Purdue University Logo
Department of Horticulture and Landscape Architecture
 
Horticulture Home Page
Agriculture Home Page
Purdue Home Page
Blackboard
HORT640 Home Page
N Use By Plants
Nitrate Assimilation
Ammonia Assimilation
Glu, Gln, Asn, Gly, Ser
Aminotransferases
Asp, Ala, GABA
Val, Leu, Ileu, Thr, Lys
Pro, Arg, Orn
Polyamines
Non-protein AAs
Alkaloids
Sulfate Assimilation
Cys, Met, AdoMet, ACC
His, Phe, Tyr, Tryp
Secondary Products
Onium Compounds
Enzymes
Methods
Simulation
References
HORT640 - Metabolic Plant Physiology

References, P450 or P-450

Abdulrazzak N, Pollet B, Ehlting J, Larsen K, Asnaghi C, Ronseau S, Proux C, Erhardt M, Seltzer V, Renou JP, Ullmann P, Pauly M, Lapierre C, Werck-Reichhart D. A coumaroyl-ester-3-hydroxylase insertion mutant reveals the existence of nonredundant meta-hydroxylation pathways and essential roles for phenolic precursors in cell expansion and plant growth. Plant Physiol. 140: 30-48 (2006).

Aharoni A, Giri AP, Verstappen FW, Bertea CM, Sevenier R, Sun Z, Jongsma MA, Schwab W, Bouwmeester HJ. Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species. Plant Cell 16: 3110-3131 (2004).

Akashi T, Aoki T, Ayabe Si. Cloning and functional expression of a cytochrome P450 cDNA encoding 2-hydroxyisoflavanone synthase involved in biosynthesis of the isoflavonoid skeleton in licorice. Plant Physiol. 121: 821-828 (1999).

Andersen MD, Busk PK, Svendsen I, Moller BL. Cytochromes P-450 from cassava (Manihot esculenta Crantz) catalyzing the first steps in the biosynthesis of the cyanogenic glucosides linamarin and lotaustralin. Cloning, functional expression in Pichia pastoris, and … J. Biol. Chem. 275: 1966-1975 (2000).

Aniya Y, Anders MW. Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species. J. Biol. Chem. 264: 1998-2002 (1989).

Arimoto R. Computational models for predicting interactions with cytochrome P450 enzyme. Curr. Top. Med. Chem. 6: 1609-1618 (2006).

Aya K, Ueguchi-Tanaka M, Kondo M, Hamada K, Yano K, Nishimura M, Matsuoka M. Gibberellin modulates anther development in rice via the transcriptional regulation of GAMYB. Plant Cell 21: 1453-1472 (2009).

Baerson SR, Dayan FE, Rimando AM, Nanayakkara NP, Liu CJ, Schroder J, Fishbein M, Pan Z, Kagan IA, Pratt LH, Cordonnier-Pratt MM, Duke SO. A functional genomics investigation of allelochemical biosynthesis in Sorghum bicolor root hairs. J. Biol. Chem. 283: 3231-3247 (2008).

Bagnasco SM, Montrose MH, Handler JS. Role of calcium in organic osmolyte efflux when MDCK cells are shifted from hypertonic to isotonic medium. Am. J. Physiol. 264: C1165-C1170 (1993).

Bak S, Feyereisen R. The involvement of two P450 enzymes, CYP83B1 and CYP83A1, in auxin homeostasis and glucosinolate biosynthesis. Plant Physiol. 127: 108-118 (2001).

Bak S, Kahn RA, Nielsen HL, Moller BL, Halkier BA. Cloning of three A-type cytochromes P450, CYP71E1, CYP98, and CYP99 from Sorghum bicolor (L.) Moench by a PCR approach and identification by expression in Escherichia coli of CYP71E1 as a multifunctional cytochrome P450 … Plant Mol. Biol. 36: 393-405 (1998).

Bak S, Nielsen HL, Halkier BA. The presence of CYP79 homologues in glucosinolate-producing plants shows evolutionary conservation of the enzymes in the conversion of amino acid to aldoxime in the biosynthesis of cyanogenic glucosides and glucosinolates. Plant Mol. Biol. 38: 725-734 (1998).

Bak S, Olsen CE, Halkier BA, Moller BL. Transgenic tobacco and Arabidopsis plants expressing the two multifunctional sorghum cytochrome P450 enzymes, CYP79A1 and CYP71E1, are cyanogenic and accumulate metabolites derived from intermediates in dhurrin biosynthesis. Plant Physiol. 123: 1437-1448 (2000).

Bak S, Olsen CE, Petersen BL, Moller BL, Halkier BA. Metabolic engineering of p-hydroxybenzylglucosinolate in Arabidopsis by expression of the cyanogenic CYP79A1 from Sorghum bicolor. Plant J. 20: 663-671 (1999).

Bak S, Tax FE, Feldmann KA, Galbraith DW, Feyereisen R. CYP83B1, a cytochrome P450 at the metabolic branch point in auxin and indole glucosinolate biosynthesis in Arabidopsis. Plant Cell 13: 101-111 (2001).

Bancos S, Nomura T, Sato T, Molnar G, Bishop GJ, Koncz C, Yokota T, Nagy F, Szekeres M. Regulation of transcript levels of the Arabidopsis cytochrome P450 genes involved in brassinosteroid biosynthesis. Plant Physiol. 130: 504-513 (2002).

Bate NJ, Sivasankar S, Moxon C, Riley JM, Thompson JE, Rothstein SJ. Molecular characterization of an Arabidopsis gene encoding hydroperoxide lyase, a cytochrome P-450 that is wound inducible. Plant Physiol. 117: 1393-1400 (1998).

Bell-Lelong DA, Cusumano JC, Meyer K, Chapple C. Cinnamate-4-hydroxylase expression in Arabidopsis. Regulation in response to development and the environment. Plant Physiol. 113: 729-738 (1997).

Bennett R, Donald A, Dawson G, Hick A, Wallsgrove R. Aldoxime-forming microsomal enzyme systems involved in the biosynthesis of glucosinolates in oilseed rape (Brassica napus) leaves. Plant Physiol. 102: 1307-1312 (1993).

Bennett RN, Hick AJ, Dawson GW, Wallsgrove RM. Glucosinolate biosynthesis. Further characterization of the aldoxime-forming microsomal monooxygenases in oilseed rape leaves. Plant Physiol. 109: 299-305 (1995).

Bennett RN, Kiddle G, Wallsgrove RM. Involvement of cytochrome P450 in glucosinolate biosynthesis in white mustard. A biochemical anomaly. Plant Physiol. 114: 1283-1291 (1997).

Benveniste I, Bronner R, Wang Y, Compagnon V, Michler P, Schreiber L, Salaun JP, Durst F, Pinot F. CYP94A1, a plant cytochrome P450-catalyzing fatty acid omega-hydroxylase, is selectively induced by chemical stress in Vicia sativa seedlings. Planta 221: 881-890 (2005).

Bilodeau P, Udvardi MK, Peacock WJ, Dennis ES. A prolonged cold treatment-induced cytochrome P450 gene from Arabidopsis thaliana. Plant Cell Environ. 22: 791-800 (1999).

Blee K, Choi JW, O'Connell AP, Jupe SC, Schuch W, Lewis NG, Bolwell GP. Antisense and sense expression of cDNA coding for CYP73A15, a class II cinnamate 4-hydroxylase, leads to a delayed and reduced production of lignin in tobacco. Phytochemistry 57: 1159-1166 (2001).

Blount JW, Masoud S, Sumner LW, Huhman D, Dixon RA. Over-expression of cinnamate 4-hydroxylase leads to increased accumulation of acetosyringone in elicited tobacco cell-suspension cultures. Planta 214: 902-910 (2002).

Bogaards JJ, Hissink EM, Briggs M, Weaver R, Jochemsen R, Jackson P, Bertrand M, van Bladeren PJ. Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling. Eur. J. Pharm. Sci. 12: 117-124 (2000).

Boudet AM. Evolution and current status of research in phenolic compounds. Phytochemistry 68: 2722-2735 (2007).

Braker G, Tiedje JM. Nitric oxide reductase (norB) genes from pure cultures and environmental samples. Appl. Environ. Microbiol. 69: 3476-3483 (2003).

Burlat V, Oudin A, Courtois M, Rideau M, St-Pierre B. Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids… Plant J. 38: 131-141 (2004).

Buse EL, Laties GG. Ethylene-mediated posttranscriptional regulation in ripening avocado (Persea americana) mesocarp discs. Plant Physiol. 102: 417-423 (1993).

Cahoon EB, Ripp KG, Hall SE, McGonigle B. Transgenic production of epoxy fatty acids by expression of a cytochrome P450 enzyme from Euphorbia lagascae seed. Plant Physiol. 128: 615-624 (2002).

Celenza JL. Metabolism of tyrosine and tryptophan - new genes for old pathways. Curr. Opin. Plant Biol. 4: 234-240 (2001).

Chaban C, Waller F, Furuya M, Nick P. Auxin responsiveness of a novel cytochrome p450 in rice coleoptiles. Plant Physiol. 133: 2000-2009 (2003).

Chakrabarti M, Bowen SW, Coleman NP, Meekins KM, Dewey RE, Siminszky B. CYP82E4-mediated nicotine to nornicotine conversion in tobacco is regulated by a senescence-specific signaling pathway. Plant Mol. Biol. 66: 415-427 (2008).

Chakrabarti M, Meekins KM, Gavilano LB, Siminszky B. Inactivation of the cytochrome P450 gene CYP82E2 by degenerative mutations was a key event in the evolution of the alkaloid profile of modern tobacco. New Phytol. 175: 565-574 (2007).

Chapple C. Molecular-genetic analysis of plant cytochrome P450-dependent monooxygenases. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49: 311-343 (1998).

Chapple CC. A cDNA encoding a novel cytochrome P450-dependent monooxygenase from Arabidopsis thaliana. Plant Physiol. 108: 875-876 (1995).

Chemler JA, Koffas MA. Metabolic engineering for plant natural product biosynthesis in microbes. Curr. Opin. Biotechnol. 19: 597-605 (2008).

Chen S, Glawischnig E, Jorgensen K, Naur P, Jorgensen B, Olsen CE, Hansen CH, Rasmussen H, Pickett JA, Halkier BA. CYP79F1 and CYP79F2 have distinct functions in the biosynthesis of aliphatic glucosinolates in Arabidopsis. Plant J. 33: 923-937 (2003).

Chen SY, Lin JR, Darbha R, Lin P, Liu TY, Chen YM. Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway. Cancer Res. 64: 3617-3623 (2004).

