Purdue University Logo
Department of Horticulture and Landscape Architecture
 
Horticulture Home Page
Agriculture Home Page
Purdue Home Page
Blackboard
HORT640 Home Page
N Use By Plants
Nitrate Assimilation
Ammonia Assimilation
Glu, Gln, Asn, Gly, Ser
Aminotransferases
Asp, Ala, GABA
Val, Leu, Ileu, Thr, Lys
Pro, Arg, Orn
Polyamines
Non-protein AAs
Alkaloids
Sulfate Assimilation
Cys, Met, AdoMet, ACC
His, Phe, Tyr, Tryp
Secondary Products
Onium Compounds
Enzymes
Methods
Simulation
References
HORT640 - Metabolic Plant Physiology

References, lycopene

Alba R, Cordonnier-Pratt MM, Pratt LH. Fruit-localized phytochromes regulate lycopene accumulation independently of ethylene production in tomato. Plant Physiol. 123: 363-370 (2000).

Alper H, Jin YS, Moxley JF, Stephanopoulos G. Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli. Metab. Eng. 7: 155-164 (2005).

Alper H, Stephanopoulos G. Uncovering the gene knockout landscape for improved lycopene production in E. coli. Appl. Microbiol. Biotechnol. 78: 801-810 (2008).

Alquezar B, Rodrigo MJ, Zacarķas L. Regulation of carotenoid biosynthesis during fruit maturation in the red-fleshed orange mutant Cara Cara. Phytochemistry 69: 1997-2007 (2008).

Aluru M, Xu Y, Guo R, Wang Z, Li S, White W, Wang K, Rodermel S. Generation of transgenic maize with enhanced provitamin A content. J. Exp. Bot. 59: 3551-3562 (2008).

Andrews PK, Fahy DA, Foyer CH. Relationships between fruit exocarp antioxidants in the tomato (Lycopersicon esculentum) high pigment-1 mutant during development. Physiol. Plant. 120: 519-528 (2004).

Bai L, Kim EH, Dellapenna D, Brutnell TP. Novel lycopene epsilon cyclase activities in maize revealed through perturbation of carotenoid biosynthesis. Plant J. 59: 588-599 (2009).

Baranska M, Baranski R, Schulz H, Nothnagel T. Tissue-specific accumulation of carotenoids in carrot roots. Planta 224: 1028-1037 (2006).

Baranski R, Baranska M, Schulz H. Changes in carotenoid content and distribution in living plant tissue can be observed and mapped in situ using NIR-FT-Raman spectroscopy. Planta 222: 448-457 (2005).

Barr J, White WS, Chen L, Bae H, Rodermel S. The GHOST terminal oxidase regulates developmental programming in tomato fruit. Plant Cell Environ. 27: 840-852 (2004).

Bramley PM. Regulation of carotenoid formation during tomato fruit ripening and development. J. Exp. Bot. 53: 2107-2113 (2002).

Breitenbach J, Fernandez-Gonzalez B, Vioque A, Sandmann G. A higher-plant type zeta-carotene desaturase in the cyanobacterium Synechocystis PCC6803. Plant Mol. Biol. 36: 725-732 (1998).

Breitenbach J, Sandmann G. zeta-Carotene cis isomers as products and substrates in the plant poly-cis carotenoid biosynthetic pathway to lycopene. Planta 220: 785-793 (2005).

Castillo R, Fernandez JA, Gomez-Gomez L. Implications of carotenoid biosynthetic genes in apocarotenoid formation during the stigma development of Crocus sativus and its closer relatives. Plant Physiol. 139: 674-689 (2005).

Causse M, Saliba-Colombani V, Lecomte L, Duffe P, Rousselle P, Buret M. QTL analysis of fruit quality in fresh market tomato: a few chromosome regions control the variation of sensory and instrumental traits. J. Exp. Bot. 53: 2089-2098 (2002).

Clotault J, Peltier D, Berruyer R, Thomas M, Briard M, Geoffriau E. Expression of carotenoid biosynthesis genes during carrot root development. J. Exp. Bot. 59: 3563-3573 (2008).

