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HORT640 - Metabolic Plant Physiology
References, alkaloid
Abdul Jaleel C, Manivannan P, Sankar B, Kishorekumar A, Panneerselvam R. Calcium chloride effects on salinity-induced oxidative stress, proline metabolism and indole alkaloid accumulation in Catharanthus roseus. C. R. Biol. 330: 674-683 (2007).
Abou-Donia AH, Abib A-Z, Din ASE, Evidente A, Gaber M, Scopa A. Two betaine-type alkaloids from Egyptian Pancratium maritimum. Phytochemistry 31: 2139-2141 (1992).
Afolayan AJ, Jimoh FO. Nutritional quality of some wild leafy vegetables in South Africa. Int. J. Food Sci. Nutr. Nov 26 [Epub ahead of print] (2008).
Ahmad I, Fatima I, Afza N, Malik A, Lodhi MA, Choudhary MI. Urease and serine protease inhibitory alkaloids from Isatis tinctoria. J. Enzyme Inhib. Med. Chem. 23: 918-921 (2008).
Akhtar MN, Atta-ur-Rahman, Choudhary MI, Sener B, Erdogan I, Tsuda Y. New class of steroidal alkaloids from Fritillaria imperialis. Phytochemistry 63: 115-122 (2003).
Alali FQ, Tahboub YR, Ibrahim ES, Qandil AM, Tawaha K, Burgess JP, Sy A, Nakanishi Y, Kroll DJ, Oberlies NH. Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae). Phytochemistry 69: 2341-2346 (2008).
Alcantara J, Bird DA, Franceschi VR, Facchini PJ. Sanguinarine biosynthesis is associated with the endoplasmic reticulum in cultured opium poppy cells after elicitor treatment. Plant Physiol. 138: 173-183 (2005).
Ali Z, Ferreira D, Carvalho P, Avery MA, Khan IA. Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa. J. Nat. Prod. 71: 1111-1112 (2008).
Ali Z, Khan IA. Alkaloids and saponins from blue cohosh. Phytochemistry 69: 1037-1042 (2008).
Angelo PC, Nunes-Silva CG, Brígido MM, Azevedo JS, Assuncao EN, Sousa AR, Patrício FJ, Rego MM, Peixoto JC, Oliveira WP Jr, Freitas DV, Almeida ER, Viana AM, Souza AF, Andrade EV, Acosta PO, Batista JS, Walter ME, Leomil L, Anjos DA, Coimbra RC, et al. Guarana (Paullinia cupana var. sorbilis), an anciently consumed stimulant from the Amazon rain forest: the seeded-fruit transcriptome. Plant Cell Rep. 27: 117-124 (2008).
Anke S, Gonde D, Kaltenegger E, Hansch R, Theuring C, Ober D. Pyrrolizidine alkaloid biosynthesis in Phalaenopsis orchids: developmental expression of alkaloid-specific homospermidine synthase in root tips and young flower buds. Plant Physiol. 148: 751-760 (2008).
Anke S, Niemuller D, Moll S, Hansch R, Ober D. Polyphyletic origin of pyrrolizidine alkaloids within the Asteraceae. Evidence from differential tissue expression of homospermidine synthase. Plant Physiol. 136: 4037-4047 (2004).
Arkhipova VN, Dziadevich SV, Jaffrezic-Renault N, Martelet C, Soldatkin AP. Biosensors for assay of glycoalkaloids in potato tubers. Prikl. Biokhim. Mikrobiol. 44: 347-352 (2008).
Arnqvist L, Dutta PC, Jonsson L, Sitbon F. Reduction of cholesterol and glycoalkaloid levels in transgenic potato plants by overexpression of a type 1 sterol methyltransferase cDNA. Plant Physiol. 131: 1792-1799 (2003).
Arraez-Roman D, Zurek G, Babmann C, Segura-Carretero A, Fernandez-Gutierrez A. Characterization of Atropa belladonna L. compounds by capillary electrophoresis-electrospray ionization-time of flight-mass spectrometry and capillary electrophoresis-electrospray ionization-ion trap-mass spectrometry. Electrophoresis 29: 2112-2116 (2008).
Ashihara H, Crozier A. Caffeine: a well known but little mentioned compound in plant science. Trends Plant Sci. 6: 407-413 (2001).
Ashihara H, Sano H, Crozier A. Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering. Phytochemistry 69: 841-856 (2008).
Ashihara H, Zheng XQ, Katahira R, Morimoto M, Ogita S, Sano H. Caffeine biosynthesis and adenine metabolism in transgenic Coffea canephora plants with reduced expression of N-methyltransferase genes. Phytochemistry 67: 882-886 (2006).
Astulla A, Zaima K, Matsuno Y, Hirasawa Y, Ekasari W, Widyawaruyanti A, Zaini NC, Morita H. Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities. Nat. Med. (Tokyo) 62: 470-472 (2008).
Banerjee S, Madhusudanan KP, Chattopadhyay SK, Rahman LU, Khanuja SP. Expression of tropane alkaloids in the hairy root culture of Atropa acuminata substantiated by DART mass spectrometric technique. Biomed. Chromatogr. 22: 830-834 (2008).
Beghyn T, Deprez-Poulain R, Willand N, Folleas B, Deprez B. Natural compounds: leads or ideas? Bioinspired molecules for drug discovery. Chem. Biol. Drug Des. 72: 3-15 (2008).
Bel-Kassaoui H, Lamnaouer D, Jossang A, Abdennebi el H, Charrouf Z, Bodo B. Role of hypaphorine in the toxicity of Astragalus lusitanicus. Nat. Prod. Res. 22: 453-457 (2008).
Belbahri L, Chevalier L, Bensaddek L, Gillet F, Fliniaux MA, Boerjan W, Inze D, Thomas D, Thomasset B. Different expression of an S-adenosylmethionine synthetase gene in transgenic tobacco callus modifies alkaloid biosynthesis. Biotechnol. Bioeng. 69: 11-20 (2000).
Bennett RN, Mellon FA, Rosa EA, Perkins L, Kroon PA. Profiling glucosinolates, flavonoids, alkaloids, and other secondary metabolites in tissues of Azima tetracantha L. (Salvadoraceae). J. Agric. Food Chem. 52: 5856-5862 (2004).
Bentley R. Secondary metabolite biosynthesis: the first century. Crit. Rev. Biotechnol. 19: 1-40 (1999).
Berkov S, Bastida J, Viladomat F, Codina C. Analysis of galanthamine-type alkaloids by capillary gas chromatography-mass spectrometry in plants. Phytochem. Anal. 19: 285-293 (2008).
Berkov S, Codina C, Viladomat F, Bastida J. Alkaloids from Galanthus nivalis. Phytochemistry 68: 1791-1798 (2007).
Berkov S, Sidjimova B, Evstatieva L, Popov S. Intraspecific variability in the alkaloid metabolism of Galanthus elwesii. Phytochemistry 65: 579-586 (2004).
Bhadra R, Morgan JA, Shanks JV. Transient studies of light-adapted cultures of hairy roots of Catharanthus roseus: growth and indole alkaloid accumulation. Biotechnol. Bioeng. 60: 670-678 (1998).
Bhadury P, Wright PC. Exploitation of marine algae: biogenic compounds for potential antifouling applications. Planta 219: 561-578 (2004).
Biastoff S, Brandt W, Drager B. Putrescine N-methyltransferase - the start for alkaloids. Phytochemistry Aug 1 [Epub ahead of print] (2009).
Biondi S, Fornale S, Oksman-Caldentey KM, Eeva M, Agostani S, Bagni N. Jasmonates induce over-accumulation of methylputrescine and conjugated polyamines in Hyoscyamus muticus L. root cultures. Plant Cell Rep. 19: 691-697 (2000).
Bird DA, Facchini PJ. Berberine bridge enzyme, a key branch-point enzyme in benzylisoquinoline alkaloid biosynthesis, contains a vacuolar sorting determinant. Planta 213: 888-897 (2001).
Bird DA, Franceschi VR, Facchini PJ. A tale of three cell types: alkaloid biosynthesis is localized to sieve elements in opium poppy. Plant Cell 15: 2626-2635 (2003).
Bock A, Wanner G, Zenk MH. Immunocytological localization of two enzymes involved in berberine biosynthesis. Planta 216: 57-63 (2002).
Bohlmann J, De Luca V, Eilert U, Martin W. Purification and cDNA cloning of anthranilate synthase from Ruta graveolens: modes of expression and properties of native and recombinant enzymes. Plant J. 7: 491-501 (1995).
Bohlmann J, Keeling CI. Terpenoid biomaterials. Plant J. 54: 656-669 (2008).
Bohlmann J, Lins T, Martin W, Eilert U. Anthranilate synthase from Ruta graveolens. Duplicated AS alpha genes encode tryptophan-sensitive and tryptophan-insensitive isoenzymes specific to amino acid and alkaloid biosynthesis. Plant Physiol. 111: 507-514 (1996).
Boschin G, Annicchiarico P, Resta D, D'Agostina A, Arnoldi A. Quinolizidine alkaloids in seeds of lupin genotypes of different origins. J. Agric. Food Chem. 56: 3657-3663 (2008).
Bringmann G, Feineis D. Stress-related polyketide metabolism of Dioncophyllaceae and Ancistrocladaceae. J. Exp. Bot. 52: 2015-2022 (2001).
Bringmann G, Messer K, Schwobel B, Brun R, Ake Assi L. Habropetaline A, an antimalarial naphthylisoquinoline alkaloid from Triphyophyllum peltatum. Phytochemistry 62: 345-349 (2003).
Bringmann G, Spuziak J, Faber JH, Gulder T, Kajahn I, Dreyer M, Heubl G, Brun R, Mudogo V. Six naphthylisoquinoline alkaloids and a related benzopyranone from a Congolese Ancistrocladus species related to Ancistrocladus congolensis. Phytochemistry 69: 1065-1075 (2008).
Brock A, Brandt W, Drager B. The functional divergence of short-chain dehydrogenases involved in tropinone reduction. Plant J. 54: 388-401 (2008).
Brock A, Herzfeld T, Paschke R, Koch M, Drager B. Brassicaceae contain nortropane alkaloids. Phytochemistry 67: 2050-2057 (2006).
Bruhn JG, El-Seedi HR, Stephanson N, Beck O, Shulgin AT. Ecstasy analogues found in cacti. J. Psychoactive Drugs 40: 219-222 (2008).
Burlat V, Oudin A, Courtois M, Rideau M, St-Pierre B. Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids… Plant J. 38: 131-141 (2004).
Burtin D, Michael AJ. Overexpression of arginine decarboxylase in transgenic plants. Biochem. J. 325: 331-337 (1997).
Byrne KM, Smith SK, Ondeyka JG. Biosynthesis of nodulisporic acid A: Precursor studies. J. Am. Chem. Soc. 124: 7055-7060 (2002).
Cafieri F, Fattorusso E, Taglialatela-Scafati O. Novel betaines from the marine sponge Agelas dispar. J. Nat. Prod. 61: 1171-1173 (1998).
Campos-Tamayo F, Hernandez-Domínguez E, Vazquez-Flota F. Vindoline formation in shoot cultures of Catharanthus roseus is synchronously activated with morphogenesis through the last biosynthetic step. Ann. Bot. (Lond.) 102: 409-415 (2008).
Canel C, Lopes-Cardoso MI, Whitmer S, van der Fits L, Pasquali G, van der Heijden R, Hoge JH, Verpoorte R. Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus. Planta 205: 414-419 (1998).
Cano L, Escarre J, Vrieling K, Sans FX. Palatability to a generalist herbivore, defence and growth of invasive and native Senecio species: testing the evolution of increased competitive ability hypothesis. Oecologia 159: 95-106 (2009).
Cao S, Al-Rehaily AJ, Brodie P, Wisse JH, Moniz E, Malone S, Kingston DG. Furoquinoline alkaloids of Ertela (Monnieria) trifolia (L.) Kuntze from the Suriname rainforest. Phytochemistry 69: 553-557 (2008).
Cao Y, Colegate SM, Edgar JA. Safety assessment of food and herbal products containing hepatotoxic pyrrolizidine alkaloids: interlaboratory consistency and the importance of N-oxide determination. Phytochem. Anal. 19: 526-533 (2008).
Carlson JE, Leebens-Mack JH, Wall PK, Zahn LM, Mueller LA, Landherr LL, Hu Y, Ilut DC, Arrington JM, Choirean S, Becker A, Field D, Tanksley SD, Ma H, Depamphilis CW. EST database for early flower development in California poppy (Eschscholzia californica Cham., Papaveraceae) tags over 6000 genes from a basal eudicot. Plant Mol. Biol. 62: 351-369 (2006).
Carroll AR, Addepalli R, Fechner G, Smith J, Guymer GP, Forster PI, Quinn RJ. Alkaloids from the Australian rainforest tree Ochrosia moorei. J. Nat. Prod. 71: 1063-1065 (2008).
Cataldi TR, Bianco G. Capillary electrophoresis of tropane alkaloids and glycoalkaloids occurring in Solanaceae plants. Methods Mol. Biol. 384: 171-203 (2008).
Celenza JL. Metabolism of tyrosine and tryptophan - new genes for old pathways. Curr. Opin. Plant Biol. 4: 234-240 (2001).
Chakrabarti M, Bowen SW, Coleman NP, Meekins KM, Dewey RE, Siminszky B. CYP82E4-mediated nicotine to nornicotine conversion in tobacco is regulated by a senescence-specific signaling pathway. Plant Mol. Biol. 66: 415-427 (2008).
Chakrabarti M, Meekins KM, Gavilano LB, Siminszky B. Inactivation of the cytochrome P450 gene CYP82E2 by degenerative mutations was a key event in the evolution of the alkaloid profile of modern tobacco. New Phytol. 175: 565-574 (2007).