Chiu TL, Wen Z, Rupasinghe SG, Schuler MA. Comparative molecular modeling of Anopheles gambiae CYP6Z1, a mosquito P450 capable of metabolizing DDT. Proc. Natl. Acad. Sci. U.S.A. 105: 8855-8860 (2008).

Choe S, Dilkes BP, Fujioka S, Takatsuto S, Sakurai A, Feldmann KA. The DWF4 gene of Arabidopsis encodes a cytochrome P450 that mediates multiple 22alpha-hydroxylation steps in brassinosteroid biosynthesis. Plant Cell 10: 231-243 (1998).

Chung KM, Sano H. Transactivation of wound-responsive genes containing the core sequence of the auxin-responsive element by a wound-induced protein kinase-activated transcription factor in tobacco plants. Plant Mol. Biol. 65: 763-773 (2007).

Cirino PC, Tang Y, Takahashi K, Tirrell DA, Arnold FH. Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity. Biotechnol. Bioeng. 83: 729-734 (2003).

Coleman HD, Park JY, Nair R, Chapple C, Mansfield SD. RNAi-mediated suppression of p-coumaroyl-CoA 3'-hydroxylase in hybrid poplar impacts lignin deposition and soluble secondary metabolism. Proc. Natl. Acad. Sci. U.S.A. 105: 4501-4506 (2008).

Combourieu B, Elfoul L, Delort AM, Rabot S. Identification of new derivatives of sinigrin and glucotropaeolin produced by the human digestive microflora using H-1 NMR spectroscopy analysis of in vitro incubations. Drug Metab. Dispos. 29: 1440-1445 (2001).

Cooper LD, Doss RP, Price R, Peterson K, Oliver JE. Application of Bruchin B to pea pods results in the up-regulation of CYP93C18, a putative isoflavone synthase gene, and an increase in the level of pisatin, an isoflavone phytoalexin. J. Exp. Bot. 56: 1229-1237 (2005).

Covello PS, Teoh KH, Polichuk DR, Reed DW, Nowak G. Functional genomics and the biosynthesis of artemisinin. Phytochemistry 68: 1864-1871 (2007).

Crivori P, Poggesi I. Computational approaches for predicting CYP-related metabolism properties in the screening of new drugs. Eur. J. Med. Chem. 41: 795-808 (2006).

Cutler AJ, Krochko JE. Formation and breakdown of ABA. Trends Plant Sci. 4: 472-478 (1999).

Davidson SE, Elliott RC, Helliwell CA, Poole AT, Reid JB. The pea gene NA encodes ent-kaurenoic acid oxidase. Plant Physiol. 131: 335-344 (2003).

Davidson SE, Smith JJ, Helliwell CA, Poole AT, Reid JB. The pea gene LH encodes ent-kaurene oxidase. Plant Physiol. 134: 1123-1134 (2004).

Davies C, Robinson SP. Differential screening indicates a dramatic change in mRNA profiles during grape berry ripening. Cloning and characterization of cDNAs encoding putative cell wall and stress response proteins. Plant Physiol. 122: 803-812 (2000).

Dayan FE, Watson SB, Nanayakkara NP. Biosynthesis of lipid resorcinols and benzoquinones in isolated secretory plant root hairs. J. Exp. Bot. 58: 3263-3272 (2007).

De Bartolo L, Salerno S, Curcio E, Piscioneri A, Rende M, Morelli S, Tasselli F, Bader A, Drioli E. Human hepatocyte functions in a crossed hollow fiber membrane bioreactor. Biomaterials 30: 2531-2543 (2009).

De Kraker JW, Franssen MC, Joerink M, De Groot A, Bouwmeester HJ. Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome P450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory. Plant Physiol. 129: 257-268 (2002).

De Luca V, St Pierre B. The cell and developmental biology of alkaloid biosynthesis. Trends Plant Sci. 5: 168-173 (2000).

De Mot R, Parret AH. A novel class of self-sufficient cytochrome P450 monooxygenases in prokaryotes. Trends Microbiol. 10: 502-508 (2002).

de Vetten N, ter Horst J, van Schaik HP, de Boer A, Mol J, Koes R. A cytochrome b5 is required for full activity of flavonoid 3', 5'-hydroxylase, a cytochrome P450 involved in the formation of blue flower colors. Proc. Natl. Acad. Sci. U.S.A. 96: 778-783 (1999).

de Virville JD, Cochet F, Tasseva G, Moreau F, Zachowski A. Changes in electron transport pathways in endoplasmic reticulum of rapeseed in response to cold. Planta 228: 875-882 (2008).

del Rio LA, Corpas FJ, Barroso JB. Nitric oxide and nitric oxide synthase activity in plants. Phytochemistry 65: 783-792 (2004).

Didierjean L, Gondet L, Perkins R, Lau SM, Schaller H, O'Keefe DP, Werck-Reichhart D. Engineering herbicide metabolism in tobacco and Arabidopsis with CYP76B1, a cytochrome P450 enzyme from Jerusalem artichoke. Plant Physiol. 130: 179-189 (2002).

Dixon RA. Plant natural products: the molecular genetic basis of biosynthetic diversity. Curr. Opin. Biotechnol. 10: 192-197 (1999).

Dragan CA, Blank LM, Bureik M. Increased TCA cycle activity and reduced oxygen consumption during cytochrome P450-dependent biotransformation in fission yeast. Yeast 23: 779-794 (2006).

Du L, Halkier BA. Isolation of a microsomal enzyme system involved in glucosinolate biosynthesis from seedlings of Tropaeolum majus L. Plant Physiol. 111: 831-837 (1996).

Du L, Lykkesfeldt J, Olsen CE, Halkier BA. Involvement of cytochrome P450 in oxime production in glucosinolate biosynthesis as demonstrated by an in vitro microsomal enzyme system isolated from jasmonic acid-induced seedlings of Sinapis alba L. Proc. Natl. Acad. Sci. U.S.A. 92: 12505-12509 (1995).

Duan H, Huang MY, Palacio K, Schuler MA. Variations in CYP74B2 (hydroperoxide lyase) gene expression differentially affect hexenal signaling in the Columbia and Landsberg erecta ecotypes of Arabidopsis. Plant Physiol. 139: 1529-1544 (2005).

Duan H, Schuler MA. Differential expression and evolution of the Arabidopsis CYP86A subfamily. Plant Physiol. 137: 1067-1081 (2005).

Durst F, O'Keefe DP. Plant cytochromes P450: an overview. Drug Metabol. Drug Interact. 12: 171-187 (1995).

Eberle D, Ullmann P, Werck-Reichhart D, Petersen M. cDNA cloning and functional characterisation of CYP98A14 and NADPH:cytochrome P450 reductase from Coleus blumei involved in rosmarinic acid biosynthesis. Plant Mol. Biol. 69: 239-253 (2009).

Ekman DR, Lorenz WW, Przybyla AE, Wolfe NL, Dean JF. SAGE analysis of transcriptome responses in Arabidopsis roots exposed to 2,4,6-trinitrotoluene. Plant Physiol. 133: 1397-1406 (2003).

Federolf K, Alfermann AW, Fuss E. Aryltetralin-lignan formation in two different cell suspension cultures of Linum album: deoxypodophyllotoxin 6-hydroxylase, a key enzyme for the formation of 6-methoxypodophyllotoxin. Phytochemistry 68: 1397-1406 (2007).

Fischer M, Knoll M, Sirim D, Wagner F, Funke S, Pleiss J. The Cytochrome P450 Engineering Database: a navigation and prediction tool for the cytochrome P450 protein family. Bioinformatics 23: 2015-2017 (2007).

Flipphi M, Kocialkowska J, Felenbok B. Relationships between the ethanol utilization (alc) pathway and unrelated catabolic pathways in Aspergillus nidulans. Eur. J. Biochem. 270: 3555-3564 (2003).

Foo HL, Gronning LM, Goodenough L, Bones AM, Danielsen B, Whiting DA, Rossiter JT. Purification and characterisation of epithiospecifier protein from Brassica napus: enzymic intramolecular sulphur addition within alkenyl thiohydroximates derived from alkenyl glucosinolate hydrolysis. FEBS Lett. 468: 243-246 (2000).

Forslund K, Morant M, Jorgensen B, Olsen CE, Asamizu E, Sato S, Tabata S, Bak S. Biosynthesis of the nitrile glucosides rhodiocyanoside A and D and the cyanogenic glucosides lotaustralin and linamarin in Lotus japonicus. Plant Physiol. 135: 71-84 (2004).

Fowler S, Zhang H. In vitro evaluation of reversible and irreversible cytochrome P450 inhibition: current status on methodologies and their utility for predicting drug-drug interactions. AAPS J. 10: 410-424 (2008).

Frank MR, Deyneka JM, Schuler MA. Cloning of wound-induced cytochrome P450 monooxygenases expressed in pea. Plant Physiol. 110: 1035-1046 (1996).

Franke R, Humphreys JM, Hemm MR, Denault JW, Ruegger MO, Cusumano JC, Chapple C. The Arabidopsis REF8 gene encodes the 3-hydroxylase of phenylpropanoid metabolism. Plant J. 30: 33-45 (2002).

Franke R, McMichael CM, Meyer K, Shirley AM, Cusumano JC, Chapple C. Modified lignin in tobacco and poplar plants over-expressing the Arabidopsis gene encoding ferulate 5-hydroxylase. Plant J. 22: 223-234 (2000).

Frey M, Chomet P, Glawischnig E, Stettner C, Grun S, Winklmair A, Eisenreich W, Bacher A, Meeley RB, Briggs SP, Simcox K, Gierl A. Analysis of a chemical plant defense mechanism in grasses. Science 277: 696-699 (1997).

Frey M, Kliem R, Saedler H, Gierl A. Expression of a cytochrome P450 gene family in maize. Mol. Gen. Genet. 246: 100-109 (1995).

Froehlich JE, Itoh A, Howe GA. Tomato allene oxide synthase and fatty acid hydroperoxide lyase, two cytochrome P450s involved in oxylipin metabolism, are targeted to different membranes of chloroplast envelope. Plant Physiol. 125: 306-317 (2001).

Fujita S, Ohnishi T, Watanabe B, Yokota T, Takatsuto S, Fujioka S, Yoshida S, Sakata K, Mizutani M. Arabidopsis CYP90B1 catalyses the early C-22 hydroxylation of C27, C28 and C29 sterols. Plant J. 45: 765-774 (2006).

Fukuchi-Mizutani M, Mizutani M, Tanaka Y, Kusumi T, Ohta D. Microsomal electron transfer in higher plants: cloning and heterologous expression of NADH-cytochrome b5 reductase from Arabidopsis. Plant Physiol. 119: 353-362 (1999).

