Allen DK, Libourel IG, Shachar-Hill Y. Metabolic flux analysis in plants: coping with complexity. Plant Cell Environ. Apr 22 [Epub ahead of print] (2009).

Berlin J, Fecker LF. Chapter 10. Genetic Engineering of Enzymes Diverting Amino Acids into Secondary Metabolism. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 195-216 (2000).

Bum Kim H, Smith CP, Micklefield J, Mavituna F. Metabolic flux analysis for calcium dependent antibiotic (CDA) production in Streptomyces coelicolor. Metab. Eng. 6: 313-325 (2004).

Burbulis IE, Winkel-Shirley B. Interactions among enzymes of the Arabidopsis flavonoid biosynthetic pathway. Proc. Natl. Acad. Sci. U.S.A. 96: 12929-12934 (1999).

Conrado RJ, Varner JD, Delisa MP. Engineering the spatial organization of metabolic enzymes: mimicking nature's synergy. Curr. Opin. Biotechnol. 19: 492-499 (2008).

Davies KM. Chapter 7. Plant Colour and Fragrance. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 127-163 (2000).

De Luca V. Chapter 9. Metabolic Engineering of Crops with the Tryptophan Decarboxylase of Catharanthus roseus. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 179-194 (2000).

Di Fiore S, Li Q, Leech MJ, Schuster F, Emans N, Fischer R, Schillberg S. Targeting tryptophan decarboxylase to selected subcellular compartments of tobacco plants affects enzyme stability and in vivo function and leads to a lesion-mimic phenotype. Plant Physiol. 129: 1160-1169 (2002).

Dieuaide-Noubhani M, Alonso AP, Rolin D, Eisenreich W, Raymond P. Metabolic flux analysis: recent advances in carbon metabolism in plants. EXS 97: 213-243 (2007).

Dixon RA, Lamb CJ, Masoud S, Sewalt VJ, Paiva NL. Metabolic engineering: prospects for crop improvement through the genetic manipulation of phenylpropanoid biosynthesis and defense responses--a review. Gene 179: 61-71 (1996).

Facchini PJ. Alkaloid biosynthesis in plants: biochemistry, cell biology, molecular regulation, and metabolic engineering applications. Annu. Rev. Plant Physiol. Plant Mol. Biol. 52: 29-66 (2001).

Facchini PJ, De Luca V. Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants. Plant J. 54: 763-784 (2008).

Facchini PJ, Huber-Allanach KL, Tari LW. Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications. Phytochemistry 54: 121-138 (2000).

Fischer R, Drossard J, Schillberg S, Artsaenko O, Emans N, Naehring JM. Chapter 5. Modulation of Plant Function and Plant Pathogens by Antibody Expression. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 87-109 (2000).

Hain R, Grimmig B. Chapter 11. Modification of Plant Secondary Metabolism by Genetic Engineering. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 217-231 (2000).

Harris DM, van der Krogt ZA, Klaassen P, Raamsdonk LM, Hage S, van den Berg MA, Bovenberg RA, Pronk JT, Daran JM. Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production. BMC Genomics 10: 75 (2009).

Heide L. Chapter 12. Expression of the Bacterial ubiC Gene Opens a New Biosynthetic Pathway in Plants. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 233-251 (2000).

Hooykaas PJ. Chapter 3. Agrobacterium, a Natural Metabolic Engineer of Plants. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 51-67 (2000).

Hugenholtz J, Kleerebezem M. Metabolic engineering of lactic acid bacteria: overview of the approaches and results of pathway rerouting involved in food fermentations. Curr. Opin. Biotechnol. 10: 492-497 (1999).

Hutchinson CR. Combinatorial biosynthesis for new drug discovery. Curr. Opin. Microbiol. 1: 319-329 (1998).

Jorgensen K, Rasmussen AV, Morant M, Nielsen AH, Bjarnholt N, Zagrobelny M, Bak S, Moller BL. Metabolon formation and metabolic channeling in the biosynthesis of plant natural products. Curr. Opin. Plant Biol. 8: 280-291 (2005).

Juvvadi PR, Seshime Y, Kitamoto K. Genomics reveals traces of fungal phenylpropanoid-flavonoid metabolic pathway in the filamentous fungus Aspergillus oryzae. J. Microbiol. 43 :475-486 (2005).

Kinney AJ. Manipulating flux through plant metabolic pathways. Curr. Opin. Plant Biol. 1: 173-178 (1998).

Krens FA, Keizer LCP, Capel IEM. Transgenic caraway, Carum carvi L.: a model species for metabolic engineering. Plant Cell Rep. 17: 39-43 (1997).

Kunze R, Frommer WB, Flugge UI. Metabolic engineering of plants: the role of membrane transport. Metab. Eng. 4: 57-66 (2002).

