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N Use By Plants
Nitrate Assimilation
Ammonia Assimilation
Glu, Gln, Asn, Gly, Ser
Aminotransferases
Asp, Ala, GABA
Val, Leu, Ileu, Thr, Lys
Pro, Arg, Orn
Polyamines
Non-protein AAs
Alkaloids
Sulfate Assimilation
Cys, Met, AdoMet, ACC
His, Phe, Tyr, Tryp
Secondary Products
Onium Compounds
Enzymes
Methods
Simulation
References
HORT640 - Metabolic Plant Physiology

References, 13C

Abdel-Sattar E, Ahmed AA, Hegazy ME, Farag MA, Al-Yahya MA 2007 Acylated pregnane glycosides from Caralluma russeliana. Phytochemistry 68: 1459-1463.

Acharya BR, Raina S, Maqbool SB, Jagadeeswaran G, Mosher SL, Appel HM, Schultz JC, Klessig DF, Raina R 2007 Overexpression of CRK13, an Arabidopsis cysteine-rich receptor-like kinase, results in enhanced resistance to Pseudomonas syringae. Plant J. 50: 488-499.

Adam KP, Zapp J 1998 Biosynthesis of the isoprene units of chamomile sesquiterpenes. Phytochemistry 48: 953-959.

Affek HP, Yakir D 2003 Natural abundance carbon isotope composition of isoprene reflects incomplete coupling between isoprene synthesis and photosynthetic carbon flow. Plant Physiol. 131: 1727-1736.

Ahmed AA, Mohamed Ael-H, Tzakou O, Petropoulou A, Hassan ME, El-Maghraby MA, Zeller KP 2003 Terpenes from Inula verbascifolia. Phytochemistry 62: 1191-1194.

Ahua KM, Ioset JR, Ransijn A, Mauel J, Mavi S, Hostettmann K 2004 Antileishmanial and antifungal acridone derivatives from the roots of Thamnosma rhodesica. Phytochemistry 65: 963-968.

Alabdul Magid A, Voutquenne-Nazabadioko L, Renimel I, Harakat D, Moretti C, Lavaud C 2006 Triterpenoid saponins from the stem bark of Caryocar villosum. Phytochemistry 67: 2096-2102.

Albers D, Schaefer M, Scheu S 2006 Incorporation of plant carbon into the soil animal food web of an arable system. Ecology 87: 235-245.

Alemanno L, Ramos T, Gargadenec A, Andary C, Ferriere N 2003 Localization and identification of phenolic compounds in Theobroma cacao L. somatic embryogenesis. Ann. Bot. (Lond.) 92: 613-623.

Alger JR, Shulman RG 1984 Metabolic applications of high resolution C-13 nuclear magnetic resonance spectroscopy. Brit. Med. Bull. 40: 160-164.

Allen DK, Shachar-Hill Y, Ohlrogge JB 2007 Compartment-specific labeling information in (13)C metabolic flux analysis of plants. Phytochemistry 68: 2197-2210.

Alonso AP, Vigeolas H, Raymond P, Rolin D, Dieuaide-Noubhani M 2005 A new substrate cycle in plants. Evidence for a high glucose-phosphate-to-glucose turnover from in vivo steady-state and pulse-labeling experiments with [13C]glucose and [14C]glucose. Plant Physiol. 138: 2220-2232.

Amiard V, Morvan-Bertrand A, Billard JP, Huault C, Prud'homme MP 2003 Fate of fructose supplied to leaf sheaths after defoliation of Lolium perenne L.: assessment by 13C-fructose labelling. J. Exp. Bot. 54: 1231-1243.

Amin US, Lash TD, Wilkinson BJ 1995 Proline betaine is a highly effective osmoprotectant for Staphylococcus aureus. Arch. Microbiol. 163: 138-142.

Angelidis AS, Smith LT, Hoffman LM, Smith GM 2002 Identification of opuC as a chill-activated and osmotically activated carnitine transporter in Listeria monocytogenes. Appl. Environ. Microbiol. 68: 2644-2650.

Antoniewicz MR, Kelleher JK, Stephanopoulos G 2007 Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions. Metab. Eng. 9: 68-86.

Antoniewicz MR, Kelleher JK, Stephanopoulos G 2006 Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metab. Eng. 8: 324-337.

Antoniewicz MR, Stephanopoulos G, Kelleher JK 2006 Evaluation of regression models in metabolic physiology: predicting fluxes from isotopic data without knowledge of the pathway. Metabolomics 2: 41-52.

Aranda I, Pardos M, Puertolas J, Jimenez MD, Pardos JA 2007 Water-use efficiency in cork oak (Quercus suber) is modified by the interaction of water and light availabilities. Tree Physiol. 27: 671-677.

Araus JL, Slafer GA, Reynolds MP, Royo C 2002 Plant breeding and drought in C3 cereals: what should we breed for? Ann. Bot. (Lond.) 89: 925-940.

Arauzo-Bravo MJ, Shimizu K 2001 Estimation of bidirectional metabolic fluxes from MS and NMR data using positional representations. Genome Inform. Ser. Workshop Genome Inform. 12: 63-72.

Arigoni D, Eisenreich W, Latzel C, Sagner S, Radykewicz T, Zenk MH, Bacher A 1999 Dimethylallyl pyrophosphate is not the committed precursor of isopentenyl pyrophosphate during terpenoid biosynthesis from 1-deoxyxylulose in higher plants. Proc. Natl. Acad. Sci. U.S.A. 96: 1309-1314.

Arigoni D, Sagner S, Latzel C, Eisenreich W, Bacher A, Zenk MH 1997 Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement. Proc. Natl. Acad. Sci. U.S.A. 94: 10600-10605.

Arndt SK, Clifford SC, Wanek W, Jones HG, Popp M 2001 Physiological and morphological adaptations of the fruit tree Ziziphus rotundifolia in response to progressive drought stress. Tree Physiol. 21: 705-715.

Arndt SK, Wanek W 2002 Use of decreasing foliar carbon isotope discrimination during water limitation as a carbon tracer to study whole plant carbon allocation. Plant Cell Environ. 25: 609-616.

Aubert S, Bligny R, Douce R, Gout E, Ratcliffe RG, Roberts JK 2001 Contribution of glutamate dehydrogenase to mitochondrial glutamate metabolism studied by 13C and 31P nuclear magnetic resonance. J. Exp. Bot. 52: 37-45.

Aubert S, Choler P, Pratt J, Douzet R, Gout E, Bligny R 2004 Methyl-beta-D-glucopyranoside in higher plants: accumulation and intracellular localization in Geum montanum L. leaves and in model systems studied by 13C nuclear magnetic resonance. J. Exp. Bot. 55: 2179-2189.

Aubert S, Curien G, Bligny R, Gout E, Douce R 1998 Transport, compartmentation, and metabolism of homoserine in higher plant cells. Carbon-13- and phosphorus-31-nuclear magnetic resonance studies. Plant Physiol. 116: 547-557.

Aubert S, Hennion F, Bouchereau A, Gout E, Bligny R, Dorne AJ 1999 Subcellular compartmentation of proline in the leaves of the subantarctic Kerguelen cabbage Pringlea antiscorbutica R. Br. In vivo 13C-NMR study. Plant Cell Environ. 22: 255-259.

Bachelard H, Badar-Goffer R, Ben-Yoseph O, Morris P, Thatcher N 1993 Studies on metabolic regulation using NMR spectroscopy. Dev. Neurosci. 15: 207-215.

Bago B, Pfeffer PE, Abubaker J, Jun J, Allen JW, Brouillette J, Douds DD, Lammers PJ, Shachar-Hill Y 2003 Carbon export from arbuscular mycorrhizal roots involves the translocation of carbohydrate as well as lipid. Plant Physiol. 131: 1496-1507.

Bago B, Pfeffer PE, Douds Jr DD, Brouillette J, Becard G, Shachar-Hill Y 1999 Carbon metabolism in spores of the arbuscular mycorrhizal fungus Glomus intraradices as revealed by nuclear magnetic resonance spectroscopy. Plant Physiol. 121: 263-272.