Funk C, Croteau R. Induction and characterization of a cytochrome P-450-dependent camphor hydroxylase in tissue cultures of common sage (Salvia officinalis). Plant Physiol. 101: 1231-1237 (1993).

Galbiati M, Simoni L, Pavesi G, Cominelli E, Francia P, Vavasseur A, Nelson T, Bevan M, Tonelli C. Gene trap lines identify Arabidopsis genes expressed in stomatal guard cells. Plant J. 53: 750-762 (2008).

Gang DR, Beuerle T, Ullmann P, Werck-Reichhart D, Pichersky E. Differential production of meta hydroxylated phenylpropanoids in sweet basil peltate glandular trichomes and leaves is controlled by the activities of specific acyltransferases and hydroxylases. Plant Physiol. 130: 1536-1544 (2002).

Gavilano LB, Coleman NP, Burnley LE, Bowman ML, Kalengamaliro NE, Hayes A, Bush L, Siminszky B. Genetic engineering of Nicotiana tabacum for reduced nornicotine content. J. Agric. Food Chem. 54: 9071-9078 (2006).

Gavilano LB, Siminszky B. Isolation and characterization of the cytochrome P450 gene CYP82E5v2 that mediates nicotine to nornicotine conversion in the green leaves of tobacco. Plant Cell Physiol. 48: 1567-1574 (2007).

Gentile A, Ditt RF, Dias FO, Da Silva MJ, Dornelas MC, Menossi M. Characterization of ScMat1, a putative TFIIH subunit from sugarcane. Plant Cell Rep. 28: 663-672 (2009).

Gerhold D, Lu M, Xu J, Austin C, Caskey CT, Rushmore T. Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays. Physiol. Genomics 5: 161-170 (2001).

Gesell A, Rolf M, Ziegler J, Díaz Chavez ML, Huang FC, Kutchan TM. CYP719B1 is salutaridine synthase, the C-C phenol-coupling enzyme of morphine biosynthesis in opium poppy. J. Biol. Chem. 284: 24432-24442 (2009).

Gierl A, Frey M. Evolution of benzoxazinone biosynthesis and indole production in maize. Planta 213: 493-498 (2001).

Glawischnig E, Grun S, Frey M, Gierl A. Cytochrome P450 monooxygenases of DIBOA biosynthesis: specificity and conservation among grasses. Phytochemistry 50: 925-930 (1999).

Glombitza S, Dubuis PH, Thulke O, Welzl G, Bovet L, Gotz M, Affenzeller M, Geist B, Hehn A, Asnaghi C, Ernst D, Seidlitz HK, Gundlach H, Mayer KF, Martinoia E, Werck-Reichhart D, Mauch F, Schaffner AR. Crosstalk and differential response to abiotic and biotic stressors reflected at the transcriptional level of effector genes from secondary metabolism. Plant Mol. Biol. 54: 817-835 (2004).

Goda H, Shimada Y, Asami T, Fujioka S, Yoshida S. Microarray analysis of brassinosteroid-regulated genes in Arabidopsis. Plant Physiol. 130: 1319-1334 (2002).

Groeneveld P, Rolley N, Kell DB, Kelly SL, Kelly DE. Metabolic control analysis and engineering of the yeast sterol biosynthetic pathway. Mol. Biol. Rep. 29: 27-29 (2002).

Gu R, Fonseca S, Puskas LG, Hackler L Jr, Zvara A, Dudits D, Pais MS. Transcript identification and profiling during salt stress and recovery of Populus euphratica. Tree Physiol. 24: 265-276 (2004).

Gutierrez A, Munro AW, Grunau A, Wolf CR, Scrutton NS, Roberts GC. Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues. Eur. J. Biochem. 270: 2612-2621 (2003).

Hagmann ML, Heller W, Grisebach H. Induction and characterization of a microsomal flavonoid 3'-hydroxylase from parsley cell cultures. Eur. J. Biochem. 134: 547-554 (1983).

Halbwirth H, Stich K. An NADPH and FAD dependent enzyme catalyzes hydroxylation of flavonoids in position 8. Phytochemistry 67: 1080-1087 (2006).

Hall DA, Vander Kooi CW, Stasik CN, Stevens SY, Zuiderweg ER, Matthews RG. Mapping the interactions between flavodoxin and its physiological partners flavodoxin reductase and cobalamin-dependent methionine synthase. Proc. Natl. Acad. Sci. U.S.A. 98: 9521-9526 (2001).

Hamberger B, Bohlmann J. Cytochrome P450 mono-oxygenases in conifer genomes: discovery of members of the terpenoid oxygenase superfamily in spruce and pine. Biochem. Soc. Trans. 34: 1209-1214 (2006).

Hansen CH, Du L, Naur P, Olsen CE, Axelsen KB, Hick AJ, Pickett JA, Halkier BA. CYP83b1 is the oxime-metabolizing enzyme in the glucosinolate pathway in Arabidopsis. J. Biol. Chem. 276: 24790-24796 (2001).

Hansen CH, Wittstock U, Olsen CE, Hick AJ, Pickett JA, Halkier BA. Cytochrome P450 CYP79F1 from Arabidopsis catalyzes the conversion of dihomomethionine and trihomomethionine to the corresponding aldoximes in the biosynthesis of aliphatic glucosinolates. J. Biol. Chem. 276: 11078-11085 (2001).

Hayes JD, Kelleher MO, Eggleston IM. The cancer chemopreventive actions of phytochemicals derived from glucosinolates. Eur. J. Nutr. 47 Suppl. 2: 73-88 (2008).

Hedden P, Kamiya Y. Gibberellin biosynthesis: enzymes, genes and their regulation. Annu. Rev. Plant Physiol. Plant Mol. Biol. 48: 431-460 (1997).

Hefner J, Rubenstein SM, Ketchum RE, Gibson DM, Williams RM, Croteau R. Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis. Chem. Biol. 3: 479-489 (1996).

Hemm MR, Ruegger MO, Chapple C. The Arabidopsis ref2 mutant is defective in the gene encoding CYP83A1 and shows both phenylpropanoid and glucosinolate phenotypes. Plant Cell 15: 179-194 (2003).

Hemmati S, Schneider B, Schmidt TJ, Federolf K, Alfermann AW, Fuss E. Justicidin B 7-hydroxylase, a cytochrome P450 monooxygenase from cell cultures of Linum perenne Himmelszelt involved in the biosynthesis of diphyllin. Phytochemistry 68: 2736-2743 (2007).

Hezari M, Croteau R. Taxol biosynthesis: an update. Planta Med. 63: 291-295 (1997).

Hoecker U, Toledo-Ortiz G, Bender J, Quail PH. The photomorphogenesis-related mutant red1 is defective in CYP83B1, a red light-induced gene encoding a cytochrome P450 required for normal auxin homeostasis. Planta 219: 195-200 (2004).

Hofer R, Briesen I, Beck M, Pinot F, Schreiber L, Franke R. The Arabidopsis cytochrome P450 CYP86A1 encodes a fatty acid omega-hydroxylase involved in suberin monomer biosynthesis. J. Exp. Bot. 59: 2347-2360 (2008).

Hoffmann L, Maury S, Martz F, Geoffroy P, Legrand M. Purification, cloning, and properties of an acyltransferase controlling shikimate and quinate ester intermediates in phenylpropanoid metabolism. J. Biol. Chem. 278: 95-103 (2003).

Holton TA. Modification of flower colour via manipulation of P450 gene expression in transgenic plants. Drug Metabol. Drug Interact. 12: 359-368 (1995).

Holton TA, Brugliera F, Lester DR, Tanaka Y, Hyland CD, Menting JG, Lu CY, Farcy E, Stevenson TW, Cornish EC. Cloning and expression of cytochrome P450 genes controlling flower colour. Nature 366: 276-279 (1993).

Hong Z, Ueguchi-Tanaka M, Umemura K, Uozu S, Fujioka S, Takatsuto S, Yoshida S, Ashikari M, Kitano H, Matsuoka M. A rice brassinosteroid-deficient mutant, ebisu dwarf (d2), is caused by a loss of function of a new member of cytochrome P450. Plant Cell 15: 2900-2910 (2003).

Howe GA, Lee GI, Itoh A, Li L, DeRocher AE. Cytochrome P450-dependent metabolism of oxylipins in tomato. Cloning and expression of allene oxide synthase and fatty acid hydroperoxide lyase. Plant Physiol. 123: 711-724 (2000).

Howe GA, Schilmiller AL. Oxylipin metabolism in response to stress. Curr. Opin. Plant Biol. 5: 230-236 (2002).

Huang MD, Wei FJ, Wu CC, Hsing YI, Huang AH. Analyses of advanced rice anther transcriptomes reveal global tapetum secretory functions and potential proteins for lipid exine formation. Plant Physiol. 149: 694-707 (2009).

Humphreys JM, Chapple C. Molecular 'pharming' with plant P450s. Trends Plant Sci. 5: 271-272 (2000).

Humphreys JM, Hemm MR, Chapple C. New routes for lignin biosynthesis defined by biochemical characterization of recombinant ferulate 5-hydroxylase, a multifunctional cytochrome P450-dependent monooxygenase. Proc. Natl. Acad. Sci. U.S.A. 96: 10045-10050 (1999).

Hyde GE, Crawford NM, Campbell WH. The sequence of squash NADH:nitrate reductase and its relationship to the sequences of other flavoprotein oxidoreductases. A family of flavoprotein pyridine nucleotide cytochrome reductases. J. Biol. Chem. 266: 23542-23547 (1991).

Ikezawa N, Iwasa K, Sato F. CYP719A subfamily of cytochrome P450 oxygenases and isoquinoline alkaloid biosynthesis in Eschscholzia californica. Plant Cell Rep. 28: 123-133 (2009).

Imaishi H, Matsumoto Y, Ishitobi U, Ohkawa H. Encoding of a cytochrome P450-dependent lauric acid monooxygenase by CYP703A1 specifically expressed in the floral buds of petunia hybrida. Biosci. Biotechnol. Biochem. 63: 2082-2090 (1999).

Inoue K. Carotenoid hydroxylation--P450 finally! Trends Plant Sci. 9: 515-517 (2004).

Irmler S, Schroder G, St-Pierre B, Crouch NP, Hotze M, Schmidt J, Strack D, Matern U, Schroder J. Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase. Plant J. 24: 797-804 (2000).

Jager CE, Symons GM, Nomura T, Yamada Y, Smith JJ, Yamaguchi S, Kamiya Y, Weller JL, Yokota T, Reid JB. Characterization of two brassinosteroid C-6 oxidase genes in pea. Plant Physiol. 143: 1894-1904 (2007).

