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N Use By Plants
Nitrate Assimilation
Ammonia Assimilation
Glu, Gln, Asn, Gly, Ser
Aminotransferases
Asp, Ala, GABA
Val, Leu, Ileu, Thr, Lys
Pro, Arg, Orn
Polyamines
Non-protein AAs
Alkaloids
Sulfate Assimilation
Cys, Met, AdoMet, ACC
His, Phe, Tyr, Tryp
Secondary Products
Onium Compounds
Enzymes
Methods
Simulation
References
HORT640 - Metabolic Plant Physiology

References, mannitol or sorbitol

Aarnikunnas J, Von Weymarn N, Ronnholm K, Leisola M, Palva A. Metabolic engineering of Lactobacillus fermentum for production of mannitol and pure L-lactic acid or pyruvate. Biotechnol. Bioeng. 82: 653-663 (2003).

Abbasi AR, Hajirezaei M, Hofius D, Sonnewald U, Voll LM. Specific roles of alpha- and gamma-tocopherol in abiotic stress responses of transgenic tobacco. Plant Physiol. 143: 1720-1738 (2007).

Abebe T, Guenzi AC, Martin B, Cushman JC. Tolerance of mannitol-accumulating transgenic wheat to water stress and salinity. Plant Physiol. 131: 1748-1755 (2003).

Affenzeller MJ, Darehshouri A, Andosch A, Lutz C, Lutz-Meindl U. Salt stress-induced cell death in the unicellular green alga Micrasterias denticulata. J. Exp. Bot. 60: 939-954 (2009).

Agarwal PK, Agarwal P, Jain P, Jha B, Reddy MK, Sopory SK. Constitutive overexpression of a stress-inducible small GTP-binding protein PgRab7 from Pennisetum glaucum enhances abiotic stress tolerance in transgenic tobacco. Plant Cell Rep. 27: 105-115 (2008).

Ahmad I, Larher F, Stewart GR. Sorbitol, a compatible osmotic solute in Plantago maritima. New Phytol. 82: 671-678 (1979).

Akinterinwa O, Khankal R, Cirino PC. Metabolic engineering for bioproduction of sugar alcohols. Curr. Opin. Biotechnol. 19: 461-467 (2008).

Aldridge P, Metzger M, Geider K. Genetics of sorbitol metabolism in Erwinia amylovora and its influence on bacterial virulence. Mol. Gen. Genet. 256: 611-619 (1997).

Ali M, Rellos P, Cox TM. Hereditary fructose intolerance. J. Med. Genet. 35: 353-365 (1998).

Allakhverdiev SI, Sakamoto A, Nishiyama Y, Inaba M, Murata N. Ionic and osmotic effects of NaCl-induced inactivation of Photosystems I and II in Synechococcus sp. Plant Physiol. 123: 1047-1056 (2000).

Allakhverdiev SI, Sakamoto A, Nishiyama Y, Murata N. Inactivation of photosystems I and II in response to osmotic stress in Synechococcus. Contribution of water channels. Plant Physiol. 122: 1201-1208 (2000).

Anil VS, Rajkumar P, Kumar P, Mathew MK. A plant Ca2+ pump, ACA2, relieves salt hypersensitivity in yeast. Modulation of cytosolic calcium signature and activation of adaptive Na+ homeostasis. J. Biol. Chem. 283: 3497-3506 (2008).

Aposhian HV, Zakharyan RA, Avram MD, Kopplin MJ, Wollenberg ML. Oxidation and detoxification of trivalent arsenic species. Toxicol. Appl. Pharmacol. 193: 1-8 (2003).

Bagchi D, Garg A, Krohn RL, Bagchi M, Tran MX, Stohs SJ. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res. Commun. Mol. Pathol. Pharmacol. 95: 179-189 (1997).

Bagnasco S, Balaban R, Fales HM, Yang Y-M, Burg M. Predominant osmotically active organic solutes in rat and rabbit renal medullas. J. Biol. Chem. 261: 5872-5877 (1986).

Bagniewska-Zadworna A, Zenkteler E, Karolewski P, Zadworny M. Phenolic compound localisation in Polypodium vulgare L. rhizomes after mannitol-induced dehydration and controlled desiccation. Plant Cell Rep. 27: 1251-1259 (2008).

Bago B, Pfeffer PE, Douds Jr DD, Brouillette J, Becard G, Shachar-Hill Y. Carbon metabolism in spores of the arbuscular mycorrhizal fungus Glomus intraradices as revealed by nuclear magnetic resonance spectroscopy. Plant Physiol. 121: 263-272 (1999).

Banzai T, Hanagata N, Dubinsky Z, Karube I. Fructose-2,6-bisphosphate contents were increased in response to salt, water and osmotic stress in leaves of Bruguiera gymnorrhiza by differential changes in the activity of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate … Plant Mol. Biol. 53: 51-59 (2003).