Bago B, Zipfel W, Williams RM, Jun J, Arreola R, Lammers PJ, Pfeffer PE, Shachar-Hill Y 2002 Translocation and utilization of fungal storage lipid in the arbuscular mycorrhizal symbiosis. Plant Physiol. 128: 108-124.

Baldocchi DD, Bowling DR 2003 Modelling the discrimination of (CO2)-C-13 above and within a temperate broad-leaved forest canopy on hourly to seasonal time scales. Plant Cell Environ. 26: 231-244.

Banci L, Bertini I, Cramaro F, Del Conte R, Viezzoli MS 2002 The solution structure of reduced dimeric copper zinc superoxide dismutase. The structural effects of dimerization. Eur. J. Biochem. 269: 1905-1915.

Bao X, Focke M, Pollard M, Ohlrogge J 2000 Understanding in vivo carbon precursor supply for fatty acid synthesis in leaf tissue. Plant J. 22: 39-50.

Barakat A, Winter H, Rondeau-Mouro C, Saake B, Chabbert B, Cathala B 2007 Studies of xylan interactions and cross-linking to synthetic lignins formed by bulk and end-wise polymerization: a model study of lignin carbohydrate complex formation. Planta 226: 267-281.

Barber RD, Donohue TJ 1998 Function of a glutathione-dependent formaldehyde dehydrogenase in Rhodobacter sphaeroides formaldehyde oxidation and assimilation. Biochemistry 37: 530-537.

Barbour MM, Farquhar GD 2000 Relative humidity- and ABA-induced variation in carbon and oxygen isotope ratios of cotton leaves Plant Cell Environ. 23: 473-485.

Barbour MM, McDowell NG, Tcherkez G, Bickford CP, Hanson DT 2007 A new measurement technique reveals rapid post-illumination changes in the carbon isotope composition of leaf-respired CO2. Plant Cell Environ. 30: 469-482.

Barbour MM, Walcroft AS, Farquhar GD 2002 Seasonal variation in delta C-13 and delta O-18 of cellulose from growth rings of Pinus radiata. Plant Cell Environ. 25: 1483-1499.

Barlow AJ, Lorimer SD, Morgan ER, Weavers RT 2003 Biosynthesis of the sesquiterpene hodgsonox from the New Zealand liverwort Lepidolaena hodgsoniae. Phytochemistry 63: 25-29.

Barnard HR, Ryan MG 2003 A test of the hydraulic limitation hypothesis in fast-growing Eucalyptus saligna. Plant Cell Environ. 26: 1235-1245.

Barragan-Huerta BE, Peralta-Cruz J, Gonzalez-Laredo RF, Karchesy J 2004 Neocandenatone, an isoflavan-cinnamylphenol quinone methide pigment from Dalbergia congestiflora. Phytochemistry 65: 925-928.

Baxter CJ, Liu JL, Fernie AR, Sweetlove LJ 2007 Determination of metabolic fluxes in a non-steady-state system. Phytochemistry 68: 2313-2319.

Baxter CJ, Redestig H, Schauer N, Repsilber D, Patil KR, Nielsen J, Selbig J, Liu J, Fernie AR, Sweetlove LJ 2007 The metabolic response of heterotrophic Arabidopsis cells to oxidative stress. Plant Physiol. 143: 312-325.

Becker J, Klopprogge C, Zelder O, Heinzle E, Wittmann C 2005 Amplified expression of fructose 1,6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sources. Appl. Environ. Microbiol. 71: 8587-8596.

Bederman IR, Kasumov T, Reszko AE, David F, Brunengraber H, Kelleher JK 2004 In vitro modeling of fatty acid synthesis under conditions simulating the zonation of lipogenic [13C]acetyl-CoA enrichment in the liver. J. Biol. Chem. 279: 43217-43226.

Bederman IR, Reszko AE, Kasumov T, David F, Wasserman DH, Kelleher JK, Brunengraber H 2004 Zonation of labeling of lipogenic acetyl-CoA across the liver: implications for studies of lipogenesis by mass isotopomer analysis. J. Biol. Chem. 279: 43207-43216.

Beerling DJ, Rundgren M 2000 Leaf metabolic and morphological responses of dwarf willow (Salix herbacea) in the sub-arctic to the past 9000 years of global environmental change. New Phytol. 145: 257-269.

Behrens A, Maie N, Knicker H, Kogel-Knabner I 2003 MALDI-TOF mass spectrometry and PSD fragmentation as means for the analysis of condensed tannins in plant leaves and needles. Phytochemistry 62: 1159-1170.

Bernards MA, Fleming WD, Llewellyn DB, Priefer R, Yang X, Sabatino A, Plourde GL 1999 Biochemical characterization of the suberization-associated anionic peroxidase of potato. Plant Physiol. 121: 135-146.

Berthon HA, Bubb WA, Kuchel PW 1993 13C NMR isotopomer and computer-simulation studies of the nonoxidative pentose-phosphate pathway of human erythrocytes. Biochem. J. 296: 379-387.

Betson NR, Gottlicher SG, Hall M, Wallin G, Richter A, Hogberg P 2007 No diurnal variation in rate or carbon isotope composition of soil respiration in a boreal forest. Tree Physiol. 27: 749-756.

Beylot M, Previs SF, David F, Brunengraber H 1993 Determination of the C-13 labeling pattern of glucose by gas chromatography mass spectrometry. Anal. Biochem. 212: 526-531.

Bhupinderpal-Singh, Nordgren A, Lofvenius MO, Hogberg MN, Mellander PE, Hogberg P 2003 Tree root and soil heterotrophic respiration as revealed by girdling of boreal Scots pine forest: extending observations beyond the first year. Plant Cell Environ. 26: 1287-1296.

Bishop GR, Zhu Z, Whitehead TL, Hicks RP, Davidson VL 1998 Identification of reaction products and intermediates of aromatic-amine dehydrogenase by 15N and 13C NMR. Biochem. J. 330: 1159-1163.

Bladon KD, Silins U, Landhausser SM, Messier C, Lieffers VJ 2007 Carbon isotope discrimination and water stress in trembling aspen following variable retention harvesting. Tree Physiol. 27: 1065-1071.

Blank LM, Kuepfer L, Sauer U 2005 Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast. Genome Biol. 6: R49.

Blank LM, Lehmbeck F, Sauer U 2005 Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts. FEMS Yeast Res. 5: 545-558.

Bligny R, Douce R 2001 NMR and plant metabolism. Curr. Opin. Plant Biol. 4: 191-196.

Bonarius HP, Ozemre A, Timmerarends B, Skrabal P, Tramper J, Schmid G, Heinzle E 2001 Metabolic-flux analysis of continuously cultured hybridoma cells using (13)CO(2) mass spectrometry in combination with (13)C-lactate nuclear magnetic resonance spectroscopy and metabolite balancing. Biotechnol. Bioeng. 74: 528-538.

Bonarius HP, Timmerarends B, de Gooijer CD, Tramper J 1998 Metabolite-balancing techniques vs. 13C tracer experiments to determine metabolic fluxes in hybridoma cells. Biotechnol. Bioeng. 58: 258-262.

Bootten TJ, Harris PJ, Melton LD, Newman RH 2004 Solid-state 13C-NMR spectroscopy shows that the xyloglucans in the primary cell walls of mung bean (Vigna radiata L.) occur in different domains: a new model for xyloglucan-cellulose interactions in the cell wall. J. Exp. Bot. 55: 571-583.

Borland AM, Griffiths H, Broadmeadow M, Fordham MC, Maxwell C 1994 Carbon-isotope composition of biochemical fractions and the regulation of carbon balance in leaves of the C3-Crassulacean acid metabolism intermediate Clusia minor L. growing in Trinidad. Plant Physiol. 106: 493-501.

Borodina I, Scholler C, Eliasson A, Nielsen J 2005 Metabolic network analysis of Streptomyces tenebrarius, a Streptomyces species with an active Entner-Doudoroff pathway. Appl. Environ. Microbiol. 71: 2294-2302.

