 (2000).

Alfthan G, Tapani K, Nissinen K, Saarela J, Aro A. The effect of low doses of betaine on plasma homocysteine in healthy volunteers. Br. J. Nutr. 92: 665-669 (2004).

Allen RH, Stabler SP, Lindenbaum J. Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism 42: 1448-1460 (1993).

Alves S, Prata MJ, Ferreira F, Amorim A. Screening of thiopurine S-methyltransferase mutations by horizontal conformation-sensitive gel electrophoresis. Hum. Mutat. 15: 246-253 (2000).

Ament K, Kant MR, Sabelis MW, Haring MA, Schuurink RC. Jasmonic acid is a key regulator of spider mite-induced volatile terpenoid and methyl salicylate emission in tomato. Plant Physiol. 135: 2025-2037 (2004).

Ando S, Sakai S. Isolation of an ethylene-responsive gene (ERAF16) for a putative methyltransferase and correlation of ERAF16 gene expression with female flower formation in cucumber plants (Cucumis sativus). Physiol. Plant. 116: 213-222 (2002).

Angelaccio S, Chiaraluce R, Consalvi V, Buchenau B, Giangiacomo L, Bossa F, Contestabile R. Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii. J. Biol. Chem. 278: 41789-41797 (2003).

Anterola AM, Jeon JH, Davin LB, Lewis NG. Transcriptional control of monolignol biosynthesis in Pinus taeda - Factors affecting monolignol ratios and carbon allocation in phenylpropanoid metabolism. J. Biol. Chem. 277: 18272-18280 (2002).

Anterola AM, Lewis NG. Trends in lignin modification: a comprehensive analysis of the effects of genetic manipulations/mutations on lignification and vascular integrity. Phytochemistry 61: 221-294 (2002).

Arendsen AF, Soliman MQ, Ragsdale SW. Nitrate-dependent regulation of acetate biosynthesis and nitrate respiration by Clostridium thermoaceticum. J. Bacteriol. 181: 1489-1495 (1999).

Arnqvist L, Dutta PC, Jonsson L, Sitbon F. Reduction of cholesterol and glycoalkaloid levels in transgenic potato plants by overexpression of a type 1 sterol methyltransferase cDNA. Plant Physiol. 131: 1792-1799 (2003).

Artigues A, Birkett A, Schirch V. Evidence for the in vivo deamidation and isomerization of an asparaginyl residue in cytosolic serine hydroxymethyltransferase. J. Biol. Chem. 265: 4853-4858 (1990).

Ashihara H, Crozier A. Caffeine: a well known but little mentioned compound in plant science. Trends Plant Sci. 6: 407-413 (2001).

Ashihara H, Sano H, Crozier A. Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering. Phytochemistry 69: 841-856 (2008).

Ashihara H, Zheng XQ, Katahira R, Morimoto M, Ogita S, Sano H. Caffeine biosynthesis and adenine metabolism in transgenic Coffea canephora plants with reduced expression of N-methyltransferase genes. Phytochemistry 67: 882-886 (2006).

Attaran E, Zeier TE, Griebel T, Zeier J. Methyl salicylate production and jasmonate signaling are not essential for systemic acquired resistance in Arabidopsis. Plant Cell 21: 954-971 (2009).

Attieh J, Djiana R, Koonjul P, Etienne C, Sparace SA, Saini HS. Cloning and functional expression of two plant thiol methyltransferases: a new class of enzymes involved in the biosynthesis of sulfur volatiles. Plant Mol. Biol. 50: 511-521 (2002).

Attieh J, Kleppinger-Sparace KF, Nunes C, Sparace SA, Saini HS. Evidence implicating a novel thiol methyltransferase in the detoxification of glucosinolate hydrolysis products in Brassica oleracea L. Plant Cell Environ. 23: 165-174 (2000).

Attieh J, Sparace SA, Saini HS. Purification and properties of multiple isoforms of a novel thiol methyltransferase involved in the production of volatile sulfur compounds from Brassica oleracea. Arch. Biochem. Biophys. 380: 257-266 (2000).

Aufsatz W, Mette MF, Matzke AJ, Matzke M. The role of MET1 in RNA-directed de novo and maintenance methylation of CG dinucleotides. Plant Mol. Biol. 54: 793-804 (2004).

Augoustides-Savvopoulou P, Luka Z, Karyda S, Stabler SP, Allen RH, Patsiaoura K, Wagner C, Mudd SH. Glycine N-methyltransferase deficiency: a new patient with a novel mutation. J. Inherit. Metab. Dis. 26: 745-759 (2003).

Ay N, Irmler K, Fischer A, Uhlemann R, Reuter G, Humbeck K. Epigenetic programming via histone methylation at WRKY53 controls leaf senescence in Arabidopsis thaliana. Plant J. 58: 333-346 (2009).

Babinger P, Volkl R, Cakstina I, Maftei A, Schmitt R. Maintenance DNA methyltransferase (Met1) and silencing of CpG-methylated foreign DNA in Volvox carteri. Plant Mol. Biol. 63: 325-336 (2007).

Baburina OK, Shevyakova NI. Betaines as methyl group donors in alfalfa shoots exposed to saline media. Russ. J. Plant Physiol. 42: 764-771 (1995).

Bae HH, Herman E, Bailey B, Bae HJ, Sicher R. Exogenous trehalose alters Arabidopsis transcripts involved in cell wall modification, abiotic stress, nitrogen metabolism, and plant defense. Physiol. Plant. 125: 114-126 (2005).

Baerson SR, Dayan FE, Rimando AM, Nanayakkara NP, Liu CJ, Schroder J, Fishbein M, Pan Z, Kagan IA, Pratt LH, Cordonnier-Pratt MM, Duke SO. A functional genomics investigation of allelochemical biosynthesis in Sorghum bicolor root hairs. J. Biol. Chem. 283: 3231-3247 (2008).

Bagard M, Le Thiec D, Delacote E, Hasenfratz-Sauder MP, Banvoy J, Gerard J, Dizengremel P, Jolivet Y. Ozone-induced changes in photosynthesis and photorespiration of hybrid poplar in relation to the developmental stage of the leaves. Physiol. Plant. 134: 559-574 (2008).

Baggott JE. Hydrolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate at pH 2.5 to 4.5. Biochemistry 39: 14647-14653 (2000).

Baigori M, Grau R, Morbidoni HR, de Mendoza D. Isolation and characterization of Bacillus subtilis mutants blocked in the synthesis of pantothenic acid. J. Bacteriol. 173: 4240-4242 (1991).

Bailey K, Cowling R, Tan EW, Webb D. A colormetric assay for catechol-O-methyltransferase. Bioorg. Med. Chem. 12: 595-601 (2004).

Baldridge GD, O'Neill NR, Samac DA. Alfalfa (Medicago sativa L.) resistance to the root-lesion nematode, Pratylenchus penetrans: defense-response gene mRNA and isoflavonoid phytoalexin levels in roots. Plant Mol. Biol. 38: 999-1010 (1998).

Banerjee R, Ragsdale SW. The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes. Annu. Rev. Biochem. 72: 209-247 (2003).

Banerjee RV, Harder SR, Ragsdale SW, Matthews RG. Mechanism of reductive activation of cobalamin-dependent methionine synthase: an electron paramagnetic resonance spectroelectrochemical study. Biochemistry 29: 1129-1135 (1990).

Barak AJ, Beckenhauer HC, Mailliard ME, Kharbanda KK, Tuma DJ. Betaine lowers elevated S-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats. J. Nutr. 133: 2845-2848 (2003).

Barel G, Ginzberg I. Potato skin proteome is enriched with plant defence components. J. Exp. Bot. 59: 3347-3357 (2008).

Baric I, Fumic K, Glenn B, Cuk M, Schulze A, Finkelstein JD, James SJ, Mejaski-Bosnjak V, Pazanin L, Pogribny IP, Rados M, Sarnavka V, Scukanec-Spoljar M, Allen RH, Stabler S, Uzelac L, Vugrek O, Wagner C, Zeisel S, Mudd SH. S-Adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. Proc. Natl. Acad. Sci. U.S.A. 101: 4234-4239 (2004).

Barkman TJ. Evidence for positive selection on the floral scent gene isoeugenol-O-methyltransferase. Mol. Biol. Evol. 20: 168-172 (2003).

Barkman TJ, Martins TR, Sutton E, Stout JT. Positive selection for single amino acid change promotes substrate discrimination of a plant volatile-producing enzyme. Mol. Biol. Evol. 24: 1320-1329 (2007).

Barra D, Martini F, Angelaccio S, Bossa F, Gavilanes F, Peterson D, Bullis B, Schirch L. Sequence homology between prokaryotic and eukaryotic forms of serine hydroxymethyltransferase. Biochem. Biophys. Res. Commun. 116: 1007-1012 (1983).

Bauwe H, Kolukisaoglu U. Genetic manipulation of glycine decarboxylation. J. Exp. Bot. 54: 1523-1535 (2003).

Beaudouin C, Haurat G, Fraisse L, Souppe J, Renaud B. Assay of phenylethanolamine N-methyltransferase activity using high-performance liquid chromatography with ultraviolet absorbance detection. J. Chromatogr. 613: 51-58 (1993).

Beckmann K, Dzuibany C, Biehler K, Fock H, Hell R, Migge A, Becker TW. Photosynthesis and fluorescence quenching, and the mRNA levels of plastidic GS or of mitochondrial SHMT in the leaves of the wild-type and of the SHMT-deficient stm mutant of Arabidopsis thaliana in relation to the rate of photorespiration. Planta 202: 379-386 (1997).

Bender J. DNA methylation and epigenetics. Annu. Rev. Plant Biol. 55: 41-68 (2004).

Bendt AK, Burkovski A, Schaffer S, Bott M, Farwick M, Hermann T. Towards a phosphoproteome map of Corynebacterium glutamicum. Proteomics 3: 1637-1646 (2003).

Bergmuller E, Porfirova S, Dormann P. Characterization of an Arabidopsis mutant deficient in gamma-tocopherol methyltransferase. Plant Mol. Biol. 52: 1181-1190 (2003).

Berim A, Schneider B, Petersen M. Methyl allyl ether formation in plants: novel S-adenosyl L-methionine:coniferyl alcohol 9-O-methyltransferase from suspension cultures of three Linum species. Plant Mol. Biol. 64: 279-291 (2007).

Berim A, Spring O, Conrad J, Maitrejean M, Boland W, Petersen M. Enhancement of lignan biosynthesis in suspension cultures of Linum nodiflorum by coronalon, indanoyl-isoleucine and methyl jasmonate. Planta 222: 769-776 (2005).

Bernes S, Siman-Tov R, Ankri S. Epigenetic and classical activation of Entamoeba histolytica heat shock protein 100 (EHsp100) expression. FEBS Lett. 579: 6395-6402 (2005).

Besson V, Rebeille F, Neuburger M, Douce R, Cossins EA. Effects of tetrahydrofolate polyglutamates on the kinetic parameters of serine hydroxymethyltransferase and glycine decarboxylase from pea leaf mitochondria. Biochem. J. 292: 425-430 (1993).

Beudeker RF, Tabita FR. Control of photorespiratory glycolate metabolism in an oxygen-resistant mutant of Chlorella sorokiniana. J. Bacteriol. 155: 650-656 (1983).

Bhatt AN, Khan MY, Bhakuni V. The C-terminal domain of dimeric serine hydroxymethyltransferase plays a key role in stabilization of the quaternary structure and cooperative unfolding of protein: domain swapping studies with enzymes having high sequence identity. Protein Sci. 13: 2184-2195 (2004).

Bhavani S, Trivedi V, Jala VR, Subramanya HS, Kaul P, Prakash V, Appaji Rao N, Savithri HS. Role of Lys-226 in the catalytic mechanism of Bacillus stearothermophilus serine hydroxymethyltransferase--crystal structure and kinetic studies. Biochemistry 44: 6929-6937 (2005).

Bhuiyan NH, Liu W, Liu G, Selvaraj G, Wei Y, King J. Transcriptional regulation of genes involved in the pathways of biosynthesis and supply of methyl units in response to powdery mildew attack and abiotic stresses in wheat. Plant Mol. Biol. 64: 305-318 (2007).

Bhuiyan NH, Selvaraj G, Wei Y, King J. Gene expression profiling and silencing reveal that monolignol biosynthesis plays a critical role in penetration defence in wheat against powdery mildew invasion. J. Exp. Bot. 60: 509-521 (2009).

Bianchi MW, Damerval C, Vartanian N. Identification of proteins regulated by cross-talk between drought and hormone pathways in Arabidopsis wild-type and auxin-insensitive mutants, axr1 and axf2. Funct. Plant Biol. 29: 55-61 (2002).

Biastoff S, Brandt W, Drager B. Putrescine N-methyltransferase - the start for alkaloids. Phytochemistry Aug 1 [Epub ahead of print] (2009).

Biondi S, Fornale S, Oksman-Caldentey KM, Eeva M, Agostani S, Bagni N. Jasmonates induce over-accumulation of methylputrescine and conjugated polyamines in Hyoscyamus muticus L. root cultures. Plant Cell Rep. 19: 691-697 (2000).

Block MA, Tewari AK, Albrieux C, Marechal E, Joyard J. The plant S-adenosyl-L-methionine:Mg-protoporphyrin IX methyltransferase is located in both envelope and thylakoid chloroplast membranes. Eur. J. Biochem. 269: 240-248 (2002).

Boissier F, Bardou F, Guillet V, Uttenweiler-Joseph S, Daffe M, Quemard A, Mourey L. Further insight into S-adenosylmethionine-dependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis. J. Biol. Chem. 281: 4434-4445 (2006).

Bolognese CP, McGraw P. The isolation and characterization in yeast of a gene for Arabidopsis S-adenosylmethionine:phospho-ethanolamine N-methyltransferase. Plant Physiol. 124: 1800-1813 (2000).

Bose N, Greenspan P, Momany C. Expression of recombinant human betaine: homocysteine S-methyltransferase for X-ray crystallographic studies and further characterization of interaction with S-adenosylmethionine. Protein Expr. Purif. 25: 73-80 (2002).

Bourgis F, Roje S, Nuccio ML, Fisher DB, Tarczynski MC, Li C, Herschbach C, Rennenberg H, Pimenta MJ, Shen TL, Gage DA, Hanson AD. S-Methylmethionine plays a major role in phloem sulfur transport and is synthesized by a novel type of methyltransferase. Plant Cell 11: 1485-1498 (1999).

Bourguignon J, Macherel D, Neuburger M, Douce R. Isolation, characterization, and sequence analysis of a cDNA clone encoding L-protein, the dihydrolipoamide dehydrogenase component of the glycine cleavage system from pea-leaf mitochondria. Eur. J. Biochem. 204: 865-873 (1992).

Bourguignon J, Neuburger M, Douce R. Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase. Biochem. J. 255: 169-178 (1988).

Boyles AL, Billups AV, Deak KL, Siegel DG, Mehltretter L, Slifer SH, Bassuk AG, Kessler JA, Reed MC, Nijhout HF, George TM, Enterline DS, Gilbert JR, Speer MC; NTD Collaborative Group. Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. Environ. Health Perspect. 114: 1547-1552 (2006).

Braun SD, Volksch B, Nuske J, Spiteller D. 3-Methylarginine from Pseudomonas syringae pv. syringae 22d/93 suppresses the bacterial blight caused by its close relative Pseudomonas syringae pv. glycinea. Chembiochem. 9: 1913-1920 (2008).

Breksa AP 3rd, Garrow TA. Recombinant human liver betaine-homocysteine S-methyltransferase: identification of three cysteine residues critical for zinc binding. Biochemistry 38: 13991-13398 (1999).

Breksa AP 3rd, Garrow TA. Random mutagenesis of the zinc-binding motif of betaine-homocysteine methyltransferase reveals that Gly 214 is essential. Arch. Biochem. Biophys. 399: 73-80 (2002).

Brosnan JT. The 1986 Borden award lecture. The role of the kidney in amino acid metabolism and nutrition. Can. J. Physiol. Pharmacol. 65: 2355-2362 (1987).

Brosnan JT, Brosnan ME. The sulfur-containing amino acids: an overview. J. Nutr. 136: 1636S-1640S (2006).

Brosnan JT, Jacobs RL, Stead LM, Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim. Pol. 51: 405-413 (2004).

Buchanan MS, Carroll AR, Fechner GA, Boyle A, Simpson M, Addepalli R, Avery VM, Forster PI, Guymer GP, Cheung T, Chen H, Quinn RJ. Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx. Phytochemistry 69: 1886-1889 (2008).

Buchenau B, Thauer RK. Tetrahydrofolate-specific enzymes in Methanosarcina barkeri and growth dependence of this methanogenic archaeon on folic acid or p-aminobenzoic acid. Arch. Microbiol. 182: 313-325 (2004).

Bujnicki JM, Radlinska M. Is the HemK family of putative S-adenosylmethionine-dependent methyltransferases a "missing" zeta subfamily of adenine methyltransferases? A hypothesis. IUBMB Life 48: 247-249 (1999).

Busam G, Junghanns KT, Kneusel RE, Kassemeyer HH, Matern U. Characterization and expression of caffeoyl-coenzyme A 3-O-methyltransferase proposed for the induced resistance response of Vitis vinifera L. Plant Physiol. 115: 1039-1048 (1997).

Byrne PC, Sanders PG, Snell K. Translational control of mammalian serine hydroxymethyltransferase expression. Biochem. Biophys. Res. Commun. 214: 496-502 (1995).

Byrne PC, Sanders PG, Snell K. Nucleotide sequence and expression of a cDNA encoding rabbit liver cytosolic serine hydroxymethyltransferase. Biochem. J. 286: 117-123 (1992).

Cai H, Clarke S. A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli. J. Biol. Chem. 274: 13470-13479 (1999).

Cakici O, Sikorski M, Stepkowski T, Bujacz G, Jaskolski M. Cloning, expression, purification, crystallization and preliminary X-ray analysis of NodS N-methyltransferase from Bradyrhizobium japonicum WM9. Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 64: 1149-1152 (2008).

Campa C, Noirot M, Bourgeois M, Pervent M, Ky CL, Chrestin H, Hamon S, De Kochko A. Genetic mapping of a caffeoyl-coenzyme A 3-O-methyltransferase gene in coffee trees. Impact on chlorogenic acid content. Theor. Appl. Genet. 107: 751-756 (2003).

Capellades M, Torres MA, Bastisch I, Stiefel V, Vignols F, Bruce WB, Peterson D, Puigdomenech P, Rigau J. The maize caffeic acid O-methyltransferase gene promoter is active in transgenic tobacco and maize plant tissues. Plant Mol. Biol. 31: 307-322 (1996).

Capelluto DG, Hellman U, Cazzulo JJ, Cannata JJ. Purification and some properties of serine hydroxymethyltransferase from Trypanosoma cruzi. Eur. J. Biochem. 267: 712-719 (2000).

Capelluto DG, Hellman U, Cazzulo JJ, Cannata JJ. Purification and partial characterization of three isoforms of serine hydroxymethyltransferase from Crithidia fasciculata. Mol. Biochem. Parasitol. 98: 187-201 (1999).

Carland FM, Fujioka S, Takatsuto S, Yoshida S, Nelson T. The identification of CVP1 reveals a role for sterols in vascular patterning. Plant Cell 14: 2045-2058 (2002).

Casas-Mollano JA, Lao NT, Kavanagh TA. Intron-regulated expression of SUVH3, an Arabidopsis Su(var)3-9 homologue. J. Exp. Bot. 57: 3301-3311 (2006).

Castro C, Gratson AA, Evans JC, Jiracek J, Collinsova M, Ludwig ML, Garrow TA. Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. Biochemistry 43: 5341-5351 (2004).

Castro C, Millian NS, Garrow TA. Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc. Arch. Biochem. Biophys. 472: 26-33 (2008).

Castro R, Rivera I, Struys EA, Jansen EE, Ravasco P, Camilo ME, Blom HJ, Jakobs C, Tavares de Almeida I. Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin. Chem. 49: 1292-1296 (2003).

Caudill MA, Wang JC, Melnyk S, Pogribny IP, Jernigan S, Collins MD, Santos-Guzman J, Swendseid ME, Cogger EA, James SJ. Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. J. Nutr. 131: 2811-2818 (2001).

Cazzonelli CI, Cuttriss AJ, Cossetto SB, Pye W, Crisp P, Whelan J, Finnegan EJ, Turnbull C, Pogson BJ. Regulation of carotenoid composition and shoot branching in Arabidopsis by a chromatin modifying histone methyltransferase, SDG8. Plant Cell 21: 39-53 (2009).

Chadwick LH, McCandless SE, Silverman GL, Schwartz S, Westaway D, Nadeau JH. Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes. Genomics 70: 66-73 (2000).

Chakauya E, Coxon KM, Wei M, Macdonald MV, Barsby T, Abell C, Smith AG. Towards engineering increased pantothenate (vitamin B(5)) levels in plants. Plant Mol. Biol. 68: 493-503 (2008).

Chan VL, Bingham HL. Complete sequence of the Campylobacter jejuni glyA gene encoding serine hydroxymethyltransferase. Gene 101: 51-58 (1991).

Charron JB, Breton G, Danyluk J, Muzac I, Ibrahim RK, Sarhan F. Molecular and biochemical characterization of a cold-regulated phosphoethanolamine N-methyltransferase from wheat. Plant Physiol. 129: 363-373 (2002).

Chaturvedi S, Bhakuni V. Unusual structural, functional, and stability properties of serine hydroxymethyltransferase from Mycobacterium tuberculosis. J. Biol. Chem. 278: 40793-40805 (2003).

Chaudhuri BN, Sawaya MR, Kim CY, Waldo GS, Park MS, Terwilliger TC, Yeates TO. The crystal structure of the first enzyme in the pantothenate biosynthetic pathway, ketopantoate hydroxymethyltransferase, from M tuberculosis. Structure (Camb.) 11: 753-764 (2003).

Chen C, Meyermans H, Burggraeve B, De Rycke RM, Inoue K, De Vleesschauwer V, Steenackers M, Van Montagu MC, Engler GJ, Boerjan WA. Cell-specific and conditional expression of caffeoyl-coenzyme A-3-O-methyltransferase in poplar. Plant Physiol. 123: 853-868 (2000).