Jameson N, Georgelis N, Fouladbash E, Martens S, Hannah LC, Lal S. Helitron mediated amplification of cytochrome P450 monooxygenase gene in maize. Plant Mol. Biol. 67: 295-304 (2008).

Jennings JC, Coolbaugh RC, Nakata DA, West CA. Characterization and solubilization of kaurenoic acid hydroxylase from Gibberella fujikuroi. Plant Physiol. 101: 925-930 (1993).

Johnson TN, Kerbusch T, Jones B, Tucker GT, Rostami-Hodjegan A, Milligan PA. Assessing the efficiency of mixed effects modelling in quantifying metabolism based drug-drug interactions: using in vitro data as an aid to assess study power. Pharm. Stat. 8: 186-202 (2009).

Kahn RA, Bak S, Svendsen I, Halkier BA, Moller BL. Isolation and reconstitution of cytochrome P450ox and in vitro reconstitution of the entire biosynthetic pathway of the cyanogenic glucoside dhurrin from sorghum. Plant Physiol. 115: 1661-1670 (1997).

Kai K, Shimizu B, Mizutani M, Watanabe K, Sakata K. Accumulation of coumarins in Arabidopsis thaliana. Phytochemistry 67: 379-386 (2006).

Kaltenbach M, Schroder G, Schmelzer E, Lutz V, Schroder J. Flavonoid hydroxylase from Catharanthus roseus: cDNA, heterologous expression, enzyme properties and cell-type specific expression in plants. Plant J. 19: 183-193 (1999).

Kandel S, Morant M, Benveniste I, Blee E, Werck-Reichhart D, Pinot F. Cloning, functional expression and characterization of CYP709C1 the first sub-terminal hydroxylase of long chain fatty acid in plant. Induction by chemicals and methyl jasmonate. J. Biol. Chem. 280: 35881-35889 (2005).

Kandel S, Sauveplane V, Compagnon V, Franke R, Millet Y, Schreiber L, Werck-Reichhart D, Pinot F. Characterization of a methyl jasmonate and wounding-responsive cytochrome P450 of Arabidopsis thaliana catalyzing dicarboxylic fatty acid formation in vitro. FEBS J. 274: 5116-5127 (2007).

Kawakatsu T, Itoh J, Miyoshi K, Kurata N, Alvarez N, Veit B, Nagato Y. PLASTOCHRON2 regulates leaf initiation and maturation in rice. Plant Cell 18: 612-625 (2006).

Keates SE, Kostman TA, Anderson JD, Bailey BA. Altered gene expression in three plant species in response to treatment with nep1, a fungal protein that causes necrosis. Plant Physiol. 132: 1610-1622 (2003).

Kim GT, Fujioka S, Kozuka T, Tax FE, Takatsuto S, Yoshida S, Tsukaya H. CYP90C1 and CYP90D1 are involved in different steps in the brassinosteroid biosynthesis pathway in Arabidopsis thaliana. Plant J. 41: 710-721 (2005).

Kim J, Smith JJ, Tian L, Dellapenna D. The evolution and function of carotenoid hydroxylases in Arabidopsis. Plant Cell Physiol. 50: 463-479 (2009).

Kim TW, Chang SC, Lee JS, Hwang B, Takatsuto S, Yokota T, Kim SK. Cytochrome P450-catalyzed brassinosteroid pathway activation through synthesis of castasterone and brassinolide in Phaseolus vulgaris. Phytochemistry 65: 679-689 (2004).

Kim TW, Hwang JY, Kim YS, Joo SH, Chang SC, Lee JS, Takatsuto S, Kim SK. Arabidopsis CYP85A2, a cytochrome P450, mediates the Baeyer-Villiger oxidation of castasterone to brassinolide in brassinosteroid biosynthesis. Plant Cell 17: 2397-2412 (2005).

Kitada C, Gong Z, Tanaka Y, Yamazaki M, Saito K. Differential expression of two cytochrome P450s involved in the biosynthesis of flavones and anthocyanins in chemo-varietal forms of Perilla frutescens. Plant Cell Physiol. 42: 1338-1344 (2001).

Kitada C, Gong ZZ, Tanaka Y, Yamazaki M, Saito K. Differential expression of two cytochrome P450s involved in the biosynthesis of flavones and anthocyanins in chemo-varietal forms of Perilla frutescens. Plant Cell Physiol. 42: 1338-1344 (2001).

Kitahata N, Saito S, Miyazawa Y, Umezawa T, Shimada Y, Min YK, Mizutani M, Hirai N, Shinozaki K, Yoshida S, Asami T. Chemical regulation of abscisic acid catabolism in plants by cytochrome P450 inhibitors. Bioorg. Med. Chem. 13: 4491-4498 (2005).

Kitazume T, Tanaka A, Takaya N, Nakamura A, Matsuyama S, Suzuki T, Shoun H. Kinetic analysis of hydroxylation of saturated fatty acids by recombinant P450foxy produced by an Escherichia coli expression system. Eur. J. Biochem. 269: 2075-2082 (2002).

Kolattukudy PE. Polyesters in higher plants. Adv. Biochem. Eng. Biotechnol. 71: 1-49 (2001).

Konishi K, Ohta T, Oinuma K, Hashimoto Y, Kitagawa T, Kobayashi M. Discovery of a reaction intermediate of aliphatic aldoxime dehydratase involving heme as an active center. Proc. Natl. Acad. Sci. U.S.A. 103: 564-568 (2006).

Koopmann E, Logemann E, Hahlbrock K. Regulation and functional expression of cinnamate 4-hydroxylase from parsley. Plant Physiol. 119: 49-56 (1999).

Krochko JE, Abrams GD, Loewen MK, Abrams SR, Cutler AJ. (+)-Abscisic acid 8'-hydroxylase is a cytochrome P450 monooxygenase. Plant Physiol. 118: 849-860 (1998).

Kuhn-Velten WN. Effects of compatible solutes on mammalian cytochrome P450 stability. Z. Naturforsch. [C] 52: 132-135 (1997).

Kuhnl T, Koch U, Heller W, Wellmann E. Chlorogenic acid biosynthesis: characterization of a light-induced microsomal 5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase from carrot (Daucus carota L.) cell suspension cultures. Arch. Biochem. Biophys. 258: 226-32 (1987).

Kuo WN, Kocis JM, Webb J. Protein denitration/modification by Escherichia coli nitrate reductase and mammalian cytochrome P-450 reductase. Front. Biosci. 7: A9-A14 (2002).

Kurdyukov S, Faust A, Trenkamp S, Bar S, Franke R, Efremova N, Tietjen K, Schreiber L, Saedler H, Yephremov A. Genetic and biochemical evidence for involvement of HOTHEAD in the biosynthesis of long-chain alpha-,omega-dicarboxylic fatty acids and formation of extracellular matrix. Planta 224: 315-329 (2006).

Lampe JW, Peterson S. Brassica, biotransformation and cancer risk: genetic polymorphisms alter the preventive effects of cruciferous vegetables. J. Nutr. 132: 2991-2994 (2002).

Lapcík O. Isoflavonoids in non-leguminous taxa: a rarity or a rule? Phytochemistry 68: 2909-2916 (2007).

Lee JY, Duke RK, Tran VH, Hook JM, Duke CC. Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry 67: 2550-2560 (2006).

Lee TD, Sadda MR, Mendler MH, Bottiglieri T, Kanel G, Mato JM, Lu SC. Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin. Exp. Res. 28: 173-181 (2004).

Leon J, Shulaev V, Yalpani N, Lawton MA, Raskin I. Benzoic acid 2-hydroxylase, a soluble oxygenase from tobacco, catalyzes salicylic acid biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 92: 10413-10417 (1995).

Leonard E, Yan Y, Koffas MA. Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli. Metab. Eng. 8: 172-181 (2006).

Li H, Sun J, Fan X, Sui X, Zhang L, Wang Y, He Z. Considerations and recent advances in QSAR models for cytochrome P450-mediated drug metabolism prediction. J. Comput. Aided Mol. Des. 22: 843-855 (2008).

Li L, Cheng H, Gai J, Yu D. Genome-wide identification and characterization of putative cytochrome P450 genes in the model legume Medicago truncatula. Planta 226: 109-123 (2007).

Li Y, Beisson F, Koo AJ, Molina I, Pollard M, Ohlrogge J. Identification of acyltransferases required for cutin biosynthesis and production of cutin with suberin-like monomers. Proc. Natl. Acad. Sci. U.S.A. 104: 18339-18344 (2007).

Lieber CS. New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments. Curr. Gastroenterol. Rep. 6: 60-65 (2004).

Lisso J, Altmann T, Mussig C. Metabolic changes in fruits of the tomato d(x) mutant. Phytochemistry 67: 2232-2238 (2006).

Liu CJ, Dixon RA. Elicitor-induced association of isoflavone O-methyltransferase with endomembranes prevents the formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis. Plant Cell 13: 2643-2658 (2001).

Liu CJ, Huhman D, Sumner LW, Dixon RA. Regiospecific hydroxylation of isoflavones by cytochrome p450 81E enzymes from Medicago truncatula. Plant J. 36: 471-484 (2003).

Lucker J, Schwab W, Franssen MC, Van Der Plas LH, Bouwmeester HJ, Verhoeven HA. Metabolic engineering of monoterpene biosynthesis: two-step production of (+)-trans-isopiperitenol by tobacco. Plant J. 39: 135-145 (2004).

Luo P, Wang YH, Wang GD, Essenberg M, Chen XY. Molecular cloning and functional identification of (+)-delta-cadinene-8-hydroxylase, a cytochrome P450 mono-oxygenase (CYP706B1) of cotton sesquiterpene biosynthesis. Plant J. 28: 95-104 (2001).

Ma H, Zhang S, Ji L, Zhu H, Yang S, Fang X, Yang R. Fine mapping and in silico isolation of the EUI1 gene controlling upper internode elongation in rice. Plant Mol. Biol. 60: 87-94 (2006).

Mahesh V, Million-Rousseau R, Ullmann P, Chabrillange N, Bustamante J, Mondolot L, Morant M, Noirot M, Hamon S, de Kochko A, Werck-Reichhart D, Campa C. Functional characterization of two p-coumaroyl ester 3'-hydroxylase genes from coffee tree: evidence of a candidate for chlorogenic acid biosynthesis. Plant Mol. Biol. 64: 145-159 (2007).

Malolepsza U. Nitric oxide production in plants. Postepy. Biochem. 53: 263-271 (2007).