Daraselia ND, Tarchevskaya S, Narita JO. The promoter for tomato 3-hydroxy-3-methylglutaryl coenzyme A reductase gene 2 has unusual regulatory elements that direct high-level expression. Plant Physiol. 112: 727-733 (1996).

Davidovich-Rikanati R, Lewinsohn E, Bar E, Iijima Y, Pichersky E, Sitrit Y. Overexpression of the lemon basil alpha-zingiberene synthase gene (ZIS) increases both mono- and sesquiterpene contents in tomato fruit. Plant J. 56: 228-238 (2008).

Diretto G, Welsch R, Tavazza R, Mourgues F, Pizzichini D, Beyer P, Giuliano G. Silencing of beta-carotene hydroxylase increases total carotenoid and beta-carotene levels in potato tubers. BMC Plant Biol. 7: 11 (2007).

Estrada AF, Maier D, Scherzinger D, Avalos J, Al-Babili S. Novel apocarotenoid intermediates in Neurospora crassa mutants imply a new biosynthetic reaction sequence leading to neurosporaxanthin formation. Fungal Genet. Biol. 45: 1497-1505 (2008).

Fang J, Chai C, Qian Q, Li C, Tang J, Sun L, Huang Z, Guo X, Sun C, Liu M, Zhang Y, Lu Q, Wang Y, Lu C, Han B, Chen F, Cheng Z, Chu C. Mutations of genes in synthesis of the carotenoid precursors of ABA lead to pre-harvest sprouting and photo-oxidation in rice. Plant J. 54: 177-189 (2008).

Farmer WR, Liao JC. Improving lycopene production in Escherichia coli by engineering metabolic control. Nat. Biotechnol. 18: 533-537 (2000).

Farmer WR, Liao JC. Precursor balancing for metabolic engineering of lycopene production in Escherichia coli. Biotechnol. Prog. 17: 57-61 (2001).

Fraser PD, Enfissi EM, Bramley PM. Genetic engineering of carotenoid formation in tomato fruit and the potential application of systems and synthetic biology approaches. Arch. Biochem. Biophys. 483: 196-204 (2009).

Frigaard NU, Maresca JA, Yunker CE, Jones AD, Bryant DA. Genetic manipulation of carotenoid biosynthesis in the green sulfur bacterium Chlorobium tepidum. J. Bacteriol. 186: 5210-5220 (2004).

Galpaz N, Ronen G, Khalfa Z, Zamir D, Hirschberg J. A chromoplast-specific carotenoid biosynthesis pathway is revealed by cloning of the tomato white-flower locus. Plant Cell 18: 1947-1960 (2006).

Galpaz N, Wang Q, Menda N, Zamir D, Hirschberg J. Abscisic acid deficiency in the tomato mutant high-pigment 3 leading to increased plastid number and higher fruit lycopene content. Plant J. 53: 717-730 (2008).

Giliberto L, Perrotta G, Pallara P, Weller JL, Fraser PD, Bramley PM, Fiore A, Tavazza M, Giuliano G. Manipulation of the blue light photoreceptor cryptochrome 2 in tomato affects vegetative development, flowering time, and fruit antioxidant content. Plant Physiol. 137: 199-208 (2005).

Graham JE, Bryant DA. The biosynthetic pathway for myxol-2' fucoside (myxoxanthophyll) in the cyanobacterium Synechococcus sp. strain PCC 7002. J. Bacteriol. 191: 3292-3300 (2009).

Harada H, Yu F, Okamoto S, Kuzuyama T, Utsumi R, Misawa N. Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli. Appl. Microbiol. Biotechnol. 81: 915-925 (2009).

Harjes CE, Rocheford TR, Bai L, Brutnell TP, Kandianis CB, Sowinski SG, Stapleton AE, Vallabhaneni R, Williams M, Wurtzel ET, Yan J, Buckler ES. Natural genetic variation in lycopene epsilon cyclase tapped for maize biofortification. Science 319: 330-333 (2008).

Harker M, Bramley PM. Expression of prokaryotic 1-deoxy-D-xylulose-5-phosphatases in Escherichia coli increases carotenoid and ubiquinone biosynthesis. FEBS Lett. 448: 115-119 (1999).