Chandran D, Tai YC, Hather G, Dewdney J, Denoux C, Burgess DG, Ausubel FM, Speed TP, Wildermuth MC. Temporal global expression data reveal known and novel salicylate-impacted processes and regulators mediating powdery mildew growth and reproduction on Arabidopsis. Plant Physiol. 149: 1435-1451 (2009).
Chemler JA, Koffas MA. Metabolic engineering for plant natural product biosynthesis in microbes. Curr. Opin. Biotechnol. 19: 597-605 (2008).
Chen MY, Cai JT, Du Q, Wang LJ, Chen JM, Shao LM. Reliable experimental model of hepatic veno-occlusive disease caused by monocrotaline. Hepatobiliary Pancreat. Dis. Int. 7: 395-400 (2008).
Cheng XY, Shi Y, Zheng SL, Jin W, Sun H. Two new protoberberine quaternary alkaloids from Corydalis yanhusuo. J. Asian Nat. Prod. Res. 10: 1117-1121 (2008).
Cheplogoi PK, Mulholland DA, Coombes PH, Randrianarivelojosia M. An azole, an amide and a limonoid from Vepris uguenensis (Rutaceae). Phytochemistry 69: 1384-1388 (2008).
Chintapakorn Y, Hamill JD. Antisense-mediated down-regulation of putrescine N-methyltransferase activity in transgenic Nicotiana tabacum L. can lead to elevated levels of anatabine at the expense of nicotine. Plant Mol. Biol. 53: 87-105 (2003).
Chintapakorn Y, Hamill JD. Antisense-mediated reduction in ADC activity causes minor alterations in the alkaloid profile of cultured hairy roots and regenerated transgenic plants of Nicotiana tabacum. Phytochemistry 68: 2465-2479 (2007).
Chitturi S, Farrell GC. Hepatotoxic slimming aids and other herbal hepatotoxins. J. Gastroenterol. Hepatol. 23: 366-373 (2008).
Choi YH, Tapias EC, Kim HK, Lefeber AW, Erkelens C, Verhoeven JT, Brzin J, Zel J, Verpoorte R. Metabolic discrimination of Catharanthus roseus leaves infected by phytoplasma using 1H-NMR spectroscopy and multivariate data analysis. Plant Physiol. 135: 2398-2410 (2004).
Chung IM, Hong SB, Peebles CA, Kim JA, San KY. Effect of the engineered indole pathway on accumulation of phenolic compounds in Catharanthus roseus hairy roots. Biotechnol. Prog. 23: 327-332 (2007).
Clay K, Schardl C. Evolutionary origins and ecological consequences of endophyte symbiosis with grasses. Am. Nat. 160 Suppl. 4: S99-S127 (2002).
Courdavault V, Thiersault M, Courtois M, Gantet P, Oudin A, Doireau P, St-Pierre B, Giglioli-Guivarc'h N. CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathwayin Catharanthus roseus cells. Plant Mol. Biol. 57: 855-870 (2005).
Csupor D, Wenzig EM, Zupko I, Wolkart K, Hohmann J, Bauer R. Qualitative and quantitative analysis of aconitine-type and lipo-alkaloids of Aconitum carmichaelii roots. J. Chromatogr. A. 1216: 2079-2086 (2009).
De Carolis E, De Luca V. Purification, characterization, and kinetic analysis of a 2-oxoglutarate-dependent dioxygenase involved in vindoline biosynthesis from Catharanthus roseus. J. Biol. Chem. 268: 5504-5511 (1993).
De Luca V. Chapter 9. Metabolic Engineering of Crops with the Tryptophan Decarboxylase of Catharanthus roseus. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 179-194 (2000).
De Luca V, Laflamme P. The expanding universe of alkaloid biosynthesis. Curr. Opin. Plant Biol. 4: 225-233 (2001).
De Luca V, St Pierre B. The cell and developmental biology of alkaloid biosynthesis. Trends Plant Sci. 5: 168-173 (2000).
Deboer KD, Lye JC, Aitken CD, Su AK, Hamill JD. The A622 gene in Nicotiana glauca (tree tobacco): evidence for a functional role in pyridine alkaloid synthesis. Plant Mol. Biol. 69: 299-312 (2009).
Dembitsky VM. Bioactive cyclobutane-containing alkaloids. Nat. Med. (Tokyo) 62: 1-33 (2008).
Devkota KP, Lenta BN, Fokou PA, Sewald N. Terpenoid alkaloids of the Buxaceae family with potential biological importance. Nat. Prod. Rep. 25: 612-630 (2008).
Dhakulkar S, Ganapathi TR, Bhargava S, Bapat VA. Induction of hairy roots in Gmelina arborea Roxb. and production of verbascoside in hairy roots. Plant Sci. 169: 812-818 (2005).
Di Fiore S, Li Q, Leech MJ, Schuster F, Emans N, Fischer R, Schillberg S. Targeting tryptophan decarboxylase to selected subcellular compartments of tobacco plants affects enzyme stability and in vivo function and leads to a lesion-mimic phenotype. Plant Physiol. 129: 1160-1169 (2002).
Diaz JG, Ruiz JG, Herz W. Alkaloids from Delphinium pentagynum. Phytochemistry 65: 2123-2127 (2004).
Dien PH, Lin LG, Tang CP, Ke CQ, Ye Y. Bisbenzopyrans and alkaloids from the roots of Stemona cochinchinensis. Nat. Prod. Res. 22: 915-920 (2008).
Ding Y, Williams RM, Sherman DH. Molecular analysis of a 4-dimethylallyltryptophan synthase from Malbranchea aurantiaca. J. Biol. Chem. 283: 16068-16076 (2008).
Dinkins CL, Peterson RK. A human dietary risk assessment associated with glycoalkaloid responses of potato to Colorado potato beetle defoliation. Food Chem. Toxicol. 46: 2837-2840 (2008).
Ditengou FA, Beguiristain T, Lapeyrie F. Root hair elongation is inhibited by hypaphorine, the indole alkaloid from the ectomycorrhizal fungus Pisolithus tinctorius, and restored by indole-3-acetic acid. Planta 211: 722-728 (2000).
Ditengou FA, Raudaskoski M, Lapeyrie F. Hypaphorine, an indole-3-acetic acid antagonist delivered by the ectomycorrhizal fungus Pisolithus tinctorius, induces reorganisation of actin and the microtubule cytoskeleton in Eucalyptus globulus ssp bicostata root hairs. Planta 218: 217-225 (2003).
Drager B. Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism. Phytochemistry 67: 327-337 (2006).
Dragull K, Yoshida WY, Tang CS. Piperidine alkaloids from Piper methysticum. Phytochemistry 63: 193-198 (2003).
Du H, Wang Y, Yan C, Zhou LG, Hao XJ. Alkaloids from Anabasis aphylla L. J. Asian Nat. Prod. Res. 10: 1093-1095 (2008).
Duran-Patron R, O'Hagan D, Hamilton JTG, Wong CW. Biosynthetic studies on the tropane ring system of the tropane alkaloids from Datura stramonium. Phytochemistry 53: 777-784 (2000).
Dussert S, Laffargue A, Kochko AD, Joet T. Effectiveness of the fatty acid and sterol composition of seeds for the chemotaxonomy of Coffea subgenus Coffea. Phytochemistry 69: 2950-2960 (2008).
Dutta A, Batra J, Pandey-Rai S, Singh D, Kumar S, Sen J. Expression of terpenoid indole alkaloid biosynthetic pathway genes corresponds to accumulation of related alkaloids in Catharanthus roseus (L.) G. Don. Planta 220: 376-383 (2005).
Eilert U, De Luca V, Constabel F, Kurz WG. Elicitor-mediated induction of tryptophan decarboxylase and strictosidine synthase activities in cell suspension cultures of Catharanthus roseus. Arch. Biochem. Biophys. 254: 491-497 (1987).
el Jaber-Vazdekis N, Barres ML, Ravelo AG, Zarate R. Effects of elicitors on tropane alkaloids and gene expression in Atropa baetica transgenic hairy roots. J. Nat. Prod. 71: 2026-2031 (2008).
el-Shazly A, Wink M. Tropane and pyrrolidine alkaloids from Convolvulus lanatus Vahl. Z. Naturforsch. [C.] 63: 321-325 (2008).
Endler A, Martens S, Wellmann F, Matern U. Unusually divergent 4-coumarate:CoA-ligases from Ruta graveolens L. Plant Mol. Biol. 67: 335-346 (2008).
Epifano F, Genovese S, Menghini L, Curini M. Chemistry and pharmacology of oxyprenylated secondary plant metabolites. Phytochemistry 68: 939-953 (2007).
Evidente A, Andolfi A, Abou-Donia AH, Touema SM, Hammoda HM, Shawky E, Motta A. (-)-Amarbellisine, a lycorine-type alkaloid from Amaryllis belladonna L. growing in Egypt. Phytochemistry 65: 2113-2118 (2004).
Facchini PJ. Alkaloid biosynthesis in plants: biochemistry, cell biology, molecular regulation, and metabolic engineering applications. Annu. Rev. Plant Physiol. Plant Mol. Biol. 52: 29-66 (2001).
Facchini PJ, Bird DA, St-Pierre B. Can Arabidopsis make complex alkaloids? Trends Plant Sci. 9: 116-122 (2004).
Facchini PJ, De Luca V. Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants. Plant J. 54: 763-784 (2008).
Facchini PJ, De Luca V. Phloem-specific expression of tyrosine/dopa decarboxylase genes and the biosynthesis of isoquinoline alkaloids in opium poppy. Plant Cell 7: 1811-1821 (1995).
Facchini PJ, De Luca V. Differential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy. J. Biol. Chem. 269: 26684-26690 (1994).
Facchini PJ, DiCosmo F. Secondary metabolite biosynthesis in cultured cells of Catharanthus roseus (L.) G. Don immobilized by adhesion to glass fibres. Appl. Microbiol. Biotechnol. 35: 382-392 (1991).
Facchini PJ, Huber-Allanach KL, Tari LW. Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications. Phytochemistry 54: 121-138 (2000).
Facchini PJ, Johnson AG, Poupart J, de Luca V. Uncoupled defense gene expression and antimicrobial alkaloid accumulation in elicited opium poppy cell cultures. Plant Physiol. 111: 687-697 (1996).
Facchini PJ, Loukanina N, Blanche V. Genetic transformation via somatic embryogenesis to establish herbicide-resistant opium poppy. Plant Cell Rep. 27: 719-727 (2008).
Facchini PJ, Penzes C, Johnson AG, Bull D. Molecular characterization of berberine bridge enzyme genes from opium poppy. Plant Physiol. 112: 1669-1677 (1996).
Facchini PJ, Penzes-Yost C, Samanani N, Kowalchuk B. Expression patterns conferred by tyrosine/dihydroxyphenylalanine decarboxylase promoters from opium poppy are conserved in transgenic tobacco. Plant Physiol. 118: 69-81 (1998).
Facchini PJ, St-Pierre B. Synthesis and trafficking of alkaloid biosynthetic enzymes. Curr. Opin. Plant Biol. 8: 657-666 (2005).
Farber K, Schumann B, Miersch O, Roos W. Selective desensitization of jasmonate- and pH-dependent signaling in the induction of benzophenanthridine biosynthesis in cells of Eschscholzia californica. Phytochemistry 62: 491-500 (2003).
Fellows LE, Kite GC, Nash RJ, Simmonds MSJ, Scofield AM. Distribution and biological activity of alkaloidal glycosidase inhibitors from plants. In "Nitrogen Metabolism of Plants" (K Mengel, DJ Pilbeam eds) Clarendon Press, Oxford, pp. 271-282 (1992).
Feng SX, Lin LD, Xu HH, Wei XY. Two new piperidine alkaloids from the leaves of Microcos paniculata. J. Asian Nat. Prod. Res. 10: 1155-1158 (2008).
Ferguson LR, Philpott M. Nutrition and mutagenesis. Annu. Rev. Nutr. 28: 313-329 (2008).
Filippi SB, Azevedo RA, Sodek L, Mazzafera P. Allantoin has a limited role as nitrogen source in cultured coffee cells. J. Plant Physiol. 164: 544-552 (2007).
Fletcher SP, Geyer BC, Smith A, Evron T, Joshi L, Soreq H, Mor TS. Tissue distribution of cholinesterases and anticholinesterases in native and transgenic tomato plants. Plant Mol. Biol. 55: 33-43 (2004).
Fliniaux O, Mesnard F, Raynaud-Le Grandic S, Baltora-Rosset S, Bienaime C, Robins RJ, Fliniaux MA. Altered nitrogen metabolism associated with de-differentiated suspension cultures derived from root cultures of Datura stramonium studied by heteronuclear multiple bond coherence (HMBC) NMR spectroscopy. J. Exp. Bot. 55: 1053-1060 (2004).
Flores HE, Dai Y, Cuello JL, Maldonado-Mendoza IE, Loyola-Vargas VM. Green roots: photosynthesis and photoautotrophy in an underground plant organ. Plant Physiol. 101: 363-371 (1993).
Foguel D, Chaloub RM. Effects of the alkaloid gramine on the light-harvesting, energy transfer, and growth of Anabaena sp. (PCC 7119). Plant Physiol. 101: 633-639 (1993).
Ford YY, Ratcliffe RG, Robins RJ. Phytohormone-induced GABA production in transformed root cultures of Datura stramonium: an in vivo N-15 NMR study. J. Exp. Bot. 47: 811-818 (1996).
Ford YY, Ratcliffe RG, Robins RJ. In vivo NMR analysis of tropane alkaloid metabolism in transformed root and de-differentiated cultures of Datura stramonium. Phytochemistry 43: 115-120 (1996).