Manabe Y, Tinker N, Colville A, Miki B. CSR1, the sole target of imidazolinone herbicide in Arabidopsis thaliana. Plant Cell Physiol. 48: 1340-1358 (2007).

Martens S, Forkmann G. Cloning and expression of flavone synthase II from Gerbera hybrids. Plant J. 20: 611-618 (1999).

Martens S, Mithofer A. Flavones and flavone synthases. Phytochemistry 66: 2399-2407 (2005).

Matsunaga I, Sumimoto T, Ayata M, Ogura H. Functional modulation of a peroxygenase cytochrome P450: novel insight into the mechanisms of peroxygenase and peroxidase enzymes. FEBS Lett. 528: 90-94 (2002).

Matsuno M, Nagatsu A, Ogihara Y, Ellis BE, Mizukami H. CYP98A6 from Lithospermum erythrorhizon encodes 4-coumaroyl-4'-hydroxyphenyllactic acid 3-hydroxylase involved in rosmarinic acid biosynthesis. FEBS Lett. 514: 219-224 (2002).

McCartney AW, Dyer JM, Dhanoa PK, Kim PK, Andrews DW, McNew JA, Mullen RT. Membrane-bound fatty acid desaturases are inserted co-translationally into the ER and contain different ER retrieval motifs at their carboxy termini. Plant J. 37: 156-173 (2004).

McLean S, Duncan AJ. Pharmacological perspectives on the detoxification of plant secondary metabolites: implications for ingestive behavior of herbivores. J. Chem. Ecol. 32: 1213-1228 (2006).

Meijer AH, Lopes Cardoso MI, Voskuilen JT, de Waal A, Verpoorte R, Hoge JH. Isolation and characterization of a cDNA clone from Catharanthus roseus encoding NADPH:cytochrome P-450 reductase, an enzyme essential for reactions catalysed by cytochrome P-450 mono-oxygenases in plants. Plant J. 4: 47-60 (1993).

Menting JG, Cornish E, Scopes RK. Purification and partial characterization of NADPH-cytochrome c reductase from Petunia hybrida flowers. Plant Physiol. 106: 643-650 (1994).

Meyer K, Cusumano JC, Somerville C, Chapple CC. Ferulate-5-hydroxylase from Arabidopsis thaliana defines a new family of cytochrome P450-dependent monooxygenases. Proc. Natl. Acad. Sci. U.S.A. 93: 6869-6874 (1996).

Meyer K, Shirley AM, Cusumano JC, Bell-Lelong DA, Chapple C. Lignin monomer composition is determined by the expression of a cytochrome P450-dependent monooxygenase in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 95: 6619-6623 (1998).

Mihlan M, Homann V, Liu TW, Tudzynski B. AREA directly mediates nitrogen regulation of gibberellin biosynthesis in Gibberella fujikuroi, but its activity is not affected by NMR. Mol. Microbiol. 47: 975-991 (2003).

Mikkelsen MD, Fuller VL, Hansen BG, Nafisi M, Olsen CE, Nielsen HB, Halkier BA. Controlled indole-3-acetaldoxime production through ethanol-induced expression of CYP79B2. Planta 229: 1209-1217 (2009).

Mikkelsen MD, Halkier BA. Metabolic engineering of valine- and isoleucine-derived glucosinolates in Arabidopsis expressing CYP79D2 from cassava. Plant Physiol. 131: 773-779 (2003).

Mikkelsen MD, Hansen CH, Wittstock U, Halkier BA. Cytochrome P450 CYP79B2 from Arabidopsis catalyzes the conversion of tryptophan to indole-3-acetaldoxime, a precursor of indole glucosinolates and indole-3-acetic acid. J. Biol. Chem. 275: 33712-33717 (2000).

Mikkelsen MD, Petersen BL, Olsen CE, Halkier BA. Biosynthesis and metabolic engineering of glucosinolates. Amino Acids 22: 279-295 (2002).

Miller GP. Advances in the interpretation and prediction of CYP2E1 metabolism from a biochemical perspective. Expert Opin. Drug Metab. Toxicol. 4: 1053-1064 (2008).

Mita G, Quarta A, Fasano P, De Paolis A, Di Sansebastiano GP, Perrotta C, Iannacone R, Belfield E, Hughes R, Tsesmetzis N, Casey R, Santino A. Molecular cloning and characterization of an almond 9-hydroperoxide lyase, a new CYP74 targeted to lipid bodies. J. Exp. Bot. 56: 2321-2333 (2005).

Mizutani M, Ohta D, Sato R. Isolation of a cDNA and a genomic clone encoding cinnamate 4-hydroxylase from Arabidopsis and its expression manner in planta. Plant Physiol. 113: 755-763 (1997).

Mizutani M, Ward E, Ohta D. Cytochrome P450 superfamily in Arabidopsis thaliana: isolation of cDNAs, differential expression, and RFLP mapping of multiple cytochromes P450. Plant Mol. Biol. 37: 39-52 (1998).

Mol J, Cornish E, Mason J, Koes R. Novel coloured flowers. Curr. Opin. Biotechnol. 10: 198-201 (1999).

Molog GA, Empt U, Kuhlmann S, van Uden W, Pras N, Alfermann AW, Petersen M. Deoxypodophyllotoxin 6-hydroxylase, a cytochrome P450 monooxygenase from cell cultures of Linum flavum involved in the biosynthesis of cytotoxic lignans. Planta 214: 288-294 (2001).

Morant M, Bak S, Moller BL, Werck-Reichhart D. Plant cytochromes P450: tools for pharmacology, plant protection and phytoremediation. Curr. Opin. Biotechnol. 14: 151-162 (2003).

Morant M, Jorgensen K, Schaller H, Pinot F, Moller BL, Werck-Reichhart D, Bak S. CYP703 is an ancient cytochrome P450 in land plants catalyzing in-chain hydroxylation of lauric acid to provide building blocks for sporopollenin synthesis in pollen. Plant Cell 19: 1473-1487 (2007).

Morikawa T, Mizutani M, Aoki N, Watanabe B, Saga H, Saito S, Oikawa A, Suzuki H, Sakurai N, Shibata D, Wadano A, Sakata K, Ohta D. Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato. Plant Cell 18: 1008-1022 (2006).

Morikawa T, Saga H, Hashizume H, Ohta D. CYP710A genes encoding sterol C22-desaturase in Physcomitrella patens as molecular evidence for the evolutionary conservation of a sterol biosynthetic pathway in plants. Planta 229: 1311-1322 (2009).

Munro AW, Leys DG, McLean KJ, Marshall KR, Ost TW, Daff S, Miles CS, Chapman SK, Lysek DA, Moser CC, Page CC, Dutton PL. P450 BM3: the very model of a modern flavocytochrome. Trends Biochem. Sci. 27: 250-257 (2002).

Nafisi M, Goregaoker S, Botanga CJ, Glawischnig E, Olsen CE, Halkier BA, Glazebrook J. Arabidopsis cytochrome P450 monooxygenase 71A13 catalyzes the conversion of indole-3-acetaldoxime in camalexin synthesis. Plant Cell 19: 2039-2052 (2007).

Nair RB, Joy RW IV, Kurylo E, Shi X, Schnaider J, Datla RS, Keller WA, Selvaraj G. Identification of a CYP84 family of cytochrome P450-dependent mono-oxygenase genes in Brassica napus and perturbation of their expression for engineering sinapine reduction in the seeds. Plant Physiol. 123: 1623-1634 (2000).

Nair RB, Xia Q, Kartha CJ, Kurylo E, Hirji RN, Datla R, Selvaraj G. Arabidopsis CYP98A3 mediating aromatic 3-hydroxylation. Developmental regulation of the gene, and expression in yeast. Plant Physiol. 130: 210-220 (2002).

Nakamura M, Satoh T, Tanaka S, Mochizuki N, Yokota T, Nagatani A. Activation of the cytochrome P450 gene, CYP72C1, reduces the levels of active brassinosteroids in vivo. J. Exp. Bot. 56: 833-840 (2005).

Narusaka Y, Narusaka M, Seki M, Umezawa T, Ishida J, Nakajima M, Enju A, Shinozaki K. Crosstalk in the responses to abiotic and biotic stresses in Arabidopsis: analysis of gene expression in cytochrome P450 gene superfamily by cDNA microarray. Plant Mol. Biol. 55: 327-342 (2004).

Naur P, Petersen BL, Mikkelsen MD, Bak S, Rasmussen H, Olsen CE, Halkier BA. CYP83A1 and CYP83B1, two nonredundant cytochrome P450 enzymes metabolizing oximes in the biosynthesis of glucosinolates in Arabidopsis. Plant Physiol. 133: 63-72 (2003).

Nedelkina S, Jupe SC, Blee KA, Schalk M, Werck-Reichhart D, Bolwell GP. Novel characteristics and regulation of a divergent cinnamate 4-hydroxylase (CYP73A15) from French bean: engineering expression in yeast. Plant Mol. Biol. 39: 1079-1090 (1999).

Neeli R, Girvan HM, Lawrence A, Warren MJ, Leys D, Scrutton NS, Munro AW. The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase. FEBS Lett. 579: 5582-5588 (2005).

Nelson DR, Schuler MA, Paquette SM, Werck-Reichhart D, Bak S. Comparative genomics of rice and Arabidopsis. Analysis of 727 cytochrome P450 genes and pseudogenes from a monocot and a dicot. Plant Physiol. 135: 756-772 (2004).

Nezbedova L, Hesse M, Drandarov K, Bigler L, Werner C. Phenol oxidative coupling in the biogenesis of the macrocyclic spermine alkaloids aphelandrine and orantine in Aphelandra sp. Planta 213: 411-417 (2001).

Nielsen JS, Moller BL. Cloning and expression of cytochrome P450 enzymes catalyzing the conversion of tyrosine to p-hydroxyphenylacetaldoxime in the biosynthesis of cyanogenic glucosides in Triglochin maritima. Plant Physiol. 122: 1311-1322 (2000).

Nielsen JS, Moller BL. Biosynthesis of cyanogenic glucosides in Triglochin maritima and the involvement of cytochrome P450 enzymes. Arch. Biochem. Biophys. 368: 121-130 (1999).

Nielsen KA, Olsen CE, Pontoppidan K, Moller BL. Leucine-derived cyano glucosides in barley. Plant Physiol. 129: 1066-1075 (2002).

Nohl H, Staniek K, Kozlov AV. The existence and significance of a mitochondrial nitrite reductase. Redox Rep. 10: 281-286 (2005).

O'Brien M, Chantha SC, Rahier A, Matton DP. Lipid signaling in plants. Cloning and expression analysis of the obtusifoliol 14{alpha}-demethylase from Solanum chacoense Bitt., a pollination- and fertilization-induced gene with both obtusifoliol and lanosterol demethylase activity. Plant Physiol. 139: 734-749 (2005).