Hirschberg J. Carotenoid biosynthesis in flowering plants. Curr. Opin. Plant Biol. 4: 210-218 (2001).

Huang FC, Horvath G, Molnar P, Turcsi E, Deli J, Schrader J, Sandmann G, Schmidt H, Schwab W. Substrate promiscuity of RdCCD1, a carotenoid cleavage oxygenase from Rosa damascena. Phytochemistry 70: 457-464 (2009).

Ibdah M, Azulay Y, Portnoy V, Wasserman B, Bar E, Meir A, Burger Y, Hirschberg J, Schaffer AA, Katzir N, Tadmor Y, Lewinsohn E. Functional characterization of CmCCD1, a carotenoid cleavage dioxygenase from melon. Phytochemistry 67: 1579-1589 (2006).

Isaacson T, Ohad I, Beyer P, Hirschberg J. Analysis in vitro of the enzyme CRTISO establishes a poly-cis-carotenoid biosynthesis pathway in plants. Plant Physiol. 136: 4246-4255 (2004).

Isaacson T, Ronen G, Zamir D, Hirschberg J. Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of beta-carotene and xanthophylls in plants. Plant Cell 14: 333-342 (2002).

Jin YS, Stephanopoulos G. Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli. Metab. Eng. 9: 337-347 (2007).

Jones KL, Kim SW, Keasling JD. Low-copy plasmids can perform as well as or better than high-copy plasmids for metabolic engineering of bacteria. Metab. Eng. 2: 328-338 (2000).

Kato M, Ikoma Y, Matsumoto H, Sugiura M, Hyodo H, Yano M. Accumulation of carotenoids and expression of carotenoid biosynthetic genes during maturation in citrus fruit. Plant Physiol. 134: 824-837 (2004).

Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, von Lintig J. Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. J. Biol. Chem. 276: 14110-14116 (2001).

Kim SW, Keasling JD. Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production. Biotechnol. Bioeng. 72: 408-415 (2001).

Kitagawa M, Ito H, Shiina T, Nakamura N, Inakuma T, Kasumi T, Ishiguro Y, Yabe K, Ito Y. Characterization of tomato fruit ripening and analysis of gene expression in F-1 hybrids of the ripening inhibitor (rin) mutant. Physiol. Plant. 123: 331-338 (2005).

Klebanov GI, Kapitanov AB, Teselkin YuO, Babenkova IV, Zhambalova BA, Lyubitsky OB, Nesterova OA, Vasil'eva OV, Popov IN, Lewin G, Vladimirov YuA. The antioxidant properties of lycopene. Membr. Cell Biol. 12: 287-300 (1998).

Kovacs K, Zhang L, Linforth RS, Whittaker B, Hayes CJ, Fray RG. Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit. Transgenic Res. 16: 121-126 (2007).

La Rocca N, Rascio N, Oster U, Rudiger W. Inhibition of lycopene cyclase results in accumulation of chlorophyll precursors. Planta 225: 1019-1029 (2007).

Lewinsohn E, Schalechet F, Wilkinson J, Matsui K, Tadmor Y, Nam KH, Amar O, Lastochkin E, Larkov O, Ravid U, Hiatt W, Gepstein S, Pichersky E. Enhanced levels of the aroma and flavor compound S-linalool by metabolic engineering of the terpenoid pathway in tomato fruits. Plant Physiol. 127: 1256-1265 (2001).

Li F, Murillo C, Wurtzel ET. Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization. Plant Physiol. 144: 1181-1189 (2007).

Lindgren LO, Stalberg KG, Hoglund AS. Seed-specific overexpression of an endogenous Arabidopsis phytoene synthase gene results in delayed germination and increased levels of carotenoids, chlorophyll, and abscisic acid. Plant Physiol. 132: 779-785 (2003).

Liu Q, Xu J, Liu Y, Zhao X, Deng X, Guo L, Gu J. A novel bud mutation that confers abnormal patterns of lycopene accumulation in sweet orange fruit (Citrus sinensis L. Osbeck). J. Exp. Bot. 58: 4161-4171 (2007).

Liu Q, Zhu A, Chai L, Zhou W, Yu K, Ding J, Xu J, Deng X. Transcriptome analysis of a spontaneous mutant in sweet orange [Citrus sinensis (L.) Osbeck] during fruit development. J. Exp. Bot. 60: 801-813 (2009).