Chen F, D'Auria JC, Tholl D, Ross JR, Gershenzon J, Noel JP, Pichersky E. An Arabidopsis thaliana gene for methylsalicylate biosynthesis, identified by a biochemical genomics approach, has a role in defense. Plant J. 36: 577-588 (2003).

Chen F, Srinivasa Reddy MS, Temple S, Jackson L, Shadle G, Dixon RA. Multi-site genetic modulation of monolignol biosynthesis suggests new routes for formation of syringyl lignin and wall-bound ferulic acid in alfalfa (Medicago sativa L.). Plant J. 48: 113-124 (2006).

Chen J, Kyte C, Valcin M, Chan W, Wetmur JG, Selhub J, Hunter DJ, Ma J. Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int. J. Cancer 110: 617-620 (2004).

Chen L, Auh C, Chen F, Cheng X, Aljoe H, Dixon RA, Wang Z. Lignin deposition and associated changes in anatomy, enzyme activity, gene expression, and ruminal degradability in stems of tall fescue at different developmental stages. J. Agric. Food Chem. 50: 5558-5565 (2002).

Chen SY, Lai MC, Lai SJ, Lee YC. Characterization of osmolyte betaine synthesizing sarcosine dimethylglycine N-methyltransferase from Methanohalophilus portucalensis. Arch. Microbiol. Aug 20 [Epub ahead of print] (2009).

Chen SY, Lin JR, Darbha R, Lin P, Liu TY, Chen YM. Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway. Cancer Res. 64: 3617-3623 (2004).

Chen TH, Murata N. Enhancement of tolerance of abiotic stress by metabolic engineering of betaines and other compatible solutes. Curr. Opin. Plant Biol. 5: 250-257 (2002).

Chen X. MicroRNA biogenesis and function in plants. FEBS Lett. 579: 5923-5931 (2005).

Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule regulators of protein arginine methyltransferases. J. Biol. Chem. 279: 23892-23899 (2004).

Cheng X, Roberts RJ. AdoMet-dependent methylation, DNA methyltransferases and base flipping. Nucleic Acids Res. 29: 3784-3795 (2001).

Cheng Z, Sattler S, Maeda H, Sakuragi Y, Bryant DA, DellaPenna D. Highly divergent methyltransferases catalyze a conserved reaction in tocopherol and plastoquinone synthesis in cyanobacteria and photosynthetic eukaryotes. Plant Cell 15: 2343-2356 (2003).

Cheong JJ, Choi YD. Methyl jasmonate as a vital substance in plants. Trends Genet. 19: 409-413 (2003).

Chintapakorn Y, Hamill JD. Antisense-mediated down-regulation of putrescine N-methyltransferase activity in transgenic Nicotiana tabacum L. can lead to elevated levels of anatabine at the expense of nicotine. Plant Mol. Biol. 53: 87-105 (2003).

Chiron H, Drouet A, Claudot AC, Eckerskorn C, Trost M, Heller W, Ernst D, Sandermann H Jr. Molecular cloning and functional expression of a stress-induced multifunctional O-methyltransferase with pinosylvin methyltransferase activity from Scots pine (Pinus sylvestris L.). Plant Mol. Biol. 44: 733-745 (2000).

Chiron H, Drouet A, Lieutier F, Payer HD, Ernst D, Sandermann H Jr. Gene induction of stilbene biosynthesis in Scots pine in response to ozone treatment, wounding, and fungal infection. Plant Physiol. 124: 865-872 (2000).

Chirwa NT, Herrington MB. Role of MetR and PurR in the activation of glyA by CsgD in Escherichia coli K-12. Can. J. Microbiol. 50: 683-690 (2004).

Chistoserdova LV, Lidstrom ME. Genetics of the serine cycle in Methylobacterium extorquens AM1: cloning, sequence, mutation, and physiological effect of glyA, the gene for serine hydroxymethyltransferase. J. Bacteriol. 176: 6759-6762 (1994).

Chlumsky LJ, Zhang L, Jorns MS. Sequence analysis of sarcosine oxidase and nearby genes reveals homologies with key enzymes of folate one-carbon metabolism. J. Biol. Chem. 270: 18252-18259 (1995).

Cho JH, Park Y, Ahn JH, Lim Y, Rhee S. Structural and functional insights into O-methyltransferase from Bacillus cereus. J. Mol. Biol. 382: 987-997 (2008).

Choi JY, Martin WE, Murphy RC, Voelker DR. Phosphatidylcholine and N-methylated phospholipids are non-essential in Saccharomyces cerevisiae. J. Biol. Chem. 279: 42321-42330 (2004).

Christensen AB, Gregersen PL, Olsen CE, Collinge DB. A flavonoid 7-O-methyltransferase is expressed in barley leaves in response to pathogen attack. Plant Mol. Biol. 36: 219-227 (1998).

Christensen B, Nielsen J. Metabolic network analysis of Penicillium chrysogenum using 13C-labeled glucose. Biotechnol. Bioeng. 68: 652-659 (2000).

Chu J, Shoeman R, Hart J, Coleman T, Mazaitis A, Kelker N, Brot N, Weissbach H. Cloning and expression of the metE gene in Escherichia coli. Arch. Biochem. Biophys. 239: 467-474 (1985).

Coiner H, Schroder G, Wehinger E, Liu CJ, Noel JP, Schwab W, Schroder J. Methylation of sulfhydryl groups: a new function for a family of small molecule plant O-methyltransferases. Plant J. 46: 193-205 (2006).

Colditz F, Nyamsuren O, Niehaus K, Eubel H, Braun HP, Krajinski F. Proteomic approach: identification of Medicago truncatula proteins induced in roots after infection with the pathogenic oomycete Aphanomyces euteiches. Plant Mol. Biol. 55: 109-120 (2004).

Collakova E, DellaPenna D. Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis. Plant Physiol. 131: 632-642 (2003).

Collakova E, DellaPenna D. The role of homogentisate phytyltransferase and other tocopherol pathway enzymes in the regulation of tocopherol synthesis during abiotic stress. Plant Physiol. 133: 930-940 (2003).

Collakova E, Goyer A, Naponelli V, Krassovskaya I, Gregory JF 3rd, Hanson AD, Shachar-Hill Y. Arabidopsis 10-formyl tetrahydrofolate deformylases are essential for photorespiration. Plant Cell 20: 1818-1832 (2008).

Collazo P, Montoliu L, Puigdomenech P, Rigau J. Structure and expression of the lignin O-methyltransferase gene from Zea mays L. Plant Mol. Biol. 20: 857-867 (1992).

Collinsova M, Strakova J, Jiracek J, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice. J. Nutr. 136: 1493-1497 (2006).

Contestabile R, Angelaccio S, Bossa F, Wright HT, Scarsdale N, Kazanina G, Schirch V. Role of tyrosine 65 in the mechanism of serine hydroxymethyltransferase. Biochemistry 39: 7492-7500 (2000).

Contestabile R, Paiardini A, Pascarella S, di Salvo ML, D'Aguanno S, Bossa F. L-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions. Eur. J. Biochem. 268: 6508-6525 (2001).

Cook RJ, Wagner C. Glycine N-methyltransferase is a folate binding protein of rat liver cytosol. Proc. Natl. Acad. Sci. U.S.A. 81: 3631-3634 (1984).

Cooke JEK, Brown KA, Wu R, Davis JM. Gene expression associated with N-induced shifts in resource allocation in poplar. Plant Cell Environ. 26: 757-770 (2003).

Cossins EA, Chan PY, Combepine G. One-carbon metabolism in Neurospora crassa wild-type and in mutants partially deficient in serine hydroxymethyltransferase. Biochem. J. 160: 305-314 (1976).

Costet L, Dorey S, Fritig B, Kauffmann S. A pharmacological approach to test the diffusible signal activity of reactive oxygen intermediates in elicitor-treated tobacco leaves. Plant Cell Physiol. 43: 91-98 (2002).

Cronan JE Jr, Littel KJ, Jackowski S. Genetic and biochemical analyses of pantothenate biosynthesis in Escherichia coli and Salmonella typhimurium. J. Bacteriol. 149: 916-922 (1982).

Crowell DN, Kennedy M. Identification and functional expression in yeast of a prenylcysteine alpha-carboxyl methyltransferase gene from Arabidopsis thaliana. Plant Mol. Biol. 45: 469-476 (2001).

Crowell DN, Sen SE, Randall SK. Prenylcysteine alpha-carboxyl methyltransferase in suspension-cultured tobacco cells. Plant Physiol. 118: 115-123 (1998).

Cruz-Ramirez A, Lopez-Bucio J, Ramirez-Pimentel G, Zurita-Silva A, Sanchez-Calderon L, Ramirez-Chavez E, Gonzalez-Ortega E, Herrera-Estrella L. The xipotl mutant of Arabidopsis reveals a critical role for phospholipid metabolism in root system development and epidermal cell integrity. Plant Cell 16: 2020-2034 (2004).

Cummins I, Brazier-Hicks M, Stobiecki M, Franski R, Edwards R. Selective disruption of wheat secondary metabolism by herbicide safeners. Phytochemistry 67: 1722-1730 (2006).

Curir P, Lanzotti V, Dolci M, Dolci P, Pasini C, Tollin G. Purification and properties of a new S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase from carnation (Dianthus caryophyllus L.). Eur. J. Biochem. 270: 3422-3431 (2003).

Cutanda-Perez MC, Ageorges A, Gomez C, Vialet S, Terrier N, Romieu C, Torregrosa L. Ectopic expression of VlmybA1 in grapevine activates a narrow set of genes involved in anthocyanin synthesis and transport. Plant Mol. Biol. 69: 633-648 (2009).

da Costa KA, Kozyreva OG, Song J, Galanko JA, Fischer LM, Zeisel SH. Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J. 20: 1336-1344..

Dayan FE, Watson SB, Nanayakkara NP. Biosynthesis of lipid resorcinols and benzoquinones in isolated secretory plant root hairs. J. Exp. Bot. 58: 3263-3272 (2007).

De Luca V, Ibrahim RK. Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. I. Partial purification and some properties of S-adenosyl-L-methionine:flavonol 3-, 6-, 7-, and 4'-O-methyltransferases. Arch. Biochem. Biophys. 238: 596-605 (1985).

De Luca V, Ibrahim RK. Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. II. Substrate interaction and product inhibition studies of flavonol 3-, 6-, and 4'-O-methyltransferases. Arch. Biochem. Biophys. 238: 606-618 (1985).

De Luca V, Laflamme P. The expanding universe of alkaloid biosynthesis. Curr. Opin. Plant Biol. 4: 225-233 (2001).

De Luca V, St Pierre B. The cell and developmental biology of alkaloid biosynthesis. Trends Plant Sci. 5: 168-173 (2000).

de Rudder KE, Lopez-Lara IM, Geiger O. Inactivation of the gene for phospholipid N-methyltransferase in Sinorhizobium meliloti: phosphatidylcholine is required for normal growth. Mol. Microbiol. 37: 763-772 (2000).

de Rudder KE, Thomas-Oates JE, Geiger O. Rhizobium meliloti mutants deficient in phospholipid N-methyltransferase still contain phosphatidylcholine. J. Bacteriol. 179: 6921-6928 (1997).

de Rudder KEE, Sohlenkamp C, Geiger O. Plant exuded choline is used for rhizobial membrane lipid biosynthesis by phosphatidylcholine synthase. J. Biol. Chem. 274: 20011-20016 (1999).

De Sutter V, Vanderhaeghen R, Tilleman S, Lammertyn F, Vanhoutte I, Karimi M, Inze D, Goossens A, Hilson P. Exploration of jasmonate signalling via automated and standardized transient expression assays in tobacco cells. Plant J. 44: 1065-1076 (2005).

Deavours BE, Liu CJ, Naoumkina MA, Tang Y, Farag MA, Sumner LW, Noel JP, Dixon RA. Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula. Plant Mol. Biol. 62: 715-733 (2006).

Delle Fratte S, Iurescia S, Angelaccio S, Bossa F, Schirch V. The function of arginine 363 as the substrate carboxyl-binding site in Escherichia coli serine hydroxymethyltransferase. Eur. J. Biochem. 225: 395-401 (1994).

Delle Fratte S, White RH, Maras B, Bossa F, Schirch V. Purification and properties of serine hydroxymethyltransferase from Sulfolobus solfataricus. J. Bacteriol. 179: 7456-7461 (1997).

DeLong CJ, Shen YJ, Thomas MJ, Cui Z. Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway. J. Biol. Chem. 274: 29683-29688 (1999).

Demirci H, Gregory ST, Dahlberg AE, Jogl G. Multiple-site trimethylation of ribosomal protein L11 by the PrmA methyltransferase. Structure 16: 1059-1066 (2008).

Desel C, Hubbermann EM, Schwarz K, Krupinska K. Nitration of gamma-tocopherol in plant tissues. Planta 226: 1311-1322 (2007).

Devi MT, Raghavendra AS. Photorespiration in C3-C4, intermediate species of Alternanthera and Parthenium: reduced ammonia production and increased capacity CO2 refixation in the light. Photosynth. Res. 38: 177-184 (1993).

Devi MT, Rajagopalan AV, Raghavendra AS. Predominant localization of mitochondria enriched with glycine decarboxylating enzymes in bundle-sheath cells of Alternanthera tenella, a C3-C4 intermediate species. Plant Cell Environ. 18: 589-594 (1995).

di Salvo ML, Delle Fratte S, De Biase D, Bossa F, Schirch V. Purification and characterization of recombinant rabbit cytosolic serine hydroxymethyltransferase. Protein Expr. Purif. 13: 177-183 (1998).

Diab F, Bernard T, Bazire A, Haras D, Blanco C, Jebbar M. Succinate-mediated catabolite repression control on the production of glycine betaine catabolic enzymes in Pseudomonas aeruginosa PAO1 under low and elevated salinities. Microbiology 152: 1395-1406 (2006).

Ding Y, Wang X, Su L, Zhai J, Cao S, Zhang D, Liu C, Bi Y, Qian Q, Cheng Z, Chu C, Cao X. SDG714, a histone H3K9 methyltransferase, is involved in Tos17 DNA methylation and transposition in rice. Plant Cell 19: 9-22 (2007).

Dinkins RD, Majee SM, Nayak NR, Martin D, Xu Q, Belcastro MP, Houtz RL, Beach CM, Downie AB. Changing transcriptional initiation sites and alternative 5'- and 3'-splice site selection of the first intron deploys Arabidopsis protein isoaspartyl methyltransferase2 variants to different subcellular compartments. Plant J. 55: 1-13 (2008).

Dixon RA. Plant natural products: the molecular genetic basis of biosynthetic diversity. Curr. Opin. Biotechnol. 10: 192-197 (1999).

Do CT, Pollet B, Thevenin J, Sibout R, Denoue D, Barriere Y, Lapierre C, Jouanin L. Both caffeoyl coenzyme A 3-O-methyltransferase 1 and caffeic acid O-methyltransferase 1 are involved in redundant functions for lignin, flavonoids and sinapoyl malate biosynthesis in Arabidopsis. Planta 226: 1117-1129 (2007).

Douce R, Bourguignon J, Neuburger M, Rebeille F. The glycine decarboxylase system: a fascinating complex. Trends Plant Sci. 6: 167-176 (2001).

Dudareva N, Raguso RA, Wang J, Ross JR, Pichersky E. Floral scent production in Clarkia breweri. III. Enzymatic synthesis and emission of benzenoid esters. Plant Physiol. 116: 599-604 (1998).

Ebbs ML, Bender J. Locus-specific control of DNA methylation by the Arabidopsis SUVH5 histone methyltransferase. Plant Cell 18: 1166-1176 (2006).

Eckardt NA. Probing the mysteries of lignin biosynthesis: the crystal structure of caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase provides new insights. Plant Cell 14: 1185-1189 (2002).

Effmert U, Saschenbrecker S, Ross J, Negre F, Fraser CM, Noel JP, Dudareva N, Piechulla B. Floral benzenoid carboxyl methyltransferases: from in vitro to in planta function. Phytochemistry 66: 1211-1230 (2005).

Eisenhut M, Kahlon S, Hasse D, Ewald R, Lieman-Hurwitz J, Ogawa T, Ruth W, Bauwe H, Kaplan A, Hagemann M. The plant-like C2 glycolate pathway and the bacterial-like glycerate cycle cooperate in phosphoglycolate metabolism in cyanobacteria. Plant Physiol. 142: 333-342 (2006).

Ellis DR, Sors TG, Brunk DG, Albrecht C, Orser C, Lahner B, Wood KV, Harris HH, Pickering IJ, Salt DE. Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase. BMC Plant Biol. 4: 1 (2004).

Emmert JL, Garrow TA, Baker DH. Hepatic betaine-homocysteine methyltransferase activity in the chicken is influenced by dietary intake of sulfur amino acids, choline and betaine. J. Nutr. 126: 2050-2058 (1996).

Fan Q, Miao J, Cui L, Cui L. Characterization of PRMT1 from Plasmodium falciparum. Biochem. J. 421: 107-118 (2009).

Federolf K, Alfermann AW, Fuss E. Aryltetralin-lignan formation in two different cell suspension cultures of Linum album: deoxypodophyllotoxin 6-hydroxylase, a key enzyme for the formation of 6-methoxypodophyllotoxin. Phytochemistry 68: 1397-1406 (2007).

Fellenberg C, Milkowski C, Hause B, Lange PR, Böttcher CT, Schmidt J, Vogt T. Tapetum specific location of a cation-dependent O-methyltransferase in Arabidopsis thaliana. Plant J. 56: 132-145 (2008).

Ferrer JL, Zubieta C, Dixon RA, Noel JP. Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase. Plant Physiol. 137: 1009-1017 (2005).

Ferron F, Longhi S, Henrissat B, Canard B. Viral RNA-polymerases -- a predicted 2'-O-ribose methyltransferase domain shared by all Mononegavirales. Trends Biochem. Sci. 27: 222-224 (2002).

Ferry JG. Enzymology of one-carbon metabolism in methanogenic pathways. FEMS Microbiol. Rev. 23: 13-38 (1999).

Finkelstein JD. Inborn errors of sulfur-containing amino acid metabolism. J. Nutr. 136: 1750S-1754S (2006).

Finkelstein JD, Martin JJ. Methionine metabolism in mammals. Adaptation to methionine excess. J. Biol. Chem. 261: 1582-1587 (1986).

Finkelstein JD, Martin JJ. Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. J. Biol. Chem. 259: 9508-9513 (1984).

Finnegan EJ, Dennis ES. Isolation and identification by sequence homology of a putative cytosine methyltransferase from Arabidopsis thaliana. Nucleic Acids Res. 21: 2383-2388 (1993).

Finnegan EJ, Genger RK, Peacock WJ, Dennis ES. DNA methylation in plants. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49: 223-247 (1998).

Finnegan EJ, Kovac KA. Plant DNA methyltransferases. Plant Mol. Biol. 43: 189-201 (2000).

Fischer JA, McCann MP, Snetselaar KM. Methylation is involved in the Ustilago maydis mating response. Fungal Genet. Biol. 34: 21-35 (2001).

Fisher MC, Zeisel SH, Mar MH, Sadler TW. Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro. FASEB J. 16: 619-621 (2002).

Fontecave M, Atta M, Mulliez E. S-Adenosylmethionine: nothing goes to waste. Trends Biochem. Sci. 29: 243-249 (2004).

Foster JW, Moreno M. Inducible acid tolerance mechanisms in enteric bacteria. Novartis Found. Symp. 221: 55-69 (1999).

Fowler B. Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. Semin. Vasc. Med. 5: 77-86 (2005).

Franca SC, Roberto PG, Marins MA, Puga RD, Rodrigues A, Pereira JO. Biosynthesis of secondary metabolites in sugarcane. Genet. Mol. Biol. 24: 243-250 (2001).

Frasca V, Banerjee RV, Dunham WR, Sands RH, Matthews RG. Cobalamin-dependent methionine synthase from Escherichia coli B: electron paramagnetic resonance spectra of the inactive form and the active methylated form of the enzyme. Biochemistry 27: 8458-8465 (1988).

Freitag A, Mendez C, Salas JA, Kammerer B, Li SM, Heide L. Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512. Metab. Eng. 8: 653-661 (2006).

Frick S, Kutchan TM. Molecular cloning and functional expression of O-methyltransferases common to isoquinoline alkaloid and phenylpropanoid biosynthesis. Plant J. 17: 329-339 (1999).

Frick S, Ounaroon A, Kutchan TM. Combinatorial biochemistry in plants: the case of O-methyltransferases. Phytochemistry 56: 1-4 (2001).

Fu TF, Boja ES, Safo MK, Schirch V. Role of proline residues in the folding of serine hydroxymethyltransferase. J. Biol. Chem. 278: 31088-31094 (2003).

Fu TF, Rife JP, Schirch V. The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in mcf-7 cells as determined by 13C NMR. Arch. Biochem. Biophys. 393: 42-50 (2001).

Fujioka M. Mammalian small molecule methyltransferases: their structural and functional features. Int. J. Biochem. 24: 1917-1924 (1992).

Fujiwara K, Okamura-Ikeda K, Motokawa Y. Amino acid sequence of the phosphopyridoxyl peptide from P-protein of the chicken liver glycine cleavage system. Biochem. Biophys. Res. Commun. 149: 621-627 (1987).

Fujiwara K, Okamura-Ikeda K, Ohmura Y, Motokawa Y. Mechanism of the glycine cleavage reaction: retention of C-2 hydrogens of glycine on the intermediate attached to H-protein and evidence for the inability of serine hydroxymethyltransferase to catalyze the glycine decarboxylation. Arch. Biochem. Biophys. 251: 121-127 (1986).

Gang DR. Evolution of flavors and scents. Annu. Rev. Plant Biol. 56: 301-325 (2005).

Gang DR, Lavid N, Zubieta C, Chen F, Beuerle T, Lewinsohn E, Noel JP, Pichersky E. Characterization of phenylpropene O-methyltransferases from sweet basil: facile change of substrate specificity and convergent evolution within a plant O-methyltransferase family. Plant Cell 14: 505-519 (2002).

Garat A, Cauffiez C, Renault N, Lo-Guidice JM, Allorge D, Chevalier D, Houdret N, Chavatte P, Loriot MA, Gala JL, Broly F. Characterisation of novel defective thiopurine S-methyltransferase allelic variants. Biochem. Pharmacol. 76: 404-415 (2008).