O'Keefe DP, Tepperman JM, Dean C, Leto KJ, Erbes DL, Odell JT. Plant expression of a bacterial cytochrome P450 that catalyzes activation of a sulfonylurea pro-herbicide. Plant Physiol. 105: 473-482 (1994).

Oda Y, Hirayama T, Watanabe T. Genotoxic activation of the environmental pollutant 3,6-dinitrobenzo[e]pyrene in Salmonella typhimurium umu strains expressing human cytochrome P450 and N-acetyltransferase. Toxicol. Lett. 188: 258-262 (2009).

Ohnishi T, Nomura T, Watanabe B, Ohta D, Yokota T, Miyagawa H, Sakata K, Mizutani M. Tomato cytochrome P450 CYP734A7 functions in brassinosteroid catabolism. Phytochemistry 67: 1895-1906 (2006).

Ohnishi T, Szatmari AM, Watanabe B, Fujita S, Bancos S, Koncz C, Lafos M, Shibata K, Yokota T, Sakata K, Szekeres M, Mizutani M. C-23 hydroxylation by Arabidopsis CYP90C1 and CYP90D1 reveals a novel shortcut in brassinosteroid biosynthesis. Plant Cell 18: 3275-3288 (2006).

Olry A, Schneider-Belhaddad F, Heintz D, Werck-Reichhart D. A medium-throughput screening assay to determine catalytic activities of oxygen-consuming enzymes: a new tool for functional characterization of cytochrome P450 and other oxygenases. Plant J. 51: 331-340 (2007).

Olsen KM, Hsu SC, Small LL. Evidence on the molecular basis of the Ac/ac adaptive cyanogenesis polymorphism in white clover (Trifolium repens L.). Genetics 179: 517-526 (2008).

Pan G, Zhang X, Liu K, Zhang J, Wu X, Zhu J, Tu J. Map-based cloning of a novel rice cytochrome P450 gene CYP81A6 that confers resistance to two different classes of herbicides. Plant Mol. Biol. 61: 933-943 (2006).

Pan Y, Michael TP, Hudson ME, Kay SA, Chory J, Schuler MA. Cytochrome P450 monooxygenases as reporters for circadian-regulated pathways. Plant Physiol. 150: 858-878 (2009).

Panavas T, Pikula A, Reid PD, Rubinstein B, Walker EL. Identification of senescence-associated genes from daylily petals. Plant Mol. Biol. 40: 237-248 (1999).

Parera CA, Cantliffe DJ, McCarty DR, Hannah LC. Improving vigor in shrunken-2 corn seedlings. J. Am. Soc. Hortic. Sci. 121: 1069-1075 (1996).

Payne GA, Nierman WC, Wortman JR, Pritchard BL, Brown D, Dean RA, Bhatnagar D, Cleveland TE, Machida M, Yu J. Whole genome comparison of Aspergillus flavus and A. oryzae. Med. Mycol. 44: S9-S11 (2006).

Payne WJ, Liu MY, Bursakov SA, Le Gall J. Microbial and plant metabolism of NO. Biofactors 6: 47-52 (1997).

Persans MW, Schuler MA. Differential induction of cytochrome P450-mediated triasulfuron metabolism by naphthalic anhydride and triasulfuron. Plant Physiol. 109: 1483-1490 (1995).

Petersen BL, Andreasson E, Bak S, Agerbirk N, Halkier BA. Characterization of transgenic Arabidopsis thaliana with metabolically engineered high levels of p-hydroxybenzylglucosinolate. Planta 212: 612-618 (2001).

Petersen M. Cinnamic acid 4-hydroxylase from cell cultures of the hornwort Anthoceros agrestis. Planta 217: 96-101 (2003).

Pfalz M, Vogel H, Kroymann J. The gene controlling the indole glucosinolate modifier1 quantitative trait locus alters indole glucosinolate structures and aphid resistance in Arabidopsis. Plant Cell 21: 985-999 (2009).

Pinot F, Benveniste I, Sala n JP, Durst F. Methyl jasmonate induces lauric acid omega-hydroxylase activity and accumulation of CYP94A1 transcripts but does not affect epoxide hydrolase activities in Vicia sativa seedlings. Plant Physiol. 118: 1481-1486 (1998).

Pinot F, Bosch H, Alayrac C, Mioskowski C, Vendais A, Durst F, Salaun JP. [omega]-Hydroxylation of oleic acid in Vicia sativa microsomes. Inhibition by substrate analogs and inactivation by terminal acetylenes. Plant Physiol. 102: 1313-1318 (1993).

Poschl G, Stickel F, Wang XD, Seitz HK. Alcohol and cancer: genetic and nutritional aspects. Proc. Nutr. Soc. 63: 65-71 (2004).

Poupin P, Ducrocq V, Hallier-Soulier S, Truffaut N. Cloning and characterization of the genes encoding a cytochrome P450 (PipA) involved in piperidine and pyrrolidine utilization and its regulatory protein (PipR) in Mycobacterium smegmatis mc2155. J. Bacteriol. 181: 3419-3426 (1999).

Pylypenko O, Schlichting I. Structural aspects of ligand binding to and electron transfer in bacterial and fungal P450s. Annu. Rev. Biochem. 73: 991-1018 (2004).

Qi X, Bakht S, Qin B, Leggett M, Hemmings A, Mellon F, Eagles J, Werck-Reichhart D, Schaller H, Lesot A, Melton R, Osbourn A. A different function for a member of an ancient and highly conserved cytochrome P450 family: from essential sterols to plant defense. Proc. Natl. Acad. Sci. U.S.A. 103: 18848-18853 (2006).

Ranson H, Claudianos C, Ortelli F, Abgrall C, Hemingway J, Sharakhova MV, Unger MF, Collins FH, Feyereisen R. Evolution of supergene families associated with insecticide resistance. Science 298: 179-181 (2002).

Reintanz B, Lehnen M, Reichelt M, Gershenzon J, Kowalczyk M, Sandberg G, Godde M, Uhl R, Palme K. bus, a Bushy Arabidopsis cyp79f1 knockout mutant with abolished synthesis of short-chain aliphatic glucosinolates. Plant Cell 13: 351-367 (2001).

Ringer KL, Davis EM, Croteau R. Monoterpene metabolism. Cloning, expression, and characterization of (-)-isopiperitenol/(-)-carveol dehydrogenase of peppermint and spearmint. Plant Physiol. 137: 863-872 (2005).

Ro DK, Arimura G, Lau SY, Piers E, Bohlmann J. Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase. Proc. Natl. Acad. Sci. U.S.A. 102: 8060-8065 (2005).

Ro DK, Bohlmann J. Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1). Phytochemistry 67: 1572-1578 (2006).

Ro DK, Ehlting J, Douglas CJ. Cloning, functional expression, and subcellular localization of multiple NADPH-cytochrome P450 reductases from hybrid poplar. Plant Physiol. 130: 1837-1851 (2002).

Ro DK, Mah N, Ellis BE, Douglas CJ. Functional characterization and subcellular localization of poplar (Populus trichocarpa x Populus deltoides) cinnamate 4-hydroxylase. Plant Physiol. 126: 317-329 (2001).

Robineau T, Batard Y, Nedelkina S, Cabello-Hurtado F, LeRet M, Sorokine O, Didierjean L, Werck-Reichhart D. The chemically inducible plant cytochrome P450 CYP76B1 actively metabolizes phenylureas and other xenobiotics. Plant Physiol. 118: 1049-1056 (1998).

Rojas MC, Urrutia O, Cruz C, Gaskin P, Tudzynski B, Hedden P. Kaurenolides and fujenoic acids are side products of the gibberellin P450-1 monooxygenase in Gibberella fujikuroi. Phytochemistry 65: 821-830 (2004).

Saito S, Hirai N, Matsumoto C, Ohigashi H, Ohta D, Sakata K, Mizutani M. Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid. Plant Physiol. 134: 1439-1449 (2004).

Sakamoto T, Morinaka Y, Ohnishi T, Sunohara H, Fujioka S, Ueguchi-Tanaka M, Mizutani M, Sakata K, Takatsuto S, Yoshida S, Tanaka H, Kitano H, Matsuoka M. Erect leaves caused by brassinosteroid deficiency increase biomass production and grain yield in rice. Nat. Biotechnol. 24: 105-109 (2005).

Sawada Y, Kinoshita K, Akashi T, Aoki T, Ayabe S. Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase. Plant J. 31: 555-564 (2002).

Schalk M, Batard Y, Seyer A, Nedelkina S, Durst F, Werck-Reichhart D. Design of fluorescent substrates and potent inhibitors of CYP73As, P450s that catalyze 4-hydroxylation of cinnamic acid in higher plants. Biochemistry 36: 15253-15261 (1997).

Schalk M, Cabello-Hurtado F, Pierrel MA, Atanossova R, Saindrenan P, Werck-Reichhart D. Piperonylic acid, a selective, mechanism-based inactivator of the trans-cinnamate 4-hydroxylase: A new tool to control the flux of metabolites in the phenylpropanoid pathway. Plant Physiol. 118: 209-218 (1998).

Schardl CL, Panaccione DG, Tudzynski P. Ergot alkaloids - biology and molecular biology. Alkaloids Chem. Biol. 63: 45-86 (2006).

Schlangen K, Miosic S, Castro A, Freudmann K, Luczkiewicz M, Vitzthum F, Schwab W, Gamsjager S, Musso M, Halbwirth H. Formation of UV-honey guides in Rudbeckia hirta. Phytochemistry 70: 889-898 (2009).

Schluter U, Kopke D, Altmann T, Mussig C. Analysis of carbohydrate metabolism of CPD antisense plants and the brassinosteroid-deficient cbb1 mutant. Plant Cell Environ. 25: 783-791 (2002).

Schmidt B, Joussen N, Bode M, Schuphan I. Oxidative metabolic profiling of xenobiotics by human P450s expressed in tobacco cell suspension cultures. Biochem. Soc. Trans. 34: 1241-1245 (2006).

Schoch G, Goepfert S, Morant M, Hehn A, Meyer D, Ullmann P, Werck-Reichhart D. CYP98A3 from Arabidopsis thaliana is a 3'-hydroxylase of phenolic esters, a missing link in the phenylpropanoid pathway. J. Biol. Chem. 276: 36566-36574 (2001).

Schoch GA, Attias R, Belghazi M, Dansette PM, Werck-Reichhart D. Engineering of a water-soluble plant cytochrome P450, CYP73A1, and NMR-based orientation of natural and alternate substrates in the active site. Plant Physiol. 133: 1198-1208 (2003).