Ford YY, Ratcliffe RG, Robins RJ. In vivo nuclear magnetic resonance analysis of polyamine and alkaloid metabolism in transformed root cultures of Datura stramonium L.: evidence for the involvement of putrescine in phytohormone-induced de-differentiation Planta 205: 205-213 (1998).
Francis PS, Adcock JL, Costin JW, Purcell SD, Pfeffer FM, Barnett NW. Chemiluminescence detection of opium poppy (Papaver somniferum) alkaloids. J. Pharm. Biomed. Anal. 48: 508-518 (2008).
Francisco MC, Nasser AL, Lopes LM. Tetrahydroisoquinoline alkaloids and 2-deoxyribonolactones from Aristolochia arcuata. Phytochemistry 62: 1265-1270 (2003).
Franco OL, Rigden DJ, Melo FR, Grossi-De-Sa MF. Plant alpha-amylase inhibitors and their interaction with insect alpha-amylases. Eur. J. Biochem. 269: 397-412 (2002).
Frederich M, Choi YH, Angenot L, Harnischfeger G, Lefeber AW, Verpoorte R. Metabolomic analysis of Strychnos nux-vomica, Strychnos icaja and Strychnos ignatii extracts by (1)H nuclear magnetic resonance spectrometry and multivariate analysis techniques. Phytochemistry 65: 1993-2001 (2004).
Frick S, Kutchan TM. Molecular cloning and functional expression of O-methyltransferases common to isoquinoline alkaloid and phenylpropanoid biosynthesis. Plant J. 17: 329-339 (1999).
Frick S, Ounaroon A, Kutchan TM. Combinatorial biochemistry in plants: the case of O-methyltransferases. Phytochemistry 56: 1-4 (2001).
Fritz C, Palacios-Rojas N, Feil R, Stitt M. Regulation of secondary metabolism by the carbon-nitrogen status in tobacco: nitrate inhibits large sectors of phenylpropanoid metabolism. Plant J. 46: 533-548 (2006).
Frolich C, Hartmann T, Ober D. Tissue distribution and biosynthesis of 1,2-saturated pyrrolizidine alkaloids in Phalaenopsis hybrides (Orchidaceae). Phytochemistry 67: 1493-1502 (2006).
Frolich C, Ober D, Hartmann T. Tissue distribution, core biosynthesis and diversification of pyrrolizidine alkaloids of the lycopsamine type in three Boraginaceae species. Phytochemistry 68: 1026-1037 (2007).
Fujii N, Inui T, Iwasa K, Morishige T, Sato F. Knockdown of berberine bridge enzyme by RNAi accumulates (S)-reticuline and activates a silent pathway in cultured California poppy cells. Transgenic Res. 16: 363-375 (2007).
Fukuhara K, Shimizu K, Kubo I. Arudonine, an allelopathic steroidal glycoalkaloid from the root bark of Solanum arundo Mattei. Phytochemistry 65: 1283-1286 (2004).
Gantet P, Imbault N, Thiersault M, Doireau P. Necessity of a functional octadecanoic pathway for indole alkaloid synthesis by Catharanthus roseus cell suspensions cultured in an auxin-starved medium. Plant Cell Physiol. 39: 220-225 (1998).
Gatto P, Vrhovsek U, Muth J, Segala C, Romualdi C, Fontana P, Pruefer D, Stefanini M, Moser C, Mattivi F, Velasco R. Ripening and genotype control stilbene accumulation in healthy grapes. J. Agric. Food Chem. 56: 11773-11785 (2008).
Gavilano LB, Coleman NP, Bowen SW, Siminszky B. Functional analysis of nicotine demethylase genes reveals insights into the evolution of modern tobacco. J. Biol. Chem. 282: 249-256 (2007).
Gavilano LB, Coleman NP, Burnley LE, Bowman ML, Kalengamaliro NE, Hayes A, Bush L, Siminszky B. Genetic engineering of Nicotiana tabacum for reduced nornicotine content. J. Agric. Food Chem. 54: 9071-9078 (2006).
Gavilano LB, Siminszky B. Isolation and characterization of the cytochrome P450 gene CYP82E5v2 that mediates nicotine to nornicotine conversion in the green leaves of tobacco. Plant Cell Physiol. 48: 1567-1574 (2007).
Geissler R, Brandt W, Ziegler J. Molecular modeling and site-directed mutagenesis reveal the benzylisoquinoline binding site of the short-chain dehydrogenase/reductase salutaridine reductase. Plant Physiol. 143: 1493-1503 (2007).
Gerasimenko I, Sheludko Y, Ma X, Stockigt J. Heterologous expression of a Rauvolfia cDNA encoding strictosidine glucosidase, a biosynthetic key to over 2000 monoterpenoid indole alkaloids. Eur. J. Biochem. 269: 2204-2213 (2002).
Gesell A, Rolf M, Ziegler J, Díaz Chavez ML, Huang FC, Kutchan TM. CYP719B1 is salutaridine synthase, the C-C phenol-coupling enzyme of morphine biosynthesis in opium poppy. J. Biol. Chem. 284: 24432-24442 (2009).
Giacomelli SR, Maldaner G, Gonzaga WA, Garcia CM, da Silva UF, Dalcol II, Morel AF. Cyclic peptide alkaloids from the bark of Discaria americana. Phytochemistry 65: 933-937 (2004).
Gilani GS, Nasim A. Impact of foods nutritionally enhanced through biotechnology in alleviating malnutrition in developing countries. J. AOAC Int. 90: 1440-1444 (2007).
Gillissen B, Burkle L, Andre B, Kuhn C, Rentsch D, Brandl B, Frommer WB. A new family of high-affinity transporters for adenine, cytosine, and purine derivatives in Arabidopsis. Plant Cell 12: 291-300 (2000).
Goddijn OJ, de Kam RJ, Zanetti A, Schilperoort RA, Hoge JH. Auxin rapidly down-regulates transcription of the tryptophan decarboxylase gene from Catharanthus roseus. Plant Mol. Biol. 18: 1113-1120 (1992).
Goddijn OJ, Lohman FP, de Kam RJ, Schilperoort RA, Hoge JH. Nucleotide sequence of the tryptophan decarboxylase gene of Catharanthus roseus and expression of tdc-gusA gene fusions in Nicotiana tabacum. Mol. Gen. Genet. 242: 217-225 (1994).
Goddijn OJ, Pennings EJ, van der Helm P, Schilperoort RA, Verpoorte R, Hoge JH. Overexpression of a tryptophan decarboxylase cDNA in Catharanthus roseus crown gall calluses results in increased tryptamine levels but not in increased terpenoid indole alkaloid production. Transgenic Res. 4: 315-323 (1995).
Graser G, Hartmann T. Biosynthesis of spermidine, a direct precursor of pyrrolizidine alkaloids in root cultures of Senecio vulgaris L. Planta 211: 239-245 (2000).
Graser G, Hartmann T. Biosynthetic incorporation of the aminobutyl group of spermidine into pyrrolizidine alkaloids. Phytochemistry 45: 1591-1595 (1997).
Gressler V, Stuker CZ, Dias Gde O, Dalcol II, Burrow RA, Schmidt J, Wessjohann L, Morel AF. Quinolone alkaloids from Waltheria douradinha. Phytochemistry 69: 994-999 (2008).
Grycova L, Dostal J, Marek R. Quaternary protoberberine alkaloids. Phytochemistry 68: 150-175 (2007).
Grynkiewicz G, Gadzikowska M. Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs. Pharmacol. Rep. 60: 439-463 (2008).
Guo A, Jin L, Deng Z, Cai S, Guo S, Lin W. New stemona alkaloids from the roots of Stemona sessilifolia. Chem. Biodivers. 5: 598-605 (2008).
Hagel JM, Weljie AM, Vogel HJ, Facchini PJ. Quantitative 1H NMR metabolite profiling as a functional genomics platform to investigate alkaloid biosynthesis in opium poppy. Plant Physiol. 147: 1805-1821 (2008).
Hagel JM, Yeung EC, Facchini PJ. Got milk? The secret life of laticifers. Trends Plant Sci. 13: 631-639 (2008).
Hain R, Grimmig B. Chapter 11. Modification of Plant Secondary Metabolism by Genetic Engineering. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 217-231 (2000).
Hakkinen ST, Moyano E, Cusido RM, Palazon J, Pinol MT, Oksman-Caldentey KM. Enhanced secretion of tropane alkaloids in Nicotiana tabacum hairy roots expressing heterologous hyoscyamine-6beta-hydroxylase. J. Exp. Bot. 56: 2611-2618 (2005).
Hakkinen ST, Tilleman S, Swiatek A, De Sutter V, Rischer H, Vanhoutte I, Van Onckelen H, Hilson P, Inze D, Oksman-Caldentey KM, Goossens A. Functional characterisation of genes involved in pyridine alkaloid biosynthesis in tobacco. Phytochemistry 68: 2773-2785 (2007).
Hansen BG, Halkier BA. New insight into the biosynthesis and regulation of indole compounds in Arabidopsis thaliana. Planta 221: 603-606 (2005).
Hashimoto T, Nakajima K, Ongena G, Yamada Y. Two tropinone reductases with distinct stereospecificities from cultured roots of Hyoscyamus niger. Plant Physiol. 100: 836-845 (1992).
Hashimoto T, Yamada Y. New genes in alkaloid metabolism and transport. Curr. Opin. Biotechnol. 14: 163-168 (2003).
Hauschild K, Pauli HH, Kutchan TM. Isolation and analysis of a gene bbe1 encoding the berberine bridge enzyme from the California poppy Eschscholzia californica. Plant Mol. Biol. 36: 473-478 (1998).
Heim WG, Jelesko JG. Association of diamine oxidase and S-adenosylhomocysteine hydrolase in Nicotiana tabacum extracts. Plant Mol. Biol. 56: 299-308 (2004).
Henriques AT, Lopes SO, Paranhos JT, Gregianini TS, Von Poser GL, Fett-Neto AG, Schripsema J. N,beta-D-Glucopyranosyl vincosamide, a light regulated indole alkaloid from the shoots of Psychotria leiocarpa. Phytochemistry 65: 449-454 (2004).
Herminghaus S, Schreier PH, McCarthy JE, Landsmann J, Botterman J, Berlin J. Expression of a bacterial lysine decarboxylase gene and transport of the protein into chloroplasts of transgenic tobacco. Plant Mol. Biol. 17: 475-486 (1991).
Hibi N, Fujita T, Hatano M, Hashimoto T, Yamada Y. Putrescine N-methyltransferase in cultured roots of Hyoscyamus niger. n-Butylamine as a potent inhibitor of the transferase both in vitro and in vivo. Plant Physiol. 100: 826-835 (1992).
Hirata K, Poeaknapo C, Schmidt J, Zenk MH. 1,2-Dehydroreticuline synthase, the branch point enzyme opening the morphinan biosynthetic pathway. Phytochemistry 65: 1039-1046 (2004).
Hollinger JL, Hommes OR, van de Wiel TJ, Kok JC, Jansen MJ. In vitro studies of 5, 10-methylenetetrahydrofolate reductase: inhibition by folate derivatives, folate antagonists, and monoamine derivatives. J. Neurochem. 38: 638-642 (1982).
Hong SB, Hughes EH, Shanks JV, San KY, Gibson SI. Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. Biotechnol. Prog. 19: 1105-1108 (2003).
Hong SB, Peebles CA, Shanks JV, San KY, Gibson SI. Expression of the Arabidopsis feedback-insensitive anthranilate synthase holoenzyme and tryptophan decarboxylase genes in Catharanthus roseus hairy roots. J. Biotechnol. 122: 28-38 (2006).
Hughes EH, Hong SB, Gibson SI, Shanks JV, San KY. Expression of a feedback-resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levels. Biotechnol. Bioeng. 86: 718-727 (2004).
Hughes EH, Hong SB, Gibson SI, Shanks JV, San KY. Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine. Metab. Eng. 6: 268-276 (2004).
Hughes EH, Shanks JV. Metabolic engineering of plants for alkaloid production. Metab. Eng. 4: 41-48 (2002).
Hunt MG, Rasmussen S, Newton PCD, Parsons AJ, Newman JA. Near-term impacts of elevated CO2, nitrogen and fungal endophyte-infection on Lolium perenne L. growth, chemical composition and alkaloid production. Plant Cell Environ. 28: 1345-1354 (2005).
Iijima Y, Nakamura Y, Ogata Y, Tanaka K, Sakurai N, Suda K, Suzuki T, Suzuki H, Okazaki K, Kitayama M, Kanaya S, Aoki K, Shibata D. Metabolite annotations based on the integration of mass spectral information. Plant J. 54: 949-962 (2008).
Ikezawa N, Iwasa K, Sato F. CYP719A subfamily of cytochrome P450 oxygenases and isoquinoline alkaloid biosynthesis in Eschscholzia californica. Plant Cell Rep. 28: 123-133 (2009).
Imanshahidi M, Hosseinzadeh H. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother. Res. 22: 999-1012 (2008).
Irmler S, Schroder G, St-Pierre B, Crouch NP, Hotze M, Schmidt J, Strack D, Matern U, Schroder J. Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. Plant J. 24: 797-804 (2000).
Irwin RE, Adler LS. Nectar secondary compounds affect self-pollen transfer: implications for female and male reproduction. Ecology 89: 2207-2217 (2008).
Ishida M, Kitao N, Mizuno K, Tanikawa N, Kato M. Occurrence of theobromine synthase genes in purine alkaloid-free species of Camellia plants. Planta 229: 559-568 (2009).
Ishida S, Okasaka M, Ramos F, Kashiwada Y, Takaishi Y, Kodzhimatov OK, Ashurmetov O. New alkaloid from the aerial parts of Codonopsis clematidea. Nat. Med. (Tokyo). 62: 236-238 (2008).