Garrido F, Gasset M, Sanz-Aparicio J, Alfonso C, Pajares MA. Rat liver betaine homocysteine S-methyltransferase equilibrium unfolding: insights into intermediate structure through tryptophan substitutions. Biochem. J. 391: 589-599 (2005).

Garrow TA. Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase. J. Biol. Chem. 271: 22831-22838 (1996).

Garrow TA, Brenner AA, Whitehead VM, Chen XN, Duncan RG, Korenberg JR, Shane B. Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization. J. Biol. Chem. 268: 11910-11916 (1993).

Gavilanes F, Peterson D, Bullis B, Schirch L. Structure and reactivity of cysteine residues in mitochondrial serine hydroxymethyltransferase. J. Biol. Chem. 258: 13155-13159 (1983).

Geisel J, Hubner U, Bodis M, Schorr H, Knapp JP, Obeid R, Herrmann W. The role of genetic factors in the development of hyperhomocysteinemia. Clin. Chem. Lab. Med. 41: 1427-1434 (2003).

Gelling CL, Piper MD, Hong SP, Kornfeld GD, Dawes IW. Identification of a novel one-carbon metabolism regulon in Saccharomyces cerevisiae. J. Biol. Chem. 279: 7072-7081 (2004).

Genger RK, Kovac KA, Dennis ES, Peacock WJ, Finnegan EJ. Multiple DNA methyltransferase genes in Arabidopsis thaliana. Plant Mol. Biol. 41: 269-278 (1999).

Germann S, Juul-Jensen T, Letarnec B, Gaudin V. DamID, a new tool for studying plant chromatin profiling in vivo, and its use to identify putative LHP1 target loci. Plant J. 48: 153-163 (2006).

Giannino D, Mele G, Cozza R, Bruno L, Testone G, Ticconi C, Frugis G, Bitonti MB, Innocenti AM, Mariotti D. Isolation and characterization of a maintenance DNA-methyltransferase gene from peach (Prunus persica [L.] Batsch): transcript localization in vegetative and reproductive meristems of triple buds. J. Exp. Bot. 54: 2623-2633 (2003).

Goeger DE, Ganther HE. Homocysteine-dependent demethylation of trimethylselenonium ion and selenobetaine with methionine formation. Arch. Biochem. Biophys. 302: 222-227 (1993).

Gong Z, Koiwa H, Cushman MA, Ray A, Bufford D, Kore-eda S, Matsumoto TK, Zhu J, Cushman JC, Bressan RA, Hasegawa PM. Genes that are uniquely stress regulated in salt overly sensitive (sos) mutants. Plant Physiol. 126: 363-375 (2001).

Gonzalez B, Pajares MA, Martinez-Ripoll M, Blundell TL, Sanz-Aparicio J. Crystal structure of rat liver betaine homocysteine S-methyltransferase reveals new oligomerization features and conformational changes upon substrate binding. J. Mol. Biol. 338: 771-782 (2004).

Gonzalez B, Pajares MA, Too HP, Garrido F, Blundell TL, Sanz-Aparicio J. Crystallization and preliminary X-ray study of recombinant betaine-homocysteine S-methyltransferase from rat liver. Acta Crystallogr. D. Biol.Crystallogr. 58: 1507-1510 (2002).

Goubet F, Mohnen D. Solubilization and partial characterization of homogalacturonan-methyltransferase from microsomal membranes of suspension-cultured tobacco cells. Plant Physiol. 121: 281-290 (1999).

Goubet F, Mohnen D. Subcellular localization and topology of homogalacturonan methyltransferase in suspension-cultured Nicotiana tabacum cells. Planta 209: 112-117 (1999).

Goujon T, Sibout R, Pollet B, Maba B, Nussaume L, Bechtold N, Lu F, Ralph J, Mila I, Barriere Y, Lapierre C, Jouanin L. A new Arabidopsis thaliana mutant deficient in the expression of O-methyltransferase impacts lignins and sinapoyl esters. Plant Mol. Biol. 51: 973-989 (2003).

Goyer A, Collakova E, Diaz de la Garza R, Quinlivan EP, Williamson J, Gregory JF 3rd, Shachar-Hill Y, Hanson AD. 5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves. J. Biol. Chem. 280: 26137-26142 (2005).

Grabau W, Rudiger H. Purification and properties of the tetrahydropteroylglutamate methyltransferase from green beans. Hoppe Seylers Z. Physiol. Chem. 358: 695-698 (1977).

Grebenok RJ, Galbraith DW, Penna DD. Characterization of Zea mays endosperm C-24 sterol methyltransferase: one of two types of sterol methyltransferase in higher plants. Plant Mol. Biol. 34: 891-896 (1997).

Green JM, Ballou DP, Matthews RG. Examination of the role of methylenetetrahydrofolate reductase in incorporation of methyltetrahydrofolate into cellular metabolism. FASEB J. 2: 42-47 (1988).

Grienenberger E, Besseau S, Geoffroy P, Debayle D, Heintz D, Lapierre C, Pollet B, Heitz T, Legrand M. A BAHD acyltransferase is expressed in tapetum of Arabidopsis anthers and is involved in the synthesis of hydroxycinnamoyl spermidines. Plant J. 58: 246-259 (2009).

Guattari B. High-performance liquid chromatographic determination, with ultraviolet detection, of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in rat tissues … J. Chromatogr. 567: 254-260 (1991).

Guinel FC, Ireland RJ. Immunogold localization and quantitative distribution of two proteins of the glycine decarboxylase complex in developing leaflets of pea (Pisum sativum L). Int. J. Plant Sci. 157: 539-545 (1996).

Gunawardene YI, Tobe SS, Bendena WG, Chow BK, Yagi KJ, Chan SM. Function and cellular localization of farnesoic acid O-methyltransferase (FAMeT) in the shrimp, Metapenaeus ensis. Eur. J. Biochem. 269: 3587-3595 (2002).

Guo D, Chen F, Dixon RA. Monolignol biosynthesis in microsomal preparations from lignifying stems of alfalfa (Medicago sativa L.). Phytochemistry 61: 657-667 (2002).

Guo D, Chen F, Inoue K, Blount JW, Dixon RA. Downregulation of caffeic acid 3-O-methyltransferase and caffeoyl CoA 3-O-methyltransferase in transgenic alfalfa. Impacts on lignin structure and implications for the biosynthesis of G and S lignin. Plant Cell 13: 73-88 (2001).

Hao B, Gong WM, Ferguson TK, James CM, Krzycki JA, Chan MK. A new UAG-encoded residue in the structure of a methanogen methyltransferase. Science 296: 1462-1466 (2002).

Hartung W, Ratcliffe RG. Utilization of glycine and serine as nitrogen sources in the roots of Zea mays and Chamaegigas intrepidus. J. Exp. Bot. 53: 2305-2314 (2002).

Hase Y, Fujioka S, Yoshida S, Sun G, Umeda M, Tanaka A. Ectopic endoreduplication caused by sterol alteration results in serrated petals in Arabidopsis. J. Exp. Bot. 56: 1263-1268 (2005).

Hasegawa T, Mihara M, Nakamuro K, Sayato Y. Mechanisms of selenium methylation and toxicity in mice treated with selenocystine. Arch. Toxicol. 71: 31-38 (1996).

Hashimoto T, Shoji T, Mihara T, Oguri H, Tamaki K, Suzuki K, Yamada Y. Intraspecific variability of the tandem repeats in Nicotiana putrescine N-methyltransferases Plant Mol. Biol. 37: 25-37 (1998).

Hashimoto T, Tamaki K, Suzuki K, Yamada Y. Molecular cloning of plant spermidine synthases. Plant Cell Physiol. 39: 73-79 (1998).

Hashizume K, Tozawa K, Endo M, Aramaki I. S-Adenosyl-L-methionine-dependent O-methylation of 2-hydroxy-3-alkylpyrazine in wine grapes: a putative final step of methoxypyrazine biosynthesis. Biosci. Biotechnol. Biochem. 65: 795-801 (2001).

Hashizume K, Tozawa K, Hiraga Y, Aramaki I. Purification and characterization of a O-methyltransferase capable of methylating 2-hydroxy-3-alkylpyrazine from Vitis vinifera L. (cv. Cabernet Sauvignon). Biosci. Biotechnol. Biochem. 65: 2213-2219 (2001).

He XZ, Dixon RA. Genetic manipulation of isoflavone 7-O-methyltransferase enhances biosynthesis of 4'-O-methylated isoflavonoid phytoalexins and disease resistance in alfalfa. Plant Cell 12: 1689-1702 (2000).

He XZ, Reddy JT, Dixon RA. Stress responses in alfalfa (Medicago sativa L). XXII. cDNA cloning and characterization of an elicitor-inducible isoflavone 7-O-methyltransferase. Plant Mol. Biol. 36: 43-54 (1998).

Heil SG, Lievers KJ, Boers GH, Verhoef P, den Heijer M, Trijbels FJ, Blom HJ. Betaine-homocysteine methyltransferase (BHMT): genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans. Mol. Genet. Metab. 71: 511-519 (2000).

Hendricks CL, Ross JR, Pichersky E, Noel JP, Zhou ZS. An enzyme-coupled colorimetric assay for S-adenosylmethionine-dependent methyltransferases. Anal. Biochem. 326: 100-105 (2004).

Hermann C, Legrand M, Geoffroy P, Fritig B. Enzymatic synthesis of lignin: purification to homogeneity of the three O-methyltransferases of tobacco and production of specific antibodies. Arch. Biochem. Biophys. 253: 367-376 (1987).

Hermes M, Geisler H, Osswald H, Riehle R, Kloor D. Alterations in S-adenosylhomocysteine metabolism decrease O6-methylguanine DNA methyltransferase gene expression without affecting promoter methylation. Biochem. Pharmacol. 75: 2100-2111 (2008).

Hibi N, Fujita T, Hatano M, Hashimoto T, Yamada Y. Putrescine N-methyltransferase in cultured roots of Hyoscyamus niger. n-Butylamine as a potent inhibitor of the transferase both in vitro and in vivo. Plant Physiol. 100: 826-835 (1992).

Hibi N, Higashiguchi S, Hashimoto T, Yamada Y. Gene expression in tobacco low-nicotine mutants. Plant Cell 6: 723-735 (1994).

Hiraga K, Koyata H. Abnormal metabolism of substances related to glycine and beta-alanine. Nippon Rinsho 50: 1575-1580 (1992).

Ho CL, Saito K. Molecular biology of the plastidic phosphorylated serine biosynthetic pathway in Arabidopsis thaliana. Amino Acids 20: 243-259 (2001).

Holm PI, Bleie O, Ueland PM, Lien EA, Refsum H, Nordrehaug JE, Nygard O. Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation. Arterioscler. Thromb. Vasc. Biol. 24: 301-307 (2004).

Holmberg N, Harker M, Gibbard CL, Wallace AD, Clayton JC, Rawlins S, Hellyer A, Safford R. Sterol C-24 methyltransferase type 1 controls the flux of carbon into sterol biosynthesis in tobacco seed. Plant Physiol. 130: 303-311 (2002).

Holmberg N, Harker M, Wallace AD, Clayton JC, Gibbard CL, Safford R. Co-expression of N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase and C24-sterol methyltransferase type 1 in transgenic tobacco enhances carbon flux towards end-product sterols. Plant J. 36: 12-20 (2003).

Hong MC, Wu ML, Chang MC. Cloning and complete nucleotide sequence of Acinetobacter radioresistens CMC-1 AglyA gene encoding serine hydroxymethyltransferase. FEMS Microbiol. Lett. 170: 413-418 (1999).

Hopkins S, Schirch V. Properties of a serine hydroxymethyltransferase in which an active site histidine has been changed to an asparagine by site-directed mutagenesis. J. Biol. Chem. 261: 3363-3369 (1986).

Hopkins S, Schirch V. Properties of a serine hydroxymethyltransferase in which an active site histidine has been changed to an asparagine by site-directed mutagenesis. J. Biol. Chem. 261: 3363-3369 (1986).

Hourton-Cabassa C, Ambard-Bretteville F, Moreau F, Davy de Virville J, Remy R, Francs-Small CC. Stress induction of mitochondrial formate dehydrogenase in potato leaves. Plant Physiol. 116: 627-635 (1998).

Hsiao YY, Tsai WC, Kuoh CS, Huang TH, Wang HC, Wu TS, Leu YL, Chen WH, Chen HH. Comparison of transcripts in Phalaenopsis bellina and Phalaenopsis equestris (Orchidaceae) flowers to deduce monoterpene biosynthesis pathway. BMC Plant Biol. 6: 14 (2006).

Huang TS, Anzellotti D, Dedaldechamp F, Ibrahim RK. Partial purification, kinetic analysis, and amino acid sequence information of a flavonol 3-O-methyltransferase from Serratula tinctoria. Plant Physiol. 134: 1366-1376 (2004).

Huang Y, Komoto J, Konishi K, Takata Y, Ogawa H, Gomi T, Fujioka M, Takusagawa F. Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes. J. Mol. Biol. 298: 149-162 (2000).

Huennekens FM, Duffy TH, Vitols KS. Folic acid metabolism and its disruption by pharmacologic agents. N.C.I. Monogr. 5: 1-8 (1987).

Humphreys JM, Hemm MR, Chapple C. New routes for lignin biosynthesis defined by biochemical characterization of recombinant ferulate 5-hydroxylase, a multifunctional cytochrome P450-dependent monooxygenase. Proc. Natl. Acad. Sci. U.S.A. 96: 10045-10050 (1999).

Ibar C, Orellana A. The import of S-adenosylmethionine into the Golgi apparatus is required for the methylation of homogalacturonan. Plant Physiol. 145: 504-512 (2007).

Ibrahim RK, Bruneau A, Bantignies B. Plant O-methyltransferases: molecular analysis, common signature and classification. Plant Mol. Biol. 36: 1-10 (1998).

Igamberdiev AU, Bykova NV, Kleczkowski LA. Origins and metabolism of formate in higher plants. Plant Physiol. Biochem. 37: 503-513 (1999).

Im CS, Grossman AR. Identification and regulation of high light-induced genes in Chlamydomonas reinhardtii. Plant J. 30: 301-313 (2002).

Imanishi S, Hashizume K, Nakakita M, Kojima H, Matsubayashi Y, Hashimoto T, Sakagami Y, Yamada Y, Nakamura K. Differential induction by methyl jasmonate of genes encoding ornithine decarboxylase and other enzymes involved in nicotine biosynthesis in tobacco cell cultures. Plant Mol. Biol. 38: 1101-1111 (1998).

Incharoensakdi A, Waditee R. Degradation of glycinebetaine by betaine-homocysteine methyltransferase in Aphanothece halophytica: effect of salt downshock and starvation. Curr. Microbiol. 41: 227-231 (2000).

Inoue K, Parvathi K, Dixon RA. Substrate preferences of caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferases in developing stems of alfalfa (Medicago sativa L.). Arch. Biochem. Biophys. 375: 175-182 (2000).

Inoue K, Sewalt VJ, Murray GB, Ni W, Sturzer C, Dixon RA. Developmental expression and substrate specificities of alfalfa caffeic acid 3-O-methyltransferase and caffeoyl coenzyme A 3-O-methyltransferase in relation to lignification. Plant Physiol. 117: 761-770 (1998).

Isakovic L, Saavedra OM, Llewellyn DB, Claridge S, Zhan L, Bernstein N, Vaisburg A, Elowe N, Petschner AJ, Rahil J, Beaulieu N, Gauthier F, MacLeod AR, Delorme D, Besterman JM, Wahhab A. Constrained (L-)-S-adenosyl-L-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg. Med. Chem. Lett. 19: 2742-2746 (2009).

Ishikawa A, Kuma T, Sasaki H, Sasaki N, Ozeki Y, Kobayashi N, Kitamura Y. Constitutive expression of bergaptol O-methyltransferase in Glehnia littoralis cell cultures. Plant Cell Rep. 28: 257-265 (2009).

Ishikawa M, Kuroyama H, Takeuchi Y, Tsumuraya Y. Characterization of pectin methyltransferase from soybean hypocotyls. Planta 210: 782-791 (2000).

Ishitani M, Majumder AL, Bornhouser A, Michalowski CB, Jensen RG, Bohnert HJ. Coordinate transcriptional induction of myo-inositol metabolism during environmental stress. Plant J. 9: 537-548 (1996).

Itoh N, Toda H, Matsuda M, Negishi T, Taniguchi T, Ohsawa N. Involvement of S-adenosylmethionine-dependent halide/thiol methyltransferase (HTMT) in methyl halide emissions from agricultural plants: isolation and characterization of an HTMT-coding gene from Raphanus sativus (daikon radish). BMC Plant Biol. 9: 116 (2009).

Jacobs RL, Stead LM, Devlin C, Tabas I, Brosnan ME, Brosnan JT, Vance DE. Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J. Biol. Chem. 280: 28299-28305 (2005).

Jagath-Reddy J, Ganesan K, Savithri HS, Datta A, Rao NA. cDNA cloning, overexpression in Escherichia coli, purification and characterization of sheep liver cytosolic serine hydroxymethyltransferase. Eur. J. Biochem. 230: 533-537 (1995).

Jain A, Ziegler J, Liscombe DK, Facchini PJ, Tucker PA, Panjikar S. Purification, crystallization and X-ray diffraction analysis of pavine N-methyltransferase from Thalictrum flavum. Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 64: 1066-1069 (2008).

Jamai A, Salome PA, Schilling SH, Weber AP, McClung CR. Arabidopsis photorespiratory serine hydroxymethyltransferase activity requires the mitochondrial accumulation of ferredoxin-dependent glutamate synthase. Plant Cell 21: 595-606 (2009).

James F, Nolte KD, Hanson AD. Purification and properties of S-adenosyl-L-methionine:L-methionine S-methyltransferase from Wollastonia biflora leaves. J. Biol. Chem. 270: 22344-22350 (1995).

James SJ, Melnyk S, Pogribna M, Pogribny IP, Caudill MA. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J. Nutr. 132: 2361S-2366S (2002).

Jansen M, Hansen TA. Tetrahydrofolate serves as a methyl acceptor in the demethylation of dimethylsulfoniopropionate in cell extracts of sulfate-reducing bacteria. Arch. Microbiol. 169: 84-87 (1998).

Jasencakova Z, Soppe WJ, Meister A, Gernand D, Turner BM, Schubert I. Histone modifications in Arabidopsis- high methylation of H3 lysine 9 is dispensable for constitutive heterochromatin. Plant J. 33: 471-480 (2003).

Jay M, De Luca V, Ibrahim RK. Purification, properties and kinetic mechanism of flavonol 8-O-methyltransferase from Lotus corniculatus L. Eur. J. Biochem. 153: 321-325 (1985).

Jehnes S, Betz G, Bahnweg G, Haberer K, Sandermann H, Rennenberg H. Tree internal signalling and defence reactions under ozone exposure in sun and shade leaves of European beech (Fagus sylvatica L.) trees. Plant Biol. (Stuttg.) 9: 253-264 (2007).

Jeong SS, Schirch V. Role of cytosolic serine hydroxymethyltransferase in one-carbon metabolism in Neurospora crassa. Arch. Biochem. Biophys. 335: 333-341 (1996).

Ji C, Shinohara M, Vance D, Than TA, Ookhtens M, Chan C, Kaplowitz N. Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcohol Clin. Exp. Res. 32: 1049-1058 (2008).

Jiracek J, Collinsova M, Rosenberg I, Budesinsky M, Protivinska E, Netusilova H, Garrow TA. S-Alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase. J. Med. Chem. 49: 3982-3989 (2006).

Jones CE, Brook JM, Buck D, Abell C, Smith AG. Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme. J. Bacteriol. 175: 2125-2130 (1993).

Joshi CP, Chiang VL. Conserved sequence motifs in plant S-adenosyl-L-methionine-dependent methyltransferases. Plant Mol. Biol. 37: 663-674 (1998).

Jost R, Berkowitz O, Shaw J, Masle J. Biochemical characterization of two wheat phosphoethanolamine N-methyltransferase isoforms with different sensitivities to inhibition by phosphatidic acid. J. Biol. Chem. Sep 17 [Epub ahead of print] (2009).

Jouanin L, Goujon T, de Nadai V, Martin MT, Mila I, Vallet C, Pollet B, Yoshinaga A, Chabbert B, Petit-Conil M, Lapierre C. Lignification in transgenic poplars with extremely reduced caffeic acid O-methyltransferase activity. Plant Physiol. 123: 1363-1374 (2000).

Kacprzak MM, Lewandowska I, Matthews RG, Paszewski A. Transcriptional regulation of methionine synthase by hornocysteine and choline in Aspergillus nidulans. Biochem. J. 376: 517-524 (2003).

Kaczorowski T, Sektas M, Skowron P, Podhajska AJ. The FokI methyltransferase from Flavobacterium okeanokoites. Purification and characterization of the enzyme and its truncated derivatives. Mol. Biotechnol. 13: 1-15 (1999).

Kai G, Zhang Y, Chen J, Li L, Yan X, Zhang R, Liao P, Lu X, Wang W, Zhou G. Molecular characterization and expression analysis of two distinct putrescine N-methyltransferases from roots of Anisodus acutangulus. Physiol. Plant. 135: 121-129 (2009).

Kai K, Mizutani M, Kawamura N, Yamamoto R, Tamai M, Yamaguchi H, Sakata K, Shimizu BI. Scopoletin is biosynthesized via ortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase in Arabidopsis thaliana. Plant J. 55: 989-999 (2008).

Kapoor A, Agius F, Zhu JK. Preventing transcriptional gene silencing by active DNA demethylation. FEBS Lett. 579: 5889-5898 (2005).

Karpinska B, Karlsson M, Srivastava M, Stenberg A, Schrader J, Sterky F, Bhalerao R, Wingsle G. MYB transcription factors are differentially expressed and regulated during secondary vascular tissue development in hybrid aspen. Plant Mol. Biol. 56: 255-270 (2004).

Kastanos EK, Woldman YY, Appling DR. Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae. Biochemistry 36: 14956-14964 (1997).

Kato M, Mizuno K. Caffeine synthase and related methyltransferases in plants. Front. Biosci. 9: 1833-1842 (2004).

Kato M, Mizuno K, Crozier A, Fujimura T, Ashihara H. Caffeine synthase gene from tea leaves. Nature 406: 956-957 (2000).