Schoch GA, Attias R, Le Ret M, Werck-Reichhart D. Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1. Eur. J. Biochem. 270: 3684-3695 (2003).

Schoch GA, Nikov GN, Alworth WL, Werck-Reichhart D. Chemical inactivation of the cinnamate 4-hydroxylase allows for the accumulation of salicylic acid in elicited cells. Plant Physiol. 130: 1022-1031 (2002).

Schoenbohm C, Martens S, Eder C, Forkmann G, Weisshaar B. Identification of the Arabidopsis thaliana flavonoid 3'-hydroxylase gene and functional expression of the encoded P450 enzyme. Biol. Chem. 381: 749-753 (2000).

Schroder G, Unterbusch E, Kaltenbach M, Schmidt J, Strack D, De Luca V, Schroder J. Light-induced cytochrome P450-dependent enzyme in indole alkaloid biosynthesis: tabersonine 16-hydroxylase. FEBS Lett. 458: 97-102 (1999).

Schroder P, Abele C, Gohr P, Stuhlfauth-Roisch U, Grosse W. Latest on enzymology of serotonin biosynthesis in walnut seeds. Adv. Exp. Med. Biol. 467: 637-644 (1999).

Schuhegger R, Nafisi M, Mansourova M, Petersen BL, Olsen CE, Svatos A, Halkier BA, Glawischnig E. CYP71B15 (PAD3) catalyzes the final step in camalexin biosynthesis. Plant Physiol. 141: 1248-1254 (2006).

Schuler MA. The role of cytochrome P450 monooxygenases in plant-insect interactions. Plant Physiol. 112: 1411-1419 (1996).

Schuler MA, Werck-Reichhart D. Functional genomics of P450s. Annu. Rev. Plant Biol. 54: 629-667 (2003).

Schullehner K, Dick R, Vitzthum F, Schwab W, Brandt W, Frey M, Gierl A. Benzoxazinoid biosynthesis in dicot plants. Phytochemistry 69: 2668-2677 (2008).

Schwab W. Metabolome diversity: too few genes, too many metabolites? Phytochemistry 62: 837-849 (2003).

Seitz C, Ameres S, Forkmann G. Identification of the molecular basis for the functional difference between flavonoid 3'-hydroxylase and flavonoid 3',5'-hydroxylase. FEBS Lett. 581: 3429-3434 (2007).

Seitz C, Eder C, Deiml B, Kellner S, Martens S, Forkmann G. Cloning, functional identification and sequence analysis of flavonoid 3'-hydroxylase and flavonoid 3',5'-hydroxylase cDNAs reveals independent evolution of flavonoid 3',5'-hydroxylase in the Asteraceae family. Plant Mol. Biol. 61: 365-381 (2006).

Shelton D, Leach D, Baverstock P, Henry R. Isolation of genes involved in secondary metabolism from Melaleuca alternifolia (Cheel) using expressed sequence tags (ESTs). Plant Sci. 162: 9-15 (2002).

Shimada N, Aoki T, Sato S, Nakamura Y, Tabata S, Ayabe S. A cluster of genes encodes the two types of chalcone isomerase involved in the biosynthesis of general flavonoids and legume-specific 5-deoxy(iso)flavonoids in Lotus japonicus. Plant Physiol. 131: 941-951 (2003).

Shimada Y, Nakano-Shimada R, Ohbayashi M, Okinaka Y, Kiyokawa S, Kikuchi Y. Expression of chimeric P450 genes encoding flavonoid-3', 5'-hydroxylase in transgenic tobacco and petunia plants. FEBS Lett. 461: 241-245 (1999).

Shiota N, Nagasawa A, Sakaki T, Yabusaki Y, Ohkawa H. Herbicide-resistant tobacco plants expressing the fused enzyme between rat cytochrome P4501A1 (CYP1A1) and yeast NADPH-cytochrome P450 oxidoreductase. Plant Physiol. 106: 17-23 (1994).

Siqueira-Junior CL, Jardim BC, Urmenyi TP, Vicente AC, Hansen E, Otsuki K, da Cunha M, Madureira HC, de Carvalho DR, Jacinto T. Wound response in passion fruit (Passiflora f. edulis flavicarpa) plants: gene characterization of a novel chloroplast-targeted allene oxide synthase up-regulated by mechanical injury and methyl jasmonate. Plant Cell Rep. 27: 387-397 (2008).

Siritunga D, Sayre R. Engineering cyanogen synthesis and turnover in cassava (Manihot esculenta). Plant Mol. Biol. 56: 661-669 (2004).

Siritunga D, Sayre RT. Generation of cyanogen-free transgenic cassava. Planta 217: 367-373 (2003).

Skirycz A, Reichelt M, Burow M, Birkemeyer C, Rolcik J, Kopka J, Zanor MI, Gershenzon J, Strnad M, Szopa J, Mueller-Roeber B, Witt I. DOF transcription factor AtDof1.1 (OBP2) is part of a regulatory network controlling glucosinolate biosynthesis in Arabidopsis. Plant J. 47: 10-24 (2006).

Smolen G, Bender J. Arabidopsis cytochrome P450 cyp83B1 mutations activate the tryptophan biosynthetic pathway. Genetics 160: 323-332 (2002).

Spiering MJ, Faulkner JR, Zhang DX, Machado C, Grossman RB, Schardl CL. Role of the LolP cytochrome P450 monooxygenase in loline alkaloid biosynthesis. Fungal Genet. Biol. 45: 1307-1314 (2008).

Sreevidya V, Srinivasa Rao C, Sullia S, Ladha JK, Reddy PM. Metabolic engineering of rice with soybean isoflavone synthase for promoting nodulation gene expression in rhizobia. J. Exp. Bot. 57: 1957-1969 (2006).

Stanley Kim H, Yu Y, Snesrud EC, Moy LP, Linford LD, Haas BJ, Nierman WC, Quackenbush J. Transcriptional divergence of the duplicated oxidative stress-responsive genes in the Arabidopsis genome. Plant J. 41: 212-220 (2005).

Starrett DA, Laties GG. Ethylene and wound-induced gene expression in the preclimacteric phase of ripening avocado fruit and mesocarp discs. Plant Physiol. 103: 227-234 (1993).

Stumpe M, Carsjens JG, Gobel C, Feussner I. Divinyl ether synthesis in garlic bulbs. J. Exp. Bot. 59: 907-915 (2008).

Stumpe M, Gobel C, Demchenko K, Hoffmann M, Klosgen RB, Pawlowski K, Feussner I. Identification of an allene oxide synthase (CYP74C) that leads to formation of alpha-ketols from 9-hydroperoxides of linoleic and linolenic acid in below-ground organs of potato. Plant J. 47: 883-896 (2006).

Szczyglowski K, Hamburger D, Kapranov P, de Bruijn FJ. Construction of a Lotus japonicus late nodulin expressed sequence tag library and identification of novel nodule-specific genes. Plant Physiol. 114: 1335-1346 (1997).

Takahashi N, Nakazawa M, Shibata K, Yokota T, Ishikawa A, Suzuki K, Kawashima M, Ichikawa T, Shimada H, Matsui M. shk1-D, a dwarf Arabidopsis mutant caused by activation of the CYP72C1 gene, has altered brassinosteroid levels. Plant J. 42: 13-22 (2005).

Takaya N. Response to hypoxia, reduction of electron acceptors, and subsequent survival by filamentous fungi. Biosci. Biotechnol. Biochem. 73: 1-8 (2009).

Takei K, Yamaya T, Sakakibara H. Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-zeatin. J. Biol. Chem. 279: 41866-41872 (2004).

Tallman G. Are diurnal patterns of stomatal movement the result of alternating metabolism of endogenous guard cell ABA and accumulation of ABA delivered to the apoplast around guard cells by transpiration? J. Exp. Bot. 55: 1963-1976 (2004).

Tanabe S, Ashikari M, Fujioka S, Takatsuto S, Yoshida S, Yano M, Yoshimura A, Kitano H, Matsuoka M, Fujisawa Y, Kato H, Iwasaki Y. A novel cytochrome P450 is implicated in brassinosteroid biosynthesis via the characterization of a rice dwarf mutant, dwarf11, with reduced seed length. Plant Cell 17: 776-790 (2005).

Tantikanjana T, Mikkelsen MD, Hussain M, Halkier BA, Sundaresan V. Functional analysis of the tandem-duplicated P450 genes SPS/BUS/CYP79F1 and CYP79F2 in glucosinolate biosynthesis and plant development by Ds transposition-generated double mutants. Plant Physiol. 135: 840-848 (2004).

Thies F, Backhaus T, Bossmann B, Grimme LH. Xenobiotic biotransformation in unicellular green algae. Involvement of cytochrome P450 in the activation and selectivity of the pyridazinone pro-herbicide metflurazon. Plant Physiol. 112: 361-370 (1996).

Thornalley PJ. Isothiocyanates: mechanism of cancer chemopreventive action. Anti-Cancer Drugs 13: 331-338 (2002).

Thorsoe KS, Bak S, Olsen CE, Imberty A, Breton C, Moller BL. Determination of catalytic key amino acids and UDP sugar donor specificity of the cyanohydrin glycosyltransferase UGT85B1 from Sorghum bicolor. Molecular modeling substantiated by site-specific mutagenesis and biochemical analyses. Plant Physiol. 139: 664-673 (2005).

Tian L, Dixon RA. Engineering isoflavone metabolism with an artificial bifunctional enzyme. Planta 224: 496-507 (2006).

Toguri T, Umemoto N, Kobayashi O, Ohtani T. Activation of anthocyanin synthesis genes by white light in eggplant hypocotyl tissues, and identification of an inducible P-450 cDNA. Plant Mol. Biol. 23: 933-946 (1993).

Tranbarger TJ, Forward BS, Misra S. Regulation of NADPH-cytochrome P450 reductase expressed during Douglas-fir germination and seedling development. Plant Mol. Biol. 44: 141-153 (2000).

Trognitz F, Manosalva P, Gysin R, Nino-Liu D, Simon R, Herrera MD, Trognitz B, Ghislain M, Nelson R. Plant defense genes associated with quantitative resistance to potato late blight in Solanum phureja x dihaploid S. tuberosum hybrids. Mol. Plant Microbe Interact. 15: 587-597 (2002).

Troncoso C, Carcamo J, Hedden P, Tudzynski B, Rojas MC. Influence of electron transport proteins on the reactions catalyzed by Fusarium fujikuroi gibberellin monooxygenases. Phytochemistry 69: 672-683 (2008).