Long M, Millar DJ, Kimura Y, Donovan G, Rees J, Fraser PD, Bramley PM, Bolwell GP. Metabolite profiling of carotenoid and phenolic pathways in mutant and transgenic lines of tomato: identification of a high antioxidant fruit line. Phytochemistry 67: 1750-1757 (2006).

Martinez I, Zhu J, Lin H, Bennett GN, San KY. Replacing Escherichia coli NAD-dependent glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with a NADP-dependent enzyme from Clostridium acetobutylicum facilitates NADPH dependent pathways. Metab. Eng. 10: 352-359 (2008).

Masamoto K, Wada H, Kaneko T, Takaichi S. Identification of a gene required for cis-to-trans carotene isomerization in carotenogenesis of the cyanobacterium Synechocystis sp. PCC 6803. Plant Cell Physiol. 42: 1398-1402 (2001).

Matthews PD, Luo R, Wurtzel ET. Maize phytoene desaturase and {zeta}-carotene desaturase catalyse a poly-Z desaturation pathway: implications for genetic engineering of carotenoid content among cereal crops. J. Exp. Bot. 54: 2215-2230 (2003).

Matthews PD, Wurtzel ET. Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase. Appl. Microbiol. Biotechnol. 53: 396-400 (2000).

Misawa N, Shimada H. Metabolic engineering for the production of carotenoids in non-carotenogenic bacteria and yeasts. J. Biotechnol. 59: 169-181 (1997).

Miura Y, Kondo K, Shimada H, Saito T, Nakamura K, Misawa N. Production of lycopene by the food yeast, Candida utilis that does not naturally synthesize carotenoid. Biotechnol. Bioeng. 58: 306-308 (1998).

Moro I, Dalla Vecchia F, La Rocca N, Navari-Izzo F, Quartacci MF, Di Baccio D, Rudiger W, Rascio N. Impaired carotenogenesis can affect organization and functionality of etioplast membranes. Physiol. Plant. 122: 123-132 (2004).

Muir SR, Collins GJ, Robinson S, Hughes S, Bovy A, De Vos CHR, van Tunen AJ, Verhoeyen ME. Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols. Nat. Biotechnol. 19: 470-474 (2001).

Orset SC, Young AJ. Exposure to low irradiances favors the synthesis of 9-cis beta, beta-carotene in Dunaliella salina. Plant Physiol. 122: 609-618 (2000).

Park H, Kreunen SS, Cuttriss AJ, DellaPenna D, Pogson BJ. Identification of the carotenoid isomerase provides insight into carotenoid biosynthesis, prolamellar body formation, and photomorphogenesis. Plant Cell 14: 321-332 (2002).

Ravanello MP, Ke D, Alvarez J, Huang B, Shewmaker CK. Coordinate expression of multiple bacterial carotenoid genes in canola leading to altered carotenoid production. Metab. Eng. 5: 255-263 (2003).

Rodriguez-Concepcion M, Gruissem W. Arachidonic acid alters tomato HMG expression and fruit growth and induces 3-hydroxy-3-methylglutaryl coenzyme A reductase-independent lycopene accumulation. Plant Physiol. 119: 41-48 (1999).

Ronen G, Cohen M, Zamir D, Hirschberg J. Regulation of carotenoid biosynthesis during tomato fruit development: expression of the gene for lycopene epsilon-cyclase is down-regulated during ripening and is elevated in the mutant Delta. Plant J. 17: 341-351 (1999).

Rosati C, Aquilani R, Dharmapuri S, Pallara P, Marusic C, Tavazza R, Bouvier F, Camara B, Giuliano G. Metabolic engineering of beta-carotene and lycopene content in tomato fruit. Plant J. 24: 413-420 (2000).

Sandmann G, Takaichi S, Fraser PD. C(35)-apocarotenoids in the yellow mutant Neurospora crassa YLO. Phytochemistry 69: 2886-2890 (2008).

Schaub P, Al-Babili S, Drake R, Beyer P. Why is golden rice golden (yellow) instead of red? Plant Physiol. 138: 441-450 (2005).