Kato M, Mizuno K, Fujimura T, Iwama M, Irie M, Crozier A, Ashihara H. Purification and characterization of caffeine synthase from tea leaves. Plant Physiol. 120: 579-586 (1999).

Kato N, Dubouzet E, Kokabu Y, Yoshida S, Taniguchi Y, Dubouzet JG, Yazaki K, Sato F. Identification of a WRKY protein as a transcriptional regulator of benzylisoquinoline alkaloid biosynthesis in Coptis japonica. Plant Cell Physiol. 48: 8-18 (2007).

Kawasaki S, Arai H, Kodama T, Igarashi Y. Gene cluster for dissimilatory nitrite reductase (nir) from Pseudomonas aeruginosa: sequencing and identification of a locus for heme d1biosynthesis. J. Bacteriol. 179: 235-242 (1997).

Keating JN, Trimble KC, Mulcahy F, Scott JM, Weir DG. Evidence of brain methyltransferase inhibition and early brain involvement in HIV-positive patients. Lancet 337: 935-939 (1991).

Keogh MR, Courtney PD, Kinney AJ, Dewey RE. Functional characterization of phospholipid N-methyltransferases from Arabidopsis and soybean. J. Biol. Chem. 284: 15439-15447 (2009).

Kharbanda KK. Alcoholic liver disease and methionine metabolism. Semin Liver Dis. 29: 155-165 (2009).

Kharbanda KK, Rogers DD 2nd, Mailliard ME, Siford GL, Barak AJ, Beckenhauer HC, Sorrell MF, Tuma DJ. Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine. Biochem. Pharmacol. 70: 1883-1890 (2005).

Kharbanda KK, Vigneswara V, McVicker BL, Newlaczyl AU, Bailey K, Tuma D, Ray DE, Carter WG. Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats. Biochem. Biophys. Res. Commun. 381: 523-527 (2009).

Khouri HE, De Luca V, Ibrahim RK. Enzymatic synthesis of polymethylated flavonols in Chrysosplenium americanum. III. Purification and kinetic analysis of S-adenosyl-L-methionine:3-methylquercetin 7-O-methyltransferase. Arch. Biochem. Biophys. 265: 1-7 (1988).

Kim BG, Lee Y, Hur HG, Lim Y, Ahn JH. Flavonoid 3'-O-methyltransferase from rice: cDNA cloning, characterization and functional expression. Phytochemistry 67: 387-394 (2006).

Kim DW, Delle Fratte S, Jeong SS, Schirch V. Determination of serine hydroxymethyltransferase and reduced folate pools in tissue extracts. Anal. Biochem. 253: 201-209 (1997).

Kim DW, Huang T, Schirch D, Schirch V. Properties of tetrahydropteroylpentaglutamate bound to 10-formyltetrahydrofolate dehydrogenase. Biochemistry 35: 15772-15783 (1996).

Kim EH, Kim YS, Park SH, Koo YJ, Choi YD, Chung YY, Lee IJ, Kim JK. Methyl jasmonate reduces grain yield by mediating stress signals to alter spikelet development in rice. Plant Physiol. 149: 1751-1760 (2009).

Kim HJ, Yano A, Wada Y, Sano H. Properties of a tobacco DNA methyltransferase, NtMET1 and its involvement in chromatin movement during cell division. Ann. Bot. (Lond.) 99: 845-856 (2007).

Kim TW, Chang SC, Lee JS, Takatsuto S, Yokota T, Kim SK. Novel biosynthetic pathway of castasterone from cholesterol in tomato. Plant Physiol. 135: 1231-1242 (2004).

Kimura S, Hayatsu H, Arimoto-Kobayashi S. Glycine betaine in beer as an antimutagenic substance against 2-chloro-4-methylthiobutanoic acid, the sanma-fish mutagen. Mut. Res. 439: 267-276 (1999).

Kinney AJ. Metabolic engineering in plants for human health and nutrition. Curr. Opin. Biotechnol. 17: 130-138 (2006).

Kishimoto N, Sakai H, Jackson J, Jacobsen SE, Meyerowitz EM, Dennis ES, Finnegan EJ. Site specificity of the Arabidopsis METI DNA methyltransferase demonstrated through hypermethylation of the superman locus. Plant Mol. Biol. 46: 171-183 (2001).

Klarzynski O, Plesse B, Joubert JM, Yvin JC, Kopp M, Kloareg B, Fritig B. Linear beta-1,3 glucans are elicitors of defense responses in tobacco. Plant Physiol. 124: 1027-1038 (2000).

Kloor D, Karnahl K, Kompf J. Characterization of glycine N-methyltransferase from rabbit liver. Biochem. Cell. Biol. 82: 369-374 (2004).

Kloor D, Osswald H. S-Adenosylhomocysteine hydrolase as a target for intracellular adenosine action. Trends Pharmacol. Sci. 25: 294-297 (2004).

Klug RM, Benning C. Two enzymes of diacylglyceryl-0-4 '-(N,N,N,- trimethyl)homoserine biosynthesis are encoded by btaA and btaB in the purple bacterium Rhodobacter sphaeroides. Proc. Natl. Acad. Sci. U.S.A. 98: 5910-5915 (2001).

Ko K, Yang H, Noureddin M, Iglesia-Ara A, Xia M, Wagner C, Luka Z, Mato JM, Lu SC. Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice. Lab. Invest. 88: 1121-1129 (2008).

Koch M, Lemke R, Heise KP, Mock HP. Characterization of gamma-tocopherol methyltransferases from Capsicum annuum L and Arabidopsis thaliana. Eur. J. Biochem. 270: 84-92 (2003).

Kocsis MG, Ranocha P, Gage DA, Simon ES, Rhodes D, Peel GJ, Mellema S, Saito K, Awazuhara M, Li C, Meeley RB, Tarczynski MC, Wagner C, Hanson AD. Insertional inactivation of the methionine S-methyltransferase gene eliminates the S-methylmethionine cycle and increases the methylation ratio. Plant Physiol. 131: 1808-1815 (2003).

Kodaki T, Yamashita S. Characterization of the methyltransferases in the yeast phosphatidylethanolamine methylation pathway by selective gene disruption. Eur. J. Biochem. 185: 243-251 (1989).

Kodama Y, Shinya T, Sano H. Dimerization of N-methyltransferases involved in caffeine biosynthesis. Biochimie. 90: 547-551 (2008).

Koeduka T, Baiga TJ, Noel JP, Pichersky E. Biosynthesis of t-anethole in anise: characterization of t-anol/isoeugenol synthase and a O-methyltransferase specific for a C7-C8 propenyl side chain. Plant Physiol. 149: 384-394 (2009).

Kolosova N, Gorenstein N, Kish CM, Dudareva N. Regulation of circadian methyl benzoate emission in diurnally and nocturnally emitting plants. Plant Cell 13: 2333-2347 (2001).

Kolosova N, Sherman D, Karlson D, Dudareva N. Cellular and subcellular localization of S-adenosyl-L-methionine:benzoic acid carboxyl methyltransferase, the enzyme responsible for biosynthesis of the volatile ester methylbenzoate in snapdragon flowers. Plant Physiol. 126: 956-964 (2001).

Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H. Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol. Proc. Natl. Acad. Sci. U.S.A. 105: 7422-7427 (2008).

Koo YJ, Kim MA, Kim EH, Song JT, Jung C, Moon JK, Kim JH, Seo HS, Song SI, Kim JK, Lee JS, Cheong JJ, Choi YD. Overexpression of salicylic acid carboxyl methyltransferase reduces salicylic acid-mediated pathogen resistance in Arabidopsis thaliana. Plant Mol. Biol. 64: 1-15 (2007).

Kopriva S, Bauwe H. Serine hydroxymethyltransferase from Solanum tuberosum. Plant Physiol. 107: 271-272 (1995).

Koshiishi C, Kato A, Yama S, Crozier A, Ashihara H. A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S-adenosyl-L-methionine cycle. FEBS Lett. 499: 50-54 (2001).

Kota P, Guo D, Zubieta C, Noel J, Dixon RA. O-Methylation of benzaldehyde derivatives by "lignin specific" caffeic acid 3-O-methyltransferase. Phytochemistry 65: 837-846 (2004).

Koutmos M, Pejchal R, Bomer TM, Matthews RG, Smith JL, Ludwig ML. Metal active site elasticity linked to activation of homocysteine in methionine synthases. Proc. Natl. Acad. Sci. U.S.A. 105: 3286-3291 (2008).

Krupkova E, Immerzeel P, Pauly M, Schmulling T. The TUMOROUS SHOOT DEVELOPMENT2 gene of Arabidopsis encoding a putative methyltransferase is required for cell adhesion and co-ordinated plant development. Plant J. 50: 735-750 (2007).

Kruschwitz HL, McDonald D, Cossins EA, Schirch V. 5-Formyltetrahydropteroylpolyglutamates are the major folate derivatives in Neurospora crassa conidiospores. J. Biol. Chem. 269: 28757-28763 (1994).

Kurtov D, Kinghorn JR, Unkles SE. The Aspergillus nidulans panB gene encodes ketopantoate hydroxymethyltransferase, required for biosynthesis of pantothenate and Coenzyme A. Mol. Gen. Genet. 262: 115-120 (1999).

Kutrzeba L, Dayan FE, Howell J, Feng J, Giner JL, Zjawiony JK. Biosynthesis of salvinorin A proceeds via the deoxyxylulose phosphate pathway. Phytochemistry 68: 1872-1881 (2007).

Lai MC, Wang CC, Chuang MJ, Wu YC, Lee YC. Effects of substrate and potassium on the betaine-synthesizing enzyme glycine sarcosine dimethylglycine N-methyltransferase from a halophilic methanoarchaeon Methanohalophilus portucalensis. Res. Microbiol. 157: 948-955 (2006).

Lakowski TM, Frankel A. Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. Biochem. J. 421: 253-261 (2009).

Lam KC, Ibrahim RK, Behdad B, Dayanandan S. Structure, function, and evolution of plant O-methyltransferases. Genome 50: 1001-1013 (2007).

Lamango NS, Ayuk-Takem LT, Nesby R, Zhao WQ, Charlton CG. Inhibition mechanism of S-adenosylmethionine-induced movement deficits by prenylcysteine analogs. Pharmacol. Biochem. Behav. 76: 433-442 (2003).

Lambert BD, Titgemeyer EC, Stokka GL, DeBey BM, Loest CA. Methionine supply to growing steers affects hepatic activities of methionine synthase and betaine-homocysteine methyltransferase, but not cystathionine synthase. J. Nutr. 132: 2004-2009 (2002).

Lamblin F, Saladin G, Dehorter B, Cronier D, Grenier E, Lacoux J, Bruyant P, Laine E, Chabbert B, Girault F, Monties B, Morvan C, David H, David A. Overexpression of a heterologous sam gene encoding S-adenosylmethionine synthetase in flax (Linum usitatissimum) cells: Consequences on methylation of lignin precursors and pectins. Physiol. Plant. 112: 223-232 (2001).

Lamers Y, Williamson J, Theriaque DW, Shuster JJ, Gilbert LR, Keeling C, Stacpoole PW, Gregory JF 3rd. Production of 1-carbon units from glycine is extensive in healthy men and women. J. Nutr. 139: 666-671 (2009).

Lapierre C, Pollet B, Petit-Conil M, Toval G, Romero J, Pilate G, Leple JC, Boerjan W, Ferret V, De Nadai V, Jouanin L. Structural alterations of lignins in transgenic poplars with depressed cinnamyl alcohol dehydrogenase or caffeic acid O-methyltransferase activity have an opposite impact on the efficiency of industrial kraft pulping. Plant Physiol. 119: 153-164 (1999).

Lara MV, Offermann S, Smith M, Okita TW, Andreo CS, Edwards GE. Leaf development in the single-cell C4 system in Bienertia sinuspersici: expression of genes and peptide levels for C4 metabolism in relation to chlorenchyma structure under different light conditions. Plant Physiol. 148: 593-610 (2008).

Larsson KA, Zetterlund I, Delp G, Jonsson LM. N-Methyltransferase involved in gramine biosynthesis in barley: cloning and characterization. Phytochemistry 67: 2002-2008 (2006).

Lautala P, Ulmanen I, Taskinen J. Radiochemical high-performance liquid chromatographic assay for the determination of catechol O-methyltransferase activity towards various substrates. J. Chromatogr. B. Biomed. Sci. Appl. 736: 143-151 (1999).

Lavid N, Wang J, Shalit M, Guterman I, Bar E, Beuerle T, Menda N, Shafir S, Zamir D, Adam Z, Vainstein A, Weiss D, Pichersky E, Lewinsohn E. O-Methyltransferases involved in the biosynthesis of volatile phenolic derivatives in rose petals. Plant Physiol. 129: 1899-1907 (2002).

Le Guen L, Santos R, Camadro JM. Functional analysis of the hemK gene product involvement in protoporphyrinogen oxidase activity in yeast. FEMS Microbiol. Lett. 173: 175-182 (1999).

LeDuc DL, Tarun AS, Montes-Bayon M, Meija J, Malit MF, Wu CP, AbdelSamie M, Chiang CY, Tagmount A, DeSouza M, Neuhierl B, Bock A, Caruso J, Terry N. Overexpression of selenocysteine methyltransferase in Arabidopsis and Indian mustard increases selenium tolerance and accumulation. Plant Physiol. 135: 377-383 (2004).

Lee CS, Salcedo E, Wang Q, Wang P, Sims PF, Hyde JE. Characterization of three genes encoding enzymes of the folate biosynthetic pathway in Plasmodium falciparum. Parasitology 122: 1-13 (2001).

Lee HH, Kim do J, Ahn HJ, Ha JY, Suh SW. Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia. J. Biol. Chem. 279: 50514-50523 (2004).

Lee J, Parthier B, Lobler M. Jasmonate signalling can be uncoupled from abscisic acid signalling in barley: identification of jasmonate-regulated transcripts which are not induced by abscisic acid. Planta 199: 625-632 (1996).

Lee KH, Cava M, Amiri P, Ottoboni T, Lindquist RN. Betaine:homocysteine methyltransferase from rat liver: purification and inhibition by a boronic acid substrate analog. Arch. Biochem. Biophys. 292: 77-86 (1992).

Lee M, Huang T, Toro-Ramos T, Fraga M, Last RL, Jander G. Reduced activity of Arabidopsis thaliana HMT2, a methionine biosynthetic enzyme, increases seed methionine content. Plant J. 54: 310-320 (2008).

Lee MB, Blunt JW, Lever M, George PM. A nuclear-magnetic-resonance-based assay for betaine-homocysteine methyltransferase activity. Anal. Biochem. 330: 199-205 (2004).

Leland TJ, Hanson AD. Induction of a specific N-methyltransferase enzyme by long-term heat stress during barley leaf growth. Plant Physiol. 79: 451-457 (1985).

Lenne C, Neuburger M, Douce R. Effect of high physiological temperatures on NAD+ content of green leaf mitochondria. Apparent inhibition of glycine oxidation. Plant Physiol. 102: 1157-1162 (1993).

Leustek T, Smith M, Murillo M, Singh DP, Smith AG, Woodcock SC, Awan SJ, Warren MJ. Siroheme biosynthesis in higher plants. Analysis of an S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase from Arabidopsis thaliana. J. Biol. Chem. 272: 2744-2752 (1997).

Levac D, Murata J, Kim WS, De Luca V. Application of carborundum abrasion for investigating the leaf epidermis: molecular cloning of Catharanthus roseus 16-hydroxytabersonine-16-O-methyltransferase. Plant J. 53: 225-236 (2008).

Lever M, Sizeland PCM, Frampton CM, Chambers ST. Short and long-term variation of plasma glycine betaine concentrations in humans. Clin. Biochem. 37: 184-190 (2004).

Lewinsohn E, Ziv-Raz II, Dudai N, Tadmor Y, Lastochkin E, Larkov O, Chaimovitsh D, Ravid U, Putievsky E, Pichersky E, Shoham Y. Biosynthesis of estragole and methyl-eugenol in sweet basil (Ocimum basilicum L). Developmental and chemotypic association of allylphenol O-methyltransferase activities. Plant Sci. 160: 27-35 (2000).

Lewis RM, Godfrey KM, Jackson AA, Cameron IT, Hanson MA. Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply. J. Clin. Endocrinol. Metab. 90: 1594-1598 (2005).

Li CH, Yu N, Jiang SM, Shangguan XX, Wang LJ, Chen XY. Down-regulation of S-adenosyl-L-homocysteine hydrolase reveals a role of cytokinin in promoting transmethylation reactions. Planta 228: 125-136 (2008).

Li F, Feng Q, Lee C, Wang S, Pelleymounter LL, Moon I, Eckloff BW, Wieben ED, Schaid DJ, Yee V, Weinshilboum RM. Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization. Mol. Genet. Metab. 94: 326-335 (2008).

Li HM, Rotter D, Hartman TG, Pak FE, Havkin-Frenkel D, Belanger FC. Evolution of novel O-methyltransferases from the Vanilla planifolia caffeic acid O-methyltransferase. Plant Mol. Biol. 61: 537-552 (2006).

Li L, Hou X, Tsuge T, Ding M, Aoyama T, Oka A, Gu H, Zhao Y, Qu LJ. The possible action mechanisms of indole-3-acetic acid methyl ester in Arabidopsis. Plant Cell Rep. 27: 575-584 (2008).

Li L, Osakabe Y, Joshi CP, Chiang VL. Secondary xylem-specific expression of caffeoyl-coenzyme A 3-O-methyltransferase plays an important role in the methylation pathway associated with lignin biosynthesis in loblolly pine. Plant Mol. Biol. 40: 555-565 (1999).

Li L, Popko JL, Umezawa T, Chiang VL. 5-Hydroxyconiferyl aldehyde modulates enzymatic methylation for syringyl monolignol formation, a new view of monolignol biosynthesis in angiosperms. J. Biol. Chem. 275: 6537-6545 (2000).

Li L, Popko JL, Zhang XH, Osakabe K, Tsai CJ, Joshi CP, Chiang VL. A novel multifunctional O-methyltransferase implicated in a dual methylation pathway associated with lignin biosynthesis in loblolly pine. Proc. Natl. Acad. Sci. U.S.A. 94: 5461-5466 (1997).

Li R, Moore M, King J. Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana. Plant Cell Physiol. 44: 233-241 (2003).

Li Z, Vance DE. Thematic review series: glycerolipids. Phosphatidylcholine and choline homeostasis. J. Lipid Res. 49: 1187-1194 (2008).

Liang CR, Leow CK, Neo JC, Tan GS, Lo SL, Lim JW, Seow TK, Lai PB, Chung MC. Proteome analysis of human hepatocellular carcinoma tissues by two-dimensional difference gel electrophoresis and mass spectrometry. Proteomics 5: 2258-2271 (2005).

Liao YJ, Liu SP, Lee CM, Yen CH, Chuang PC, Chen CY, Tsai TF, Huang SF, Lee YH, Chen YM. Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: implications of the gender disparity in liver cancer susceptibility. Int. J. Cancer 124: 816-826 (2009).

Lieber CS. New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments. Curr. Gastroenterol. Rep. 6: 60-65 (2004).

Lin YZ, Chen HY, Kao R, Chang SP, Chang SJ, Lai EM. Proteomic analysis of rice defense response induced by probenazole. Phytochemistry 69: 715-728 (2008).

Lin Z, Sparling R. Investigation of serine hydroxymethyltransferase in methanogens. Can. J. Microbiol. 44: 652-656 (1998).

Liu CJ, Dixon RA. Elicitor-induced association of isoflavone O-methyltransferase with endomembranes prevents the formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis. Plant Cell 13: 2643-2658 (2001).

Liu J, Benedict CR, Stipanovic RD, Bell AA. Purification and characterization of S-adenosyl-L-methionine:desoxyhemigossypol-6-O-methyltransferase from cotton plants. An enzyme capable of methylating the defense terpenoids of cotton. Plant Physiol. 121: 1017-1024 (1999).

Liu S, Yu Y, Ruan Y, Meyer D, Wolff M, Xu L, Wang N, Steinmetz A, Shen WH. Plant SET- and RING-associated domain proteins in heterochromatinization. Plant J. 52: 914-926 (2007).

Liu X, Reig B, Nasrallah IM, Stover PJ. Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein. Biochemistry 39: 11523-11531 (2000).

Liu X, Szebenyi DM, Anguera MC, Thiel DJ, Stover PJ. Lack of catalytic activity of a murine mRNA cytoplasmic serine hydroxymethyltransferase splice variant: evidence against alternative splicing as a regulatory mechanism. Biochemistry 40: 4932-4939 (2001).

Lobo SA, Brindley A, Warren MJ, Saraiva LM. Functional characterization of the early steps of tetrapyrrole biosynthesis and modification in Desulfovibrio vulgaris Hildenborough. Biochem. J. 420: 317-325 (2009).

Lorenzin D, Webb C, Summers PS, Weretilnyk EA. Enzymes of choline synthesis in diverse plants: variation in phosphobase N-methyltransferase activities. Can. J. Bot. 79: 897-904 (2001).

Lu WD, Chi ZM, Su CD. Identification of glycine betaine as compatible solute in Synechococcus sp. WH8102 and characterization of its N-methyltransferase genes involved in betaine synthesis. Arch. Microbiol. 186: 495-506 (2006).

Ludwig ML, Matthews RG. Structure-based perspectives on B12-dependent enzymes. Annu. Rev. Biochem. 66: 269-313 (1997).

Luka Z, Capdevila A, Mato JM, Wagner C. A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme. Transgenic Res. 15: 393-397 (2006).

Luka Z, Cerone R, Phillips JA 3rd, Mudd HS, Wagner C. Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. Hum. Genet. 110: 68-74 (2002).

Luka Z, Ham AJ, Norris JL, Yeo EJ, Yermalitsky V, Glenn B, Caprioli RM, Liebler DC, Wagner C. Identification of phosphorylation sites in glycine N-methyltransferase from rat liver. Protein Sci. 15: 785-794 (2006).

Luka Z, Pakhomova S, Loukachevitch LV, Egli M, Newcomer ME, Wagner C. 5-Methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase. J. Biol. Chem. 282: 4069-4075 (2007).

Luka Z, Pakhomova S, Luka Y, Newcomer ME, Wagner C. Destabilization of human glycine N-methyltransferase by H176N mutation. Protein Sci. 16: 1957-1964 (2007).

Luka Z, Wagner C. Expression and purification of glycine N-methyltransferases in Escherichia coli. Protein Expr. Purif. 28: 280-286 (2003).

