Andresen PA, Kaasen I, Styrvold OB, Boulnois G, Strom AR. Molecular cloning, physical mapping and expression of the bet genes governing the osmoregulatory choline-glycine betaine pathway of Escherichia coli. J. Gen. Microbiol. 134: 1737-1746 (1988).

Arias C, Valero H, Tapia R. Inhibition of brain glutamate decarboxylase activity is related to febrile seizures in rat pups. J. Neurochem. 58: 369-373 (1992).

Barlow P, Marchbanks RM. The effects of inhibiting choline dehydrogenase on choline metabolism in mice. Biochem. Pharmacol. 34: 3117-3122 (1985).

Barrett MC, Dawson AP. The reaction of choline dehydrogenase with some electron acceptors. Biochem. J. 151: 677-683 (1975).

Bhattacharya RC, Maheswari M, Dineshkumar V, Kirti PB, Bhat SR, Chopra VL. Transformation of Brassica oleracea var. capitata with bacterial betA gene enhances tolerance to salt stress. Sci. Hortic. 100: 215-227 (2004).

Boch J, Kempf B, Schmid R, Bremer E. Synthesis of the osmoprotectant glycine betaine in Bacillus subtilis: characterization of the gbsAB genes. J. Bacteriol. 178: 5121-5129 (1996).

Boch J, Nau-Wagner G, Kneip S, Bremer E. Glycine betaine aldehyde dehydrogenase from Bacillus subtilis: characterization of an enzyme required for the synthesis of the osmoprotectant glycine betaine. Arch. Microbiol. 168: 282-289 (1997).

Boncompagni E, Osteras M, Poggi MC, Le Rudulier D. Occurrence of choline and glycine betaine uptake and metabolism in the family Rhizobiaceae and their roles in osmoprotection. Appl. Environ. Microbiol. 65: 2072-2077 (1999).

Burnet M, Lafontaine PJ, Hanson AD. Assay, purification, and partial characterization of choline monooxygenase from spinach. Plant Physiol. 108: 581-588 (1995).

Burns SP, Holmes HC, Chalmers RA, Johnson A, Iles RA. Proton NMR spectroscopic analysis of multiple acyl-CoA dehydrogenase deficiency-capacity of the choline oxidation pathway for methylation in vivo. Biochim. Biophys. Acta 1406: 274-282 (1998).

Canovas D, Vargas C, Kneip S, Moron MJ, Ventosa A, Bremer E, Nieto JJ. Genes for the synthesis of the osmoprotectant glycine betaine from choline in the moderately halophilic bacterium Halomonas elongata DSM 3043, USA. Microbiology 146: 455-463 (2000).

Cavener DR. GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities. J. Mol. Biol. 223: 811-814 (1992).

Chen TH, Murata N. Enhancement of tolerance of abiotic stress by metabolic engineering of betaines and other compatible solutes. Curr. Opin. Plant Biol. 5: 250-257 (2002).

Chern MK, Pietruszko R. Evidence for mitochondrial localization of betaine aldehyde dehydrogenase in rat liver: purification, characterization, and comparison with human cytoplasmic E3 isozyme. Biochem. Cell Biol. 77: 179-187 (1999).

Chung YL, Rider LG, Bell JD, Summers RM, Zemel LS, Rennebohm RM, Passo MH, Hicks J, Miller FW, Scott DL; Juvenile Dermatomyositis Disease Activity Collaborative Study Group. Muscle metabolites, detected in urine by proton spectroscopy, correlate with disease damage in juvenile idiopathic inflammatory myopathies. Arthritis Rheum. 53: 565-570 (2005).

da Costa KA, Kozyreva OG, Song J, Galanko JA, Fischer LM, Zeisel SH. Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J. 20: 1336-1344..

Duan X, Song Y, Yang A, Zhang J. The transgene pyramiding tobacco with betaine synthesis and heterologous expression of AtNHX1 is more tolerant to salt stress than either of the tobacco lines with betaine synthesis or AtNHX1. Physiol. Plant. 135: 281-295 (2009).

Fan F, Germann MW, Gadda G. Mechanistic studies of choline oxidase with betaine aldehyde and its isosteric analogue 3,3-dimethylbutyraldehyde. Biochemistry 45: 1979-1986 (2006).

Fougere F, Le Rudulier D. Glycine betaine biosynthesis and catabolism in bacteroids of Rhizobium meliloti - effect of salt stress. J. Gen. Microbiol. 136: 2503-2510 (1990).

Ghanem M, Fan F, Francis K, Gadda G. Spectroscopic and kinetic properties of recombinant choline oxidase from Arthrobacter globiform. Biochemistry 42: 15179-15188 (2003).