Boyaval P, Deborde C, Corre C, Blanco C, Begue E 1999 Stress and osmoprotection in propionibacteria. Lait 79: 59-69.

Bracher A, Eisenreich W, Schramek N, Ritz H, Gotze E, Herrmann A, Gutlich M, Bacher A 1998 Biosynthesis of pteridines. NMR studies on the reaction mechanisms of GTP cyclohydrolase I, pyruvoyltetrahydropterin synthase, and sepiapterin reductase. J. Biol. Chem. 273: 28132-28141.

Breitenbach J, Sandmann G 2005 zeta-Carotene cis isomers as products and substrates in the plant poly-cis carotenoid biosynthetic pathway to lycopene. Planta 220: 785-793.

Brendel O, Pot D, Plomion C, Rozenberg P, Guehl JM 2002 Genetic parameters and QTL analysis of delta C-13 and ring width in maritime pine. Plant Cell Environ. 25: 945-953.

Brennan L, Shine A, Hewage C, Malthouse JPG, Brindle KM, McClenaghan N, Flatt PR, Newsholme P 2002 A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line. Metabolism of L-alanine is important to the regulation of insulin secretion. Diabetes 51: 1714-1721.

Brilli F, Barta C, Fortunati A, Lerdau M, Loreto F, Centritto M 2007 Response of isoprene emission and carbon metabolism to drought in white poplar (Populus alba) saplings. New Phytol. 175: 244-254.

Brimer L 1988 Determination of cyanide and cyanogenic compounds in biological systems. Ciba Found. Symp. 140: 177-200.

Bringmann G, Feineis D 2001 Stress-related polyketide metabolism of Dioncophyllaceae and Ancistrocladaceae. J. Exp. Bot. 52: 2015-2022.

Brouquisse R, Rolin D, Cortes S, Gaudillere M, Evrard A, Roby C 2007 A metabolic study of the regulation of proteolysis by sugars in maize root tips: effects of glycerol and dihydroxyacetone. Planta 225: 693-709.

Brown RH, Byrd GT, Bouton JH, Bassett CL 1993 Photosynthetic characteristics of segregates from hybrids between Flaveria brownii (C4 like) and Flaveria linearis (C3-C4). Plant Physiol. 101: 825-831.

Burgess SC, Weis B, Jones JG, Smith E, Merritt ME, Margolis D, Dean Sherry A, Malloy CR 2003 Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine. Anal. Biochem. 312: 228-234.

Byrne KM, Smith SK, Ondeyka JG 2002 Biosynthesis of nodulisporic acid A: Precursor studies. J. Am. Chem. Soc. 124: 7055-7060.

Calatayud PA, Baron CH, Velasquez H, Arroyave JA, Lamaze T 2002 Wild Manihot species do not possess C4 photosynthesis. Ann. Bot. (Lond.) 89: 125-127.

Cannizzaro C, Christensen B, Nielsen J, Stockar U 2004 Metabolic network analysis on Phaffia rhodozyma yeast using (13)C-labeled glucose and gas chromatography-mass spectrometry. Metab. Eng. 6: 340-351.

Canonaco F, Hess TA, Heri S, Wang T, Szyperski T, Sauer U 2001 Metabolic flux response to phosphoglucose isomerase knock-out in Escherichia coli and impact of overexpression of the soluble transhydrogenase UdhA. FEMS Microbiol. Lett. 204: 247-252.

Canovas D, Vargas C, Csonka LN, Ventosa A, Nieto JJ 1996 Osmoprotectants in Halomonas elongata: high-affinity betaine transport system and choline-betaine pathway. J. Bacteriol. 178: 7221-7226.

Canovas D, Vargas C, Iglesias-Guerra F, Csonka LN, Rhodes D, Ventosa A, Nieto JJ 1997 Isolation and characterization of salt-sensitive mutants of the moderate halophile Halomonas elongata and cloning of the ectoine synthesis genes. J. Biol. Chem. 272: 25794-25801.

Carvalho RA, Jeffrey FMH, Sherry AD, Malloy CR 1998 C-13 isotopomer analysis of glutamate by heteronuclear multiple quantum coherence total correlation spectroscopy (HMQC-TOCSY). FEBS Lett. 440: 382-386.

Carvalho RA, Jones JG, McGuirk C, Sherry AD, Malloy CR 2002 Hepatic gluconeogenesis and Krebs cycle fluxes in a CCl(4) model of acute liver failure. NMR Biomed. 15: 45-51.

Cayley S, Record MT Jr, Lewis BA 1989 Accumulation of 3-(N-morpholino)propanesulfonate by osmotically stressed Escherichia coli K-12. J. Bacteriol. 171: 3597-3602.

Cernusak LA, Arthur DJ, Pate JS, Farquhar GD 2003 Water relations link carbon and oxygen isotope discrimination to phloem sap sugar concentration in Eucalyptus globulus. Plant Physiol. 131: 1544-1554.

Chance EM, Seeholzer SH, Kobayashi K, Williamson JR 1983 Mathematical analysis of isotope labeling in the citric acid cycle with applications to C-13 NMR studies in perfused rat hearts. J. Biol. Chem. 258: 3785-3794.

Chase JR, Rothman DL, Shulman RG 2001 Flux control in the rat gastrocnemius glycogen synthesis pathway by in vivo 13C/31P NMR spectroscopy. Am. J. Physiol. Endocrinol. Metab. 280: E598-E607.

Chatauret N, Desjardins P, Zwingmann C, Rose C, Rao KV, Butterworth RF 2006 Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure. J. Hepatol. 44: 1083-1088.

Chatham JC, Forder JR, Glickson JD, Chance EM 1995 Calculation of absolute metabolic flux and the elucidation of the pathways of glutamate labeling in perfused rat heart by 13C NMR spectroscopy and nonlinear least squares analysis. J. Biol. Chem. 270: 7999-8008.

Chen L, Spiliotis ET, Roberts MF 1998 Biosynthesis of di-myo-inositol-1,1'-phosphate, a novel osmolyte in hyperthermophilic archaea. J. Bacteriol. 180: 3785-3792.

Chhina N, Kuestermann E, Halliday J, Simpson LJ, Macdonald IA, Bachelard HS, Morris PG 2001 Measurement of human tricarboxylic acid cycle rates during visual activation by 13C magnetic resonance spectroscopy. J. Neurosci. Res. 66: 737-746.

Chikaraishi Y, Naraoka H 2003 Compound-specific deltaD-delta13C analyses of n-alkanes extracted from terrestrial and aquatic plants. Phytochemistry 63: 361-371.

Chikaraishi Y, Naraoka H, Poulson SR 2004 Hydrogen and carbon isotopic fractionations of lipid biosynthesis among terrestrial (C3, C4 and CAM) and aquatic plants. Phytochemistry 65: 1369-1381.

Choe S, Noguchi T, Fujioka S, Takatsuto S, Tissier CP, Gregory BD, Ross AS, Tanaka A, Yoshida S, Tax FE, Feldmann KA 1999 The Arabidopsis dwf7/ste1 mutant is defective in the delta7 sterol C-5 desaturation step leading to brassinosteroid biosynthesis. Plant Cell 11: 207-221.

Choi IY, Wu C, Okar DA, Lange AJ, Gruetter R 2002 Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo (13)C NMR measurements of hepatic carbohydrate metabolism. Eur. J. Biochem. 269: 4418-4426.

Christensen AM, Schaefer J 1993 Solid-state NMR determination of intra- and intermolecular 31P-13C distances for shikimate 3-phosphate and [1-13C]glyphosate bound to enolpyruvylshikimate-3-phosphate synthase. Biochemistry 32: 2868-2873.

Christensen B, Christiansen T, Gombert AK, Thykaer J, Nielsen J 2001 Simple and robust method for estimation of the split between the oxidative pentose phosphate pathway and the Embden-Meyerhof-Parnas pathway in microorganisms. Biotechnol. Bioeng. 74: 517-523.