Ito S, Eto T, Tanaka S, Yamauchi N, Takahara H, Ikeda T. Tomatidine and lycotetraose, hydrolysis products of alpha-tomatine by Fusarium oxysporum tomatinase, suppress induced defense responses in tomato cells. FEBS Lett. 571: 31-34 (2004).
Itoh A, Tanahashi T, Nagakura N, Nishi T. Two chromone-secoiridoid glycosides and three indole alkaloid glycosides from Neonauclea sessilifolia. Phytochemistry 62: 359-369 (2003).
Iwase A, Aoyagi H, Ohme-Takagi M, Tanaka H. Development of a novel system for producing ajmalicine and serpentine using direct culture of leaves in Catharanthus roseus intact plant. J. Biosci. Bioeng. 99: 208-215 (2005).
Jacobs DI, Gaspari M, van der Greef J, van der Heijden R, Verpoorte R. Proteome analysis of the medicinal plant Catharanthus roseus. Planta 221: 690-704 (2005).
Jain A, Ziegler J, Liscombe DK, Facchini PJ, Tucker PA, Panjikar S. Purification, crystallization and X-ray diffraction analysis of pavine N-methyltransferase from Thalictrum flavum. Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 64: 1066-1069 (2008).
Jain SC, Pandey MK, Upadhyay RK, Kumar R, Hundal G, Hundal MS. Alkaloids from Toddalia aculeata. Phytochemistry 67: 1005-1010 (2006).
Jaleel CA, Manivannan P, Sankar B, Kishorekumar A, Gopi R, Somasundaram R, Panneerselvam R. Pseudomonas fluorescens enhances biomass yield and ajmalicine production in Catharanthus roseus under water deficit stress. Colloids Surf. B. Biointerfaces 60: 7-11 (2007).
Jambois A, Dauphin A, Kawano T, Ditengou FA, Bouteau F, Legue V, Lapeyrie F. Competitive antagonism between IAA and indole alkaloid hypaphorine must contribute to regulate ontogenesis. Physiol. Plant. 123: 120-129 (2005).
Jambois A, Ditengou FA, Kawano T, Delbarre A, Lapeyrie F. The indole alkaloids brucine, yohimbine, and hypaphorine are indole-3-acetic acid-specific competitors which do not alter auxin transport. Physiol. Plant. 120: 501-508 (2004).
Jenett-Siems K, Weigl R, Kaloga M, Schulz J, Eich E. Ipobscurines C and D: macrolactam-type indole alkaloids from the seeds of Ipomoea obscura. Phytochemistry 62: 1257-1263 (2003).
Jerzykiewicz J. Alkaloids of Solanaceae (nightshade plants). Postepy. Biochem. 53: 280-286 (2007).
Jin HZ, Du JL, Zhang WD, Yan SK, Chen HS, Lee JH, Lee JJ. A new quinazolinedione alkaloid from the fruits of Evodia officinalis. Fitoterapia 79: 317-318 (2008).
Jones AC, Gu L, Sorrels CM, Sherman DH, Gerwick WH. New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Curr. Opin. Chem. Biol. 13: 216-223 (2009).
Jordan M, Humam M, Bieri S, Christen P, Poblete E, Munoz O. In vitro shoot and root organogenesis, plant regeneration and production of tropane alkaloids in some species of Schizanthus. Phytochemistry 67: 570-578 (2006).
Jorgensen K, Rasmussen AV, Morant M, Nielsen AH, Bjarnholt N, Zagrobelny M, Bak S, Moller BL. Metabolon formation and metabolic channeling in the biosynthesis of plant natural products. Curr. Opin. Plant Biol. 8: 280-291 (2005).
Julsing MK, Koulman A, Woerdenbag HJ, Quax WJ, Kayser O. Combinatorial biosynthesis of medicinal plant secondary metabolites. Biomol. Eng. 23: 265-279 (2006).
Juma BF, Majinda RR. Erythrinaline alkaloids from the flowers and pods of Erythrina lysistemon and their DPPH radical scavenging properties. Phytochemistry 65: 1397-1404 (2004).
Junghanns KT, Kneusel RE, Groger D, Matern U. Differential regulation and distribution of acridone synthase in Ruta graveolens. Phytochemistry 49: 403-411 (1998).
Kai G, Zhang Y, Chen J, Li L, Yan X, Zhang R, Liao P, Lu X, Wang W, Zhou G. Molecular characterization and expression analysis of two distinct putrescine N-methyltransferases from roots of Anisodus acutangulus. Physiol. Plant. 135: 121-129 (2009).
Kaiser H, Richter U, Keiner R, Brabant A, Hause B, Drager B. Immunolocalisation of two tropinone reductases in potato (Solanum tuberosum L.) root, stolon, and tuber sprouts. Planta 225: 127-137 (2006).
Kajikawa M, Hirai N, Hashimoto T. A PIP-family protein is required for biosynthesis of tobacco alkaloids. Plant Mol. Biol. 69: 287-298 (2009).
Kam TS, Choo YM. Venalstonine and dioxokopsan derivatives from Kopsia fruticosa. Phytochemistry 65: 2119-2122 (2004).
Kam TS, Choo YM. Alkaloids from Alstonia angustifolia. Phytochemistry 65: 603-608 (2004).
Kanegae T, Kajiya H, Amano Y, Hashimoto T, Yamada Y. Species-dependent expression of the hyoscyamine 6 beta-hydroxylase gene in the pericycle. Plant Physiol. 105: 483-490 (1994).
Kaplan I, Halitschke R, Kessler A, Sardanelli S, Denno RF. Constitutive and induced defenses to herbivory in above- and belowground plant tissues. Ecology 89: 392-406 (2008).
Kaplan I, Halitschke R, Kessler A, Sardanelli S, Denno RF. Effects of plant vascular architecture on aboveground-belowground-induced responses to foliar and root herbivores on Nicotiana tabacum. J. Chem. Ecol. 34: 1349-1359 (2008).
Kato A, Kato N, Miyauchi S, Minoshima Y, Adachi I, Ikeda K, Asano N, Watson AA, Nash RJ. Iminosugars from Baphia nitida Lodd. Phytochemistry 69: 1261-1265 (2008).
Kato M, Mizuno K. Caffeine synthase and related methyltransferases in plants. Front. Biosci. 9: 1833-1842 (2004).
Kato M, Mizuno K, Fujimura T, Iwama M, Irie M, Crozier A, Ashihara H. Purification and characterization of caffeine synthase from tea leaves. Plant Physiol. 120: 579-586 (1999).
Kato N, Dubouzet E, Kokabu Y, Yoshida S, Taniguchi Y, Dubouzet JG, Yazaki K, Sato F. Identification of a WRKY protein as a transcriptional regulator of benzylisoquinoline alkaloid biosynthesis in Coptis japonica. Plant Cell Physiol. 48: 8-18 (2007).
Kawano T. Roles of the reactive oxygen species-generating peroxidase reactions in plant defense and growth induction. Plant Cell Rep. 21: 829-837 (2003).
Keasling J. From yeast to alkaloids. Nat. Chem. Biol. 4: 524-525 (2008).
Keiner R, Kaiser H, Nakajima K, Hashimoto T, Drager B. Molecular cloning, expression and characterization of tropinone reductase II, an enzyme of the SDR family in Solanum tuberosum (L.). Plant Mol. Biol. 48: 299-308 (2002).
Kellmann R, Mihali TK, Jeon YJ, Pickford R, Pomati F, Neilan BA. Biosynthetic intermediate analysis and functional homology reveal a saxitoxin gene cluster in cyanobacteria. Appl. Environ. Microbiol. 74: 4044-4053 (2008).
Kempf M, Beuerle T, Buhringer M, Denner M, Trost D, von der Ohe K, Bhavanam VB, Schreier P. Pyrrolizidine alkaloids in honey: risk analysis by gas chromatography-mass spectrometry. Mol. Nutr. Food Res. 52: 1193-1200 (2008).
Kidd SK, Melillo AA, Lu RH, Reed DG, Kuno N, Uchida K, Furuya M, Jelesko JG. The A and B loci in tobacco regulate a network of stress response genes, few of which are associated with nicotine biosynthesis. Plant Mol. Biol. 60: 699-716 (2006).
Kim BJ, Gibson DM, Shuler ML. Effect of the plant peptide regulator, phytosulfokine-alpha, on the growth and Taxol production from Taxus sp. suspension cultures. Biotechnol. Bioeng. 95: 8-14 (2006).
Kim YS, Sano H. Pathogen resistance of transgenic tobacco plants producing caffeine. Phytochemistry 69: 882-888 (2008).
Kinnersley AM, Lin F. Receptor modifiers indicate that 4-aminobutyric acid (GABA) is a potential modulator of ion transport in plants. Plant Growth Regul. 32: 65-76 (2000).
Kliebenstein DJ. Secondary metabolites and plant/environment interactions: a view through Arabidopsis thaliana tinged glasses. Plant Cell Environ. 27: 675-684 (2004).
Klvana M, Chen J, Lepine F, Legros R, Jolicoeur M. Analysis of secondary metabolites from Eschscholtzia californica by high-performance liquid chromatography. Phytochem. Anal. 17: 236-242 (2006).
Kohara A, Nakajima C, Hashimoto K, Ikenaga T, Tanaka H, Shoyama Y, Yoshida S, Muranaka T. A novel glucosyltransferase involved in steroid saponin biosynthesis in Solanum aculeatissimum. Plant Mol. Biol. 57: 225-239 (2005).
Kolak U, Ozturk M, Ozgokce F, Ulubelen A. Norditerpene alkaloids from Delphinium linearilobum and antioxidant activity. Phytochemistry 67: 2170-2175 (2006).
Korpan YI, Nazarenko EA, Skryshevskaya IV, Martelet C, Jaffrezic-Renault N, El'skaya AV. Potato glycoalkaloids: true safety or false sense of security? Trends Biotechnol. 22: 147-151 (2004).
Kotera M, McDonald AG, Boyce S, Tipton KF. Eliciting possible reaction equations and metabolic pathways involving orphan metabolites. J. Chem. Inf. Model. 48: 2335-2349 (2008).
Koulman A, Lane GA, Christensen MJ, Fraser K, Tapper BA. Peramine and other fungal alkaloids are exuded in the guttation fluid of endophyte-infected grasses. Phytochemistry 68: 355-360 (2007).
Koulman A, Seeliger C, Edwards PJ, Fraser K, Simpson W, Johnson L, Cao M, Rasmussen S, Lane GA. E/Z-Thesinine-O-4'-alpha-rhamnoside, pyrrolizidine conjugates produced by grasses (Poaceae). Phytochemistry 69: 1927-1932 (2008).
Koyama K, Hirasawa Y, Zaima K, Hoe TC, Chan KL, Morita H. Alstilobanines A-E, new indole alkaloids from Alstonia angustiloba. Bioorg. Med. Chem. 16: 6483-6488 (2008).
Krska R, Crews C. Significance, chemistry and determination of ergot alkaloids: a review. Food Addit. Contam. 25: 722-731 (2008).
Krska R, Stubbings G, Macarthur R, Crews C. Simultaneous determination of six major ergot alkaloids and their epimers in cereals and foodstuffs by LC-MS-MS. Anal. Bioanal. Chem. 391: 563-576 (2008).
Kucht S, Gross J, Hussein Y, Grothe T, Keller U, Basar S, Konig WA, Steiner U, Leistner E. Elimination of ergoline alkaloids following treatment of Ipomoea asarifolia (Convolvulaceae) with fungicides. Planta 219: 619-625 (2004).
Kutchan TM. Alkaloid biosynthesis - the basis for metabolic engineering of medicinal plants. Plant Cell 7: 1059-1070 (1995).
Kutchan TM. A role for intra- and intercellular translocation in natural product biosynthesis. Curr. Opin. Plant Biol. 8: 292-300 (2005).
Kutchan TM. Strictosidine: from alkaloid to enzyme to gene. Phytochemistry 32: 493-506 (1993).
Kutchan TM. Expression of enzymatically active cloned strictosidine synthase from the higher plant Rauvolfia serpentina in Escherichia coli. FEBS Lett. 257: 127-130 (1989).
Kuzovkina I, Al'terman I, Schneider B. Specific accumulation and revised structures of acridone alkaloid glucosides in the tips of transformed roots of Ruta graveolens. Phytochemistry 65: 1095-1100 (2004).
Laflamme P, St-Pierre B, De Luca V. Molecular and biochemical analysis of a Madagascar periwinkle root-specific minovincinine-19-hydroxy-O-acetyltransferase. Plant Physiol. 125: 189-198 (2001).
Lam KC, Ibrahim RK, Behdad B, Dayanandan S. Structure, function, and evolution of plant O-methyltransferases. Genome 50: 1001-1013 (2007).
Lannuzel A, Hoglinger GU, Champy P, Michel PP, Hirsch EC, Ruberg M. Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae? J. Neural Transm. Suppl. 70: 153-157 (2006).
Lantin S, O'Brien M, Matton DP. Pollination, wounding and jasmonate treatments induce the expression of a developmentally regulated pistil dioxygenase at a distance, in the ovary, in the wild potato Solanum chacoense Bitt. Plant Mol. Biol. 41: 371-386 (1999).
Larsson KA, Zetterlund I, Delp G, Jonsson LM. N-Methyltransferase involved in gramine biosynthesis in barley: cloning and characterization. Phytochemistry 67: 2002-2008 (2006).
Larsson S. The "new" chemosystematics: phylogeny and phytochemistry. Phytochemistry 68: 2904-2908 (2007).