Schmidt-Dannert C, Umeno D, Arnold FH. Molecular breeding of carotenoid biosynthetic pathways. Nat. Biotechnol. 18: 750-753 (2000).

Simkin AJ, Schwartz SH, Auldridge M, Taylor MG, Klee HJ. The tomato carotenoid cleavage dioxygenase 1 genes contribute to the formation of the flavor volatiles beta-ionone, pseudoionone, and geranylacetone. Plant J. 40: 882-892 (2004).

Singh M, Lewis PE, Hardeman K, Bai L, Rose JK, Mazourek M, Chomet P, Brutnell TP. Activator mutagenesis of the pink scutellum1/viviparous7 locus of maize. Plant Cell 15: 874-884 (2003).

Smolke CD, Martin VJ, Keasling JD. Controlling the metabolic flux through the carotenoid pathway using directed mRNA processing and stabilization. Metab. Eng. 3: 313-321 (2001).

Steinbrenner J, Linden H. Light induction of carotenoid biosynthesis genes in the green alga Haematococcus pluvialis: regulation by photosynthetic redox control. Plant Mol. Biol. 52: 343-356 (2003).

Takats Z, Wiseman JM, Gologan B, Cooks RG. Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 306: 471-473 (2004).

Telef N, Stammitti-Bert L, Mortain-Bertrand A, Maucourt M, Carde JP, Rolin D, Gallusci P. Sucrose deficiency delays lycopene accumulation in tomato fruit pericarp discs. Plant Mol. Biol. 62: 453-469 (2006).

Tsuchiya T, Takaichi S, Misawa N, Maoka T, Miyashita H, Mimuro M. The cyanobacterium Gloeobacter violaceus PCC 7421 uses bacterial-type phytoene desaturase in carotenoid biosynthesis. FEBS Lett. 579: 2125-2129 (2005).

Tucker G. Nutritional enhancement of plants. Curr. Opin. Biotechnol. 14: 221-225 (2003).

Vadali RV, Bennett GN, San KY. Applicability of CoA/acetyl-CoA manipulation system to enhance isoamyl acetate production in Escherichia coli. Metab. Eng. 6: 294-299 (2004).

Vidhyavathi R, Venkatachalam L, Sarada R, Ravishankar GA. Regulation of carotenoid biosynthetic genes expression and carotenoid accumulation in the green alga Haematococcus pluvialis under nutrient stress conditions. J. Exp. Bot. 59: 1409-1418 (2008).

Vogel JT, Tan BC, McCarty DR, Klee HJ. The carotenoid cleavage dioxygenase 1 enzyme has broad substrate specificity, cleaving multiple carotenoids at two different bond positions. J. Biol. Chem. 283: 11364-11373 (2008).

Wang Cw, Oh MK, Liao JC. Directed evolution of metabolically engineered Escherichia coli for carotenoid production. Biotechnol. Prog. 16: 922-926 (2000).

Wang F, Jiang JG, Chen Q. Progress on molecular breeding and metabolic engineering of biosynthesis pathways of C(30), C(35), C(40), C(45), C(50) carotenoids. Biotechnol. Adv. 25: 211-222 (2007).

Wang GY, Keasling JD. Amplification of HMG-CoA reductase production enhances carotenoid accumulation in Neurospora crassa. Metab. Eng. 4: 193-201 (2002).

Zhu C, Yamamura S, Koiwa H, Nishihara M, Sandmann G. cDNA cloning and expression of carotenogenic genes during flower development in Gentiana lutea. Plant Mol. Biol. 48: 277-285 (2002).

Zhu YH, Jiang JG, Chen Q. Characterization of cDNA of lycopene beta-cyclase responsible for a high level of beta-carotene accumulation in Dunaliella salina. Biochem. Cell Biol. 86: 285-292 (2008).

Number of references = 85

| PubMed Search | Entrez Protein Search | ISI Web of Knowledge Search | Scirus Search |

David Rhodes
Department of Horticulture & Landscape Architecture
Horticulture Building
625 Agriculture Mall Drive
Purdue University
West Lafayette, IN 47907-2010
Last Update: 10/01/09