Christensen B, Gombert AK, Nielsen J 2002 Analysis of flux estimates based on (13)C-labelling experiments. Eur. J. Biochem. 269: 2795-2800.

Christensen B, Nielsen J 1999 Isotopomer analysis using GC-MS. Metab. Eng. 1: 282-290.

Christensen B, Nielsen J 2002 Reciprocal 13C-labeling: a method for investigating the catabolism of cosubstrates. Biotechnol. Prog. 18: 163-166.

Christensen B, Nielsen J 2000 Metabolic network analysis of Penicillium chrysogenum using 13C-labeled glucose. Biotechnol. Bioeng. 68: 652-659.

Christiansen T, Christensen B, Nielsen J 2002 Metabolic network analysis of Bacillus clausii on minimal and semirich medium using 13C-labeled glucose. Metab. Eng. 4: 159-169.

Ciulla RA, Roberts MF 1999 Effects of osmotic stress on Methanococcus thermolithotrophicus: 13C-edited 1H-NMR studies of osmolyte turnover. Biochim. Biophys. Acta 1427: 193-204.

Clark AJ, Blissett KJ, Oliver RP 2003 Investigating the role of polyols in Cladosporium fulvum during growth under hyper-osmotic stress and in planta. Planta 216: 614-619.

Clearwater MJ, Lowe RG, Hofstee BJ, Barclay C, Mandemaker AJ, Blattmann P 2004 Hydraulic conductance and rootstock effects in grafted vines of kiwifruit. J. Exp. Bot. 55: 1371-1382.

Cline GW, LePine RL, Papas KK, Kibbey RG, Shulman GI 2004 13C-NMR isotopomer analysis of anaplerotic pathways in INS-1 cells. J. Biol. Chem. 279: 44370-44375.

Cousins AB, Badger MR, von Caemmerer S 2006 Carbonic anhydrase and its influence on carbon isotope discrimination during C4 photosynthesis. Insights from antisense RNA in Flaveria bidentis. Plant Physiol. 141: 232-242.

Cramer MD, Kleizen C, Morrow C 2007 Does the prostrate-leaved geophyte Brunsvigia orientalis utilize soil-derived CO2 for photosynthesis? Ann. Bot. (Lond.) 99: 835-844.

Crecelius F, Streb P, Feierabend J 2003 Malate metabolism and reactions of oxidoreduction in cold-hardened winter rye (Secale cereale L.) leaves. J. Exp. Bot. 54: 1075-1083.

Cruz F, Cerdan S 1999 Quantitative 13C NMR studies of metabolic compartmentation in the adult mammalian brain. NMR Biomed. 12: 451-462.

Cummings SP, Williamson MP, Gilmour DJ 1993 Turgor regulation in a novel Halomonas species. Arch. Microbiol. 160: 319-323.

Cvejic JH, Rohmer M 2000 CO2 as main carbon source for isoprenoid biosynthesis via the mevalonate-independent methylerythritol 4-phosphate route in the marine diatoms Phaeodactylum tricornutum and Nitzschia ovalis. Phytochemistry 53: 21-28.

D'Souza-Ault MR, Smith LT, Smith GM 1993 Roles of N-acetylglutaminylglutamine amide and glycine betaine in adaptation of Pseudomonas aeruginosa to osmotic stress. Appl. Environ. Microbiol. 59: 473-478.

Damesin C, Lelarge C 2003 Carbon isotope composition of current-year shoots from Fagus sylvatica in relation to growth, respiration and use of reserves. Plant Cell Environ. 26: 207-219.

Dauner M, Bailey JE, Sauer U 2001 Metabolic flux analysis with a comprehensive isotopomer model in Bacillus subtilis. Biotechnol. Bioeng. 76: 144-156.

Dauner M, Storni T, Sauer U 2001 Bacillus subtilis metabolism and energetics in carbon-limited and excess-carbon chemostat culture. J. Bacteriol. 183: 7308-7317.

David H, Krogh AM, Roca C, Akesson M, Nielsen J 2005 CreA influences the metabolic fluxes of Aspergillus nidulans during growth on glucose and xylose. Microbiology 151: 2209-2221.

Davies LM, Harris PJ 2003 Atomic force microscopy of microfibrils in primary cell walls. Planta 217: 283-289.

Davin LB, Wang CZ, Helms GL, Lewis NG 2003 [13C]-Specific labeling of 8-2' linked (-)-cis-blechnic, (-)-trans-blechnic and (-)-brainic acids in the fern Blechnum spicant. Phytochemistry 62: 501-511.

Dawson GW, Pickett JA, Smiley DW 1996 The aphid sex pheromone cyclopentanoids: synthesis in the elucidation of structure and biosynthetic pathways. Bioorg. Med. Chem. 4: 351-361.

de Graaf AA, Eggeling L, Sahm H 2001 Metabolic engineering for L-lysine production by Corynebacterium glutamicum. Adv. Biochem. Eng. Biotechnol. 73: 9-29.

de Graaf AA, Mahle M, Mollney M, Wiechert W, Stahmann P, Sahm H 2000 Determination of full 13C isotopomer distributions for metabolic flux analysis using heteronuclear spin echo difference NMR spectroscopy. J. Biotechnol. 77: 25-35.

de Graaf AA, Striegel K, Wittig RM, Laufer B, Schmitz G, Wiechert W, Sprenger GA, Sahm H 1999 Metabolic state of Zymomonas mobilis in glucose-, fructose-, and xylose-fed continuous cultures as analysed by 13C- and 31P-NMR spectroscopy. Arch. Microbiol. 171: 371-385.

de Meer K, Roef MJ, Kulik W, Jakobs C 1999 In vivo research with stable isotopes in biochemistry, nutrition and clinical medicine: an overview. Isotopes in Environ. & Health Studies 35: 19-37.

de Pascoli IC, Nascimento IR, Lopes LM 2006 Configurational analysis of cubebins and bicubebin from Aristolochia lagesiana and Aristolochia pubescens. Phytochemistry 67: 735-742.

de Souza CR, Maroco JP, Dos Santos TP, Rodrigues ML, Lopes CM, Pereira JS, Chaves MM 2005 Impact of deficit irrigation on water use efficiency and carbon isotope composition ({delta}13C) of field-grown grapevines under Mediterranean climate. J. Exp. Bot. 56: 2163-2172.

De-Eknamkul W, Potduang B 2003 Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. Phytochemistry 62: 389-398.

Dean JV, Devarenne TP, Lee IS, Orlofsky LE 1995 Properties of a maize glutathione S-transferase that conjugates coumaric acid and other phenylpropanoids. Plant Physiol. 108: 985-994.

Deborde C, Rolin DB, Boyaval P 1999 In vivo 13C NMR study of the bidirectional reactions of the Wood-Werkman cycle and around the pyruvate node in Propionibacterium freudenreichii subsp. shermanii and Propionibacterium acidipropionici. Metab. Eng. 1: 309-319.

Denton TM, Schmidt S, Critchley C, Stewart GR 2001 Natural abundance of stable carbon and nitrogen isotopes in Cannabis sativa reflects growth conditions. Aust. J. Plant Physiol. 28: 1005-1012.

Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, Fernandez CA, Brunengraber H 1995 Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis. J. Biol. Chem. 270: 10027-10036.

Des Rosiers C, Lloyd S, Comte B, Chatham JC 2004 A critical perspective of the use of (13)C-isotopomer analysis by GCMS and NMR as applied to cardiac metabolism. Metab. Eng. 6: 44-58.

Des Rosiers C, Montgomery JA, Desrochers S, Garneau M, David F, Mamer OA, Brunengraber H 1988 Interference of 3-hydroxyisobutyrate with measurements of ketone body concentration and isotopic enrichment by gas chromatography-mass spectrometry. Anal. Biochem. 173: 96-105.

Deutsch JC, Kolhouse JF 1993 Ascorbate and dehydroascorbate measurements in aqueous solutions and plasma determined by gas chromatography-mass spectrometry. Anal. Chem. 65: 321-326.