Le Flem-Bonhomme V, Laurain-Mattar D, Fliniaux MA. Hairy root induction of Papaver somniferum var. album, a difficult-to-transform plant, by A. rhizogenes LBA 9402. Planta 218: 890-893 (2004).
Lee SY, Kim HU, Park JH, Park JM, Kim TY. Metabolic engineering of microorganisms: general strategies and drug production. Drug Discov. Today 14: 78-88 (2009).
Leech MJ, May K, Hallard D, Verpoorte R, De Luca V, Christou P. Expression of two consecutive genes of a secondary metabolic pathway in transgenic tobacco: molecular diversity influences levels of expression and product accumulation. Plant Mol. Biol. 38: 765-774 (1998).
Lehtonen PT, Helander M, Siddiqui SA, Lehto K, Saikkonen K. Endophytic fungus decreases plant virus infections in meadow ryegrass (Lolium pratense). Biol. Lett. 2: 620-623 (2006).
Lemenager D, Ouelhazi L, Mahroug S, Veau B, St-Pierre B, Rideau M, Aguirreolea J, Burlat V, Clastre M. Purification, molecular cloning, and cell-specific gene expression of the alkaloid-accumulation associated protein CrPS in Catharanthus roseus. J. Exp. Bot. 56: 1221-1228 (2005).
Leonard E, Runguphan W, O'Connor S, Prather KJ. Opportunities in metabolic engineering to facilitate scalable alkaloid production. Nat. Chem. Biol. 5: 292-300 (2009).
Levac D, Murata J, Kim WS, De Luca V. Application of carborundum abrasion for investigating the leaf epidermis: molecular cloning of Catharanthus roseus 16-hydroxytabersonine-16-O-methyltransferase. Plant J. 53: 225-236 (2008).
Li J, Li QW, Gao DW, Han ZS, Li K. Antitumor effects of total alkaloids isolated from Solanum nigrum in vitro and in vivo. Pharmazie. 63: 534-538 (2008).
Li N, Shao L, Zhang CF, Zhang M. Two new flavonoid alkaloids from Senecio argunensis. J. Asian Nat. Prod. Res. 10: 1143-1146 (2008).
Lim KH, Thomas NF, Abdullah Z, Kam TS. Seco-tabersonine alkaloids from Tabernaemontana corymbosa. Phytochemistry 70: 424-429 (2009).
Liscombe DK, Facchini PJ. Evolutionary and cellular webs in benzylisoquinoline alkaloid biosynthesis. Curr. Opin. Biotechnol. 19: 173-180 (2008).
Liu F, Vantoai T, Moy LP, Bock G, Linford LD, Quackenbush J. Global transcription profiling reveals comprehensive insights into hypoxic response in Arabidopsis. Plant Physiol. 137: 1115-1129 (2005).
Long M, Millar DJ, Kimura Y, Donovan G, Rees J, Fraser PD, Bramley PM, Bolwell GP. Metabolite profiling of carotenoid and phenolic pathways in mutant and transgenic lines of tomato: identification of a high antioxidant fruit line. Phytochemistry 67: 1750-1757 (2006).
Lopez-Meyer M, Nessler CL. Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminata which are differentially expressed during development and stress. Plant J. 11: 1167-1175 (1997).
Lu H, Gorman E, McKnight TD. Molecular characterization of two anthranilate synthase alpha subunit genes in Camptotheca acuminata. Planta 221: 352-360 (2005).
Lu H, McKnight TD. Tissue-specific expression of the beta-subunit of tryptophan synthase in Camptotheca acuminata, an indole alkaloid-producing plant. Plant Physiol. 120: 43-52 (1999).
Lu ZM, Zhang QJ, Chen RY, Yu DQ. Four new alkaloids from Polyalthia nemoralis (Annonaceae). J. Asian Nat. Prod. Res. 10: 656-664 (2008).
Ma X, Panjikar S, Koepke J, Loris E, Stockigt J. The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins. Plant Cell 18: 907-920 (2006).
Macel M, Vrieling K, Klinkhamer PG. Variation in pyrrolizidine alkaloid patterns of Senecio jacobaea. Phytochemistry 65: 865-873 (2004).
Machado SR, Gregorio EA, Guimaraes E. Ovary peltate trichomes of Zeyheria montana (Bignoniaceae): developmental ultrastructure and secretion in relation to function. Ann. Bot. (Lond.) 97: 357-369 (2006).
Magnotta M, Murata J, Chen J, De Luca V. Expression of deacetylvindoline-4-O-acetyltransferase in Catharanthus roseus hairy roots. Phytochemistry 68: 1922-1931 (2007).
Magnotta M, Murata J, Chen J, De Luca V. Identification of a low vindoline accumulating cultivar of Catharanthus roseus (L.) G. Don by alkaloid and enzymatic profiling. Phytochemistry 67: 1758-1764 (2006).
Mahroug S, Courdavault V, Thiersault M, St-Pierre B, Burlat V. Epidermis is a pivotal site of at least four secondary metabolic pathways in Catharanthus roseus aerial organs. Planta 223: 1191-1200 (2006).
Maldonado-Mendoza IE, Lopez-Meyer M, Galef JR, Burnett RJ, Nessler CL. Molecular analysis of a new member of the opium poppy tyrosine/3,4-dihydroxyphenylalanine decarboxylase gene family. Plant Physiol. 110: 43-49 (1996).
Maldonado-Mendoza IE, Vincent RM, Nessler CL. Molecular characterization of three differentially expressed members of the Camptotheca acuminata 3-hydroxy-3-methylglutaryl CoA reductase (HMGR) gene family. Plant Mol. Biol. 34: 781-790 (1997).
Marconi PL, Alvarez MA, Pitta-Alvarez SI. How polyamine synthesis inhibitors and cinnamic acid affect tropane alkaloid production. Appl. Biochem. Biotechnol. 136: 63-75 (2007).
Markert A, Steffan N, Ploss K, Hellwig S, Steiner U, Drewke C, Li SM, Boland W, Leistner E. Biosynthesis and accumulation of ergoline alkaloids in a mutualistic association between Ipomoea asarifolia (Convolvulaceae) and a clavicipitalean fungus. Plant Physiol. 147: 296-305 (2008).
Martinez-Luis S, Perez-Vasquez A, Mata R. Natural products with calmodulin inhibitor properties. Phytochemistry 68: 1882-1903 (2007).
Mathouet H, Elomri A, Lameiras P, Daich A, Verite P. An alkaloid, two conjugate sesquiterpenes and a phenylpropanoid from Pachypodanthium confine Engl. and Diels. Phytochemistry 68: 1813-1818 (2007).
Mattern-Dogru E, Ma X, Hartmann J, Decker H, Stockigt J. Potential active-site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site-directed mutagenesis. Eur. J. Biochem. 269: 2889-2896 (2002).
Matthews D, Jones H, Gans P, Coates S, Smith LM. Toxic secondary metabolite production in genetically modified potatoes in response to stress. J. Agric. Food Chem. 53: 7766-7776 (2005).
Matz C, Webb JS, Schupp PJ, Phang SY, Penesyan A, Egan S, Steinberg P, Kjelleberg S. Marine biofilm bacteria evade eukaryotic predation by targeted chemical defense. PLoS ONE 3: e2744 (2008).
Maximo P, Lourenco A, Tei A, Wink M. Chemotaxonomy of Portuguese Ulex: quinolizidine alkaloids as taxonomical markers. Phytochemistry 67: 1943-1949 (2006).
McNulty J, Nair JJ, Bastida J, Pandey S, Griffin C. Structure-activity studies on the lycorine pharmacophore: a potent inducer of apoptosis in human leukemia cells. Phytochemistry 70: 913-919 (2009).
McNulty J, Nair JJ, Codina C, Bastida J, Pandey S, Gerasimoff J, Griffin C. Selective apoptosis-inducing activity of crinum-type Amaryllidaceae alkaloids. Phytochemistry 68: 1068-1074 (2007).
Meijer AH, Lopes Cardoso MI, Voskuilen JT, de Waal A, Verpoorte R, Hoge JH. Isolation and characterization of a cDNA clone from Catharanthus roseus encoding NADPH:cytochrome P-450 reductase, an enzyme essential for reactions catalysed by cytochrome P-450 mono-oxygenases in plants. Plant J. 4: 47-60 (1993).
Memelink J. The use of genetics to dissect plant secondary pathways. Curr. Opin. Plant Biol. 8: 230-235 (2005).
Memelink J, Menkw FL, van der Fits L, Kijne JW. Chapter 6. Transcriptional Regulators to Modify Secondary Metabolism. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 111-125 (2000).
Memelink J, Verpoorte R, Kijne JW. ORCAnization of jasmonate-responsive gene expression in alkaloid metabolism. Trends Plant Sci. 6: 212-219 (2001).
Menke FL, Champion A, Kijne JW, Memelink J. A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2. EMBO J. 18: 4455-4463 (1999).
Menke FL, Parchmann S, Mueller MJ, Kijne JW, Memelink J. Involvement of the octadecanoid pathway and protein phosphorylation in fungal elicitor-induced expression of terpenoid indole alkaloid biosynthetic genes in Catharanthus roseus. Plant Physiol. 119: 1289-1296 (1999).
Mesnard F, Azaroual N, Marty D, Fliniaux MA, Robins RJ, Vermeersch G, Monti JP. Use of 15N reverse gradient two-dimensional nuclear magnetic resonance spectroscopy to follow metabolic activity in Nicotiana plumbaginifolia cell-suspension cultures. Planta 210: 446-453 (2000).
Mesnard F, Marty D, Gillet-Manceau F, Fliniaux MA, Monti JP. Glutamine synthetase activity in Solanaceous cell suspensions accumulating alkaloids or not. 13C NMR and enzymatic assay. C. R. Acad. Sci. III 322: 743-748 (1999).
Mesnard F, Ratcliffe RG. NMR analysis of plant nitrogen metabolism. Photosynth. Res. 83: 163-180 (2005).
Minami H, Kim JS, Ikezawa N, Takemura T, Katayama T, Kumagai H, Sato F. Microbial production of plant benzylisoquinoline alkaloids. Proc. Natl. Acad. Sci. U.S.A. 105: 7393-7398 (2008).
Minguet EG, Vera F, Marina A, Carbonell J, Blazquez MA. Evolutionary diversification in polyamine biosynthesis. Mol. Biol. Evol. 25: 2119-2128 (2008).
Misra N, Luthra R, Kumar S. Enzymology of indole alkaloid biosynthesis in Catharanthus roseus. Indian J. Biochem. Biophys. 33: 261-273 (1996).
Moco S, Bino RJ, Vorst O, Verhoeven HA, de Groot J, van Beek TA, Vervoort J, de Vos CH. A liquid chromatography-mass spectrometry-based metabolome database for tomato. Plant Physiol. 141: 1205-1218 (2006).
Moco S, Capanoglu E, Tikunov Y, Bino RJ, Boyacioglu D, Hall RD, Vervoort J, De Vos RC. Tissue specialization at the metabolite level is perceived during the development of tomato fruit. J. Exp. Bot. 58: 4131-4146 (2007).
Mohn T, Plitzko I, Hamburger M. A comprehensive metabolite profiling of Isatis tinctoria leaf extracts. Phytochemistry 70: 924-934 (2009).
Moll S, Anke S, Kahmann U, Hansch R, Hartmann T, Ober D. Cell-specific expression of homospermidine synthase, the entry enzyme of the pyrrolizidine alkaloid pathway in Senecio vernalis, in comparison with its ancestor, deoxyhypusine synthase. Plant Physiol. 130: 47-57 (2002).
Molyneux RJ, Lee ST, Gardner DR, Panter KE, James LF. Phytochemicals: the good, the bad and the ugly? Phytochemistry 68: 2973-2985 (2007).
Mondolot L, LA Fisca P, Buatois B, Talansier E, DE Kochko A, Campa C. Evolution in caffeoylquinic acid content and histolocalization during Coffea canephora leaf development. Ann. Bot. (Lond.) 98: 33-40 (2006).
Morant M, Bak S, Moller BL, Werck-Reichhart D. Plant cytochromes P450: tools for pharmacology, plant protection and phytoremediation. Curr. Opin. Biotechnol. 14: 151-162 (2003).
Moreno PR, Schlatmann JE, van der Heijden R, van Gulik WM, ten Hoopen HJ, Verpoorte R, Heijnen JJ. Induction of ajmalicine formation and related enzyme activities in Catharanthus roseus cells: effect of inoculum density. Appl. Microbiol. Biotechnol. 39: 42-47 (1993).
Morgan JA, Shanks JV. Quantification of metabolic flux in plant secondary metabolism by a biogenetic organizational approach. Metab. Eng. 4: 257-262 (2002).
Morgan JA, Shanks JV. Determination of metabolic rate-limitations by precursor feeding in Catharanthus roseus hairy root cultures. J. Biotechnol. 79: 137-145 (2000).
Morino K, Matsuda F, Miyazawa H, Sukegawa A, Miyagawa H, Wakasa K. Metabolic profiling of tryptophan-overproducing rice calli that express a feedback-insensitive alpha subunit of anthranilate synthase. Plant Cell Physiol. 46: 514-521 (2005).
Morishige T, Dubouzet E, Choi KB, Yazaki K, Sato F. Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells. Eur. J. Biochem. 269: 5659-5667 (2002).
Morishige T, Tsujita T, Yamada Y, Sato F. Molecular characterization of the S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase involved in isoquinoline alkaloid biosynthesis in Coptis japonica. J. Biol. Chem. 275: 23398-23405 (2000).
Mosaleeyanon K, Zobayed SMA, Afreen F, Kozai T. Relationships between net photosynthetic rate and secondary metabolite contents in St. John's wort. Plant Sci. 169: 523-531 (2005).