Gonzalez-Segura L, Velasco-Garcia R, Munoz-Clares RA. Modulation of the reactivity of the essential cysteine residue of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa. Biochem. J. 361: 577-585 (2002).

Grossman EB, Hebert SC. Renal inner medullary choline dehydrogenase activity: characterization and modulation. Am. J. Physiol. 256: F107-F112 (1989).

Grunewald RW, Eckstein A. Osmotic regulation of the betaine metabolism in immortalized renal cells. Kidney Int. 48: 1714-1720 (1995).

Hanschmann H, Kleber HP. Purification and characterization of D(+)-carnitine dehydrogenase from Agrobacterium sp.--a new enzyme of carnitine metabolism. Biochim. Biophys. Acta 1337: 133-142 (1997).

Hibino T, Waditee R, Araki E, Ishikawa H, Aoki K, Tanaka Y, Takabe T. Functional characterization of choline monooxygenase, an enzyme for betaine synthesis in plants. J. Biol. Chem. 277: 41352-41360 (2002).

Holmstrom KO, Somersalo S, Mandal A, Palva TE, Welin B. Improved tolerance to salinity and low temperature in transgenic tobacco producing glycine betaine. J. Exp. Bot. 51: 177-185 (2000).

Kishitani S, Takanami T, Suzuki M, Oikawa M, Yokoi S, Ishitani M, Alvarez-Nakase AM, Takabe T, Takabe T. Compatibility of glycinebetaine in rice plants: evaluation using transgenic rice plants with a gene for peroxisomal betaine aldehyde dehydrogenase from barley. Plant Cell Environ. 23: 107-114 (2000).

Klawitter J, Rivard CJ, Brown LM, Capasso JM, Almeida NE, Maunsbach AB, Pihakaski-Maunsbach K, Berl T, Leibfritz D, Christians U, Chan L. A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicity. Nephron Physiol. 109: 1-10 (2008).

Lamark T, Kaasen I, Eshoo MW, Falkenberg P, McDougall J, Strom AR. DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli. Mol. Microbiol. 5: 1049-1064 (1991).

Lamark T, Rokenes TP, McDougall J, Strom AR. The complex bet promoters of Escherichia coli: regulation by oxygen (ArcA), choline (BetI), and osmotic stress. J. Bacteriol. 178: 1655-1662 (1996).

Landfald B, Strom AR. Choline-glycine betaine pathway confers a high level of osmotic tolerance in Escherichia coli. J. Bacteriol. 165: 849-855 (1986).

Lilius G, Holmberg N, Bulow L. Enhanced NaCl stress tolerance in transgenic tobacco expressing bacterial choline dehydrogenase. Bio/Technology 14: 177-180 (1996).

Liu JY, Yi YJ, Luo AL, Ma DQ, Wang XC, Liang Z. Purification and antibody preparation of choline monooxygenase in spinach leaves. Acta Bot. Sin. 41: 785-787 (1999).

Mandon K, Osteras M, Boncompagni E, Trinchant JC, Spennato G, Poggi MC, Le Rudulier D. The Sinorhizobium meliloti glycine betaine biosynthetic genes (betlCBA) are induced by choline and highly expressed in bacteroids. Mol. Plant Microbe Interact. 16: 709-719 (2003).

Mattoo AK, Sobolev AP, Neelam A, Goyal RK, Handa AK, Segre AL. NMR spectroscopy based metabolite profiling of transgenic tomato fruit engineered to accumulate spermidine and spermine reveals enhanced anabolic and nitrogen-carbon interactions. Plant Physiol. 142: 1759-1770 (2006).

Meng YL, Wang YM, Zhang B, Nii N. Isolation of a choline monooxygenase cDNA clone from Amaranthus tricolor and its expressions under stress conditions. Cell Res. 11: 187-193 (2001).

Miller B, Schmid H, Chen TJ, Schmolke M, Guder WG. Determination of choline dehydrogenase activity along the rat nephron. Biol. Chem. Hoppe Seyler 377: 129-137 (1996).

Moeckel GW, Lien YH. Bicarbonate dependency of betaine synthesis in cultured LLC-PK1 cells. Am. J. Physiol. 266: F512-F515 (1994).

Munoz-Clares RA, Díaz-Sanchez AG, Gonzalez-Segura L, Montiel C. Kinetic and structural features of betaine aldehyde dehydrogenases: mechanistic and regulatory implications. Arch. Biochem. Biophys. Sep 17 [Epub ahead of print] (2009).