Luka Z, Wagner C. Human glycine N-methyltransferase is unfolded by urea through a compact monomer state. Arch. Biochem. Biophys. 420: 153-160 (2003).

Luka Z, Wagner C. Effect of naturally occurring mutations in human glycine N-methyltransferase on activity and conformation. Biochem. Biophys. Res. Commun. 312: 1067-1072 (2003).

Lukacin R, Matern U, Specker S, Vogt T. Cations modulate the substrate specificity of bifunctional class I O-methyltransferase from Ammi majus. FEBS Lett. 577: 367-370 (2004).

Lundrigan MD, De Veaux LC, Mann BJ, Kadner RJ. Separate regulatory systems for the repression of metE and btuB by vitamin B12 in Escherichia coli. Mol. Gen. Genet. 206: 401-407 (1987).

Lunkenbein S, Salentijn EM, Coiner HA, Boone MJ, Krens FA, Schwab W. Up- and down-regulation of Fragariaxananassa O-methyltransferase: impacts on furanone and phenylpropanoid metabolism. J. Exp. Bot. 57: 2445-2453 (2006).

Lyi SM, Heller LI, Rutzke M, Welch RM, Kochian LV, Li L. Molecular and biochemical characterization of the selenocysteine Se-methyltransferase gene and Se-methylselenocysteine synthesis in broccoli. Plant Physiol. 138: 409-420 (2005).

Lyi SM, Zhou X, Kochian LV, Li L. Biochemical and molecular characterization of the homocysteine S-methyltransferase from broccoli (Brassica oleracea var. italica). Phytochemistry 68: 1112-1119 (2007).

Ma QH. The expression of caffeic acid 3-O-methyltransferase in two wheat genotypes differing in lodging resistance. J. Exp. Bot. 60: 2763-2771 (2009).

Macfarlane AJ, Liu X, Perry CA, Flodby P, Allen RH, Stabler SP, Stover PJ. Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. J. Biol. Chem. 283: 25846-25853 (2008).

Macfarlane AJ, Perry CA, Girnary HH, Gao D, Allen RH, Stabler SP, Shane B, Stover PJ. Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. J. Biol. Chem. 284: 1533-1539 (2009).

Macherel D, Bourguignon J, Douce R. Cloning of the gene (gdcH) encoding H-protein, a component of the glycine decarboxylase complex of pea (Pisum sativum L.). Biochem. J. 286: 627-630 (1992).

Madlung A, Masuelli RW, Watson B, Reynolds SH, Davison J, Comai L. Remodeling of DNA methylation and phenotypic and transcriptional changes in synthetic Arabidopsis allotetraploids. Plant Physiol. 129: 733-746 (2002).

Malanovic N, Streith I, Wolinski H, Rechberger G, Kohlwein SD, Tehlivets O. S-Adenosyl-L-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosis. J. Biol. Chem. 283: 23989-23999 (2008).

Marita JM, Ralph J, Hatfield RD, Guo D, Chen F, Dixon RA. Structural and compositional modifications in lignin of transgenic alfalfa down-regulated in caffeic acid 3-O-methyltransferase and caffeoyl coenzyme A 3-O-methyltransferase. Phytochemistry 62: 53-65 (2003).

Marti S, Roca M, Andres J, Moliner V, Silla E, Tunon I, Bertran J. Theoretical insights in enzyme catalysis. Chem. Soc. Rev. 33: 98-107 (2004).

Martinez M, Cuskelly GJ, Williamson J, Toth JP, Gregory JF. Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. J. Nutr. 130: 1115-1123 (2000).

Martínez-Chantar ML, Vazquez-Chantada M, Ariz U, Martínez N, Varela M, Luka Z, Capdevila A, Rodríguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, Wagner C, Mato JM. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology 47: 1191-1199 (2008).

Martínez-Lopez N, Varela-Rey M, Ariz U, Embade N, Vazquez-Chantada M, Fernandez-Ramos D, Gomez-Santos L, Lu SC, Mato JM, Martinez-Chantar ML. S-Adenosylmethionine and proliferation: new pathways, new targets. Biochem. Soc. Trans. 36: 848-852 (2008).

Martini F, Angelaccio S, Pascarella S, Barra D, Bossa F, Schirch V. The primary structure of rabbit liver cytosolic serine hydroxymethyltransferase. J. Biol. Chem. 262: 5499-5509 (1987).

Martini F, Maras B, Tanci P, Angelaccio S, Pascarella S, Barra D, Bossa F, Schirch V. The primary structure of rabbit liver mitochondrial serine hydroxymethyltransferase. J. Biol. Chem. 264: 8509-8519 (1989).

Martinov MV, Vitvitsky VM, Mosharov EV, Banerjee R, Ataullakhanov FI. A substrate switch: a new mode of regulation in the methionine metabolic pathway. J. Theor. Biol. 204: 521-532 (2000).

Martz F, Maury S, Pincon G, Legrand M. cDNA cloning, substrate specificity and expression study of tobacco caffeoyl-CoA 3-O-methyltransferase, a lignin biosynthetic enzyme. Plant Mol. Biol. 36: 427-437 (1998).

Matthews RG. Cobalamin-dependent methyltransferases. Acc. Chem. Res. 34: 681-689 (2001).

Matthews RG, Ghose C, Green JM, Matthews KD, Dunlap RB. Folylpolyglutamates as substrates and inhibitors of folate-dependent enzymes. Adv. Enzyme Reg. 26: 157-171 (1987).

Matthews RG, Koutmos M, Datta S. Cobalamin-dependent and cobamide-dependent methyltransferases. Curr. Opin. Struct. Biol. 18: 658-666 (2008).

Matthews RG, Smith AE, Zhou ZHS, Taurog RE, Bandarian V, Evans JC, Ludwig M. Cobalamin-dependent and cobalamin-independent methionine synthases: are there two solutions to the same chemical problem? Helv. Chim. Acta 86: 3939-3954 (2003).

Maury S, Geoffroy P, Legrand M. Tobacco O-methyltransferases involved in phenylpropanoid metabolism. The … Plant Physiol. 121: 215-224 (1999).

McBride AE, Weiss VH, Kim HK, Hogle JM, Silver PA. Analysis of the yeast arginine methyltransferase hmt1p/rmt1p and its in vivo function. Cofactor binding and substrate interactions. J. Biol. Chem. 275: 3128-3136 (2000).

McCarthy AA, McCarthy JG. The structure of two N-methyltransferases from the caffeine biosynthetic pathway. Plant Physiol. 144: 879-889 (2007).

McClung CR, Davis CR, Page KM, Denome SA. Characterization of the formate (for) locus, which encodes the cytosolic serine hydroxymethyltransferase of Neurospora crassa. Mol. Cell Biol. 12: 1412-1421 (1992).

McClung CR, Hsu M, Painter JE, Gagne JM, Karlsberg SD, Salome PA. Integrated temporal regulation of the photorespiratory pathway. Circadian regulation of two Arabidopsis genes encoding serine hydroxymethyltransferase. Plant Physiol. 123: 381-392 (2000).

McCoy JG, Bailey LJ, Ng YH, Bingman CA, Wrobel R, Weber AP, Fox BG, Phillips GN Jr. Discovery of sarcosine dimethylglycine methyltransferase from Galdieria sulphuraria. Proteins 74: 368-377 (2009).

McMullen MH, Rowling MJ, Ozias MK, Schalinske KL. Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific. Arch. Biochem. Biophys. 401: 73-80 (2002).

McNeil JB, Bognar AL, Pearlman RE. In vivo analysis of folate coenzymes and their compartmentation in Saccharomyces cerevisiae. Genetics 142: 371-381 (1996).

McNeil JB, Flynn J, Tsao N, Monschau N, Stahmann K, Haynes RH, McIntosh EM, Pearlman RE. Glycine metabolism in Candida albicans: characterization of the serine hydroxymethyltransferase (SHM1, SHM2) and threonine aldolase (GLY1) genes. Yeast 16: 167-175 (2000).

McNeil JB, McIntosh EM, Taylor BV, Zhang FR, Tang S, Bognar AL. Cloning and molecular characterization of three genes, including two genes encoding serine hydroxymethyltransferases, whose inactivation is required to render yeast auxotrophic for glycine. J. Biol. Chem. 269: 9155-9165 (1994).

McNeil SD, Nuccio ML, Rhodes D, Shachar-Hill Y, Hanson AD. Radiotracer and computer modeling evidence that phospho-base methylation is the main route of choline synthesis in tobacco. Plant Physiol. 123: 371-380 (2000).

McNeil SD, Nuccio ML, Ziemak MJ, Hanson AD. Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N-methyltransferase. Proc. Natl. Acad. Sci. U.S.A. 98: 10001-10005 (2001).

Melse-Boonstra A, Holm PI, Ueland PM, Olthof M, Clarke R, Verhoef P. Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations. Am. J. Clin. Nutr. 81: 1378-1382 (2005).

Meng H, Campbell WH. Substrate profiles and expression of caffeoyl coenzyme A and caffeic acid O-methyltransferases in secondary xylem of aspen during seasonal development. Plant Mol. Biol. 38: 513-520 (1998).

Meyer K, Fredriksen A, Ueland PM. High-level multiplex genotyping of polymorphisms involved in folate or homocysteine metabolism by matrix-assisted laser desorption/ionization mass spectrometry. Clin. Chem. 50: 391-402 (2004).

Miller CA, Leonard HS, Pinsky IG, Turner BM, Williams SR, Harrison L Jr, Fletcher AF, Shen G, Bryant DA, Schluchter WM. Biogenesis of phycobiliproteins. III. CpcM is the asparagine methyltransferase for phycobiliprotein beta -subunits in cyanobacteria. J. Biol. Chem. 283: 19293-19300 (2008).

Miller CM, Szegedi SS, Garrow TA. Conformation-dependent inactivation of human betaine-homocysteine S-methyltransferase by hydrogen peroxide in vitro. Biochem. J. 392: 443-448 (2005).

Miller JW, Shukitt-Hale B, Villalobos-Molina R, Nadeau MR, Selhub J, Joseph JA. Effect of L-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats. Clin. Neuropharmacol. 20: 55-66 (1997).

Millian NS, Garrow TA. Human betaine-homocysteine methyltransferase is a zinc metalloenzyme. Arch. Biochem. Biophys. 356: 93-98 (1998).

Minguet EG, Vera F, Marina A, Carbonell J, Blazquez MA. Evolutionary diversification in polyamine biosynthesis. Mol. Biol. Evol. 25: 2119-2128 (2008).

Miyata A, Yoshida T, Yamaguchi K, Yokoyama C, Tanabe T, Toh H, Mitsunaga T, Izumi Y. Molecular cloning and expression of the gene for serine hydroxymethyltransferase from an obligate methylotroph Hyphomicrobium methylovorum GM2. Eur. J. Biochem. 212: 745-750 (1993).

Monschau N, Stahmann KP, Sahm H, McNeil JB, Bognar AL. Identification of Saccharomyces cerevisiae GLY1 as a threonine aldolase: a key enzyme in glycine biosynthesis. FEMS Microbiol. Lett. 150: 55-60 (1997).

Moreno JI, Martin R, Castresana C. Arabidopsis SHMT1, a serine hydroxymethyltransferase that functions in the photorespiratory pathway influences resistance to biotic and abiotic stress. Plant J. 41: 451-463 (2005).

Morishige T, Dubouzet E, Choi KB, Yazaki K, Sato F. Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells. Eur. J. Biochem. 269: 5659-5667 (2002).

Morishige T, Tsujita T, Yamada Y, Sato F. Molecular characterization of the S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica. J. Biol. Chem. 275: 23398-23405 (2000).

Morreel K, Ralph J, Lu F, Goeminne G, Busson R, Herdewijn P, Goeman JL, Van der Eycken J, Boerjan W, Messens E. Phenolic profiling of caffeic acid O-methyltransferase-deficient poplar reveals novel benzodioxane oligolignols. Plant Physiol. 136: 4023-4036 (2004).

Mosli Waldhauser SS, Gillies FM, Crozier A, Baumann TW. Separation of the N-7 methyltransferase, the key enzyme in caffeine biosynthesis. Phytochemistry 45: 1407-1414 (1997).

Motohashi R, Ito T, Kobayashi M, Taji T, Nagata N, Asami T, Yoshida S, Yamaguchi-Shinozaki K, Shinozaki K. Functional analysis of the 37 kDa inner envelope membrane polypeptide in chloroplast biogenesis using a Ds-tagged Arabidopsis pale-green mutant. Plant J. 34: 719-731 (2003).

Mou Z, Wang X, Fu Z, Dai Y, Han C, Ouyang J, Bao F, Hu Y, Li J. Silencing of phosphoethanolamine N-methyltransferase results in temperature-sensitive male sterility and salt hypersensitivity in Arabidopsis. Plant Cell 14: 2031-2043 (2002).

Mouille G, Ralet MC, Cavelier C, Eland C, Effroy D, Hematy K, McCartney L, Truong HN, Gaudon V, Thibault JF, Marchant A, Hofte H. Homogalacturonan synthesis in Arabidopsis thaliana requires a Golgi-localized protein with a putative methyltransferase domain. Plant J. 50: 605-614 (2007).

Mouillon JM, Aubert S, Bourguignon J, Gout E, Douce R, Rebeille F. Glycine and serine catabolism in non-photosynthetic higher plant cells: their role in C1 metabolism. Plant J. 20: 197-205 (1999).

Moyano E, Fornale S, Palazon J, Cusido RM, Bagni N, Pinol MT. Alkaloid production in Duboisia hybrid hairy root cultures overexpressing the pmt gene. Phytochemistry 59: 697-702 (2002).

Moyano E, Jouhikainen K, Tammela P, Palazon J, Cusido RM, Pinol MT, Teeri TH, Oksman-Caldentey KM. Effect of pmt gene overexpression on tropane alkaloid production in transformed root cultures of Datura metel and Hyoscyamus muticus. J. Exp. Bot. 54: 203-211 (2003).

Mudd SH, Cerone R, Schiaffino MC, Fantasia AR, Minniti G, Caruso U, Lorini R, Watkins D, Matiaszuk N, Rosenblatt DS, Schwahn B, Rozen R, LeGros L, Kotb M, Capdevila A, Luka Z, Finkelstein JD, Tangerman A, Stabler SP, Allen RH, Wagner C. Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia. J. Inherit. Metab. Dis. 24: 448-464 (2001).

Mudgett MB, Lowenson JD, Clarke S. Protein repair L-isoaspartyl methyltransferase in plants. Phylogenetic distribution and the accumulation of substrate proteins in aged barley seeds. Plant Physiol. 115: 1481-1489 (1997).

Murata J, Luca VD. Localization of tabersonine 16-hydroxylase and 16-OH tabersonine-16-O-methyltransferase to leaf epidermal cells defines them as a major site of precursor biosynthesis in the vindoline pathway in Catharanthus roseus. Plant J. 44: 581-594 (2005).

Murata J, Roepke J, Gordon H, De Luca V. The leaf epidermome of Catharanthus roseus reveals its biochemical specialization. Plant Cell 20: 524-542 (2008).

Murfitt LM, Kolosova N, Mann CJ, Dudareva N. Purification and characterization of S-adenosyl-L-methionine:benzoic acid carboxyl methyltransferase, the enzyme responsible for biosynthesis of the volatile ester methyl benzoate in flowers of Antirrhinum majus. Arch. Biochem. Biophys. 382: 145-151 (2000).

Muzac I, Wang J, Anzellotti D, Zhang H, Ibrahim RK. Functional expression of an Arabidopsis cDNA clone encoding a flavonol 3'-O-methyltransferase and characterization of the gene product. Arch. Biochem. Biophys. 375: 385-388 (2000).

Nam YW, Tichit L, Leperlier M, Cuerq B, Marty I, Lelievre JM. Isolation and characterization of mRNAs differentially expressed during ripening of wild strawberry (Fragaria vesca L.) fruits. Plant Mol. Biol. 39: 629-636 (1999).

Nanao K, Takada G, Takahashi E, Seki N, Komatsu Y, Okamura-Ikeda K, Motokawa Y, Hayasaka K. Structure and chromosomal localization of the aminomethyltransferase gene. Genomics 19: 27-30 (1994).

Narasimha Chary S, Bultema RL, Packard CE, Crowell DN. Prenylcysteine alpha-carboxyl methyltransferase expression and function in Arabidopsis thaliana. Plant J. 32: 735-747 (2002).

Neece DJ, Griffiths MA, Garrow TA. Isolation and characterization of a mouse betaine-homocysteine S-methyltransferase gene and pseudogene. Gene 250: 31-40 (2000).

Negre F, Kish CM, Boatright J, Underwood B, Shibuya K, Wagner C, Clark DG, Dudareva N. Regulation of methylbenzoate emission after pollination in snapdragon and petunia flowers. Plant Cell 15: 2992-3006 (2003).

Negre F, Kolosova N, Knoll J, Kish CM, Dudareva N. Novel S-adenosyl-L-methionine:salicylic acid carboxyl methyltransferase, an enzyme responsible for biosynthesis of methyl salicylate and methyl benzoate, is not involved in floral scent production in snapdragon flowers. Arch. Biochem. Biophys. 406: 261-270 (2002).

Negrel J, Javelle F. Purification, characterization and partial amino acid sequencing of hydroxycinnamoyl-CoA:tyramine N-(hydroxycinnamoyl)transferase from tobacco cell-suspension cultures. Eur. J. Biochem. 247: 1127-1135 (1997).

Nelson DE, Rammesmayer G, Bohnert HJ. Regulation of cell-specific inositol metabolism and transport in plant salinity tolerance. Plant Cell 10: 753-764 (1998).

Neuhierl B, Thanbichler M, Lottspeich F, Bock A. A family of S-methylmethionine-dependent thiol/selenol methyltransferases. Role in selenium tolerance and evolutionary relation. J. Biol. Chem. 274: 5407-5414 (1999).

Ni W, Sewalt V, Korth KL, Blount JW, Ballance GM, Dixon RA. Stress responses in alfalfa. XXI Activation of caffeic acid 3-O-methyltransferase and caffeoyl coenzyme A 3-O-methyltransferase genes does not contribute to changes in metabolite accumulation in elicitor-treated cell-suspension cultures. Plant Physiol. 112: 717-726 (1996).

Nieman KM, Hartz CS, Szegedi SS, Garrow TA, Sparks JD, Schalinske KL. Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats. Am. J. Physiol. Endocrinol. Metab. 291: E1235-E1242 (2006).

Nijhout HF, Gregory JF, Fitzpatrick C, Cho E, Lamers KY, Ulrich CM, Reed MC. A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. J. Nutr. 139: 784-791 (2009).

Nijhout HF, Reed MC, Lam SL, Shane B, Gregory JF 3rd, Ulrich CM. In silico experimentation with a model of hepatic mitochondrial folate metabolism. Theor. Biol. Med. Model. 3: 40 (2006).

Nishimasu H, Ishitani R, Yamashita K, Iwashita C, Hirata A, Hori H, Nureki O. Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase. Proc. Natl. Acad. Sci. U.S.A. 106: 8180-8185 (2009).

Niu L, Zhang Y, Pei Y, Liu C, Cao X. Redundant requirement for a pair of protein arginine methyltransferase 4 homologs for the proper regulation of Arabidopsis flowering time. Plant Physiol. 148: 490-503 (2008).

Niwa R, Niimi T, Honda N, Yoshiyama M, Itoyama K, Kataoka H, Shinoda T. Juvenile hormone acid O-methyltransferase in Drosophila melanogaster. Insect Biochem. Mol. Biol. 38: 714-720 (2008).

Noga AA, Stead LM, Zhao Y, Brosnan ME, Brosnan JT, Vance DE. Plasma homocysteine is regulated by phospholipid methylation. J. Biol. Chem. 278: 5952-5955 (2003).

Nuccio ML, Ziemak MJ, Henry SA, Weretilnyk EA, Hanson AD. cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme. J. Biol. Chem. 275: 14095-14101 (2000).

Nyyssola A, Kerovuo J, Kaukinen P, von Weymarn N, Reinikainen T. Extreme halophiles synthesize betaine from glycine by methylation. J. Biol. Chem. 275: 22196-22201 (2000).

Nyyssola A, Reinikainen T, Leisola M. Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase. Appl. Environ. Microbiol. 67: 2044-2050 (2001).

O'Keefe BR, Beecher C. Isolation and characterization of S-adenosyl-L-methionine:tetrahydroberberine-cis-N-methyltransferase from suspension cultures of Sanguinaria canadensis L. Plant Physiol. 105: 395-403 (1994).

Ogawa H, Gomi T, Fujioka M. Serine hydroxymethyltransferase and threonine aldolase: are they identical? Int. J. Biochem. Cell Biol. 32: 289-301 (2000).

Ogawa M, Herai Y, Koizumi N, Kusano T, Sano H. 7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties. J. Biol. Chem. 276: 8213-8218 (2001).

Oge L, Bourdais G, Bove J, Collet B, Godin B, Granier F, Boutin JP, Job D, Jullien M, Grappin P. Protein repair L-isoaspartyl methyltransferase1 is involved in both seed longevity and germination vigor in Arabidopsis. Plant Cell 20: 3022-3037 (2008).

Ogita S, Uefuji H, Morimoto M, Sano H. Application of RNAi to confirm theobromine as the major intermediate for caffeine biosynthesis in coffee plants with potential for construction of decaffeinated varieties. Plant Mol. Biol. 54: 931-941 (2004).

Oliver DJ, Raman R. Glycine decarboxylase: protein chemistry and molecular biology of the major protein in leaf mitochondria. J. Bioenerg. Biomembr. 27: 407-414 (1995).

Oppenheim EW, Adelman C, Liu X, Stover PJ. Heavy chain ferritin enhances serine hydroxymethyltransferase expression and de novo thymidine biosynthesis. J. Biol. Chem. 276: 19855-19861 (2001).

Oppenheim EW, Nasrallah IM, Mastri MG, Stover PJ. Mimosine is a cell-specific antagonist of folate metabolism. J. Biol. Chem. 275: 19268-19274 (2000).

Ottenhof HH, Ashurst JL, Whitney HM, Saldanha SA, Schmitzberger F, Gweon HS, Blundell TL, Abell C, Smith AG. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. Plant J. 37: 61-72 (2004).