Leech MJ, Burtin D, Hallard D, Hilliou F, Kemp B, Palacios N, Rocha P, O'Callaghan D, Verpoote R, Christou P. Chapter 4. Particle Gun Methodology as a Tool in Metabolic Engineering. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 69-86 (2000).

Liu R, Hu Y, Li J, Lin Z. Production of soybean isoflavone genistein in non-legume plants via genetically modified secondary metabolism pathway. Metab. Eng. 9: 1-7 (2007).

Majeran W, van Wijk KJ. Cell-type-specific differentiation of chloroplasts in C4 plants. Trends Plant Sci. 14: 100-109 (2009).

Memelink J, Menkw FL, van der Fits L, Kijne JW. Chapter 6. Transcriptional Regulators to Modify Secondary Metabolism. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 111-125 (2000).

Morgan JA, Shanks JV. Quantification of metabolic flux in plant secondary metabolism by a biogenetic organizational approach. Metab. Eng. 4: 257-262 (2002).

Naeimpoor F, Mavituna F. Metabolic flux analysis in Streptomyces coelicolor under various nutrient limitations. Metab. Eng. 2: 140-148 (2000).

Naoumkina MA, He X, Dixon RA. Elicitor-induced transcription factors for metabolic reprogramming of secondary metabolism in Medicago truncatula. BMC Plant Biol. 8: 132 (2008).

Oksman-Caldentey KM, Arroo R. Chapter 13. Regulation of Tropane Alkaloid Metabolism in Plants an Plant Cell Cultures. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 253-281 (2000).

Perrin RM, Wigge PA. Physiology and metabolism: Web alert. Curr. Opin. Plant Biol. 4: 177-178 (2001).

Piepersberg W. Pathway engineering in secondary metabolite-producing actinomycetes. Crit. Rev. Biotechnol. 14: 251-285 (1994).

Ramos RLB, Tovar FJ, Junqueira RM, Lino FB, Sachetto-Martins G. Sugarcane expressed sequences tags (ESTs) encoding enzymes involved in lignin biosynthesis pathways. Genet. Mol. Biol. 24: 235-241 (2001).

Reeves AR, Cernota WH, Brikun IA, Wesley RK, Mark Weber J. Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum. Metab. Eng. 6: 300-312 (2004).

Rhodes D, Peel GJ, Dudareva N. Metabolism, secondary: engineering pathways of. In (RM Goodman, ed) Encyclopedia of Plant and Crop Science, Marcell Dekker, N.Y., pp. 720-723 (2004).

Rischer H, Oresic M, Seppanen-Laakso T, Katajamaa M, Lammertyn F, Ardiles-Diaz W, Van Montagu MC, Inze D, Oksman-Caldentey KM, Goossens A. Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells. Proc. Natl. Acad. Sci. U.S.A. 103: 5614-5619 (2006).

Robbins MP, Morris P. Chapter 8. Metabolic Engineering of Condensed Tannins and Other Phenolic Pathways in Forage and Fodder Crops. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 165-177 (2000).

Sevilla A, Schmid JW, Mauch K, Iborra JL, Reuss M, Canovas M. Model of central and trimethylammonium metabolism for optimizing l-carnitine production by E. coli. Metab. Eng. 7: 401-425 (2005).

Tian L, Dixon RA. Engineering isoflavone metabolism with an artificial bifunctional enzyme. Planta 224: 496-507 (2006).

Treutter D. Significance of flavonoids in plant resistance and enhancement of their biosynthesis. Plant Biol. (Stuttg.) 7: 581-591 (2005).

van den Berg MA, Bovenberg RA, de Laat WT, van Velzen AG. Engineering aspects of beta-lactam biosynthesis. Antonie Van Leeuwenhoek 75: 155-161 (1999).

Verpoorte R. Chapter 1. Secondary Metabolism. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 1-29 (2000).

Verpoorte R, Memelink J. Engineering secondary metabolite production in plants. Curr. Opin. Biotechnol. 13: 181-107 (2002).

Verpoorte R, van der Heijden R, Memelink J. Chapter 2. General Strategies. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 31-50 (2000).

Verpoorte R, van der Heijden R, Memelink J. Engineering the plant cell factory for secondary metabolite production. Transgenic Res. 9: 323-343 (2000).

Viitanen PV, Devine AL, Khan MS, Deuel DL, Van Dyk DE, Daniell H. Metabolic engineering of the chloroplast genome using the Echerichia coli ubiC gene reveals that chorismate is a readily abundant plant precursor for p-hydroxybenzoic acid biosynthesis. Plant Physiol. 136: 4048-4060 (2004).

Yu O, Jez JM. Nature's assembly line: biosynthesis of simple phenylpropanoids and polyketides. Plant J. 54: 750-762 (2008).

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