Moyano E, Fornale S, Palazon J, Cusido RM, Bagni N, Pinol MT. Alkaloid production in Duboisia hybrid hairy root cultures overexpressing the pmt gene. Phytochemistry 59: 697-702 (2002).
Moyano E, Jouhikainen K, Tammela P, Palazon J, Cusido RM, Pinol MT, Teeri TH, Oksman-Caldentey KM. Effect of pmt gene overexpression on tropane alkaloid production in transformed root cultures of Datura metel and Hyoscyamus muticus. J. Exp. Bot. 54: 203-211 (2003).
Muller C, Agerbirk N, Olsen CE, Boeve JL, Schaffner U, Brakefield PM. Sequestration of host plant glucosinolates in the defensive hemolymph of the sawfly Athalia rosae. J. Chem. Ecol. 27: 2505-2516 (2001).
Murata J, Luca VD. Localization of tabersonine 16-hydroxylase and 16-OH tabersonine-16-O-methyltransferase to leaf epidermal cells defines them as a major site of precursor biosynthesis in the vindoline pathway in Catharanthus roseus. Plant J. 44: 581-594 (2005).
Murata J, Roepke J, Gordon H, De Luca V. The leaf epidermome of Catharanthus roseus reveals its biochemical specialization. Plant Cell 20: 524-542 (2008).
Nafisi M, Goregaoker S, Botanga CJ, Glawischnig E, Olsen CE, Halkier BA, Glazebrook J. Arabidopsis cytochrome P450 monooxygenase 71A13 catalyzes the conversion of indole-3-acetaldoxime in camalexin synthesis. Plant Cell 19: 2039-2052 (2007).
Naithani R, Huma LC, Holland LE, Shukla D, McCormick DL, Mehta RG, Moriarty RM. Antiviral activity of phytochemicals: a comprehensive review. Mini Rev. Med. Chem. 8: 1106-1133 (2008).
Nakamura S, Hongo M, Sugimoto S, Matsuda H, Yoshikawa M. Steroidal saponins and pseudoalkaloid oligoglycoside from Brazilian natural medicine, "fruta do lobo" (fruit of Solanum lycocarpum). Phytochemistry 69: 1565-1572 (2008).
Nakano H, Nakajima E, Hiradate S, Fujii Y, Yamada K, Shigemori H, Hasegawa K. Growth inhibitory alkaloids from mesquite (Prosopis juliflora (Sw.) DC.) leaves. Phytochemistry 65: 587-591 (2004).
Nawrot R, Kalinowski A, Gozdzicka-Jozefiak A. Proteomic analysis of Chelidonium majus milky sap using two-dimensional gel electrophoresis and tandem mass spectrometry. Phytochemistry 68: 1612-1622 (2007).
Nazario GM, Lovatt CJ. Regulation of purine metabolism in intact leaves of Coffea arabica. Plant Physiol. 103: 1195-1201 (1993).
Nehls U, Beguiristain T, Ditengou F, Lapeyrie F, Martin F. The expression of a symbiosis-regulated gene in eucalypt roots is regulated by auxins and hypaphorine, the tryptophan betaine of the ectomycorrhizal basidiomycete Pisolithus tinctorius. Planta 207: 296-302 (1998).
Netopilova M, Drsata J, Ulrichova J. Influence of sanguinarine on the GABA synthesizing enzyme glutamate decarboxylase in vitro. Pharmazie 51: 589-591 (1996).
Nezbedova L, Hesse M, Drandarov K, Bigler L, Werner C. Phenol oxidative coupling in the biogenesis of the macrocyclic spermine alkaloids aphelandrine and orantine in Aphelandra sp. Planta 213: 411-417 (2001).
Nishiyama Y, Moriyasu M, Ichimaru M, Iwasa K, Kato A, Mathenge SG, Chalo Mutiso PB, Juma FD. Secondary and tertiary isoquinoline alkaloids from Xylopia parviflora. Phytochemistry 67: 2671-2675 (2006).
Nishiyama Y, Moriyasu M, Ichimaru M, Iwasa K, Kato A, Mathenge SG, Chalo Mutiso PB, Juma FD. Quaternary isoquinoline alkaloids from Xylopia parviflora. Phytochemistry 65: 939-944 (2004).
Nurhayati N, Gonde D, Ober D. Evolution of pyrrolizidine alkaloids in Phalaenopsis orchids and other monocotyledons: identification of deoxyhypusine synthase, homospermidine synthase and related pseudogenes. Phytochemistry 70: 508-516 (2009).
O'Keefe BR, Beecher C. Isolation and characterization of S-adenosyl-L-methionine:tetrahydroberberine-cis-N-methyltransferase from suspension cultures of Sanguinaria canadensis L. Plant Physiol. 105: 395-403 (1994).
Ober D, Gibas L, Witte L, Hartmann T. Evidence for general occurrence of homospermidine in plants and its supposed origin as by-product of deoxyhypusine synthase. Phytochemistry 62: 339-344 (2003).
Ober D, Harms R, Hartmann T. Cloning and expression of homospermidine synthase from Senecio vulgaris: a revision. Phytochemistry 55: 305-309 (2000).
Ober D, Hartmann T. Phylogenetic origin of a secondary pathway: the case of pyrrolizidine alkaloids. Plant Mol. Biol. 44: 445-450 (2000).
Oksman-Caldentey KM, Arroo R. Chapter 13. Regulation of Tropane Alkaloid Metabolism in Plants an Plant Cell Cultures. In "Metabolic Engineering of Plant Secondary Metabolism" (Verpoorte R, Alfermann AW, eds), Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 253-281 (2000).
Otani M, Shitan N, Sakai K, Martinoia E, Sato F, Yazaki K. Characterization of vacuolar transport of the endogenous alkaloid berberine in Coptis japonica. Plant Physiol. 138: 1939-1946 (2005).
Oudin A, Mahroug S, Courdavault V, Hervouet N, Zelwer C, Rodríguez-Concepcion M, St-Pierre B, Burlat V. Spatial distribution and hormonal regulation of gene products from methyl erythritol phosphate and monoterpene-secoiridoid pathways in Catharanthus roseus. Plant Mol. Biol. 65: 13-30 (2007).
Ounaroon A, Decker G, Schmidt J, Lottspeich F, Kutchan TM. (R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy. Plant J. 36: 808-819 (2003).
Ouwerkerk PB, Hallard D, Verpoorte R, Memelink J. Identification of UV-B light-responsive regions in the promoter of the tryptophan decarboxylase gene from Catharanthus roseus. Plant Mol. Biol. 41: 491-503 (1999).
Ouwerkerk PB, Memelink J. Elicitor-responsive promoter regions in the tryptophan decarboxylase gene from Catharanthus roseus. Plant Mol. Biol. 39: 129-136 (1999).
Ouwerkerk PB, Trimborn TO, Hilliou F, Memelink J. Nuclear factors GT-1 and 3AF1 interact with multiple sequences within the promoter of the Tdc gene from Madagascar periwinkle: GT-1 is involved in UV light-induced expression. Mol. Gen. Genet. 261: 610-622 (1999).
Palazon J, Navarro-Ocana A, Hernandez-Vazquez L, Mirjalili MH. Application of metabolic engineering to the production of scopolamine. Molecules 13: 1722-1742 (2008).
Palumbo MJ, Putz FE, Talcott ST. Nitrogen fertilizer and gender effects on the secondary metabolism of yaupon, a caffeine-containing North American holly. Oecologia 151: 1-9 (2007).
Pandey R, Singh SC, Gupta MM. Heteroyohimbinoid type oxindole alkaloids from Mitragyna parvifolia. Phytochemistry 67: 2164-2169 (2006).
Pandey S, Gupta K, Mukherjee AK. Impact of cadmium and lead on Catharanthus roseus - a phytoremediation study. J. Environ. Biol. 28: 655-662 (2007).
Papon N, Oudin A, Vansiri A, Rideau M, Chenieux JC, Creche J. Differential expression of two type-A response regulators in plants and cell cultures of Catharanthus roseus (L.) G. Don. J. Exp. Bot. 54: 1793-1795 (2003).
Paradowska K, Wolniak M, Pisklak M, Glinski JA, Davey MH, Wawer I. (13)C, (15)N CPMAS NMR and GIAO DFT calculations of stereoisomeric oxindole alkaloids from cat's claw (Uncaria tomentosa). Solid State Nucl. Magn. Reson. 34: 202-209 (2008).
Pariera Dinkins CL, Peterson RK, Gibson JE, Hu Q, Weaver DK. Glycoalkaloid responses of potato to Colorado potato beetle defoliation. Food Chem. Toxicol. 46: 2832-2836 (2008).
Park SU, Johnson AG, Penzes-Yost C, Facchini PJ. Analysis of promoters from tyrosine/dihydroxyphenylalanine decarboxylase and berberine bridge enzyme genes involved in benzylisoquinoline alkaloid biosynthesis in opium poppy. Plant Mol. Biol. 40: 121-131 (1999).
Park SU, Yu M, Facchini PJ. Antisense RNA-mediated suppression of benzophenanthridine alkaloid biosynthesis in transgenic cell cultures of California poppy. Plant Physiol. 128: 696-706 (2002).
Park SU, Yu M, Facchini PJ. Modulation of berberine bridge enzyme levels in transgenic root cultures of California poppy alters the accumulation of benzophenanthridine alkaloids. Plant Mol. Biol. 51: 153-164 (2003).
Pasquali G, Erven AS, Ouwerkerk PB, Menke FL, Memelink J. The promoter of the strictosidine synthase gene from periwinkle confers elicitor-inducible expression in transgenic tobacco and binds nuclear factors GT-1 and GBF. Plant Mol. Biol. 39: 1299-1310 (1999).
Pasquali G, Goddijn OJ, de Waal A, Verpoorte R, Schilperoort RA, Hoge JH, Memelink J. Coordinated regulation of two indole alkaloid biosynthetic genes from Catharanthus roseus by auxin and elicitors. Plant Mol. Biol. 18: 1121-1131 (1992).
Paudler WW, Wagner S. The major alkaloid of Marrubium vulgare. Chemistry and Industry, October 19, 1963: 1693-1694 (1963).
Pauw B, Hilliou FA, Sandonis Martin V, Chatel G, de Wolf CJ, Champion A, Pre M, van Duijn B, Kijne JW, van der Fits L, Memelink J. Zinc finger proteins act as transcriptional repressors of alkaloid biosynthesis genes in Catharanthus roseus. J. Biol. Chem. 279: 52940-52948 (2004).
Pauw B, van Duijn B, Kijne JW, Memelink J. Activation of the oxidative burst by yeast elicitor in Catharanthus roseus cells occurs independently of the activation of genes involved in alkaloid biosynthesis. Plant Mol. Biol. 55: 797-805 (2004).
Pavlov A, Berkov S, Weber J, Bley T. Hyoscyamine biosynthesis in Datura stramonium hairy root in vitro systems with different ploidy levels. Appl. Biochem. Biotechnol. 157: 210-225 (2009).
Pearson LA, Moffitt MC, Ginn HP, Choi AL. The molecular genetics and regulation of cyanobacterial peptide hepatotoxin biosynthesis. Crit. Rev. Toxicol. 38: 847-856 (2008).
Peebles CA, Hong SB, Gibson SI, Shanks JV, San KY. Effects of terpenoid precursor feeding on Catharanthus roseus hairy roots over-expressing the alpha or the alpha and beta subunits of anthranilate synthase. Biotechnol. Bioeng. 93: 534-540 (2006).
Peebles CA, Hong SB, Gibson SI, Shanks JV, San KY. Transient effects of overexpressing anthranilate synthase alpha and beta subunits in Catharanthus roseus hairy roots. Biotechnol. Prog. 21: 1572-1576 (2005).
Peebles CA, Hughes EH, Shanks JV, San KY. Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time. Metab. Eng. 11: 76-86 (2009).
Peebles CA, Sander GW, Li M, Shanks JV, San KY. Five year maintenance of the inducible expression of anthranilate synthase in Catharanthus roseus hairy roots. Biotechnol. Bioeng. 102: 1521-1525 (2009).
Platis D, Drossard J, Fischer R, Ma JK, Labrou NE. New downstream processing strategy for the purification of monoclonal antibodies from transgenic tobacco plants. J. Chromatogr. A. 1211: 80-89 (2008).
Portmann C, Prestinari C, Myers T, Scharte J, Gademann K. Directed biosynthesis of phytotoxic alkaloids in the cyanobacterium Nostoc 78-12A. Chembiochem. 10: 889-895 (2009).
Potocka A, Zimowski J. Metabolism of conjugated sterols in eggplant. Part 1. UDP-glucose:sterol glucosyltransferase. Acta Biochim. Pol. 55: 127-134 (2008).
Poutrain P, Mazars C, Thiersault M, Rideau M, Pichon O. Two distinct intracellular Ca2+-release components act in opposite ways in the regulation of the auxin-dependent MIA biosynthesis in Catharanthus roseus cells. J. Exp. Bot. 60: 1387-1398 (2009).
Prasad BC, Gururaj HB, Kumar V, Giridhar P, Ravishankar GA. Valine pathway is more crucial than phenyl propanoid pathway in regulating capsaicin biosynthesis in Capsicum frutescens Mill. J. Agric. Food Chem. 54: 6660-6666 (2006).
Prasad BC, Kumar V, Gururaj HB, Parimalan R, Giridhar P, Ravishankar GA. Characterization of capsaicin synthase and identification of its gene (csy1) for pungency factor capsaicin in pepper (Capsicum sp.). Proc. Natl. Acad. Sci. U.S.A. 103: 13315-13320 (2006).
Prescott AG, John P. Dioxygenases: molecular structure and role in plant metabolism. Annu. Rev. Plant Physiol. Plant Mol. Biol. 47: 245-271 (1996).