Ou X, Yang H, Ramani K, Ara AI, Chen H, Mato JM, Lu SC. Inhibition of human betaine homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine. Biochem. J. 401: 87-96 (2007).

Ounaroon A, Decker G, Schmidt J, Lottspeich F, Kutchan TM. (R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy. Plant J. 36: 808-819 (2003).

Paessens A, Rudiger H. Purification and chemical characterization of the vitamin-B12-dependent 5-methyltetrahydrofolate: homocysteine methyltransferase from Escherichia coli B. Eur. J. Biochem. 112: 47-51 (1980).

Pajares MA, Perez-Sala D. Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism? Cell. Mol. Life Sci. 63: 2792-2803 (2006).

Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer ME. Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes. Proteins 57: 331-337 (2004).

Palmer NA, Sattler SE, Saathoff AJ, Funnell D, Pedersen JF, Sarath G. Genetic background impacts soluble and cell wall-bound aromatics in brown midrib mutants of sorghum. Planta 229: 115-127 (2008).

Park EI, Garrow TA. Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene. J. Biol. Chem. 274: 7816-7824 (1999).

Parvathi K, Chen F, Guo D, Blount J, Dixon R. Substrate preferences of O-methyltransferases in alfalfa suggest new pathways for 3-O-methylation of monolignols. Plant J. 25: 193-202 (2001).

Pascarella S, Schirch V, Bossa F. Similarity between serine hydroxymethyltransferase and other pyridoxal phosphate-dependent enzymes. FEBS Lett. 331: 145-149 (1993).

Pascarella S, Schirch V, Bossa F. Similarity between serine hydroxymethyltransferase and other pyridoxal phosphate-dependent enzymes. FEBS Lett. 331: 145-149 (1993).

Paschalidis KA, Roubelakis-Angelakis KA. Sites and regulation of polyamine catabolism in the tobacco plant. Correlations with cell division/expansion, cell cycle progression, and vascular development. Plant Physiol. 138: 2174-2184 (2005).

Pasternack LB, Laude DA Jr, Appling DR. Whole-cell detection by 13C NMR of metabolic flux through the C1-tetrahydrofolate synthase/serine hydroxymethyltransferase enzyme system and effect of antifolate exposure in Saccharomyces cerevisiae. Biochemistry 33: 7166-7173 (1994).

Pattanagul W, Madore MA. Water deficit effects on raffinose family oligosaccharide metabolism in Coleus. Plant Physiol. 121: 987-993 (1999).

Pei Y, Niu L, Lu F, Liu C, Zhai J, Kong X, Cao X. Mutations in the type II protein arginine methyltransferase AtPRMT5 result in pleiotropic developmental defects in Arabidopsis. Plant Physiol. 144: 1913-1923 (2007).

Pejchal R, Ludwig ML. Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication. PLoS Biol. 3: e31 (2005).

Peng Y, Feng Q, Wilk D, Adjei AA, Salavaggione OE, Weinshilboum RM, Yee VC. Structural basis of substrate recognition in thiopurine S-methyltransferase. Biochemistry 47: 6216-6225 (2008).

Pereira LA, Schoor S, Goubet F, Dupree P, Moffatt BA. Deficiency of adenosine kinase activity affects the degree of pectin methyl-esterification in cell walls of Arabidopsis thaliana. Planta 224: 1401-1414 (2006).

Pereira LA, Todorova M, Cai X, Makaroff C, Emery R, Moffatt B. Methyl recycling activities are co-ordinately regulated during plant development. J. Exp. Bot. 58: 1083-1098 (2007).

Perry C, Sastry R, Nasrallah IM, Stover PJ. Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication. J. Biol. Chem. 280: 396-400 (2005).

Petrossian TC, Clarke SG. Multiple motif scanning to identify methyltransferases from the yeast proteome. Mol. Cell. Proteomics 8: 1516-26 (2009).

Phenix CP, Nienaber K, Tam PH, Delbaere LT, Palmer DR. Structural, functional and calorimetric investigation of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti L5-30, does not support involvement in rhizopine biosynthesis. Chembiochem. 9: 1591-1602 (2008).

Pichersky E, Gang DR. Genetics and biochemistry of secondary metabolites in plants: an evolutionary perspective. Trends Plant Sci. 5: 439-445 (2000).

Pickering IJ, Wright C, Bubner B, Ellis D, Persans MW, Yu EY, George GN, Prince RC, Salt DE. Chemical form and distribution of selenium and sulfur in the selenium hyperaccumulator Astragalus bisulcatus. Plant Physiol. 131: 1460-1467 (2003).

Pilate G, Guiney E, Holt K, Petit-Conil M, Lapierre C, Leple JC, Pollet B, Mila I, Webster EA, Marstorp HG, Hopkins DW, Jouanin L, Boerjan W, Schuch W, Cornu D, Halpin C. Field and pulping performances of transgenic trees with altered lignification. Nat. Biotechnol. 20: 607-612 (2002).

Pillai PB, Fanatico AC, Beers KW, Blair ME, Emmert JL. Homocysteine remethylation in young broilers fed varying levels of methionine, choline, and betaine. Poult. Sci. 85: 90-95 (2006).

Pimenta MJ, Kaneta T, Larondelle Y, Dohmae N, Kamiya Y. S-adenosyl-L-methionine:L-methionine S-methyltransferase from germinating barley. Purification and localization. Plant Physiol. 118: 431-438 (1998).

Pimenta MJ, Vandercammen A, Dufour JP, Larondelle Y. Determination of S-adenosyl-L-methionine: L-methionine S-methyltransferase activity by selective adsorption of [methyl-3H]S-adenosylmethionine onto activated charcoal. Anal. Biochem. 225: 167-169 (1995).

Pincon G, Chabannes M, Lapierre C, Pollet B, Ruel K, Joseleau JP, Boudet AM, Legrand M. Simultaneous down-regulation of caffeic/5-hydroxy ferulic acid-O-methyltransferase I and cinnamoyl-coenzyme A reductase in the progeny from a cross between tobacco lines homozygous for each transgene. Plant Physiol. 126: 145-155 (2001).

Pincon G, Maury S, Hoffmann L, Geoffroy P, Lapierre C, Pollet B, Legrand M. Repression of O-methyltransferase genes in transgenic tobacco affects lignin synthesis and plant growth. Phytochemistry 57: 1167-1176 (2001).

Pintard L, Kressler D, Lapeyre B. Spb1p is a yeast nucleolar protein associated with nop1p and nop58p that is able to bind S-adenosyl-L-methionine in vitro. Mol. Cell Biol. 20: 1370-1381 (2000).

Piper MD, Hong SP, Ball GE, Dawes IW. Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae. J. Biol. Chem. 275: 30987-30995 (2000).

Piquemal J, Chamayou S, Nadaud I, Beckert M, Barriere Y, Mila I, Lapierre C, Rigau J, Puigdomenech P, Jauneau A, Digonnet C, Boudet AM, Goffner D, Pichon M. Down-regulation of caffeic acid O-methyltransferase in maize revisited using a transgenic approach. Plant Physiol. 130: 1675-1685 (2002).

Plamann MD, Rapp WD, Stauffer GV. Escherichia coli K12 mutants defective in the glycine cleavage enzyme system. Mol. Gen. Genet. 192: 15-20 (1983).

Plomion C, Pionneau C, Brach J, Costa P, Bailleres H. Compression wood-responsive proteins in developing xylem of maritime pine (Pinus pinaster Ait.). Plant Physiol. 123: 959-970 (2000).

Poeydomenge O, Boudet AM, Grima-Pettenati J. A cDNA encoding S-adenosyl-L-methionine:caffeic acid 3-O-methyltransferase from Eucalyptus. Plant Physiol. 105: 749-750 (1994).

Pontier D, Albrieux C, Joyard J, Lagrange T, Block MA. Knock-out of the Mg protoporphyrin IX methyltransferase gene in Arabidopsis. Effects on chloroplast development and on chloroplast-to-nucleus signaling. J. Biol. Chem. 282: 2297-2304 (2007).

Porter RK, Scott JM, Brand MD. Characterization of betaine efflux from rat liver mitochondria. Biochim. Biophys. Acta 1141: 269-274 (1993).

Pott MB, Effmert U, Piechulla B. Transcriptional and post-translational regulation of S-adenosyl-L-methionine: salicylic acid carboxyl methyltransferase (SAMT) during Stephanotis floribunda flower development. J. Plant Physiol. 160: 635-643 (2003).

Pott MB, Hippauf F, Saschenbrecker S, Chen F, Ross J, Kiefer I, Slusarenko A, Noel JP, Pichersky E, Effmert U, Piechulla B. Biochemical and structural characterization of benzenoid carboxyl methyltransferases involved in floral scent production in Stephanotis floribunda and Nicotiana suaveolens. Plant Physiol. 135: 1946-1955 (2004).

Prabhu V, Chatson KB, Abrams GD, King J. 13C nuclear magnetic resonance detection of interactions of serine hydroxymethyltransferase with C1-tetrahydrofolate synthase and glycine decarboxylase complex activities in Arabidopsis. Plant Physiol. 112: 207-216 (1996).

Prabhu V, Chatson KB, Lui H, Abrams GD, King J. Effects of sulfanilamide and methotrexate on 13C fluxes through the glycine decarboxylase/serine hydroxymethyltransferase enzyme system in Arabidopsis. Plant Physiol. 116: 137-144 (1998).

Preston J, Wheeler J, Heazlewood J, Li SF, Parish RW. AtMYB32 is required for normal pollen development in Arabidopsis thaliana. Plant J. 40: 979-995 (2004).

Prudhomme MP, Moore TS. Phosphatidylcholine synthesis in castor bean endosperm: occurrence of an S-adenosyl-L-methionine ethanolamine N-methyltransferase. Plant Physiol. 100: 1536-1540 (1992).

Purta E, Kaminska KH, Kasprzak JM, Bujnicki JM, Douthwaite S. YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA. RNA 14: 2234-2244 (2008).

Qin G, Gu H, Zhao Y, Ma Z, Shi G, Yang Y, Pichersky E, Chen H, Liu M, Chen Z, Qu LJ. An indole-3-acetic acid carboxyl methyltransferase regulates Arabidopsis leaf development. Plant Cell 17: 2693-2704 (2005).

Qin J, Rosen BP, Zhang Y, Wang G, Franke S, Rensing C. Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase. Proc. Natl. Acad. Sci. U.S.A. 103: 2075-2080 (2006).

Quashnock JM, Chlebowski JF, Martinez-Carrion M, Schirch L. Serine hydroxymethyltransferase. 31P nuclear magnetic resonance study of the enzyme-bound pyridoxal 5'-phosphate. J. Biol. Chem. 258: 503-507 (1983).

Radchuk VV, Sreenivasulu N, Radchuk RI, Wobus U, Weschke W. The methylation cycle and its possible functions in barley endosperm development. Plant Mol. Biol. 59: 289-307 (2005).

Rae AL, Manners JM, Jones RJ, McIntyre CL, Lu DY. Antisense suppression of the lignin biosynthetic enzyme, caffeate O-methyltransferase, improves in vitro digestibility of the tropical pasture legume, Stylosanthes humilis. Aust. J. Plant Physiol. 28: 289-297 (2001).

Rajinikanth M, Harding SA, Tsai CJ. The glycine decarboxylase complex multienzyme family in Populus. J. Exp. Bot. 58: 1761-1770 (2007).

Ramachandran V, Chen X. Small RNA metabolism in Arabidopsis. Trends Plant Sci. 13: 368-374 (2008).

Raman SB, Rathinasabapathi B. beta-Alanine N-methyltransferase of Limonium latifolium. cDNA cloning and functional expression of a novel N-methyltransferase implicated in the synthesis of the osmoprotectant beta-alanine betaine. Plant Physiol. 132: 1642-1651 (2003).

Ramirez-Ahumada MD, Timmermann BN, Gang DR. Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases. Phytochemistry 67: 2017-2029 (2006).

Ramos RLB, Tovar FJ, Junqueira RM, Lino FB, Sachetto-Martins G. Sugarcane expressed sequences tags (ESTs) encoding enzymes involved in lignin biosynthesis pathways. Genet. Mol. Biol. 24: 235-241 (2001).

Ranocha P, Bourgis F, Ziemak MJ, Rhodes D, Gage DA, Hanson AD. Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis. J. Biol. Chem. 275: 15962-15968 (2000).

Ranocha P, McNeil SD, Ziemak MJ, Li C, Tarczynski MC, Hanson AD. The S-methylmethionine cycle in angiosperms: ubiquity, antiquity and activity. Plant J. 25: 575-584 (2001).

Rao JV, Prakash V, Rao NA, Savithri HS. The role of glu74 and tyr82 in the reaction catalyzed by sheep liver cytosolic serine hydroxymethyltransferase. Eur. J. Biochem. 267: 5967-5976 (2000).

Rao NA, Talwar R, Savithri HS. Molecular organization, catalytic mechanism and function of serine hydroxymethyltransferase--a potential target for cancer chemotherapy. Int. J. Biochem. Cell Biol. 32: 405-416 (2000).

Rao SR, Ravishankar GA. Biotransformation of protocatechuic aldehyde and caffeic acid to vanillin and capsaicin in freely suspended and immobilized cell cultures of Capsicum frutescens. J. Biotechnol. 76: 137-146 (2000).

Rathinasabapathi B, Fouad WM, Sigua CA. beta-Alanine betaine synthesis in the Plumbaginaceae. Purification and characterization of a trifunctional, S-adenosyl-L-methionine-dependent N-methyltransferase from Limonium latifolium leaves. Plant Physiol. 126: 1241-1249 (2001).

Rathinasabapathi B, Sigua C, Ho J, Gage DA. Osmoprotectant beta-alanine betaine synthesis in the Plumbaginaceae: S-adenosyl-L-methionine dependent N-methylation of beta-alanine to its betaine is via N-methyl and N,N-dimethyl beta-alanines. Physiol. Plant. 109: 225-231 (2000).

Ratnam S, Wijekoon EP, Hall B, Garrow TA, Brosnan ME, Brosnan JT. Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. Am. J. Physiol. Endocrinol. Metab. 290: E933-E939 (2006).

Ravanel S, Block MA, Rippert P, Jabrin S, Curien G, Rebeille F, Douce R. Methionine metabolism in plants: chloroplasts are autonomous for de novo methionine synthesis and can import S-adenosylmethionine from the cytosol. J. Biol. Chem. 279: 22548-22557 (2004).

Ravanel S, Cherest H, Jabrin S, Grunwald D, Surdin-Kerjan Y, Douce R, Rebeille F. Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana. Proc. Natl. Acad. Sci. U.S.A. 98: 15360-15365 (2001).

Rebeille F, Neuburger M, Douce R. Interaction between glycine decarboxylase, serine hydroxymethyltransferase and tetrahydrofolate polyglutamates in pea leaf mitochondria. Biochem. J. 302: 223-228 (1994).

Reinhard K, Matern U. The biosynthesis of phytoalexins in Dianthus caryophyllus L. cell cultures: induction of benzoyl-CoA:anthranilate N-benzoyltransferase activity. Arch. Biochem. Biophys. 275: 295-301 (1989).

Renwick SB, Snell K, Baumann U. The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy. Structure 6: 1105-1116 (1998).

Reo NV, Adinehzadeh M, Foy BD. Kinetic analyses of liver phosphatidylcholine and phosphatidylethanolamine biosynthesis using 13C NMR spectroscopy. Biochim. Biophys. Acta 1580: 171-188 (2002).

Rhodes D, Gage DA, Cooper A, Hanson AD. S-Methylmethionine conversion to dimethylsulfoniopropionate: evidence for an unusual transamination reaction. Plant Physiol. 115: 1541-1548 (1997).

Riccardi F, Gazeau P, de Vienne D, Zivy M. Protein changes in response to progressive water deficit in maize. Quantitative variation and polypeptide identification. Plant Physiol. 117: 1253-1263 (1998).

Riechers DE, Timko MP. Structure and expression of the gene family encoding putrescine N-methyltransferase in Nicotiana tabacum: new clues to the evolutionary origin of cultivated tobacco. Plant Mol. Biol. 41: 387-401 (1999).

Riehl Koch J, Scherzer AJ, Eshita SM, Davis KR. Ozone sensitivity in hybrid poplar is correlated with a lack of defense-gene activation. Plant Physiol. 118: 1243-1252 (1998).

Riekhof WR, Andre C, Benning C. Two enzymes, BtaA and BtaB, are sufficient for betaine lipid biosynthesis in bacteria. Arch. Biochem. Biophys. 441: 96-105 (2005).

Rigbers O, Li SM. Ergot alkaloid biosynthesis in Aspergillus fumigatus: overproduction and biochemical characterisation of a 4-dimethylallyltryptophan N-methyltransferase. J. Biol. Chem. 283: 26859-26868 (2008).

Rival A, Jaligot E, Beule T, Finnegan EJ. Isolation and expression analysis of genes encoding MET, CMT, and DRM methyltransferases in oil palm (Elaeis guineensis Jacq.) in relation to the 'mantled' somaclonal variation. J. Exp. Bot. 59: 3271-3281 (2008).

Roberts JKM. NMR adventures in the metabolic labyrinth within plants. Trends Plant Sci. 5: 30-34 (2000).

Roberts MF, Lai MC, Gunsalus RP. Biosynthetic pathways of the osmolytes N epsilon-acetyl-beta-lysine, beta-glutamine, and betaine in Methanohalophilus strain FDF1 suggested by nuclear magnetic resonance analyses. J. Bacteriol. 174: 6688-6693 (1992).

Roberts RJ, Cheng X. Base flipping. Annu. Rev. Biochem. 67: 181-198 (1998).

Robinson PM, Roberts MF. Effects of osmolyte precursors on the distribution of compatible solutes in Methanohalophilus portucalensis. Appl. Environ. Microbiol. 63: 4032-4038 (1997).

Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS. Comparative genomics of the methionine metabolism in Gram-positive bacteria: a variety of regulatory systems. Nucleic Acids Res. 32: 3340-3353 (2004).

Roeder S, Dreschler K, Wirtz M, Cristescu SM, van Harren FJ, Hell R, Piechulla B. SAM levels, gene expression of SAM synthetase, methionine synthase and ACC oxidase, and ethylene emission from N. suaveolens flowers. Plant Mol. Biol. 70: 535-546 (2009).

Rohde B, Hans J, Martens S, Baumert A, Hunziker P, Matern U. Anthranilate N-methyltransferase, a branch-point enzyme of acridone biosynthesis. Plant J. 53: 541-553 (2008).

Rohrbeck D, Buss D, Effmert U, Piechulla B. Localization of methyl benzoate synthesis and emission in Stephanotis floribunda and Nicotiana suaveolens flowers. Plant Biol. (Stuttg.) 8: 615-626 (2006).

Ross JR, Nam KH, D'Auria JC, Pichersky E. S-Adenosyl-L-methionine:salicylic acid carboxyl methyltransferase, an enzyme involved in floral scent production and plant defense, represents a new class of plant methyltransferases. Arch. Biochem. Biophys. 367: 9-16 (1999).

Rossbach S, Hennecke H. Identification of glyA as a symbiotically essential gene in Bradyrhizobium japonicum. Mol. Microbiol. 5: 39-47 (1991).

Roth U, von Roepenack-Lahaye E, Clemens S. Proteome changes in Arabidopsis thaliana roots upon exposure to Cd2+. J. Exp. Bot. 57: 4003-4013 (2006).

Rothe G, Hachiya A, Yamada Y, Hashimoto T, Drager B. Alkaloids in plants and root cultures of Atropa belladonna overexpressing putrescine N-methyltransferase. J. Exp. Bot. 54: 2065-2070 (2003).

Rowling MJ, McMullen MH, Schalinske KL. Vitamin A and its derivatives induce hepatic glycine N-methyltransferase and hypomethylation of DNA in rats. J. Nutr. 132: 365-369 (2002).

Rowling MJ, Schalinske KL. Retinoid compounds activate and induce hepatic glycine N-methyltransferase in rats. J. Nutr. 131: 1914-1917 (2001).

Rubio A, Downs DM. Elevated levels of ketopantoate hydroxymethyltransferase (PanB) lead to a physiologically significant coenzyme A elevation in Salmonella enterica serovar Typhimurium. J. Bacteriol. 184: 2827-2832 (2002).

Rutherford K, Alphandery E, McMillan A, Daggett V, Parson WW. The V108M mutation decreases the structural stability of catechol O-methyltransferase. Biochim. Biophys. Acta 1784: 1098-1105 (2008).

Rutherford K, Le Trong I, Stenkamp RE, Parson WW. Crystal structures of human 108V and 108M catechol O-methyltransferase. J. Mol. Biol. 380: 120-130 (2008).

Ryttersgaard C, Griffith SC, Sawaya MR, MacLaren DC, Clarke S, Yeates TO. Crystal structure of human L-isoaspartyl methyltransferase. J. Biol. Chem. 277: 10642-10646 (2002).

Saedler R, Baldwin IT. Virus-induced gene silencing of jasmonate-induced direct defences, nicotine and trypsin proteinase-inhibitors in Nicotiana attenuata. J. Exp. Bot. 55: 151-157 (2004).

Sakakibara H, Takei K, Sugiyama T. Isolation and characterization of a cDNA that encodes maize uroporphyrinogen III methyltransferase, an enzyme involved in the synthesis of siroheme, which is prosthetic group of nitrite reductase. Plant J. 10: 883-892 (1996).

Samanani N, Alcantara J, Bourgault R, Zulak KG, Facchini PJ. The role of phloem sieve elements and laticifers in the biosynthesis and accumulation of alkaloids in opium poppy. Plant J. 47: 547-563 (2006).

Sandu C, Nick P, Hess D, Schiltz E, Garrow TA, Brandsch R. Association of betaine-homocysteine S-methyltransferase with microtubules. Biol. Chem. 381: 619-622 (2000).

Sato F, Hashimoto T, Hachiya A, Tamura K, Choi KB, Morishige T, Fujimoto H, Yamada Y. Metabolic engineering of plant alkaloid biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 98: 367-372 (2001).

Sattler SE, Cheng Z, DellaPenna D. From Arabidopsis to agriculture: engineering improved Vitamin E content in soybean. Trends Plant Sci. 9: 365-367 (2004).