Niu X, Zheng W, Lu BR, Ren G, Huang W, Wang S, Liu J, Tang Z, Luo D, Wang Y, Liu Y. An unusual posttranscriptional processing in two betaine aldehyde dehydrogenase loci of cereal crops directed by short, direct repeats in response to stress conditions. Plant Physiol. 143: 1929-1942 (2007).

Osteras M, Boncompagni E, Vincent N, Poggi MC, Le Rudulier D. Presence of a gene encoding choline sulfatase in Sinorhizobium meliloti bet operon: choline-O-sulfate is metabolized into glycine betaine. Proc. Natl. Acad. Sci. U.S.A. 95: 11394-11399 (1998).

Pasternack LB, Littlepage LE, Laude DA Jr, Appling DR. 13C NMR analysis of the use of alternative donors to the tetrahydrofolate-dependent one-carbon pools in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 326: 158-165 (1996).

Perrino LA, Pierce SK. Choline dehydrogenase kinetics contribute to glycine betaine regulation differences in Chesapeake Bay and Atlantic oysters. J. Exp. Zool. 286: 250-261 (2000).

Pocard JA, Vincent N, Boncompagni E, Smith LT, Poggi MC, Le Rudulier D. Molecular characterization of the bet genes encoding glycine betaine synthesis in Sinorhizobium meliloti 102F34. Microbiology 143: 1369-1379 (1997).

Qiu ZH, Lin QS. Spectra properties of rat liver mitochondrial choline dehydrogenase. Sci. China B. 33: 955-963 (1990).

Quan R, Shang M, Zhang H, Zhao Y, Zhang J. Engineering of enhanced glycine betaine synthesis improves drought tolerance in maize. Plant Biotechnol. J. 2: 477-486 (2004).

Rathinasabapathi B, McCue KF, Gage DA, Hanson AD. Metabolic engineering of glycine betaine synthesis: plant betaine aldehyde dehydrogenases lacking typical transit peptides are targeted to tobacco chloroplasts where they confer betaine aldehyde resistance. Planta 193: 155-162 (1994).

Rendina AR, Hermes JD, Cleland WW. A novel method for determining rate constants for dehydration of aldehyde hydrates. Biochemistry 23: 5148-5156 (1984).

Rhodes D, Hanson AD. Quaternary ammonium and tertiary sulfonium compounds in higher plants. Annu. Rev. Plant Physiol. Plant Mol. Biol. 44: 357-384 (1993).

Rhodes D, McNeil SD, Nuccio ML, Hanson AD. Metabolic engineering and flux analysis of glycine betaine synthesis in plants: progress and prospects. In (BN Kholodenko, HV Westerhoff, eds.) "Metabolic Engineering in the Post Genomic Era", Horizon Bioscience, Wymondham, Norfolk, U.K., pp. 409-434 (2004).

Rivero RM, Ruiz JM, Romero LM. Importance of N source on heat stress tolerance due to the accumulation of proline and quaternary ammonium compounds in tomato plants. Plant Biol. (Stuttg.) 6: 702-707 (2004).

Rokenes TP, Lamark T, Strom AR. DNA-binding properties of the BetI repressor protein of Escherichia coli: the inducer choline stimulates BetI-DNA complex formation. J. Bacteriol. 178: 1663-1670 (1996).

Russell R, Scopes RK. Use of hydrophobic chromatography for purification of the membrane-located choline dehydrogenase from a Pseudomonas strain. Bioseparation 4: 279-284 (1994).

Sage AE, Vasil AI, Vasil ML. Molecular characterization of mutants affected in the osmoprotectant-dependent induction of phospholipase C in Pseudomonas aeruginosa PAO1. Mol. Microbiol. 23: 43-56 (1997).

Sakamoto A, Murata N. The use of bacterial choline oxidase, a glycinebetaine-synthesizing enzyme, to create stress-resistant transgenic plants. Plant Physiol. 125: 180-188 (2001).

Sakamoto A, Murata N. Genetic engineering of glycinebetaine synthesis in plants: current status and implications for enhancement of stress tolerance. J. Exp. Bot. 51: 81-88 (2000).

Schlawicke Engstrom K, Nermell B, Concha G, Stromberg U, Vahter M, Broberg K. Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. Mutat. Res. 667: 4-14 (2009).

Shirasawa K, Takabe T, Takabe T, Kishitani S. Accumulation of glycinebetaine in rice plants that overexpress choline monooxygenase from spinach and evaluation of their tolerance to abiotic stress. Ann. Bot. (Lond.) 98: 565-571 (2006).