Quang DN, Spiteller P, Porzel A, Schmidt J, Geissler T, Arnold N, Wessjohann L. Alkaloids from the mushroom Pseudobaeospora pyrifera, pyriferines A-C. J. Nat. Prod. 71: 1620-1622 (2008).
Rai SP, Luthra R, Gupta MM, Kumar S. Pleiotropic morphological and abiotic stress resistance phenotypes of the hyper-abscisic acid producing Abo(-) mutant in the periwinkle Catharanthus roseus. J. Biosci. 26: 57-70 (2001).
Ramsey JS, Jander G. Testing nicotine tolerance in aphids using an artificial diet experiment. J. Vis. Exp. 15 pii: 701 (2008).
Rea PA, Li ZS, Lu YP, Drozdowicz YM, Martinoia E. From vacuolar GS-X pumps to multispecific ABC transporters. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49: 727-760 (1998).
Reimann A, Nurhayati N, Backenkohler A, Ober D. Repeated evolution of the pyrrolizidine alkaloid-mediated defense system in separate angiosperm lineages. Plant Cell 16: 2772-2784 (2004).
Ren DM, Guo HF, Yu WT, Wang SQ, Ji M, Lou HX. Stereochemistry of flavonoidal alkaloids from Dracocephalum rupestre. Phytochemistry 69: 1425-1433 (2008).
Rhodes D, Peel GJ, Dudareva N. Metabolism, secondary: engineering pathways of. In (RM Goodman, ed) Encyclopedia of Plant and Crop Science, Marcell Dekker, N.Y., pp. 720-723 (2004).
Richter U, Rothe G, Fabian AK, Rahfeld B, Drager B. Overexpression of tropinone reductases alters alkaloid composition in Atropa belladonna root cultures. J. Exp. Bot. 56: 645-652 (2005).
Richter U, Sonnewald U, Drager B. Calystegines in potatoes with genetically engineered carbohydrate metabolism. J. Exp. Bot. 58: 1603-1615 (2007).
Riechers DE, Timko MP. Structure and expression of the gene family encoding putrescine N-methyltransferase in Nicotiana tabacum: new clues to the evolutionary origin of cultivated tobacco. Plant Mol. Biol. 41: 387-401 (1999).
Rigbers O, Li SM. Ergot alkaloid biosynthesis in Aspergillus fumigatus: overproduction and biochemical characterisation of a 4-dimethylallyltryptophan N-methyltransferase. J. Biol. Chem. 283: 26859-26868 (2008).
Rischer H, Oresic M, Seppanen-Laakso T, Katajamaa M, Lammertyn F, Ardiles-Diaz W, Van Montagu MC, Inze D, Oksman-Caldentey KM, Goossens A. Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells. Proc. Natl. Acad. Sci. U.S.A. 103: 5614-5619 (2006).
Robertson AV, Marion L. The biogenesis of alkaloids. XXV. The role of hygric acid in the biogenesis of stachydrine. Can. J. Chem. 38: 396-398 (1960).
Rodrigues SP, Da Cunha M, Ventura JA, Fernandes PM. Effects of the Papaya meleira virus on papaya latex structure and composition. Plant Cell Rep. 28: 861-871 (2009).
Roessner CA, Scott AI. Genetically engineered synthesis of natural products: from alkaloids to corrins. Annu. Rev. Microbiol. 50: 467-490 (1996).
Rohde B, Hans J, Martens S, Baumert A, Hunziker P, Matern U. Anthranilate N-methyltransferase, a branch-point enzyme of acridone biosynthesis. Plant J. 53: 541-553 (2008).
Roos W, Evers S, Hieke M, Tschope M, Schumann B. Shifts of intracellular pH distribution as a part of the signal mechanism leading to the elicitation of benzophenanthridine alkaloids. Phytoalexin biosynthesis in cultured cells of Eschscholtzia californica. Plant Physiol. 118: 349-364 (1998).
Rothe G, Hachiya A, Yamada Y, Hashimoto T, Drager B. Alkaloids in plants and root cultures of Atropa belladonna overexpressing putrescine N-methyltransferase. J. Exp. Bot. 54: 2065-2070 (2003).
Ruiz JM, Blasco B, Rivero RM, Romero L. Nicotine-free and salt-tolerant tobacco plants obtained by grafting to salinity-resistant rootstocks of tomato. Physiol. Plant. 124: 465-475 (2005).
Ruiz-May E, Galaz-Avalos RM, Loyola-Vargas VM. Differential secretion and accumulation of terpene indole alkaloids in hairy roots of Catharanthus roseus treated with methyl jasmonate. Mol. Biotechnol. 41: 278-285 (2009).
Rumalla CS, Jadhav AN, Smillie T, Fronczek FR, Khan IA. Alkaloids from Heimia salicifolia. Phytochemistry 69: 1756-1762 (2008).
Runguphan W, Maresh JJ, O'Connor SE. Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture. Proc. Natl. Acad. Sci. U.S.A. 106: 13673-13678 (2009).
Runguphan W, O'Connor SE. Metabolic reprogramming of periwinkle plant culture. Nat. Chem. Biol. 5: 151-153 (2009).
Ruppert M, Woll J, Giritch A, Genady E, Ma X, Stockigt J. Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system. Planta 222: 888-898 (2005).
Sakai K, Shitan N, Sato F, Ueda K, Yazaki K. Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein. J. Exp. Bot. 53: 1879-1886 (2002).
Sakurai N, Nakagawa-Goto K, Ito J, Sakurai Y, Nakanishi Y, Bastow KF, Cragg G, Lee KH. Cytotoxic Alangium alkaloids from Alangium longiflorum. Phytochemistry 67: 894-897 (2006).
Samanani N, Alcantara J, Bourgault R, Zulak KG, Facchini PJ. The role of phloem sieve elements and laticifers in the biosynthesis and accumulation of alkaloids in opium poppy. Plant J. 47: 547-563 (2006).
Samanani N, Facchini PJ. Isolation and partial characterization of norcoclaurine synthase, the first committed step in benzylisoquinoline alkaloid biosynthesis, from opium poppy. Planta 213: 898-906 (2001).
Samanani N, Liscombe DK, Facchini PJ. Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis. Plant J. 40: 302-313 (2004).
Samanani N, Park SU, Facchini PJ. Cell type-specific localization of transcripts encoding nine consecutive enzymes involved in protoberberine alkaloid biosynthesis. Plant Cell 17: 915-926 (2005).
Satchithanandam S, Grundel E, Roach J, White KD, Mazzola E, Ganzera M, Rader JI. Alkaloids and saponins in dietary supplements of blue cohosh (Caulophyllum thalictroides). J. AOAC Int. 91: 21-32 (2008).
Satdive RK, Fulzele DP, Eapen S. Studies on production of ajmalicine in shake flasks by multiple shoot cultures of Catharanthus roseus. Biotechnol. Prog. 19: 1071-1075 (2003).
Sato F, Hashimoto T, Hachiya A, Tamura K, Choi KB, Morishige T, Fujimoto H, Yamada Y. Metabolic engineering of plant alkaloid biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 98: 367-372 (2001).
Scarpari LM, Meinhardt LW, Mazzafera P, Pomella AW, Schiavinato MA, Cascardo JC, Pereira GA. Biochemical changes during the development of witches' broom: the most important disease of cocoa in Brazil caused by Crinipellis perniciosa. J. Exp. Bot. 56: 865-877 (2005).
Schaneberg BT, Crockett S, Bedir E, Khan IA. The role of chemical fingerprinting: application to Ephedra. Phytochemistry 62: 911-918 (2003).
Schardl CL, Grossman RB, Nagabhyru P, Faulkner JR, Mallik UP. Loline alkaloids: currencies of mutualism. Phytochemistry 68: 980-996 (2007).
Schardl CL, Panaccione DG, Tudzynski P. Ergot alkaloids - biology and molecular biology. Alkaloids Chem. Biol. 63: 45-86 (2006).
Schinnerl J, Brem B, But PP, Vajrodaya S, Hofer O, Greger H. Pyrrolo- and pyridoazepine alkaloids as chemical markers in Stemona species. Phytochemistry 68: 1417-1427 (2007).
Schliemann W, Schneider B, Wray V, Schmidt J, Nimtz M, Porzel A, Bohm H. Flavonols and an indole alkaloid skeleton bearing identical acylated glycosidic groups from yellow petals of Papaver nudicaule. Phytochemistry 67: 191-201 (2006).
Schmidt A, Mordhorst T, Nieger M. Investigation of a betainic alkaloid from Punica granatum. Nat. Prod. Res. 19: 541-546 (2005).
Schmidt J, Boettcher C, Kuhnt C, Kutchan TM, Zenk MH. Poppy alkaloid profiling by electrospray tandem mass spectrometry and electrospray FT-ICR mass spectrometry after [ring-(13)C(6)]-tyramine feeding. Phytochemistry 68: 189-202 (2007).
Scholl Y, Schneider B, Drager B. Biosynthesis of calystegines: 15N NMR and kinetics of formation in root cultures of Calystegia sepium. Phytochemistry 62: 325-332 (2003).
Schroder G, Unterbusch E, Kaltenbach M, Schmidt J, Strack D, De Luca V, Schroder J. Light-induced cytochrome P450-dependent enzyme in indole alkaloid biosynthesis: tabersonine 16-hydroxylase. FEBS Lett. 458: 97-102 (1999).
Schwartze W, Roos W. The signal molecule lysophosphatidylcholine in Eschscholzia californica is rapidly metabolized by reacylation. Planta 229: 183-191 (2008).
Shanks JV, Bhadra R, Morgan J, Rijhwani S, Vani S. Quantification of metabolites in the indole alkaloid pathways of Catharanthus roseus: implications for metabolic engineering. Biotechnol. Bioeng. 58: 333-338 (1998).
Shitan N, Yazaki K. Accumulation and membrane transport of plant alkaloids. Curr. Pharm. Biotechnol. 8: 244-252 (2007).
Shoji T, Hashimoto T. Why does anatabine, but not nicotine, accumulate in jasmonate-elicited cultured tobacco BY-2 cells? Plant Cell Physiol. 49: 1209-1216 (2008).
Shoji T, Inai K, Yazaki Y, Sato Y, Takase H, Shitan N, Yazaki K, Goto Y, Toyooka K, Matsuoka K, Hashimoto T. Multidrug and toxic compound extrusion-type transporters implicated in vacuolar sequestration of nicotine in tobacco roots. Plant Physiol. 149: 708-718 (2009).
Shoji T, Ogawa T, Hashimoto T. Jasmonate-induced nicotine formation in tobacco is mediated by tobacco COI1 and JAZ genes. Plant Cell Physiol. 49: 1003-1012 (2008).
Shoji T, Winz R, Iwase T, Nakajima K, Yamada Y, Hashimoto T. Expression patterns of two tobacco isoflavone reductase-like genes and their possible roles in secondary metabolism in tobacco. Plant Mol. Biol. 50: 427-440 (2002).
Shukla AK, Shasany AK, Gupta MM, Khanuja SP. Transcriptome analysis in Catharanthus roseus leaves and roots for comparative terpenoid indole alkaloid profiles. J. Exp. Bot. 57: 3921-3932 (2006).
Siberil Y, Benhamron S, Memelink J, Giglioli-Guivarc'h N, Thiersault M, Boisson B, Doireau P, Gantet P. Catharanthus roseus G-box binding factors 1 and 2 act as repressors of strictosidine synthase gene expression in cell cultures. Plant Mol. Biol. 45: 477-488 (2001).
Siberil Y, Thiersault M, Nepumoceno G, Doireau P, Gantet P. Cloning of a cDNA encoding an E2 ubiquitin-conjugating enzyme from Catharanthus roseus: expression analysis in plant organs and in response to hormones in cell suspensions. J. Exp. Bot. 53: 149-150 (2002).
Simons L, Bultman TL, Sullivan TJ. Effects of methyl jasmonate and an endophytic fungus on plant resistance to insect herbivores. J. Chem. Ecol. 34: 1511-1517 (2008).
Simons V, Morrissey JP, Latijnhouwers M, Csukai M, Cleaver A, Yarrow C, Osbourn A. Dual effects of plant steroidal alkaloids on Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 50: 2732-2740 (2006).
Sinclair SJ, Murphy KJ, Birch CD, Hamill JD. Molecular characterization of quinolinate phosphoribosyltransferase (QPRtase) in Nicotiana. Plant Mol. Biol. 44: 603-617 (2000).
Sirikantaramas S, Sudo H, Asano T, Yamazaki M, Saito K. Transport of camptothecin in hairy roots of Ophiorrhiza pumila. Phytochemistry 68: 2881-2886 (2007).
Sirikantaramas S, Yamazaki M, Saito K. Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants. Proc. Natl. Acad. Sci. U.S.A. 105: 6782-6786 (2008).
Smith SW, Giesbrecht E, Thompson M, Nelson LS, Hoffman RS. Solanaceous steroidal glycoalkaloids and poisoning by Solanum torvum, the normally edible susumber berry. Toxicon. 52: 667-676 (2008).
Sorensen KK, Kirk HG, Olsson K, Labouriau R, Christiansen J. A major QTL and an SSR marker associated with glycoalkaloid content in potato tubers from Solanum tuberosum x S. sparsipilum located on chromosome I. Theor. Appl. Genet. 117: 1-9 (2008).
Sotelo A, Sousa H, Sanchez M. Comparative study of the chemical composition of wild and cultivated beans (Phaseolus vulgaris). Plant Foods Hum. Nutr. 47: 93-100 (1995).
Spiering MJ, Davies E, Tapper BA, Schmid J, Lane GA. Simplified extraction of ergovaline and peramine for analysis of tissue distribution in endophyte-infected grass tillers. J. Agric. Food Chem. 50: 5856-5862 (2002).