Beck FX, Burger-Kentischer A, Muller E. Cellular response to osmotic stress in the renal medulla. Pflugers Arch. 436: 814-827 (1998).

Beck FX, Muller E, Fraek ML, Dorge A, Thurau K. Inner-medullary organic osmolytes and inorganic electrolytes in K depletion. Pflugers Arch. 439: 471-476 (2000).

Beck FX, Neuhofer W. Response of renal medullary cells to osmotic stress. Contrib. Nephrol. 148: 21-34 (2005).

Bedford JJ, Burg MB, Peters E, Smith RA, Leader JP. Putative osmolytes in the kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 132: 635-644 (2002).

Bedford JJ, Schofield J, Yancey PH, Leader JP. The effects of hypoosmotic infusion on the composition of renal tissue of the Australian brush-tailed possum Trichosurus vulpecula. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 132: 645-652 (2002).

Bedford JJ, Smiley M, Leader JP. Organic osmolytes in the kidney of domesticated red deer, Cervus elaphus. Comp. Biochem. Physiol. [A] 110: 329-333 (1995).

Bellaloui N, Brown PH, Dandekar AM. Manipulation of in vivo sorbitol production alters boron uptake and transport in tobacco. Plant Physiol. 119: 735-742 (1999).

Betz C, Zajonc D, Moll M, Schweizer E. ISC1-encoded inositol phosphosphingolipid phospholipase C is involved in Na+/Li+ halotolerance of Saccharomyces cerevisiae. Eur. J. Biochem. 269: 4033-4039 (2002).

Blumenfeld JD, Hebert SC, Heilig CW, Balschi JA, Stromski ME, Gullans SR. Organic osmolytes in inner medulla of Brattleboro rat: effects of ADH and dehydration. Am. J. Physiol. 256: F916-F922 (1989).

Bondy C, Cowley BD Jr, Lightman SL, Kador PF. Feedback inhibition of aldose reductase gene expression in rat renal medulla. Galactitol accumulation reduces enzyme mRNA levels and depletes cellular inositol content. J. Clin. Invest. 86: 1103-1108 (1990).

Bordo D, van Monfort RL, Pijning T, Kalk KH, Reizer J, Saier MH Jr, Dijkstra BW. The three-dimensional structure of the nitrogen regulatory protein IIANtr from Escherichia coli. J. Mol. Biol. 279: 245-255 (1998).

Borsani J, Budde CO, Porrini L, Lauxmann MA, Lombardo VA, Murray R, Andreo CS, Drincovich MF, Lara MV. Carbon metabolism of peach fruit after harvest: changes in enzymes involved in organic acid and sugar level modifications. J. Exp. Bot. 60: 1823-1837 (2009).

Borsani O, Valpuesta V, Botella MA. Evidence for a role of salicylic acid in the oxidative damage generated by NaCl and osmotic stress in Arabidopsis seedlings. Plant Physiol. 126: 1024-1030 (2001).

Boudsocq M, Barbier-Brygoo H, Lauriere C. Identification of nine SNF1-related protein kinases 2 activated by hyperosmotic and saline stresses in Arabidopsis thaliana. J. Biol. Chem. 279: 41758-41766 (2004).

Boudsocq M, Droillard MJ, Barbier-Brygoo H, Lauriere C. Different phosphorylation mechanisms are involved in the activation of sucrose non-fermenting 1 related protein kinases 2 by osmotic stresses and abscisic acid. Plant Mol. Biol. 63: 491-503 (2007).

Boulanger Y, Legault P, Tejedor A, Vinay P, Theriault Y. Biochemical characterization and osmolytes in papillary collecting ducts from pig and dog kidneys. Can. J. Physiol. Pharmacol. 66: 1282-1290 (1988).

Briens M, Larher F. Sorbitol accumulation in Plantaginaceae; further evidence for a function in stress tolerance. Z. Pflanzenphysiol. Bd. 110: 447-458 (1983).

Brooijmans RJ, de Vos WM, Hugenholtz J. Lactobacillus plantarum WCFS1 electron transport chains. Appl. Environ. Microbiol. 75: 3580-3585 (2009).

Brown PH, Bellaloui N, Hu H, Dandekar A. Transgenically enhanced sorbitol synthesis facilitates phloem boron transport and increases tolerance of tobacco to boron deficiency. Plant Physiol. 119: 17-20 (1999).

Brunker P, Altenbuchner J, Mattes R. Structure and function of the genes involved in mannitol, arabitol and glucitol utilization from Pseudomonas fluorescens DSM50106. Gene 206: 117-126 (1998).

Brunker P, Hils M, Altenbuchner J, Mattes R. The mannitol utilization genes of Pseudomonas fluorescens are regulated by an activator: cloning, nucleotide sequence and expression of the mtlR gene. Gene 215: 19-27 (1998).