Di Donato L, Des Rosiers C, Montgomery JA, David F, Garneau M, Brunengraber H 1993 Rates of gluconeogenesis and citric acid cycle in perfused livers, assessed from the mass spectrometric assay of the 13C labeling pattern of glutamate. J. Biol. Chem. 268: 4170-4180.

Dieuaide-Noubhani M, Canioni P, Raymond P 1997 Sugar starvation induced changes of carbon metabolism in excised maize root tips. Plant Physiol. 115: 1505-1513.

Dieuaide-Noubhani M, Raffard G, Canioni P, Pradet A, Raymond P 1995 Quantification of compartmented metabolic fluxes in maize root tips using isotope distribution from 13C- or 14C-labeled glucose. J. Biol. Chem. 270: 13147-13159.

Dijkema C, Kester HC, Visser J 1985 13C NMR studies of carbon metabolism in the hyphal fungus Aspergillus nidulans. Proc. Natl. Acad. Sci. U.S.A. 82: 14-18.

Disch A, Hemmerlin A, Bach TJ, Rohmer M 1998 Mevalonate-derived isopentenyl diphosphate is the biosynthetic precursor of ubiquinone prenyl side chain in tobacco BY-2 cells. Biochem. J. 331: 615-621.

Dolle A 2000 Metabolism of D- and L-[13C]alanine in rat liver detected by 1H and 13C NMR spectroscopy in vivo and in vitro. NMR Biomed. 13: 72-81.

Dominguez H, Rollin C, Guyonvarch A, Guerquin-Kern JL, Cocaign-Bousquet M, Lindley ND 1998 Carbon-flux distribution in the central metabolic pathways of Corynebacterium glutamicum during growth on fructose. Eur. J. Biochem. 254: 96-102.

Drews M, Doverskog M, Ohman L, Chapman BE, Jacobsson U, Kuchel PW, Haggstrom L 2000 Pathways of glutamine metabolism in Spodoptera frugiperda (Sf9) insect cells: evidence for the presence of the nitrogen assimilation system, and a metabolic switch by 1H/15N NMR. J. Biotechnol. 78: 23-37.

Drysch A, El Massaoudi M, Mack C, Takors R, de Graaf AA, Sahm H 2003 Production process monitoring by serial mapping of microbial carbon flux distributions using a novel Sensor Reactor approach: II--(13)C-labeling-based metabolic flux analysis and L-lysine production. Metab. Eng. 5: 96-107.

Duan J, Zheng Y, Dong Q, Fang J 2004 Structural analysis of a pectic polysaccharide from the leaves of Diospyros kaki. Phytochemistry 65: 609-615.

Dubois F, Terce-Laforgue T, Gonzalez-Moro MB, Estavillo JM, Sangwan R, Gallais A, Hirel B 2003 Glutamate dehydrogenase in plants: is there a new story for an old enzyme? Plant Physiol. Biochem. 41: 565-576.

Dugelay S, Chauvin MF, Megnin-Chanet F, Martin G, Lareal MC, Lhoste JM, Baverel G 1999 Acetate stimulates flux through the tricarboxylic acid cycle in rabbit renal proximal tubules synthesizing glutamine from alanine: a 13C nmr study. Biochem. J. 342: 555-566.

Duran-Patron R, O'Hagan D, Hamilton JTG, Wong CW 2000 Biosynthetic studies on the tropane ring system of the tropane alkaloids from Datura stramonium. Phytochemistry 53: 777-784.

Duranceau M, Ghashghaie J, Brugnoli E 2001 Carbon isotope discrimination during photosynthesis and dark respiration in intact leaves of Nicotiana sylvestris: comparisons between wild type and mitochondrial mutant plants. Aust. J. Plant Physiol. 28: 65-71.

Dyckmans J, Flessa H, Brinkmann K, Mai C, Polle A 2002 Carbon and nitrogen dynamics in acid detergent fibre lignins of beech (Fagus sylvatica L.) during the growth phase. Plant Cell Environ. 25: 469-478.

Dyckmans J, Flessa H, Shangguan Z, Beese F 2000 A dual 13C and 15N long term labelling technique to investigate uptake and translocation of C and N in beech. Isotopes Environ. Health. Stud. 36: 63-78.

Edwards EJ, Diaz M 2006 Ecological physiology of Pereskia guamacho, a cactus with leaves. Plant Cell Environ. 29: 247-256.

Edwards S, Nguyen BT, Do B, Roberts JKM 1998 Contribution of malic enzyme, pyruvate kinase, phosphoenolpyruvate carboxylase, and the Krebs cycle to respiration and biosynthesis and to intracellular pH regulation during hypoxia in maize root tips observed by NMR and GC-MS. Plant Physiol. 116: 1073-1081.

Eigenbrode JL, Freeman KH 2006 Late Archean rise of aerobic microbial ecosystems. Proc. Natl. Acad. Sci. U.S.A. 103: 15759-15764.

Eisenreich W, Menhard B, Hylands PJ, Zenk MH, Bacher A 1996 Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin. Proc. Natl. Acad. Sci. U.S.A. 93: 6431-6436.

Eisenreich W, Slaghuis J, Laupitz R, Bussemer J, Stritzker J, Schwarz C, Schwarz R, Dandekar T, Goebel W, Bacher A 2006 13C Isotopologue perturbation studies of Listeria monocytogenes carbon metabolism and its modulation by the virulence regulator PrfA. Proc. Natl. Acad. Sci. U.S.A. 103: 2040-2045.

Eisenreich W, Strauss G, Werz U, Fuchs G, Bacher A 1993 Retrobiosynthetic analysis of carbon fixation in the phototrophic eubacterium Chloroflexus aurantiacus. Eur. J. Biochem. 215: 619-632.

El Massaoudi M, Spelthahn J, Drysch A, de Graaf A, Takors R 2003 Production process monitoring by serial mapping of microbial carbon flux distributions using a novel sensor reactor approach: I--Sensor reactor system. Metab. Eng. 5: 86-95.

Emmerling M, Dauner M, Ponti A, Fiaux J, Hochuli M, Szyperski T, Wuthrich K, Bailey JE, Sauer U 2002 Metabolic flux responses to pyruvate kinase knockout in Escherichia coli. J. Bacteriol. 184: 152-164.

Enos-Berlage JL, Downs DM 1999 Biosynthesis of the pyrimidine moiety of thiamine independent of the PurF enzyme (phosphoribosylpyrophosphate amidotransferase) in Salmonella typhimurium: incorporation of stable isotope-labeled glycine and formate. J. Bacteriol. 181: 841-848.

Ettenhuber C, Radykewicz T, Kofer W, Koop HU, Bacher A, Eisenreich W 2005 Metabolic flux analysis in complex isotopolog space. Recycling of glucose in tobacco plants. Phytochemistry 66: 323-335.

Evans L, Hedger JN, Brayford D, Stavri M, Smith E, O'donnell G, Gray AI, Griffith GW, Gibbons S 2006 An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum. Phytochemistry 67: 2110-2114.

Feild TS, Brodribb TJ 2005 A unique mode of parasitism in the conifer coral tree Parasitaxus ustus (Podocarpaceae). Plant Cell Environ. 28: 1316-1325.

Fellermeier M, Eisenreich W, Bacher A, Zenk MH 2001 Biosynthesis of cannabinoids. Incorporation experiments with 13C-labeled glucoses. Eur. J. Biochem. 268: 1596-1604.

Fellermeier M, Raschke M, Sagner S, Wungsintaweekul J, Schuhr CA, Hecht S, Kis K, Radykewicz T, Adam P, Rohdich F, Eisenreich W, Bacher A, Arigoni D, Zenk MH 2001 Studies on the nonmevalonate pathway of terpene biosynthesis. The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants. Eur. J. Biochem. 268: 6302-6310.

Feng Ma J, Hiradate S, Matsumoto H 1998 High aluminum resistance in buckwheat. II. Oxalic acid detoxifies aluminum internally. Plant Physiol. 117: 753-759.

Fernandez CA, Des Rosiers C 1995 Modeling of liver citric acid cycle and gluconeogenesis based on 13C mass isotopomer distribution analysis of intermediates. J. Biol. Chem. 270: 10037-10042.