Slow S, Garrow TA. Liver choline dehydrogenase and kidney betaine-homocysteine methyltransferase expression are not affected by methionine or choline intake in growing rats. J. Nutr. 136: 2279-2283 (2006).

Strom AR. Osmoregulation in the model organism Escherichia coli: genes governing the synthesis of glycine betaine and trehalose and their use in metabolic engineering of stress tolerance. J. Biosci. 23: 437-445 (1998).

Styrvold OB, Falkenberg P, Landfald B, Eshoo MW, Bjornsen T, Strom AR. Selection, mapping, and characterization of osmoregulatory mutants of Escherichia coli blocked in the choline-glycine betaine pathway. J. Bacteriol. 165: 856-863 (1986).

Summers PS, Weretilnyk EA. Choline synthesis in spinach in relation to salt stress. Plant Physiol. 103: 1269-1276 (1993).

Suzuki M, Yasumoto E, Baba S, Ashihara H. Effect of salt stress on the metabolism of ethanolamine and choline in leaves of the betaine-producing mangrove species Avicennia marina. Phytochemistry 64: 941-948 (2003).

Swaroop A, Ramasarma T. Heat exposure and hypothyroid conditions decrease hydrogen peroxide generation in liver mitochondria. Biochem. J. 226: 403-408 (1985).

Thorig GE, Heinstra PW, de Ruiter BL, Scharloo W. The effects of recessive lethal Notch mutations of Drosophila melanogaster on flavoprotein enzyme activities whose inhibitions cause Notch-like phenocopies. Biochem. Genet. 25: 7-25 (1987).

Treberg JR, Speers-Roesch B, Piermarini PM, Ip YK, Ballantyne JS, Driedzic WR. The accumulation of methylamine counteracting solutes in elasmobranchs with differing levels of urea: a comparison of marine and freshwater species. J. Exp. Biol. 209: 860-870 (2006).

Tsuge H, Nakano Y, Onishi H, Futamura Y, Ohashi K. A novel purification and some properties of rat liver mitochondrial choline dehydrogenase. Biochim. Biophys. Acta 614: 274-284 (1980).

Tsuge H, Sato N, Koshiba T, Ohashi Y, Narita Y, Takahashi K, Ohashi K. Change of choline metabolism in rat liver on chronic ethionine-feeding. Biochim. Biophys. Acta 881: 141-147 (1986).

Velasco-Garcia R, Gonzalez-Segura L, Munoz-Clares RA. Steady-state kinetic mechanism of the NADP+- and NAD+-dependent reactions catalysed by betaine aldehyde dehydrogenase from Pseudomonas aeruginosa. Biochem. J. 352: 675-683 (2000).

Velasco-Garcia R, Villalobos MA, Ramirez-Romero MA, Mujica-Jimenez C, Iturriaga G, Munoz-Clares RA. Betaine aldehyde dehydrogenase from Pseudomonas aeruginosa: cloning, over-expression in Escherichia coli, and regulation by choline and salt. Arch. Microbiol. 185: 14-22 (2006).

Waditee R, Bhuiyan MN, Hirata E, Hibino T, Tanaka Y, Shikata M, Takabe T. Metabolic engineering for betaine accumulation in microbes and plants. J. Biol. Chem. 282: 34185-34193 (2007).

Wang YM, Meng YL, Ishikawa H, Hibino T, Tanaka Y, Nii N, Takabe T. Photosynthetic adaptation to salt stress in three-color leaves of a C-4 plant Amaranthus tricolor. Plant Cell Physiol. 40: 668-674 (1999).

Wang YM, Meng YL, Nii N. Changes in glycine betaine and related enzyme contents in Amaranthus tricolor under salt stress. Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao 30: 496-502 (2004).

Wood AJ, Saneoka H, Rhodes D, Joly RJ, Goldsbrough PB. Betaine aldehyde dehydrogenase in sorghum. Plant Physiol. 110: 1301-1308 (1996).

Yilmaz JL, Bulow L. Enhanced stress tolerance in Escherichia coli and Nicotiana tabacum expressing a betaine aldehyde dehydrogenase/choline dehydrogenase fusion protein. Biotechnol. Prog. 18: 1176-1182 (2002).

Zeisel SH, Wurtman RJ. Developmental changes in rat blood choline concentration. Biochem. J. 198: 565-570 (1981).

Zhang J, Blusztajn JK, Zeisel SH. Measurement of the formation of betaine aldehyde and betaine in rat liver mitochondria by a high pressure liquid chromatography-radioenzymatic assay. Biochim. Biophys. Acta 1117: 333-339 (1992).

Number of references = 77