Burg MB. Molecular basis of osmotic regulation. Am. J. Physiol. 268: F983-F996 (1995).

Burg MB. Molecular basis for osmoregulation of organic osmolytes in renal medullary cells. J. Exp. Zool. 268: 171-175 (1994).

Burg MB, Kwon ED, Kultz D. Regulation of gene expression by hypertonicity. Annu. Rev. Physiol. 59: 437-455 (1997).

Burg MB, Kwon ED, Peters EM. Glycerophosphocholine and betaine counteract the effect of urea on pyruvate kinase. Kidney Int. 57: S100-S104 (1996).

Burg MB, Peters EM. Urea and methylamines have similar effects on aldose reductase activity. Am. J. Physiol. 273: F1048-F1053 (1997).

Burger-Kentischer A, Muller E, Marz J, Fraek ML, Thurau K, Beck FX. Hypertonicity-induced accumulation of organic osmolytes in papillary interstitial cells. Kidney Int. 55: 1417-1425 (1999).

Burger-Kentischer A, Muller E, Neuhofer W, Marz J, Thurau K, Beck F. Expression of Na+/Cl-/betaine and Na+/myo-inositol transporters, aldose reductase and sorbitol dehydrogenase in macula densa cells of the kidney. Pflugers Arch. 436: 807-809 (1998).

Burger-Kentischer A, Muller E, Neuhofer W, Marz J, Thurau K, Beck F. Expression of aldose reductase, sorbitol dehydrogenase and Na+/myo-inositol and Na+/Cl-/betaine transporter mRNAs in individual cells of the kidney during changes in the diuretic state. Pflugers Arch. 437: 248-254 (1999).

Bustos D, Lascano R, Villasuso AL, Machado E, Senn ME, Cordoba A, Taleisnik E. Reductions in maize root-tip elongation by salt and osmotic stress do not correlate with apoplastic O2*- levels. Ann. Bot. (Lond.) 102: 551-559 (2008).

Canelas AB, van Gulik WM, Heijnen JJ. Determination of the cytosolic free NAD/NADH ratio in Saccharomyces cerevisiae under steady-state and highly dynamic conditions. Biotechnol. Bioeng. 100: 734-743 (2008).

Cao S, Ye M, Jiang S. Involvement of GIGANTEA gene in the regulation of the cold stress response in Arabidopsis. Plant Cell Rep. 24: 683-690 (2005).

Carles C, Bies-Etheve N, Aspart L, Leon-Kloosterziel KM, Koornneef M, Echeverria M, Delseny M. Regulation of Arabidopsis thaliana Em genes: role of ABI5. Plant J. 30: 373-383 (2002).

Chai MF, Wei PC, Chen QJ, An R, Chen J, Yang S, Wang XC. NADK3, a novel cytoplasmic source of NADPH, is required under conditions of oxidative stress and modulates abscisic acid responses in Arabidopsis. Plant J. 47: 665-674 (2006).

Chak RK, Thomas TL, Quatrano RS, Rock CD. The genes ABI1 and ABI2 are involved in abscisic acid- and drought-inducible expression of the Daucus carota L. Dc3 promoter in guard cells of transgenic Arabidopsis thaliana (L.) Heynh. Planta 210: 875-883 (2000).

Chambers ST, Kunin CM. Osmoprotective activity for Escherichia coli in mammalian renal inner medulla and urine. Correlation of glycine and proline betaines and sorbitol with response to osmotic loads. J. Clin. Invest. 80: 1255-1260 (1987).

Chambers ST, Kunin CM. Isolation of glycine betaine and proline betaine from human urine. Assessment of their role as osmoprotective agents for bacteria and the kidney. J. Clin. Invest. 79: 731-737 (1987).

Chauvaux S, Paulsen IT, Saier MH Jr. CcpB, a novel transcription factor implicated in catabolite repression in Bacillus subtilis. J. Bacteriol. 180: 491-497 (1998).

Chen TH, Murata N. Enhancement of tolerance of abiotic stress by metabolic engineering of betaines and other compatible solutes. Curr. Opin. Plant Biol. 5: 250-257 (2002).

Chen W, Wright L, Li S, Cosloy SD, Russell CS. Expression of glutamyl-tRNA reductase in Escherichia coli. Biochim. Biophys. Acta 1309: 109-121 (1996).

Chen Y, Ji F, Xie H, Liang J, Zhang J. The regulator of G-protein signaling proteins involved in sugar and abscisic acid signaling in Arabidopsis seed germination. Plant Physiol. 140: 302-310 (2006).

Chen Z, Hong X, Zhang H, Wang Y, Li X, Zhu JK, Gong Z. Disruption of the cellulose synthase gene, AtCesA8/IRX1, enhances drought and osmotic stress tolerance in Arabidopsis. Plant J. 43: 273-283 (2005).