Scalliet G, Journot N, Jullien F, Baudino S, Magnard JL, Channeliere S, Vergne P, Dumas C, Bendahmane M, Cock JM, Hugueney P. Biosynthesis of the major scent components 3,5-dimethoxytoluene and 1,3,5-trimethoxybenzene by novel rose O-methyltransferases. FEBS Lett. 523: 113-118 (2002).

Scalliet G, Lionnet C, Le Bechec M, Dutron L, Magnard JL, Baudino S, Bergougnoux V, Jullien F, Chambrier P, Vergne P, Dumas C, Cock JM, Hugueney P. Role of petal-specific orcinol O-methyltransferases in the evolution of rose scent. Plant Physiol. 140: 18-29 (2006).

Scalliet G, Piola F, Douady CJ, Rety S, Raymond O, Baudino S, Bordji K, Bendahmane M, Dumas C, Cock JM, Hugueney P. Scent evolution in Chinese roses. Proc. Natl. Acad. Sci. U.S.A. 105: 5927-5932 (2008).

Scarsdale JN, Kazanina G, Radaev S, Schirch V, Wright HT. Crystal structure of rabbit cytosolic serine hydroxymethyltransferase at 2.8 A resolution: mechanistic implications. Biochemistry 38: 8347-8358 (1999).

Scarsdale JN, Radaev S, Kazanina G, Schirch V, Wright HT. Crystal structure at 2.4 A resolution of E. coli serine hydroxymethyltransferase in complex with glycine substrate and 5-formyl tetrahydrofolate. J. Mol. Biol. 296: 155-168 (2000).

Scebba F, Bernacchia G, De Bastiani M, Evangelista M, Cantoni RM, Cella R, Locci MT, Pitto L. Arabidopsis MBD proteins show different binding specificities and nuclear localization. Plant Mol. Biol. 53: 715-731 (2003).

Scebba F, De Bastiani M, Bernacchia G, Andreucci A, Galli A, Pitto L. PRMT11: a new Arabidopsis MBD7 protein partner with arginine methyltransferase activity. Plant J. 52: 210-222 (2007).

Schaeffer A, Bronner R, Benveniste P, Schaller H. The ratio of campesterol to sitosterol that modulates growth in Arabidopsis is controlled by STEROL METHYLTRANSFERASE 2;1. Plant J. 25: 605-615 (2001).

Schaller H, Bouvier-Nave P, Benveniste P. Overexpression of an Arabidopsis cDNA encoding a sterol-C24(1)-methyltransferase in tobacco modifies the ratio of 24-methyl cholesterol to sitosterol and is associated with growth reduction. Plant Physiol. 118: 461-469 (1998).

Scheer JB, Mackey AD, Gregory JF 3rd. Activities of hepatic cytosolic and mitochondrial forms of serine hydroxymethyltransferase and hepatic glycine concentration are affected by vitamin B-6 intake in rats. J. Nutr. 135: 233-238 (2005).

Scheuermann TH, Lolis E, Hodsdon ME. Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme. J. Mol. Biol. 333: 573-585 (2003).

Schirch L, Quashnock J. Evidence that tetrahydrofolate does not bind to serine hydroxymethyltransferase with positive homotropic cooperativity. J. Biol. Chem. 256: 6245-6249 (1981).

Schirch V, Hopkins S, Villar E, Angelaccio S. Serine hydroxymethyltransferase from Escherichia coli: purification and properties. J. Bacteriol. 163: 1-7 (1985).

Schirch V, Shostak K, Zamora M, Guatam-Basak M. The origin of reaction specificity in serine hydroxymethyltransferase. J. Biol. Chem. 266: 759-764 (1991).

Schirch V, Szebenyi DM. Serine hydroxymethyltransferase revisited. Curr. Opin. Chem. Biol. 9: 482-487 (2005).

Schjoerring JK, Mack G, Nielsen KH, Husted S, Suzuki A, Driscoll S, Boldt R, Bauwe H. Antisense reduction of serine hydroxymethyltransferase results in diurnal displacement of NH assimilation in leaves of Solanum tuberosum. Plant J. 45: 71-82 (2006).

Schlawicke Engstrom K, Nermell B, Concha G, Stromberg U, Vahter M, Broberg K. Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. Mutat. Res. 667: 4-14 (2009).

Schmidlin L, Poutaraud A, Claudel P, Mestre P, Prado E, Santos-Rosa M, Wiedemann-Merdinoglu S, Karst F, Merdinoglu D, Hugueney P. A stress-inducible resveratrol O-methyltransferases involved in the biosynthesis of pterostilbene in grapevine. Plant Physiol. 148: 1630-1639 (2008).

Schmidt S, Stewart GR. Glycine metabolism by plant roots and its occurrence in Australian plant communities. Aust. J. Plant Physiol. 26: 253-264 (1999).

Schmitzberger F, Smith AG, Abell C, Blundell TL. Comparative analysis of the Escherichia coli ketopantoate hydroxymethyltransferase crystal structure confirms that it is a member of the (betaalpha)8 phosphoenolpyruvate/pyruvate superfamily. J. Bacteriol. 185: 4163-4171 (2003).

Schneider R, Bannister AJ, Kouzarides T. Unsafe SETs: histone lysine methyltransferases and cancer. Trends Biochem. Sci. 27: 396-402 (2002).

Schrick K, Fujioka S, Takatsuto S, Stierhof YD, Stransky H, Yoshida S, Jurgens G. A link between sterol biosynthesis, the cell wall, and cellulose in Arabidopsis. Plant J. 38: 227-243 (2004).

Schroder G, Wehinger E, Lukacin R, Wellmann F, Seefelder W, Schwab W, Schroder J. Flavonoid methylation: a novel 4'-O-methyltransferase from Catharanthus roseus, and evidence that partially methylated flavanones are substrates of four different flavonoid dioxygenases. Phytochemistry 65: 1085-1094 (2004).

Schroder I, Thauer RK. Methylcobalamin:homocysteine methyltransferase from Methanobacterium thermoautotrophicum. Identification as the metE gene product. Eur. J. Biochem. 263: 789-796 (1999).

Schubert HL, Blumenthal RM, Cheng X. Many paths to methyltransfer: a chronicle of convergence. Trends Biochem. Sci. 28: 329-335 (2003).

Schwab W. Metabolome diversity: too few genes, too many metabolites? Phytochemistry 62: 837-849 (2003).

Schwahn BC, Wendel U, Lussier-Cacan S, Mar MH, Zeisel SH, Leclerc D, Castro C, Garrow TA, Rozen R. Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency. Metabolism 53: 594-599 (2004).

Seguin J, Muzac I, Ibrahim RK. Purification and immunological characterization of a recombinant trimethylflavonol 3'-O-methyltransferase. Phytochemistry 49: 319-325 (1998).

Sehayek E, Wang R, Ono JG, Zinchuk VS, Duncan EM, Shefer S, Vance DE, Ananthanarayanan M, Chait BT, Breslow JL. Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol. J. Lipid Res. 44: 1605-1613 (2003).

Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J. Nutr. Health Aging 6: 39-42 (2002).

Seo HS, Song JT, Cheong JJ, Lee YH, Lee YW, Hwang I, Lee JS, Choi YD. Jasmonic acid carboxyl methyltransferase: a key enzyme for jasmonate-regulated plant responses. Proc. Natl. Acad. Sci. U.S.A. 98: 4788-4793 (2001).

Sewalt VJH, Ni WT, Blount JW, Jung HG, Masoud SA, Howles PA, Lamb C, Dixon RA. Reduced lignin content and altered lignin composition in transgenic tobacco down-regulated in expression of L-phenylalanine ammonia-lyase or cinnamate 4-hydroxylase. Plant Physiol. 115: 41-50 (1997).

Sharath AN, Weinhold E, Bhagwat AS. Reviving a dead enzyme: cytosine deaminations promoted by an inactive DNA methyltransferase and an S-adenosylmethionine analogue. Biochemistry 39: 14611-14616 (2000).

She QB, Hayakawa T, Tsuge H. Alteration in the phosphatidylcholine biosynthesis of rat liver microsomes caused by vitamin B6 deficiency. Biosci. Biotechnol. Biochem. 59: 163-167 (1995).

Shen P, Chao H, Jiang C, Long Z, Wang C, Wu B. Enhancing production of L-serine by increasing the glyA gene expression in Methylobacterium sp. MB200. Appl. Biochem. Biotechnol. Mar 6 [Epub ahead of print] (2009).

Shintani D, DellaPenna D. Elevating the vitamin E content of plants through metabolic engineering. Science 282: 2098-2100 (1998).

Shoji T, Winz R, Iwase T, Nakajima K, Yamada Y, Hashimoto T. Expression patterns of two tobacco isoflavone reductase-like genes and their possible roles in secondary metabolism in tobacco. Plant Mol. Biol. 50: 427-440 (2002).

Shostak K, Schirch V. Serine hydroxymethyltransferase: mechanism of the racemization and transamination of D- and L-alanine. Biochemistry 27: 8007-8014 (1988).

Shostak K, Schirch V. Serine hydroxymethyltransferase: mechanism of the racemization and transamination of D- and L-alanine. Biochemistry 27: 8007-8014 (1988).

Simons V, Morrissey JP, Latijnhouwers M, Csukai M, Cleaver A, Yarrow C, Osbourn A. Dual effects of plant steroidal alkaloids on Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 50: 2732-2740 (2006).

Sinclair SJ, Murphy KJ, Birch CD, Hamill JD. Molecular characterization of quinolinate phosphoribosyltransferase (QPRtase) in Nicotiana. Plant Mol. Biol. 44: 603-617 (2000).

Singh A, Zubko E, Meyer P. Co-operative activity of DNA methyltransferases for maintenance of symmetrical and non-symmetrical cytosine methylation in Arabidopsis thaliana. Plant J. 56: 814-823 (2008).

Singh S, McCoy JG, Zhang C, Bingman CA, Phillips GN Jr, Thorson JS. Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM. J. Biol. Chem. 283: 22628-22636 (2008).

Sitbon F, Jonsson L. Sterol composition and growth of transgenic tobacco plants expressing type-1 and type-2 sterol methyltransferases. Planta 212: 568-572 (2001).

Skogman GS, Sjostrom JE. Factors affecting the biosynthesis of L-tryptophan by genetically modified strains of Escherichia coli. J. Gen. Microbiol. 130: 3091-3100 (1984).

Slow S, Garrow TA. Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. J. Nutr. 136: 2279-2283 (2006).

Slow S, Lever M, Lee MB, George PM, Chambers ST. Betaine analogues alter homocysteine metabolism in rats. Int. J. Biochem. Cell. Biol. 36: 870-880 (2004).

Slow S, Lever M, Lee MB, George PM, Chambers ST. Betaine analogues alter homocysteine metabolism in rats. Int. J. Biochem. Cell Biol. 36: 870-880 (2004).

Smith CD, Carson M, Friedman AM, Skinner MM, Delucas L, Chantalat L, Weise L, Shirasawa T, Chattopadhyay D. Crystal structure of human L-isoaspartyl-O-methyl-transferase with S-adenosyl homocysteine at 1.6-A resolution and modeling of an isoaspartyl-containing peptide at the active site. Protein Sci. 11: 625-635 (2002).

Smith DD, Summers PS, Weretilnyk EA. Phosphocholine synthesis in spinach: characterization of phosphoethanolamine N-methyltransferase. Physiol. Plant. 108: 286-294 (2000).

Snell K, Baumann U, Byrne PC, Chave KJ, Renwick SB, Sanders PG, Whitehouse SK. The genetic organization and protein crystallographic structure of human serine hydroxymethyltransferase. Adv. Enzyme Regul. 40: 353-403 (2000).

Solstad T, Carvalho RN, Andersen OA, Waidelich D, Flatmark T. Deamidation of labile asparagine residues in the autoregulatory sequence of human phenylalanine hydroxylase. Eur. J. Biochem. 270: 929-938 (2003).

Som S, Friedman S. Identification of a highly conserved domain in the EcoRII methyltransferase which can be photolabeled with S-adenosyl-L-[methyl-3H]methionine. Evidence for UV-induced transmethylation of cysteine 186. J. Biol. Chem. 266: 2937-2945 (1991).

Song JT, Koo YJ, Seo HS, Kim MC, Choi YD, Kim JH. Overexpression of AtSGT1, an Arabidopsis salicylic acid glucosyltransferase, leads to increased susceptibility to Pseudomonas syringae. Phytochemistry 69: 1128-1134 (2008).

Song JT, Seo HS, Song SI, Lee JS, Choi YD. NTR1 encodes a floral nectary-specific gene in Brassica campestris L. ssp. pekinensis. Plant Mol. Biol. 42: 647-655 (2000).

Sors TG, Ellis DR, Na GN, Lahner B, Lee S, Leustek T, Pickering IJ, Salt DE. Analysis of sulfur and selenium assimilation in Astragalus plants with varying capacities to accumulate selenium. Plant J. 42: 785-797 (2005).

Sors TG, Martin CP, Salt DE. Characterization of selenocysteine methyltransferases from Astragalus species with contrasting selenium accumulation capacity. Plant J. 59: 110-122 (2009).

Sparks JD, Collins HL, Chirieac DV, Cianci J, Jokinen J, Sowden MP, Galloway CA, Sparks CE. Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase. Biochem. J. 395: 363-371 (2006).

Spitzer B, Zvi MM, Ovadis M, Marhevka E, Barkai O, Edelbaum O, Marton I, Masci T, Alon M, Morin S, Rogachev I, Aharoni A, Vainstein A. Reverse genetics of floral scent: application of tobacco rattle virus-based gene silencing in Petunia. Plant Physiol. 145: 1241-1250 (2007).

Springer NM, Kaeppler SM. Evolutionary divergence of monocot and dicot methyl-CpG-binding domain proteins. Plant Physiol. 138: 92-104 (2005).

Stauffer GV, Brenchley JE. Influence of methionine biosynthesis on serine transhydroxymethylase regulation in Salmonella typhimurium LT2. J. Bacteriol. 129: 740-749 (1977).

Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL. Is it time to reevaluate methyl balance in humans? Am. J. Clin. Nutr. 83: 5-10 (2006).

Stenzel O, Teuber M, Drager B. Putrescine N-methyltransferase in Solanum tuberosum L., a calystegine-forming plant. Planta 223: 200-212 (2006).

Stevens JF, Page JE. Xanthohumol and related prenylflavonoids from hops and beer: to your good health! Phytochemistry 65: 1317-1330 (2004).

Stipanuk MH. Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu. Rev. Nutr. 24: 539-577 (2004).

Stover P, Schirch V. 5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase. J. Biol. Chem. 266: 1543-1550 (1991).

Stover P, Schirch V. Synthesis of (6S)-5-formyltetrahydropteroyl-polyglutamates and interconversion to other reduced pteroylpolyglutamate derivatives. Anal. Biochem. 202: 82-88 (1992).

Stover P, Schirch V. Serine hydroxymethyltransferase catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate. J. Biol. Chem. 265: 14227-14233 (1990).

Strong W, Joshi G, Lura R, Muthukumaraswamy N, Schirch V. 10-Formyltetrahydrofolate synthetase. Evidence for a conformational change in the enzyme upon binding of tetrahydropteroylpolyglutamates. J. Biol. Chem. 262: 12519-12525 (1987).

Strong WB, Schirch V. In vitro conversion of formate to serine: effect of tetrahydropteroylpolyglutamates and serine hydroxymethyltransferase on the rate of 10-formyltetrahydrofolate synthetase. Biochemistry 28: 9430-9439 (1989).

Strong WB, Tendler SJ, Seither RL, Goldman ID, Schirch V. Purification and properties of serine hydroxymethyltransferase and C1-tetrahydrofolate synthase from L1210 cells. J. Biol. Chem. 265: 12149-12155 (1990).

Summers PS, Nolte KD, Cooper AJL, Borgeas H, Leustek T, Rhodes D, Hanson AD. Identification and stereospecificity of the first three enzymes of 3-dimethylsulfoniopropionate biosynthesis in a chlorophyte alga. Plant Physiol. 116: 369-378 (1998).

Summers PS, Weretilnyk EA. Choline synthesis in spinach in relation to salt stress. Plant Physiol. 103: 1269-1276 (1993).

Suzuki M, Yasumoto E, Baba S, Ashihara H. Effect of salt stress on the metabolism of ethanolamine and choline in leaves of the betaine-producing mangrove species Avicennia marina. Phytochemistry 64: 941-948 (2003).

Syed SK, Kim S, Paik WK. Comparative studies on S-adenosyl-L-methionine binding sites of protein N-methyltransferases, using 8-azido-S-adenosyl-L-methionine as photoaffinity probe. J. Protein Chem. 12: 603-612 (1993).

Szebenyi DM, Liu X, Kriksunov IA, Stover PJ, Thiel DJ. Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers. Biochemistry 39: 13313-13323 (2000).

Szebenyi DM, Musayev FN, di Salvo ML, Safo MK, Schirch V. Serine hydroxymethyltransferase: role of glu75 and evidence that serine is cleaved by a retroaldol mechanism. Biochemistry 43: 6865-6876 (2004).

Szegedi SS, Castro CC, Koutmos M, Garrow TA. Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. J. Biol. Chem. 283: 8939-8945 (2008).

Szegedi SS, Garrow TA. Oligomerization is required for betaine-homocysteine S-methyltransferase function. Arch. Biochem. Biophys. 426: 32-42 (2004).

Tabuchi T, Kawaguchi Y, Azuma T, Nanmori T, Yasuda T. Similar regulation patterns of choline monooxygenase, phosphoethanolamine N-methyltransferase and S-adenosyl-L-methionine synthetase in leaves of the halophyte Atriplex nummularia L. Plant Cell Physiol. 46: 505-513 (2005).

Tagmount A, Berken A, Terry N. An essential role of S-adenosyl-L-methionine:L-methionine S-methyltransferase in selenium volatilization by plants. Methylation of selenomethionine to selenium-methyl-L-selenium-methionine, the precursor of volatile selenium. Plant Physiol. 130: 847-856 (2002).

Takahashi S, Bauwe H, Badger M. Impairment of the photorespiratory pathway accelerates photoinhibition of photosystem II by suppression of repair but not acceleration of damage processes in Arabidopsis. Plant Physiol. 144: 487-494 (2007).

Takata Y, Huang Y, Komoto J, Yamada T, Konishi K, Ogawa H, Gomi T, Fujioka M, Takusagawa F. Catalytic mechanism of glycine N-methyltransferase. Biochemistry 42: 8394-8402 (2003).

Talwar R, Jagath JR, Rao NA, Savithri HS. His230 of serine hydroxymethyltransferase facilitates the proton abstraction step in catalysis. Eur. J. Biochem. 267: 1441-1446 (2000).

Talwar R, Leelavathy V, Krishna Rao JV, Appaji Rao N, Savithri HS. Role of pro-297 in the catalytic mechanism of sheep liver serine hydroxymethyltransferase. Biochem. J. 350: 849-853 (2000).

Talwar R, Rao NA, Savithri HS. A change in reaction specificity of sheep liver serine hydroxymethyltransferase. Induction of NADH oxidation upon mutation of His230 to Tyr. Eur. J. Biochem. 267: 929-934 (2000).

Tamogami S, Rakwal R, Kodama O. Phytoalexin production elicited by exogenously applied jasmonic acid in rice leaves (Oryza sativa L.) is under the control of cytokinins and ascorbic acid. FEBS Lett. 412: 61-64 (1997).

Tanghe KA, Garrow TA, Schalinske KL. Triiodothyronine treatment attenuates the induction of hepatic glycine N-methyltransferase by retinoic acid and elevates plasma homocysteine concentrations in rats. J. Nutr. 134: 2913-2918 (2004).

Teerawanichpan P, Chandrasekharan MB, Jiang Y, Narangajavana J, Hall TC. Characterization of two rice DNA methyltransferase genes and RNAi-mediated reactivation of a silenced transgene in rice callus. Planta 218: 337-349 (2004).

Tehlivets O, Hasslacher M, Kohlwein SD. S-Adenosyl-L-homocysteine hydrolase in yeast: key enzyme of methylation metabolism and coordinated regulation with phospholipid synthesis. FEBS Lett. 577: 501-506 (2004).

Teller JH, Powers SG, Snell EE. Ketopantoate hydroxymethyltransferase. I. Purification and role in pantothenate biosynthesis. J. Biol. Chem. 251: 3780-3785 (1976).

Teuber M, Azemi ME, Namjoyan F, Meier AC, Wodak A, Brandt W, Drager B. Putrescine N-methyltransferases - a structure-function analysis. Plant Mol. Biol. 63: 787-801 (2007).

Thanbichler M, Neuhierl B, Bock A. S-methylmethionine metabolism in Escherichia coli. J. Bacteriol. 181: 662-665 (1999).

Thomas D, Becker A, Surdin-Kerjan Y. Reverse methionine biosynthesis from S-adenosylmethionine in eukaryotic cells. J. Biol. Chem. 275: 40718-40724 (2000).

Thomas DJ, Waters SB, Styblo M. Elucidating the pathway for arsenic methylation. Toxicol. Appl. Pharmacol. 198: 319-326 (2004).

Thomazeau K, Curien G, Dumas R, Biou V. Crystal structure of threonine synthase from Arabidopsis thaliana. Protein Sci. 10: 638-648 (2001).

Thong KW, Coombs GH, Sanderson BE. S-Adenosylmethionine and transmethylation reactions in trichomonads. Parasitol. Res. 73: 193-198 (1987).

Thorndike J, Beck WS. Production of formaldehyde from N5-methyltetrahydrofolate by normal and leukemic leukocytes. Cancer Res. 37: 1125-1132 (1977).

Tiimonen H, Aronen T, Laakso T, Saranpaa P, Chiang V, Ylioja T, Roininen H, Haggman H. Does lignin modification affect feeding preference or growth performance of insect herbivores in transgenic silver birch (Betula pendula Roth)? Planta 222: 699-708 (2005).

Tiwari S, Schulz R, Ikeda Y, Dytham L, Bravo J, Mathers L, Spielman M, Guzman P, Oakey RJ, Kinoshita T, Scott RJ. MATERNALLY EXPRESSED PAB C-TERMINAL, a novel imprinted gene in Arabidopsis, encodes the conserved C-terminal domain of polyadenylate binding proteins. Plant Cell 20: 2387-2398 (2008).

Toone JR, Applegarth DA, Coulter-Mackie MB, James ER. Recurrent mutations in P- and T-proteins of the glycine cleavage complex and a novel N-protein mutation (N145I): a strategy for the molecular investigation of patients with nonketotic hyperglycinemia (NKH). Mol. Genet. Metab. 72: 322-325 (2001).