Fernie AR, Roscher A, Ratcliffe RG, Kruger NJ 2001 Fructose 2,6-bisphosphate activates pyrophosphate: fructose-6-phosphate 1-phosphotransferase and increases triose phosphate to hexose phosphate cycling in heterotrophic cells. Planta 212: 250-263.

Fischer E, Sauer U 2003 Metabolic flux profiling of Escherichia coli mutants in central carbon metabolism using GC-MS. Eur. J. Biochem. 270: 880-891.

Flexas J, Ribas-Carbo M, Hanson DT, Bota J, Otto B, Cifre J, McDowell N, Medrano H, Kaldenhoff R 2006 Tobacco aquaporin NtAQP1 is involved in mesophyll conductance to CO2 in vivo. Plant J. 48: 427-439.

Flores S, Gosset G, Flores N, de Graaf AA, Bolivar F 2002 Analysis of carbon metabolism in Escherichia coli strains with an inactive phosphotransferase system by (13)C labeling and NMR spectroscopy. Metab. Eng. 4: 124-137.

Follstad BD, Stephanopoulos G 1998 Effect of reversible reactions on isotope label redistribution--analysis of the pentose phosphate pathway. Eur. J. Biochem. 252: 360-371.

Fonseca CP, Jones JG, Carvalho RA, Jeffrey FM, Montezinho LP, Geraldes CF, Castro MM 2005 Tricarboxylic acid cycle inhibition by Li+ in the human neuroblastoma SH-SY5Y cell line: a 13C NMR isotopomer analysis. Neurochem. Int. 47: 385-393.

Ford JD, Huang KS, Wang HB, Davin LB, Lewis NG 2001 Biosynthetic pathway to the cancer chemopreventive secoisolariciresinol diglucoside-hydroxymethyl glutaryl ester- linked lignan oligomers in flax (Linum usitatissimum) seed. J. Nat. Prod. 64: 1388-1397.

Francisco MC, Nasser AL, Lopes LM 2003 Tetrahydroisoquinoline alkaloids and 2-deoxyribonolactones from Aristolochia arcuata. Phytochemistry 62: 1265-1270.

Frey AD, Fiaux J, Szyperski T, Wuthrich K, Bailey JE, Kallio PT 2001 Dissection of central carbon metabolism of hemoglobin-expressing Escherichia coli by (13)C nuclear magnetic resonance flux distribution analysis in microaerobic bioprocesses. Appl. Environ. Microbiol. 67: 680-687.

Frick O, Wittmann C 2005 Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis. Microb. Cell. Fact. 4: 30.

Frings E, Kunte HJ, Galinski EA 1993 Compatible solutes in representatives of the genera Brevibacterium and Corynebacterium - occurrence of tetrahydropyrimidines and glutamine. FEMS Microbiol. Lett. 109: 25-32.

Fu TF, Rife JP, Schirch V 2001 The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in mcf-7 cells as determined by 13C NMR. Arch. Biochem. Biophys. 393: 42-50.

Fujita K, Okada M, Lei K, Ito J, Ohkura K, Adu-Gyamfi JJ, Mohapatra PK 2003 Effect of P-deficiency on photoassimilate partitioning and rhythmic changes in fruit and stem diameter of tomato (Lycopersicon esculentum) during fruit growth. J. Exp. Bot. 54: 2519-2528.

Fukusaki E, Harada K, Bamba T, Kobayashi A 2005 An isotope effect on the comparative quantification of flavonoids by means of methylation-based stable isotope dilution coupled with capillary liquid chromatography/mass spectrometry. J. Biosci. Bioeng. 99: 75-77.

Garbarino JA, Chamy MC, Piovano M, Espinoza L, Belmonte E 2004 Diterpenoids from Calceolaria inamoena. Phytochemistry 65: 903-908.

Garcia-Estepa R, Canovas D, Iglesias-Guerra F, Ventosa A, Csonka LN, Nieto JJ, Vargas C 2006 Osmoprotection of Salmonella enterica serovar Typhimurium by N(gamma)-acetyldiaminobutyrate, the precursor of the compatible solute ectoine. Syst. Appl. Microbiol. 29: 626-633.

Gaudillere JP, Van Leeuwen C, Ollat N 2002 Carbon isotope composition of sugars in grapevine, an integrated indicator of vineyard water status. J. Exp. Bot. 53: 757-763.

Gauvin A, Susperregui J, Barth P, Louis R, Deleris G, Smadja J 2004 An acetylated monoterpene and a sesquiterpene alcohol from Psiadia anchusifolia. Phytochemistry 65: 897-901.

Gebbing T, Schnyder H 1999 Pre-anthesis reserve utilization for protein and carbohydrate synthesis in grains of wheat. Plant Physiol. 121: 871-878.

Georg GI, Cheruvallath ZS, Himes RH, Mejillano MR, Burke CT 1992 Synthesis of biologically active taxol analogues with modified phenylisoserine side chains. J. Med. Chem. 35: 4230-4237.

Gerendas J, Ratcliffe RG 2000 Intracellular pH regulation in maize root tips exposed to ammonium at high external pH. J. Exp. Bot. 51: 207-219.

Gerhardt B, Fischer K, Balkenhohl TJ, Pohnert G, Kuhn H, Wasternack C, Feussner I 2005 Lipoxygenase-mediated metabolism of storage lipids in germinating sunflower cotyledons and beta-oxidation of (9Z,11E,13S)-13-hydroxy-octadeca-9,11-dienoic acid by the cotyledonary glyoxysomes. Planta 220: 919-930.

Ghashghaie J, Duranceau M, Badeck FW, Cornic G, Adeline MT, Deleens E 2001 d13C of CO2 respired in the dark in relation to d13C of leaf metabolites: comparison between Nicotiana sylvestris and Helianthus annuus under drought. Plant Cell Environ. 24: 505-515.

Ghoumari H, Benajiba MH, Garcia-Granados A, Fernandez A, Martinez A, Rivas F, Arias JM 2006 Biotransformations of ent-18-acetoxy-6-ketomanoyl oxides epimers at C-13 with filamentous fungi. Phytochemistry 67: 2294-2302.

Giege P, Heazlewood JL, Roessner-Tunali U, Millar AH, Fernie AR, Leaver CJ, Sweetlove LJ 2003 Enzymes of glycolysis are functionally associated with the mitochondrion in Arabidopsis cells. Plant Cell 15: 2140-2151.

Gillon JS, Yakir D 2000 Internal conductance to CO(2) diffusion and C(18)O2 discrimination in C(3) leaves. Plant Physiol. 123: 201-214.

Glawischnig E, Gierl A, Tomas A, Bacher A, Eisenreich W 2001 Retrobiosynthetic nuclear magnetic resonance analysis of amino acid biosynthesis and intermediary metabolism. metabolic flux in developing maize kernels. Plant Physiol. 125: 1178-1186.

Glawischnig E, Gierl A, Tomas A, Bacher A, Eisenreich W 2002 Starch biosynthesis and intermediary metabolism in maize kernels. Quantitative analysis of metabolite flux by nuclear magnetic resonance. Plant Physiol. 130: 1717-1727.

Glawischnig E, Tomas A, Eisenreich W, Spiteller P, Bacher A, Gierl A 2000 Auxin biosynthesis in maize kernels. Plant Physiol. 123: 1109-1120.

Gleixner G, Danier HJ, Werner RA, Schmidt HL 1993 Correlations between the 13C content of primary and secondary plant products in different cell compartments and that in decomposing Basidiomycetes. Plant Physiol. 102: 1287-1290.

Goese M, Kammhuber K, Bacher A, Zenk MH, Eisenreich W 1999 Biosynthesis of bitter acids in hops. A 13C-NMR and 2H-NMR study on the building blocks of humulone. Eur. J. Biochem. 263: 447-454.

Gombert AK, Moreira dos Santos M, Christensen B, Nielsen J 2001 Network identification and flux quantification in the central metabolism of Saccharomyces cerevisiae under different conditions of glucose repression. J. Bacteriol. 183: 1441-1451.