Turk EM, Fujioka S, Seto H, Shimada Y, Takatsuto S, Yoshida S, Denzel MA, Torres QI, Neff MM. CYP72B1 inactivates brassinosteroid hormones: an intersection between photomorphogenesis and plant steroid signal transduction. Plant Physiol. 133: 1643-1653 (2003).

Turk EM, Fujioka S, Seto H, Shimada Y, Takatsuto S, Yoshida S, Wang H, Torres QI, Ward JM, Murthy G, Zhang J, Walker JC, Neff MM. BAS1 and SOB7 act redundantly to modulate Arabidopsis photomorphogenesis via unique brassinosteroid inactivation mechanisms. Plant J. 42: 23-34 (2005).

Uchimura H, Enjoji H, Seki T, Taguchi A, Takaya N, Shoun H. Nitrate reductase-formate dehydrogenase couple involved in the fungal denitrification by Fusarium oxysporum. J. Biochem. 131: 579-586 (2002).

Udvardi MK, Metzger JD, Krishnapillai V, Peacock WJ, Dennis ES. Cloning and sequencing of a full-length cDNA from Thlaspi arvense L. that encodes a cytochrome P-450. Plant Physiol. 105: 755-756 (1994).

Ueda A, Shi W, Nakamura T, Takabe T. Analysis of salt-inducible genes in barley roots by differential display. J. Plant Res. 115: 119-130 (2002).

Ueno K, Araki Y, Hirai N, Saito S, Mizutani M, Sakata K, Todoroki Y. Differences between the structural requirements for ABA 8'-hydroxylase inhibition and for ABA activity. Bioorg. Med. Chem. 13: 3359-3370 (2005).

Ueyama Y, Suzuki K, Fukuchi-Mizutani M, Fukui Y, Miyazaki K, Ohkawa H, Kusumi T, Tanaka Y. Molecular and biochemical characterization of torenia flavonoid 3'-hydroxylase and flavone synthase II and modification of flower color by modulating the expression of these genes. Plant Sci. 163: 253-263 (2002).

Ullrich R, Hofrichter M. The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene. FEBS Lett. 579: 6247-6250 (2005).

Umemoto N, Kobayashi O, Ishizaki-Nishizawa O, Toguri T. cDNAs sequences encoding cytochrome P450 (CYP71 family) from eggplant seedlings. FEBS Lett. 330: 169-173 (1993).

Umezawa T, Okamoto M, Kushiro T, Nambara E, Oono Y, Seki M, Kobayashi M, Koshiba T, Kamiya Y, Shinozaki K. CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana. Plant J. 46: 171-182 (2006).

Valerio L, De Meyer M, Penel C, Dunand C. Expression analysis of the Arabidopsis peroxidase multigenic family. Phytochemistry 65: 1331-1342 (2004).

Vang O, Frandsen H, Hansen KT, Sorensen JN, Sorensen H, Andersen O. Biochemical effects of dietary intakes of different broccoli samples. I. Differential modulation of cytochrome P-450 activities in rat liver, kidney, and colon. Metab.-Clin. Exp. 50: 1123-1129 (2001).

Vang O, Mortensen J, Andersen O. Biochemical effects of dietary intake of different broccoli samples. II. Multivariate analysis of contributions of specific glucosinolates in modulating cytochrome P-450 and antioxidant defense enzyme activities. Metab.-Clin. Exp. 50: 1130-1135 (2001).

Vannelli T, Wei Qi W, Sweigard J, Gatenby AA, Sariaslani FS. Production of p-hydroxycinnamic acid from glucose in Saccharomyces cerevisiae and Escherichia coli by expression of heterologous genes from plants and fungi. Metab. Eng. 9: 142-151 (2007).

Wackett LP. Directed evolution of new enzymes and pathways for environmental biocatalysis. Ann. N.Y. Acad. Sci. 864: 142-152 (1998).

Wallenstein EJ, Barminko J, Schloss RS, Yarmush ML. Transient gene delivery for functional enrichment of differentiating embryonic stem cells. Biotechnol. Bioeng. 101: 859-872 (2008).

Wang E, Gan S, Wagner GJ. Isolation and characterization of the CYP71D16 trichome-specific promoter from Nicotiana tabacum L. J. Exp. Bot. 53: 1891-1897 (2002).

Wang E, Wagner GJ. Elucidation of the functions of genes central to diterpene metabolism in tobacco trichomes using posttranscriptional gene silencing. Planta 216: 686-691 (2003).

Wang E, Wang R, DeParasis J, Loughrin JH, Gan S, Wagner GJ. Suppression of a P450 hydroxylase gene in plant trichome glands enhances natural-product-based aphid resistance. Nat. Biotechnol. 19: 371-374 (2001).

Wang S, Nagrath D, Chen PC, Berthiaume F, Yarmush ML. Three-dimensional primary hepatocyte culture in synthetic self-assembling peptide hydrogel. Tissue Eng. Part A. 14: 227-236 (2008).

Wang Y, Li Y, Li Y, Ma X, Yang S, Yang L. Investigations into the analysis and modeling of the cytochrome P450 cycle. J. Phys. Chem. B. Condens. Matter Mater. Surf. Interfaces Biophys. 110: 10139-10143 (2006).

Wei H, Dhanaraj AL, Rowland LJ, Fu Y, Krebs SL, Arora R. Comparative analysis of expressed sequence tags from cold-acclimated and non-acclimated leaves of Rhododendron catawbiense Michx. Planta 221: 406-416 (2005).

Weng JK, Li X, Stout J, Chapple C. Independent origins of syringyl lignin in vascular plants. Proc. Natl. Acad. Sci. U.S.A. 105: 7887-7892 (2008).

Werck-Reichhart D. Cytochromes P450 in phenylpropanoid metabolism. Drug Metabol. Drug Interact. 12: 221-243 (1995).

Whitbred JM, Schuler MA. Molecular characterization of CYP73A9 and CYP82A1 P450 genes involved in plant defense in pea. Plant Physiol. 124: 47-58 (2000).

Winkler RG, Frank MR, Galbraith DW, Feyereisen R, Feldmann KA. Systematic reverse genetics of transfer-DNA-tagged lines of Arabidopsis. Isolation of mutations in the cytochrome P450 gene superfamily. Plant Physiol. 118: 743-750 (1998).

Winkler RG, Helentjaris T. The maize Dwarf3 gene encodes a cytochrome P450-mediated early step in gibberellin biosynthesis. Plant Cell 7: 1307-1317 (1995).

Wittstock U, Halkier BA. Cytochrome P450 CYP79A2 from Arabidopsis thaliana L. catalyzes the conversion of L-phenylalanine to phenylacetaldoxime in the biosynthesis of benzylglucosinolate. J. Biol. Chem. 275: 14659-14666 (2000).

Wittstock U, Halkier BA. Glucosinolate research in the Arabidopsis era. Trends Plant Sci. 7: 263-270 (2002).

Wolthers KR, Scrutton NS. Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex. FEBS J. 276: 1942-1951 (2009).

Xu W, Bak S, Decker A, Paquette SM, Feyereisen R, Galbraith DW. Microarray-based analysis of gene expression in very large gene families: the cytochrome P450 gene superfamily of Arabidopsis thaliana. Gene 272: 61-74 (2001).

Xue Y, Sherman DH. Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae. Metab. Eng. 3: 15-26 (2001).

Xue Y, Zhao L, Liu HW, Sherman DH. A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity. Proc. Natl. Acad. Sci. U.S.A. 95: 12111-12116 (1998).

Yamamoto H, Hori M, Kuwajima H, Inoue K. Formation of benzoquinol moiety in cornoside by salidroside mono-oxygenase, a cytochrome P450 enzyme, from Abeliophyllum distichumcell suspension cultures. Planta 216: 432-436 (2003).

Yan Z, Caldwell GW. Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery. Curr. Top. Med. Chem. 1: 403-425 (2001).

Yang MT, Chen SL, Lin CY, Chen YM. Chilling stress suppresses chloroplast development and nuclear gene expression in leaves of mung bean seedlings. Planta 221: 374-385 (2005).

Yang SH, Zeevaart JA. Expression of ABA 8'-hydroxylases in relation to leaf water relations and seed development in bean. Plant J. 47: 675-686 (2006).

Yoshida T, Kurella M, Beato F, Min H, Ingelfinger JR, Stears RL, Swinford RD, Gullans SR, Tang SS. Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. Kidney Int. 61: 1646-1654 (2002).

Yun CH, Ahn T, Guengerich FP, Yamazaki H, Shimada T. Phospholipase D activity of cytochrome P450 in human liver endoplasmic reticulum. Arch. Biochem. Biophys. 367: 81-88 (1999).

Zhang H, Lian C, Shen Z. Proteomic identification of small, copper-responsive proteins in germinating embryos of Oryza sativa. Ann. Bot. (Lond.) 103: 923-930 (2009).

Zhang J, Subramanian S, Zhang Y, Yu O. Flavone synthases from Medicago truncatula are flavanone-2-hydroxylases and are important for nodulation. Plant Physiol. 144: 741-751 (2007).

Zhang L, Shoun H. Purification and functional analysis of fungal nitric oxide reductase cytochrome P450nor. Methods Enzymol. 437: 117-133 (2008).

Zhang P, Bohl-Zenger S, Puonti-Kaerlas J, Potrykus I, Gruissem W. Two cassava promoters related to vascular expression and storage root formation. Planta 218: 192-203 (2003).

Zhao Y, Hull AK, Gupta NR, Goss KA, Alonso J, Ecker JR, Normanly J, Chory J, Celenza JL. Trp-dependent auxin biosynthesis in Arabidopsis: involvement of cytochrome P450s CYP79B2 and CYP79B3. Genes Dev. 16: 3100-3112 (2002).

Zhong JJ, Yue CJ. Plant cells: secondary metabolite heterogeneity and its manipulation. Adv. Biochem. Eng. Biotechnol. 100: 53-88 (2005).

Zhu Y, Nomura T, Xu Y, Zhang Y, Peng Y, Mao B, Hanada A, Zhou H, Wang R, Li P, Zhu X, Mander LN, Kamiya Y, Yamaguchi S, He Z. ELONGATED UPPERMOST INTERNODE encodes a cytochrome P450 monooxygenase that epoxidizes gibberellins in a novel deactivation reaction in rice. Plant Cell 18: 442-456 (2006).

Number of references = 345

| PubMed Search | Entrez Protein Search | ISI Web of Knowledge Search | Scirus Search |

David Rhodes
Department of Horticulture & Landscape Architecture
Horticulture Building
625 Agriculture Mall Drive
Purdue University
West Lafayette, IN 47907-2010
Last Update: 10/01/09