Spiering MJ, Faulkner JR, Zhang DX, Machado C, Grossman RB, Schardl CL. Role of the LolP cytochrome P450 monooxygenase in loline alkaloid biosynthesis. Fungal Genet. Biol. 45: 1307-1314 (2008).
Spiering MJ, Greer DH, Schmid J. Effects of the fungal endophyte, Neotyphodium lolii, on net photosynthesis and growth rates of perennial ryegrass (Lolium perenne) are independent of In Planta endophyte concentration. Ann. Bot. (Lond.) 98: 379-387 (2006).
Sriram G, Gonzalez-Rivera O, Shanks JV. Determination of biomass composition of Catharanthus roseus hairy roots for metabolic flux analysis. Biotechnol. Prog. 22: 1659-1663 (2006).
St-Pierre B, Vazquez-Flota FA, De Luca V. Multicellular compartmentation of Catharanthus roseus alkaloid biosynthesis predicts intercellular translocation of a pathway intermediate. Plant Cell 11: 887-900 (1999).
Stafford GI, Pedersen ME, van Staden J, Jager AK. Review on plants with CNS-effects used in traditional South African medicine against mental diseases. J. Ethnopharmacol. 119: 513-537 (2008).
Steiner U, Ahimsa-Muller MA, Markert A, Kucht S, Gross J, Kauf N, Kuzma M, Zych M, Lamshoft M, Furmanowa M, Knoop V, Drewke C, Leistner E. Molecular characterization of a seed transmitted clavicipitaceous fungus occurring on dicotyledoneous plants (Convolvulaceae). Planta 224: 533-544 (2006).
Stenzel O, Teuber M, Drager B. Putrescine N-methyltransferase in Solanum tuberosum L., a calystegine-forming plant. Planta 223: 200-212 (2006).
Stewart C Jr, Kang BC, Liu K, Mazourek M, Moore SL, Yoo EY, Kim BD, Paran I, Jahn MM. The Pun1 gene for pungency in pepper encodes a putative acyltransferase. Plant J. 42: 675-688 (2005).
Stobiecki M, Matysiak-Kata I, Franski R, Skala J, Szopa J. Monitoring changes in anthocyanin and steroid alkaloid glycoside content in lines of transgenic potato plants using liquid chromatography/mass spectrometry. Phytochemistry 62: 959-969 (2003).
Stockigt J, Barleben L, Panjikar S, Loris EA. 3D-structure and function of strictosidine synthase - the key enzyme of monoterpenoid indole alkaloid biosynthesis. Plant Physiol. Biochem. 46: 340-355 (2008).
Sun J, Lou H, Dai S, Xu H, Zhao F, Liu K. Indole alkoloids from Nauclea officinalis with weak antimalarial activity. Phytochemistry 69: 1405-1410 (2008).
Sun L, Ruppert M, Sheludko Y, Warzecha H, Zhao Y, Stockigt J. Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia. Plant Mol. Biol. 67: 455-467 (2008).
Szabo LF. Rigorous biogenetic network for a group of indole alkaloids derived from strictosidine. Molecules 13: 1875-1896 (2008).
Tabopda TK, Ngoupayo J, Liu J, Mitaine-Offer AC, Tanoli SA, Khan SN, Ali MS, Ngadjui BT, Tsamo E, Lacaille-Dubois MA, Luu B. Bioactive aristolactams from Piper umbellatum. Phytochemistry 69: 1726-1731 (2008).
Takats Z, Wiseman JM, Gologan B, Cooks RG. Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 306: 471-473 (2004).
Takigawa N, Tanimoto M. Vinca alkaloid and MDR1. Gan To Kagaku Ryoho 35: 1086-1089 (2008).
Tan LT. Bioactive natural products from marine cyanobacteria for drug discovery. Phytochemistry 68: 954-979 (2007).
Tanaka H, Hattori H, Tanaka T, Sakai E, Tanaka N, Kulkarni A, Etoh H. A new Erythrina alkaloid from Erythrina herbacea. Nat. Med. (Tokyo) 62: 228-231 (2008).
Terasaka K, Sakai K, Sato F, Yamamoto H, Yazaki K. Thalictrum minus cell cultures and ABC-like transporter. Phytochemistry 62: 483-489 (2003).
Teuber M, Azemi ME, Namjoyan F, Meier AC, Wodak A, Brandt W, Drager B. Putrescine N-methyltransferases - a structure-function analysis. Plant Mol. Biol. 63: 787-801 (2007).
Tiburcio AF, Kaur-Sawhney R, Ingersoll RB, Galston AW. Correlation between polyamines and pyrrolidine alkaloids in developing tobacco callus. Plant Physiol. 78: 323-326 (1985).
Tozawa Y, Hasegawa H, Terakawa T, Wakasa K. Characterization of rice anthranilate synthase alpha-subunit genes OASA1 and OASA2. Tryptophan accumulation in transgenic rice expressing a feedback-insensitive mutant of OASA1. Plant Physiol. 126: 1493-1506 (2001).
Treimer JF, Zenk MH. Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation. Eur. J. Biochem. 101: 225-233 (1979).
Tudzynski P, Holter K, Correia T, Arntz C, Grammel N, Keller U. Evidence for an ergot alkaloid gene cluster in Claviceps purpurea. Mol. Gen. Genet. 261: 133-141 (1999).
Tundis R, Menichini F, Conforti F, Loizzo MR, Bonesi M, Statti G, Menichini F. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J. Enzyme Inhib. Med. Chem. 24: 818-824 (2009).
Uhlig S, Petersen D. Lactam ergot alkaloids (ergopeptams) as predominant alkaloids in sclerotia of Claviceps purpurea from Norwegian wild grasses. Toxicon. 52: 175-185 (2008).
Unterlinner B, Lenz R, Kutchan TM. Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum. Plant J. 18: 465-475 (1999).
van der Fits L, Memelink J. ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism. Science 289: 295-297 (2000).
van der Fits L, Zhang H, Menke FL, Deneka M, Memelink J. A Catharanthus roseus BPF-1 homologue interacts with an elicitor-responsive region of the secondary metabolite biosynthetic gene Str and is induced by elicitor via a JA-independent signal transduction pathway. Plant Mol. Biol. 44: 675-685 (2000).
Vazquez-Flota F, Hernandez-Dominguez E, de Lourdes Miranda-Ham M, Monforte-Gonzalez M. A differential response to chemical elicitors in Catharanthus roseus in vitro cultures. Biotechnol. Lett. 31: 591-595 (2009).
Vazquez-Flota FA, De Luca V. Jasmonate modulates development- and light-regulated alkaloid biosynthesis in Catharanthus roseus. Phytochemistry 49: 395-402 (1998).
Viehweger K, Schwartze W, Schumann B, Lein W, Roos W. The Galpha protein controls a pH-dependent signal path to the induction of phytoalexin biosynthesis in Eschscholzia californica. Plant Cell 18: 1510-1523 (2006).
Vom Endt D, Kijne JW, Memelink J. Transcription factors controlling plant secondary metabolism: what regulates the regulators? Phytochemistry 61: 107-114 (2002).
Vom Endt D, Soares e Silva M, Kijne JW, Pasquali G, Memelink J. Identification of a bipartite jasmonate-responsive promoter element in the Catharanthus roseus ORCA3 transcription factor gene that interacts specifically with AT-Hook DNA-binding proteins. Plant Physiol. 144: 1680-1689 (2007).
Vu H, Pham NB, Quinn RJ. Direct screening of natural product extracts using mass spectrometry. J. Biomol. Screen. 13: 265-275 (2008).
Wang B, Yang S, Hou Y, Zeng X, Wu Y, Xu G. Rapid determination of alkaloids in tobacco using gas chromatography-mass spectrometry with full scan-selected ion monitoring mode. Se. Pu. 26: 314-317 (2008).
Wang BL, Liu J, Tian ZD, Song BT, Xie CH. Monitoring the expression patterns of potato genes associated with quantitative resistance to late blight during Phytophthora infestans infection using cDNA microarrays. Plant Sci. 169: 1155-1167 (2005).
Wang F, Ren FC, Liu JK. Alstonic acids A and B, unusual 2,3-secofernane triterpenoids from Alstonia scholaris. Phytochemistry 70: 650-654 (2009).
Wang JY, Liu ZP, Liu L, Liu C. Effects of NaCl on the growth and alkaloid content of Catharanthus roseus seedlings. Ying Yong Sheng Tai Xue Bao 19: 2143-2148 (2008).
Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O. Piperine, the potential functional food for mood and cognitive disorders. Food Chem. Toxicol. 46: 3106-3110 (2008).
Weid M, Ziegler J, Kutchan TM. The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum. Proc. Natl. Acad. Sci. U.S.A. 101: 13957-13962 (2004).
Weiss D, Baumert A, Vogel M, Roos W. Sanguinarine reductase, a key enzyme of benzophenanthridine detoxification. Plant Cell Environ. 29: 291-302 (2006).
Whitbred JM, Schuler MA. Molecular characterization of CYP73A9 and CYP82A1 P450 genes involved in plant defense in pea. Plant Physiol. 124: 47-58 (2000).
Whitmer S, Canel C, Hallard D, Goncalves C, Verpoorte R. Influence of precursor availability on alkaloid accumulation by transgenic cell line of Catharanthus roseus. Plant Physiol. 116: 853-857 (1998).
Wieland K, Thiele B, Schurr U. Analysis of alkaloids in single plant cells by capillary electrophoresis. Methods Mol. Biol. 384: 771-782 (2008).
Wooten JB, Kalengamaliro NE, Axelson DE. Characterization of bright tobaccos by multivariate analysis of 13C CPMAS NMR spectra. Phytochemistry 70: 940-951 (2009).
Wu TS, Leu YL, Hsu HC, Ou LF, Chen CC, Chen CF, Ou JC, Wu YC. Constituents and cytotoxic principles of Nothapodytes foetida. Phytochemistry 39: 383-385 (1995).
Xing J, Yang Z, Lv B, Xiang L. Rapid screening for cyclo-dopa and diketopiperazine alkaloids in crude extracts of Portulaca oleracea L. using liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 22: 1415-1422 (2008).
Yamazaki Y, Kitajima M, Arita M, Takayama H, Sudo H, Yamazaki M, Aimi N, Saito K. Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose. Plant Physiol. 134: 161-170 (2004).
Yamazaki Y, Urano A, Sudo H, Kitajima M, Takayama H, Yamazaki M, Aimi N, Saito K. Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants. Phytochemistry 62: 461-470 (2003).
Yang XZ, Zhu JY, Tang CP, Ke CQ, Lin G, Cheng TY, Rudd JA, Ye Y. Alkaloids from roots of Stemona sessilifolia and their antitussive activities. Planta Med. 75: 174-177 (2009).
Yazaki K. ABC transporters involved in the transport of plant secondary metabolites. FEBS Lett. 580: 1183-1191 (2006).
Zhang DX, Nagabhyru P, Schardl CL. Regulation of a chemical defense against herbivory produced by symbiotic fungi in grass plants. Plant Physiol. 150: 1072-1082 (2009).
Zhang L, Yang B, Lu B, Kai G, Wang Z, Xia Y, Ding R, Zhang H, Sun X, Chen W, Tang K. Tropane alkaloids production in transgenic Hyoscyamus niger hairy root cultures over-expressing putrescine N-methyltransferase is methyl jasmonate-dependent. Planta 225: 887-896 (2007).
Zhang X, Ye W, Zhao S, Che CT. Isoquinoline and isoindole alkaloids from Menispermum dauricum. Phytochemistry 65: 929-932 (2004).
Zhou ML, Shao JR, Tang YX. Production and metabolic engineering of terpenoid indole alkaloids in cell cultures of the medicinal plant Catharanthus roseus (L.) G. Don (Madagascar periwinkle). Biotechnol. Appl. Biochem. 52: 313-323 (2009).
Zhou YT, Wang HY, Zhou L, Wang MP, Li HP, Wang ML, Zhao Y. Analyses of the floral organ morphogenesis and the differentially expressed genes of an apetalous flower mutant in Brassica napus. Plant Cell Rep. 27: 9-20 (2008).
Ziegler J, Diaz-Chavez ML, Kramell R, Ammer C, Kutchan TM. Comparative macroarray analysis of morphine containing Papaver somniferum and eight morphine free Papaver species identifies an O-methyltransferase involved in benzylisoquinoline biosynthesis. Planta 222: 458-471 (2005).
Ziegler J, Facchini PJ, GeiBler R, Schmidt J, Ammer C, Kramell R, Voigtlander S, Gesell A, Pienkny S, Brandt W. Evolution of morphine biosynthesis in opium poppy. Phytochemistry Aug 6 [Epub ahead of print] (2009).
Ziegler J, Voigtlander S, Schmidt J, Kramell R, Miersch O, Ammer C, Gesell A, Kutchan TM. Comparative transcript and alkaloid profiling in Papaver species identifies a short chain dehydrogenase/reductase involved in morphine biosynthesis. Plant J. 48: 177-192 (2006).
Zulak KG, Cornish A, Daskalchuk TE, Deyholos MK, Goodenowe DB, Gordon PM, Klassen D, Pelcher LE, Sensen CW, Facchini PJ. Gene transcript and metabolite profiling of elicitor-induced opium poppy cell cultures reveals the coordinate regulation of primary and secondary metabolism. Planta 225: 1085-1106 (2007).
Zulak KG, Khan MF, Alcantara J, Schriemer DC, Facchini PJ. Plant defense responses in opium poppy cell cultures revealed by liquid chromatography-tandem mass spectrometry proteomics. Mol. Cell. Proteomics 8: 86-98 (2009).
Number of references = 486
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