Goshe MB, Anderson VE 1995 Determination of amino acid isotope ratios by electrospray ionization-mass spectrometry. Anal. Biochem. 231: 387-392.

Gouffi K, Pica N, Pichereau V, Blanco C 1999 Disaccharides as a new class of nonaccumulated osmoprotectants for Sinorhizobium meliloti. Appl. Environ. Microbiol. 65: 1491-1500.

Gout E, Aubert S, Bligny R, Rebeille F, Nonomura AR, Benson AA, Douce R 2000 Metabolism of methanol in plant cells. Carbon-13 nuclear magnetic resonance studies. Plant Physiol. 123: 287-296.

Gout E, Bligny R, Douce R 1992 Regulation of intracellular pH values in higher plant cells: carbon-13 and phosphorus-31 nuclear magnetic resonance studies. J. Biol. Chem. 267: 13903-13909.

Gout E, Bligny R, Genix P, Tissut M, Douce R 1992 Effect of glyphosate on plant cell metabolism. 31P and 13C NMR studies. Biochimie 74: 875-882.

Gout E, Boisson AM, Aubert S, Douce R, Bligny R 2001 Origin of the cytoplasmic pH changes during anaerobic stress in higher plant cells. Carbon-13 and phosphorous-31 nuclear magnetic resonance studies. Plant Physiol. 125: 912-925.

Graser G, Schneider B, Oldham NJ, Gershenzon J 2000 The methionine chain elongation pathway in the biosynthesis of glucosinolates in Eruca sativa (Brassicaceae). Arch. Biochem. Biophys. 378: 411-419.

Griffin JL, Nicholls AW, Keun HC, Mortishire-Smith RJ, Nicholson JK, Kuehn T 2002 Metabolic profiling of rodent biological fluids via 1H NMR spectroscopy using a 1 mm microlitre probe. Analyst 127: 582-584.

Grotkjaer T, Christakopoulos P, Nielsen J, Olsson L 2005 Comparative metabolic network analysis of two xylose fermenting recombinant Saccharomyces cerevisiae strains. Metab. Eng. 7: 437-444.

Gruetter R, Seaquist ER, Ugurbil K 2001 A mathematical model of compartmentalized neurotransmitter metabolism in the human brain. Am. J. Physiol. Endocrinol. Metab. 281: E100-E112.

Guerrini A, Sacchetti G, Muzzoli M, Moreno Rueda G, Medici A, Besco E, Bruni R 2006 Composition of the volatile fraction of Ocotea bofo Kunth (Lauraceae) calyces by GC-MS and NMR fingerprinting and its antimicrobial and antioxidant activity. J. Agric. Food Chem. 54: 7778-7788.

Guilhaudis L, Simorre JP, Blackledge M, Neuburger M, Bourguignon J, Douce R, Marion D, Gans P 1999 Investigation of the local structure and dynamics of the H subunit of the mitochondrial glycine decarboxylase using heteronuclear NMR spectroscopy. Biochemistry 38: 8334-8346.

Gunnarsson N, Bruheim P, Nielsen J 2004 Glucose metabolism in the antibiotic producing actinomycete Nonomuraea sp. ATCC 39727. Biotechnol. Bioeng. 88: 652-663.

Haber S, Lapidot A 2001 Energy fuel utilization by fetal versus young rabbit brain: a 13C MRS isotopomer analysis of [U-(13)C]glucose metabolites. Brain Res. 896: 102-117.

Haenzelmann P, Hernandez HL, Menzel C, Garcia-Serres R, Huynh BH, Johnson MK, Mendel RR, Schindelin H 2004 Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis. J. Biol. Chem. 279: 34721-34732.

Hanson AD, Rivoal J, Paquet L, Gage DA 1994 Biosynthesis of 3-dimethylsulfoniopropionate in Wollastonia biflora (L.) DC. Evidence that S-methylmethionine is an intermediate. Plant Physiol. 105: 103-110.

Hartung W, Ratcliffe RG 2002 Utilization of glycine and serine as nitrogen sources in the roots of Zea mays and Chamaegigas intrepidus. J. Exp. Bot. 53: 2305-2314.

Hashiguchi K, Takesada H, Suzuki E, Matsui H 1999 Construction of an L-isoleucine overproducing strain of Escherichia coli K-12. Biosci. Biotechnol. Biochem. 63: 672-679.

Hassel B, Johannessen CU, Sonnewald U, Fonnum F 1998 Quantification of the GABA shunt and the importance of the GABA shunt versus the 2-oxoglutarate dehydrogenase pathway in GABAergic neurons. J. Neurochem. 71: 1511-1518.

Hassel B, Sonnewald U 2002 Effects of potassium and glutamine on metabolism of glucose in astrocytes. Neurochem. Res. 27: 167-171.

Haupt-Herting S, Fock HP 2002 Oxygen exchange in relation to carbon assimilation in water-stressed leaves during photosynthesis. Ann. Bot. (Lond.) 89: 851-859.

Haupt-Herting S, Klug K, Fock HP 2001 A new approach to measure gross CO2 fluxes in leaves. Gross CO2 assimilation, photorespiration, and mitochondrial respiration in the light in tomato under drought stress. Plant Physiol. 126: 388-396.

Hausler N, Browning J, Merritt M, Storey C, Milde A, Jeffrey FM, Sherry AD, Malloy CR, Burgess SC 2006 Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver by integrated 2H and 13C NMR. Biochem. J. 394: 465-473.

Hawkins HJ, Wolf G, Stock WD 2005 Cluster roots of Leucadendron laureolum (Proteaceae) and Lupinus albus (Fabaceae) take up glycine Intact: an adaptive strategy to low mineral nitrogen in soils? Ann. Bot. (Lond.) 96: 1275-1282.

Hegemann P 1997 Vision in microalgae. Planta 203: 265-274.

Helle G, Schleser GH 2004 Beyond CO2-fixation by Rubisco - an interpretation of C-13/C-12 variations in tree rings from novel intra-seasonal studies on broad-leaf trees. Plant Cell Environ. 27: 367-380.

Henry PG, Adriany G, Deelchand D, Gruetter R, Marjanska M, Oz G, Seaquist ER, Shestov A, Ugurbil K 2006 In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective. Magn. Reson. Imaging 24: 527-539.

Hertweck C, Moore BS 2000 A plant-like biosynthesis of benzoyl-CoA in the marine bacterium 'Streptomyces maritimus'. Tetrahedron 56: 9115-9120.

Heyser JW, Chacon MJ, Warren RS 1989 Characterization of L-[5-13C]-proline biosynthesis in halophytic and nonhalophytic suspension cultures by 13C NMR. J. Plant Physiol. 135: 459-466.

Himmelreich U, Chapman BE, Kuchel PW 1999 Membrane permeability of formate in human erythrocytes: NMR measurements. Eur. Biophys. J. 28: 158-165.

Hirata K, Poeaknapo C, Schmidt J, Zenk MH 2004 1,2-Dehydroreticuline synthase, the branch point enzyme opening the morphinan biosynthetic pathway. Phytochemistry 65: 1039-1046.

Hochuli M, Patzelt H, Oesterhelt D, Wuthrich K, Szyperski T 1999 Amino acid biosynthesis in the halophilic archaeon Haloarcula hispanica. J. Bacteriol. 181: 3226-3337.

Hochuli M, Szyperski T, Wuthrich K 2000 Deuterium isotope effects on the central carbon metabolism of Escherichia coli cells grown on a D2O-containing minimal medium. J. Biomol. NMR 17: 33-42.

Hodge A 2003 N capture by Plantago lanceolata and Brassica napus from organic material: the influence of spatial dispersion, plant competition and an arbuscular mycorrhizal fungus. J. Exp. Bot. 54: 2331-2342.

Hoeffler JF, Tritsch D, Grosdemange-Billiard C, Rohmer M 2002 Isoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Eur. J. Biochem. 269: 4446-4457.