Cheng L, Zhou R, Reidel EJ, Sharkey TD, Dandekar AM. Antisense inhibition of sorbitol synthesis leads to up-regulation of starch synthesis without altering CO2 assimilation in apple leaves. Planta 220: 767-776 (2005).

Chiang YJ, Stushnoff C, McSay AE. Overexpression of mannitol-1-phosphate dehydrogenase increases mannitol accumulation and adds protection against chilling injury in petunia. J. Am. Soc. Hortic. Sci. 130: 605-610 (2005).

Chohnan S, Izawa H, Nishihara H, Takamura Y. Changes in size of intracellular pools of coenzyme A and its thioesters in Escherichia coli K-12 cells to various carbon sources and stresses. Biosci. Biotechnol. Biochem. 62: 1122-1128 (1998).

Chong BF, Bonnett GD, Glassop D, O'Shea MG, Brumbley SM. Growth and metabolism in sugarcane are altered by the creation of a new hexose-phosphate sink. Plant Biotechnol. J. 5: 240-253 (2007).

Clark AJ, Blissett KJ, Oliver RP. Investigating the role of polyols in Cladosporium fulvum during growth under hyper-osmotic stress and in planta. Planta 216: 614-619 (2003).

Clerkx EJ, El-Lithy ME, Vierling E, Ruys GJ, Blankestijn-De Vries H, Groot SP, Vreugdenhil D, Koornneef M. Analysis of natural allelic variation of Arabidopsis seed germination and seed longevity traits between the accessions Landsberg erecta and Shakdara, using a new recombinant inbred line population. Plant Physiol. 135: 432-443 (2004).

Close TJ, Lammers PJ. An osmotic stress protein of cyanobacteria is immunologically related to plant dehydrins. Plant Physiol. 101: 773-779 (1993).

Collier DE, Cummins WR. Sensitivity of the cytochrome and alternative pathways to osmotic stress in leaf-slices of Saxifraga cernua L. J. Plant Physiol. 141: 745-749 (1993).

Conde C, Agasse A, Silva P, Lemoine R, Delrot S, Tavares R, Geros H. OeMST2 encodes a monosaccharide transporter expressed throughout olive fruit maturation. Plant Cell Physiol. 48: 1299-1308 (2007).

Conde C, Silva P, Agasse A, Lemoine R, Delrot S, Tavares R, Geros H. Utilization and transport of mannitol in Olea europaea and implications on salt stress tolerance. Plant Cell Physiol. 48: 42-53 (2007).

Corradini C, Canali G, Cogliandro E, Nicoletti I. Separation of alditols of interest in food products by high-performance anion-exchange chromatography with pulsed amperometric detection. J. Chromatogr. A. 791: 343-349 (1997).

Costantino HR, Curley JG, Hsu CC. Determining the water sorption monolayer of lyophilized pharmaceutical proteins. J. Pharm. Sci. 86: 1390-1393 (1997).

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Davison IR, Reed RH. The physiological significance of mannitol accumulation in brown algae: the role of mannitol as a compatible cytoplasmic solute. Phycologia 24: 449-457 (1985).

Davison IR, Reed RH. Evidence for the subcellular compartmentation of mannitol and inorganic osmotica in brown algae. Brit. Phycol. J. 20: 183 (1985).

Dayan FE. Factors modulating the levels of the allelochemical sorgoleone in Sorghum bicolor. Planta 224: 339-346 (2006).

de Ronde JA, Spreeth MH, Cress WA. Effect of antisense L-delta1-pyrroline-5-carboxylate reductase transgenic soybean plants subjected to osmotic and drought stress. Plant Growth Regul. 32: 13-26 (2000).

de Sousa SM, Paniago MD, Arruda P, Yunes JA. Sugar levels modulate sorbitol dehydrogenase expression in maize. Plant Mol. Biol. 68: 203-213 (2008).

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Dellow WJ, Chambers ST, Lever M, Lunt H, Robson RA. Elevated glycine betaine excretion in diabetes Mellitus patients is associated with proximal tubular dysfunction and hyperglycemia. Diabetes Res. & Clin. Prac. 43: 91-99 (1999).

Desbrosses GG, Kopka J, Udvardi MK. Lotus japonicus metabolic profiling. Development of gas chromatography-mass spectrometry resources for the study of plant-microbe interactions. Plant Physiol. 137: 1302-1318 (2005).

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Gutha LR, Reddy AR. Rice DREB1B promoter shows distinct stress-specific responses, and the overexpression of cDNA in tobacco confers improved abiotic and biotic stress tolerance. Plant Mol. Biol. 68: 533-555 (2008).

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David Rhodes
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Last Update: 10/01/09