Toquin V, Grausem B, Geoffroy P, Legrand M. Structure of the tobacco caffeic acid O-methyltransferase (COMT) II gene: identification of promoter sequences involved in gene inducibility by various stimuli. Plant Mol. Biol. 52: 495-509 (2003).

Townsend JH, Davis SR, Mackey AD, Gregory JF. Folate deprivation reduces homocysteine remethylation in a human intestinal epithelial cell culture model: role of serine in one-carbon donation. Am. J. Physiol. Gastroint. Liver Physiol. 286: G588-G595 (2004).

Turner SR, Hellens R, Ireland R, Ellis N, Rawsthorne S. The organisation and expression of the genes encoding the mitochondrial glycine decarboxylase complex and serine hydroxymethyltransferase in pea (Pisum sativum). Mol. Gen. Genet. 236: 402-408 (1993).

Turner SR, Ireland R, Morgan C, Rawsthorne S. Identification and localization of multiple forms of serine hydroxymethyltransferase in pea (Pisum sativum) and characterization of a cDNA encoding a mitochondrial isoform. J. Biol. Chem. 267: 13528-13534 (1992).

Tyson K, Metheringham R, Griffiths L, Cole J. Characterisation of Escherichia coli K-12 mutants defective in formate-dependent nitrite reduction: essential roles for hemN and the menFDBCE operon. Arch. Microbiol. 168: 403-411 (1997).

Uefuji H, Ogita S, Yamaguchi Y, Koizumi N, Sano H. Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants. Plant Physiol. 132: 372-380 (2003).

Uefuji H, Tatsumi Y, Morimoto M, Kaothien-Nakayama P, Ogita S, Sano H. Caffeine production in tobacco plants by simultaneous expression of three coffee N-methyltrasferases and its potential as a pest repellant. Plant Mol. Biol. 59: 221-227 (2005).

Ueland PM, Holm PI, Hustad S. Betaine: a key modulator of one-carbon metabolism and homocysteine status. Clin. Chem. Lab. Med. 43: 1069-1075 (2005).

Ulrich CM, Neuhouser M, Liu AY, Boynton A, Gregory JF 3rd, Shane B, James SJ, Reed MC, Nijhout HF. Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiol. Biomarkers Prev. 17: 1822-1831 (2008).

Underwood BA, Tieman DM, Shibuya K, Dexter RJ, Loucas HM, Simkin AJ, Sims CA, Schmelz EA, Klee HJ, Clark DG. Ethylene-regulated floral volatile synthesis in petunia corollas. Plant Physiol. 138: 255-266 (2005).

Upmeier B, Gross W, Koster S, Barz W. Purification and properties of S-adenosyl-L-methionine:nicotinic acid-N-methyltransferase from cell suspension cultures of Glycine max L. Arch. Biochem. Biophys. 262: 445-454 (1988).

Urbanowski ML, Plamann MD, Stauffer LT, Stauffer GV. Cloning and characterization of the gene for Salmonella typhimurium serine hydroxymethyltransferase. Gene 27: 47-54 (1984).

Usha R, Savithri HS, Rao NA. Partial amino acid sequence of sheep liver serine hydroxymethyltransferase and comparison of peptide maps of the enzyme from human, ox livers and Escherichia coli. Indian J. Biochem. Biophys. 29: 183-188 (1992).

Usha R, Savithri HS, Rao NA. The primary structure of sheep liver cytosolic serine hydroxymethyltransferase and an analysis of the evolutionary relationships among serine hydroxymethyltransferases. Biochim. Biophys. Acta 1204: 75-83 (1994).

Usha R, Savithri HS, Rao NA. Arginine residues involved in binding of tetrahydrofolate to sheep liver serine hydroxymethyltransferase. J. Biol. Chem. 267: 9289-9293 (1992).

Uthus EO, Brown-Borg HM. Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse. Mech. Ageing Dev. 127: 444-450 (2006).

Vaillant I, Tutois S, Jasencakova Z, Douet J, Schubert I, Tourmente S. Hypomethylation and hypermethylation of the tandem repetitive 5S rRNA genes in Arabidopsis. Plant J. 54: 299-309 (2008).

van Dijk K, Marley KE, Jeong BR, Xu J, Hesson J, Cerny RL, Waterborg JH, Cerutti H. Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced euchromatin in Chlamydomonas. Plant Cell 17: 2439-2453 (2005).

Van Doorsselaere J, Dumas B, Baucher M, Fritig B, Legrand M, Van Montagu M, Inze D. One-step purification and characterization of a lignin-specific O-methyltransferase from poplar. Gene 133: 213-217 (1993).

Van Eenennaam AL, Li G, Venkatramesh M, Levering C, Gong X, Jamieson AC, Rebar EJ, Shewmaker CK, Case CC. Elevation of seed alpha-tocopherol levels using plant-based transcription factors targeted to an endogenous locus. Metab. Eng. 6: 101-108 (2004).

Van Eenennaam AL, Lincoln K, Durrett TP, Valentin HE, Shewmaker CK, Thorne GM, Jiang J, Baszis SR, Levering CK, Aasen ED, Hao M, Stein JC, Norris SR, Last RL. Engineering vitamin E content: from Arabidopsis mutant to soy oil. Plant Cell 15: 3007-3019 (2003).

Van Wilder V, De Brouwer V, Loizeau K, Gambonnet B, Albrieux C, Van Der Straeten D, Lambert WE, Douce R, Block MA, Rebeille F, Ravanel S. C1 metabolism and chlorophyll synthesis: the Mg-protoporphyrin IX methyltransferase activity is dependent on the folate status. New Phytol. 182: 137-145 (2009).

Vander Mijnsbrugge K, Meyermans H, Van Montagu M, Bauw G, Boerjan W. Wood formation in poplar: identification, characterization, and seasonal variation of xylem proteins. Planta 210: 589-598 (2000).

Veal N, Hsieh CL, Xiong S, Mato JM, Lu S, Tsukamoto H. Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G352-G362 (2004).

Verma A, Ahmed HA, Davis T, Jazrawi RP, Northfield TC. Demonstration and partial characterisation of phospholipid methyltransferase activity in bile canalicular membrane from hamster liver. J. Hepatol. 31: 852-859 (1999).

Vignols F, Rigau J, Torres MA, Capellades M, Puigdomenech P. The brown midrib3 (bm3) mutation in maize occurs in the gene encoding caffeic acid O-methyltransferase. Plant Cell 7: 407-416 (1995).

Villanueva JA, Halsted CH. Hepatic transmethylation reactions in micropigs with alcoholic liver disease. Hepatology 39: 1303-1310 (2004).

Vincent D, Lapierre C, Pollet B, Cornic G, Negroni L, Zivy M. Water deficits affect caffeate O-methyltransferase, lignification, and related enzymes in maize leaves. A proteomic investigation. Plant Physiol. 137: 949-960 (2005).

Vogt T. Regiospecificity and kinetic properties of a plant natural product O-methyltransferase are determined by its N-terminal domain. FEBS Lett. 561: 159-162 (2004).

Voll LM, Jamai A, Renne P, Voll H, McClung CR, Weber AP. The photorespiratory Arabidopsis shm1 mutant is deficient in SHM1. Plant Physiol. 140: 59-66 (2006).

Vollack KU, Xie J, Hartig E, Romling U, Zumft WG. Localization of denitrification genes on the chromosomal map of Pseudomonas aeruginosa. Microbiology 144: 441-448 (1998).

Waditee R, Bhuiyan MN, Rai V, Aoki K, Tanaka Y, Hibino T, Suzuki S, Takano J, Jagendorf AT, Takabe T, Takabe T. Genes for direct methylation of glycine provide high levels of glycinebetaine and abiotic-stress tolerance in Synechococcus and Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 102: 1318-1323 (2005).

Waditee R, Incharoensakdi A. Purification and kinetic properties of betaine-homocysteine methyltransferase from Aphanothece halophytica. Curr. Microbiol. 43: 107-111 (2001).

Wagner C, Koury MJ. S-Adenosylhomocysteine: a better indicator of vascular disease than homocysteine? Am. J. Clin. Nutr. 86: 1581-1585 (2007).

Waite KA, Vance DE. Why expression of phosphatidylethanolamine N-methyltransferase does not rescue chinese hamster ovary cells that have an impaired CDP-choline pathway. J. Biol. Chem. 275: 21197-21202 (2000).

Walbott H, Leulliot N, Grosjean H, Golinelli-Pimpaneau B. The crystal structure of Pyrococcus abyssi tRNA (uracil-54, C5)-methyltransferase provides insights into its tRNA specificity. Nucleic Acids Res. 36: 4929-4940 (2008).

Wan W, Zhao G, Al-Saad K, Siems WF, Zhou ZS. Rapid screening for S-adenosylmethionine-dependent methylation products by enzyme-transferred isotope patterns analysis. Rapid Commun. Mass Spectrom. 18: 319-324 (2004).

Wang J, Dudareva N, Bhakta S, Raguso RA, Pichersky E. Floral scent production in Clarkia breweri (Onagraceae). II. Localization and developmental modulation of the enzyme S-adenosyl-L-methionine:(iso)eugenol O-methyltransferase and phenylpropanoid emission. Plant Physiol. 114: 213-221 (1997).

Wang J, Pichersky E. Identification of specific residues involved in substrate discrimination in two plant O-methyltransferases. Arch. Biochem. Biophys. 368: 172-180 (1999).

Wang J, Pichersky E. Characterization of S-adenosyl-L-methionine:(iso)eugenol O-methyltransferase involved in floral scent production in Clarkia breweri. Arch. Biochem. Biophys. 349: 153-160 (1998).

Wang P, Liang Z, Zeng J, Li W, Sun X, Miao Z, Tang K. Generation of tobacco lines with widely different reduction in nicotine levels via RNA silencing approaches. J. Biosci. 33: 177-184 (2008).

Wang R, Guegler K, LaBrie ST, Crawford NM. Genomic analysis of a nutrient response in Arabidopsis reveals diverse expression patterns and novel metabolic and potential regulatory genes induced by nitrate. Plant Cell 12: 1491-1510 (2000).

Wang Y, Bock A, Neuhierl B. Acquisition of selenium tolerance by a selenium non-accumulating Astragalus species via selection. Biofactors 9: 3-10 (1999).

Watanabe K, Pecinka A, Meister A, Schubert I, Lam E. DNA hypomethylation reduces homologous pairing of inserted tandem repeat arrays in somatic nuclei of Arabidopsis thaliana. Plant J. 44: 531-540 (2005).

Webb HK, Matthews RG. 4-Chlorothreonine is substrate, mechanistic probe, and mechanism-based inactivator of serine hydroxymethyltransferase. J. Biol. Chem. 270: 17204-17209 (1995).

Weid M, Ziegler J, Kutchan TM. The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum. Proc. Natl. Acad. Sci. U.S.A. 101: 13957-13962 (2004).

Wein M, Lavid N, Lunkenbein S, Lewinsohn E, Schwab W, Kaldenhoff R. Isolation, cloning and expression of a multifunctional O-methyltransferase capable of forming 2,5-dimethyl-4-methoxy-3(2H)-furanone, one of the key aroma compounds in strawberry fruits. Plant J. 31: 755-765 (2002).

Weinshilboum RM, Otterness DM, Szumlanski CL. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu. Rev. Pharmacol. Toxicol. 39: 19-52 (1999).

Wentzinger LF, Bach TJ, Hartmann MA. Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Plant Physiol. 130: 334-346 (2002).

Weretilnyk EA, Alexander KJ, Drebenstedt M, Snider JD, Summers PS, Moffatt BA. Maintaining methylation activities during salt stress. The involvement of adenosine kinase. Plant Physiol. 125: 856-865 (2001).

Weretilnyk EA, Smith DD, Wilch GA, Summers PS. Enzymes of choline synthesis in spinach. Response of phospho- base n-methyltransferase activities to light and salinity. Plant Physiol. 109: 1085-1091 (1995).

Wijekoon EP, Hall B, Ratnam S, Brosnan ME, Zeisel SH, Brosnan JT. Homocysteine metabolism in ZDF (type 2) diabetic rats. Diabetes 54: 3245-3251 (2005).

Willemsen V, Friml J, Grebe M, Van Den Toorn A, Palme K, Scheres B. Cell polarity and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1 function. Plant Cell 15: 612-625 (2003).

Williams KT, Schalinske KL. New insights into the regulation of methyl group and homocysteine metabolism. J. Nutr. 137: 311-314 (2007).

Wingler A, Lea PJ, Leegood RC. Photorespiratory metabolism of glyoxylate and formate in glycine-accumulating mutants of barley and Amaranthus edulis. Planta 207: 518-526 (1999).

Winz RA, Baldwin IT. Molecular interactions between the specialist herbivore Manduca sexta (Lepidoptera, Sphingidae) and its natural host Nicotiana attenuata. IV. Insect-induced … Plant Physiol. 125: 2189-2202 (2001).

Woldman Y, Appling DR. A general method for determining the contribution of split pathways in metabolite production in the yeast Saccharomyces cerevisiae. Metab. Eng. 4: 170-181 (2002).

Wood RD. DNA repair in eukaryotes. Annu. Rev. Biochem. 65: 135-167 (1996).

Wu Q, Preisig CL, VanEtten HD. Isolation of the cDNAs encoding (+)6a-hydroxymaackiain 3-O-methyltransferase, the terminal step for the synthesis of the phytoalexin pisatin in Pisum sativum. Plant Mol. Biol. 35: 551-560 (1997).

Wu S, Watanabe N, Mita S, Dohra H, Ueda Y, Shibuya M, Ebizuka Y. The key role of phloroglucinol O-methyltransferase in the biosynthesis of Rosa chinensis volatile 1,3,5-trimethoxybenzene. Plant Physiol. 135: 95-102 (2004).

Wu S, Watanabe N, Mita S, Ueda Y, Shibuya M, Ebizuka Y. Two O-methyltransferases isolated from flower petals of Rosa chinensis var. spontanea involved in scent biosynthesis. J. Biosci. Bioeng. 96: 119-128 (2003).

Xiao W, Brown RC, Lemmon BE, Harada JJ, Goldberg RB, Fischer RL. Regulation of seed size by hypomethylation of maternal and paternal genomes. Plant Physiol. 142: 1160-1168 (2006).

Xiao W, Custard KD, Brown RC, Lemmon BE, Harada JJ, Goldberg RB, Fischer RL. DNA methylation is critical for Arabidopsis embryogenesis and seed viability. Plant Cell 18: 805-814 (2006).

Xu B, Timko M. Methyl jasmonate induced expression of the tobacco putrescine N -methyltransferase genes requires both G-box and GCC-motif elements. Plant Mol. Biol. 55: 743-761 (2004).

Xu Q, Belcastro MP, Villa ST, Dinkins RD, Clarke SG, Downie AB. A second protein L-isoaspartyl methyltransferase gene in Arabidopsis produces two transcripts whose products are sequestered in the nucleus. Plant Physiol. 136: 2652-2664 (2004).

Xue HH, Fujie M, Sakaguchi T, Oda T, Ogawa H, Kneer NM, Lardy HA, Ichiyama A. Flux of the L-serine metabolism in rat liver. The predominant contribution of serine dehydratase. J. Biol. Chem. 274: 16020-16027 (1999).

Xue HH, Sakaguchi T, Fujie M, Ogawa H, Ichiyama A. Flux of the L-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase. J. Biol. Chem. 274: 16028-16033 (1999).

Yang Q, Trinh HX, Imai S, Ishihara A, Zhang LQ, Nakayashiki H, Tosa Y, Mayama S. Analysis of the involvement of hydroxyanthranilate hydroxycinnamoyltransferase and caffeoyl-CoA 3-O-methyltransferase in phytoalexin biosynthesis in oat. Mol. Plant-Microbe Interact. 17: 81-89 (2004).

Yaronskaya E, Vershilovskaya I, Poers Y, Alawady AE, Averina N, Grimm B. Cytokinin effects on tetrapyrrole biosynthesis and photosynthetic activity in barley seedlings. Planta 224: 700-709 (2006).

Yaronskaya E, Ziemann V, Walter G, Averina N, Borner T, Grimm B. Metabolic control of the tetrapyrrole biosynthetic pathway for porphyrin distribution in the barley mutant albostrians. Plant J. 35: 512-522 (2003).

Ye Z, Zhong R, Morrison WH 3rd, Himmelsbach DS. Caffeoyl coenzyme A O-methyltransferase and lignin biosynthesis. Phytochemistry 57: 1177-1185 (2001).

Ye ZH. Association of caffeoyl coenzyme A 3-O-methyltransferase expression with lignifying tissues in several dicot plants. Plant Physiol. 115: 1341-1350 (1997).

Ye ZH, Varner JE. Differential expression of two O-methyltransferases in lignin biosynthesis in Zinnia elegans. Plant Physiol. 108: 459-467 (1995).

Yen CH, Hung JH, Ueng YF, Liu SP, Chen SY, Liu HH, Chou TY, Tsai TF, Darbha R, Hsieh LL, Chen YM. Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect. Toxicol. Appl. Pharmacol. 235: 296-304 (2009).

Yeo E-J, Wagner C. Purification and properties of pancreatic glycine N-methyltransferase. J. Biol. Chem. 267: 24669-24674 (1992).

Yeo EJ, Briggs WT, Wagner C. Inhibition of glycine N-methyltransferase by 5-methyltetrahydrofolate pentaglutamate. J. Biol. Chem. 274: 37559-37564 (1999).

Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J. Biol. Chem. 275: 29318-29323 (2000).

Ying Z, Mulligan RM, Janney N, Royer M, Houtz RL. Related alphaN- and epsilonN-methyltransferases methylate the large and small subunits of Rubisco. Acta Biol. Hung. 49: 173-184 (1998).

Yoshihara N, Fukuchi-Mizutani M, Okuhara H, Tanaka Y, Yabuya T. Molecular cloning and characterization of O-methyltransferases from the flower buds of Iris hollandica. J. Plant Physiol. 165: 415-422 (2008).

Young LS, Harrison BR, Um NM, Moffatt BA, Gilroy S, Masson PH. Adenosine kinase modulates root gravitropism and cap morphogenesis in Arabidopsis. Plant Physiol. 142: 564-573 (2006).

Yu Y, Dong A, Shen WH. Molecular characterization of the tobacco SET domain protein NtSET1 unravels its role in histone methylation, chromatin binding, and segregation. Plant J. 40: 699-711 (2004).

Zhang L, Robbins MP, Carver TLW, Zeyen RJ. Induction of phenylpropanoid gene transcripts in oat attacked by Erysiphe graminis at 20 degrees C and 10 degrees C. Physiol. Mol. Plant Pathol. 51: 15-33 (1997).

Zhang L, Yang B, Lu B, Kai G, Wang Z, Xia Y, Ding R, Zhang H, Sun X, Chen W, Tang K. Tropane alkaloids production in transgenic Hyoscyamus niger hairy root cultures over-expressing putrescine N-methyltransferase is methyl jasmonate-dependent. Planta 225: 887-896 (2007).

Zhang M, Xu C, Yan H, Zhao N, von Wettstein D, Liu B. Limited tissue culture induced mutations and linked epigenetic modifications in F1 hybrids of sorghum pure lines are accompanied by increased transcription of DNA methyltransferases and 5-methylcytosine glycosylases. Plant J. 57: 666-679 (2009).

Zhang Q, Wiskich JT. Activation of glycine decarboxylase in pea leaf mitochondria by ATP. Arch. Biochem. Biophys. 320: 250-256 (1995).

Zhang X, Bruice TC. Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases. Proc. Natl. Acad. Sci. U.S.A. 105: 5728-5732 (2008).

Zhao CR, Shang L, Wang W, Jacobs DO. Myocellular creatine and creatine transporter serine phosphorylation after starvation. J. Surg. Res. 105: 10-16 (2002).

Zhao N, Guan J, Lin H, Chen F. Molecular cloning and biochemical characterization of indole-3-acetic acid methyltransferase from poplar. Phytochemistry 68: 1537-1544 (2007).

Zhao WQ, Latinwo L, Liu XX, Lee ES, Lamango N, Charlton CG. L-Dopa upregulates the expression and activities of methionine adenosyl transferase and catechol-O-methyltransferase. Exp. Neurol. 171: 127-138 (2001).

Zheng XQ, Hayashibe E, Ashihara H. Changes in trigonelline (N-methylnicotinic acid) content and nicotinic acid metabolism during germination of mungbean (Phaseolus aureus) seeds. J. Exp. Bot. 56: 1615-1623 (2005).

Zhong R, III WH, Negrel J, Ye ZH. Dual methylation pathways in lignin biosynthesis. Plant Cell 10: 2033-2046 (1998).

Zhong R, Morrison WH 3rd, Himmelsbach DS, Poole FL 2nd, Ye ZH. Essential role of caffeoyl coenzyme A O-methyltransferase in lignin biosynthesis in woody poplar plants. Plant Physiol. 124: 563-578 (2000).

Zhong R, Ripperger A, Ye ZH. Ectopic deposition of lignin in the pith of stems of two Arabidopsis mutants. Plant Physiol. 123: 59-70 (2000).

Zhou S, Sauvé R, Thannhauser TW. Proteome changes induced by aluminium stress in tomato roots. J. Exp. Bot. 60: 1849-1857 (2009).

Zhu H, Curry S, Wen S, Wicker NJ, Shaw GM, Lammer EJ, Yang W, Jafarov T, Finnell RH. Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts? Am. J. Med. Genet. A. 135: 274-277 (2005).

Ziegler J, Diaz-Chavez ML, Kramell R, Ammer C, Kutchan TM. Comparative macroarray analysis of morphine containing Papaver somniferum and eight morphine free Papaver species identifies an O-methyltransferase involved in benzylisoquinoline biosynthesis. Planta 222: 458-471 (2005).

Zubieta C, He XZ, Dixon RA, Noel JP. Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases. Nat. Struct. Biol. 8: 271-279 (2001).

Zubieta C, Kota P, Ferrer JL, Dixon RA, Noel JP. Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase. Plant Cell 14: 1265-1277 (2002).

Zubieta C, Ross JR, Koscheski P, Yang Y, Pichersky E, Noel JP. Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family. Plant Cell 15: 1704-1716 (2003).

Number of references = 794