Hoon Yang T, Wittmann C, Heinzle E 2006 Respirometric (13)C flux analysis. Part II: in vivo flux estimation of lysine-producing Corynebacterium glutamicum. Metab. Eng. 8: 432-446.

Hua Q, Joyce AR, Fong SS, Palsson BO 2006 Metabolic analysis of adaptive evolution for in silico designed lactate-producing strains. Biotechnol. Bioeng. 95: 992-1002.

Huege J, Sulpice R, Gibon Y, Lisec J, Koehl K, Kopka J 2007 GC-EI-TOF-MS analysis of in vivo carbon-partitioning into soluble metabolite pools of higher plants by monitoring isotope dilution after (13)CO(2) labelling. Phytochemistry 68: 2258-2272.

Huertas IE, Colman B, Espie GS 2002 Mitochondrial-driven bicarbonate transport supports photosynthesis in a marine microalga. Plant Physiol. 130: 284-291.

Huertas IE, Espie GS, Colman B, Lubian LM 2000 Light-dependent bicarbonate uptake and CO2 efflux in the marine microalga Nannochloropsis gaditana. Planta 211: 43-49.

Hunter BK, Nicholls KM, Sanders JK 1984 Formaldehyde metabolism by Escherichia coli. In vivo carbon, deuterium, and two-dimensional NMR observations of multiple detoxifying pathways. Biochemistry 23: 508-514.

Hunter BK, Nicholls KM, Sanders JK 1985 Formaldehyde metabolism by Escherichia coli. Carbon and solvent deuterium incorporation into glycerol, 1,2-propanediol, and 1,3-propanediol. Biochemistry 24: 4148-4155.

Hussein SA, Hashim AN, El-Sharawy RT, Seliem MA, Linscheid M, Lindequist U, Nawwar MA 2007 Ericifolin: an eugenol 5-O-galloylglucoside and other phenolics from Melaleuca ericifolia. Phytochemistry 68: 1464-1470.

Hutton WC, Likos JJ, Gard JK, Garbow JR 1998 Triple resonance isotope-edited (TRIED): a powerful new NMR technique for studying metabolism. J. Labelled Compounds & Radiopharmaceuticals 41: 87-95.

Iida K, Mimura I, Kajiwara M 2002 Evaluation of two biosynthetic pathways to delta-aminolevulinic acid in Euglena gracilis. Eur. J. Biochem. 269: 291-297.

Ismail W, El-Said Mohamed M, Wanner BL, Datsenko KA, Eisenreich W, Rohdich F, Bacher A, Fuchs G 2003 Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Eur. J. Biochem. 270: 3047-3054.

Ito O, Mitsumori F 1992 Transformation and translocation of photoassimilated (CO2)-C-13 and glycine-2-C-13 in sunflower leaves detected by C-13-NMR. Soil Sci. Plant Nutr. 38: 347-360.

Ivlev AA 2002 Carbon isotope (13C/12C) effect of photorespiration in photosynthetic organisms. Evidence for existence, probable mechanism. Biofizika 47: 55-70.

Ivlev AA, Bykova NV, Igamberdiev AU 1996 Fractionation of carbon (13C/12C) isotopes in glycine decarboxylase reaction. FEBS Lett. 386: 174-176.

Iwatani S, Van Dien S, Shimbo K, Kubota K, Kageyama N, Iwahata D, Miyano H, Hirayama K, Usuda Y, Shimizu K, Matsui K 2007 Determination of metabolic flux changes during fed-batch cultivation from measurements of intracellular amino acids by LC-MS/MS. J. Biotechnol. 128: 93-111.

Jain SC, Pandey MK, Upadhyay RK, Kumar R, Hundal G, Hundal MS 2006 Alkaloids from Toddalia aculeata. Phytochemistry 67: 1005-1010.

Jaroszewski JW, Rasmussen AB, Rasmussen HB, Olsen CE, Jorgensen LB 1996 Biosynthesis of cyanohydrin glucosides from unnatural nitriles in intact tissue of Passiflora morifolia and Turnera angustifolia. Phytochemistry 42: 649-654.

Jeffrey FM, Roach JS, Storey CJ, Sherry AD, Malloy CR 2002 13C isotopomer analysis of glutamate by tandem mass spectrometry. Anal. Biochem. 300: 192-205.

Jensen NB, Christensen B, Nielsen J, Villadsen J 2002 The simultaneous biosynthesis and uptake of amino acids by Lactococcus lactis studied by 13C-labeling experiments. Biotechnol. Bioeng. 78: 11-16.

Jeong SS, Schirch V 1996 Role of cytosolic serine hydroxymethyltransferase in one-carbon metabolism in Neurospora crassa. Arch. Biochem. Biophys. 335: 333-341.

Johannessen CU, Qu H, Sonnewald U, Hassel L, Fonnum F 2001 Estimation of aspartate synthesis in GABAergic neurons in mice by C-13 NMR spectroscopy. Neuroreport 12: 3729-3732.

Jolivet P, Gans P, Triantaphylides C 1985 Determination of glycolic acid level in higher plants during photorespiration by stable isotope dilution mass spectrometry with double-labeling experiments. Anal. Biochem. 147: 86-91.

Jonsbu E, Christensen B, Nielsen J 2001 Changes of in vivo fluxes through central metabolic pathways during the production of nystatin by Streptomyces noursei in batch culture. Appl. Microbiol. Biotechnol. 56: 93-100.

Joseleau JP, Ruel K 1997 Study of lignification by noninvasive techniques in growing maize internodes. Plant Physiol. 114: 1123-1133.

Jucker BM, Lee JY, Shulman RG 1998 In vivo 13C NMR measurements of hepatocellular tricarboxylic acid cycle flux. J. Biol. Chem. 273: 12187-12194.

Juenger TE, Mckay JK, Hausmann N, Keurentjes JJB, Sen S, Stowe KA, Dawson TE, Simms EL, Richards JH 2005 Identification and characterization of QTL underlying whole-plant physiology in Arabidopsis thaliana: delta C-13, stomatal conductance and transpiration efficiency. Plant Cell Environ. 28: 697-708.

Kadirkamanathan V, Yang J, Billings SA, Wright PC 2006 Markov Chain Monte Carlo algorithm based metabolic flux distribution analysis on Corynebacterium glutamicum. Bioinformatics 22: 2681-2687.

Kagawa A, Sugimoto A, Maximov TC 2006 13CO2 pulse-labelling of photoassimilates reveals carbon allocation within and between tree rings. Plant Cell Environ. 29: 1571-1584.

Kagawa A, Sugimoto A, Yamashita K, Abe H 2005 Temporal photosynthetic carbon isotope signatures revealed in a tree ring through (CO2)-C-13 pulse-labelling. Plant Cell Environ. 28: 906-915.

Kanamori K, Ross BD 2001 The first in vivo observation of 13C-15N coupling in mammalian brain. J. Magn. Reson. 153: 193-202.

Kanaori K, Uodome N, Nagai A, Ohta D, Ogawa A, Iwasaki G, Nosaka AY 1996 113Cd nuclear magnetic resonance studies of cabbage histidinol dehydrogenase. Biochemistry 35: 5949-5954.

Kang H, Kang MY, Han KH 2000 Identification of natural rubber and characterization of rubber biosynthetic activity in fig tree. Plant Physiol. 123: 1133-1142.

Kang JH, Wang L, Giri A, Baldwin IT 2006 Silencing threonine deaminase and JAR4 in Nicotiana attenuata impairs jasmonic acid-isoleucine-mediated defenses against Manduca sexta. Plant Cell 18: 3303-3320.

Karl T, Curtis AJ, Rosenstiel TN, Monson RK, Fall R 2002 Transient releases of acetaldehyde from tree leaves - products of a pyruvate overflow mechanism?. Plant Cell Environ. 25: 1121-1131.

Karl T, Fall R, Rosenstiel TN, Prazeller P, Larsen B, Seufert G, Lindinger W 2002 On-line analysis of the 13CO2 labeling of leaf isoprene suggests multiple subcellular origins of isoprene precursors. Planta 215: 894-905.

Karppinen K, Hokkanen J, Tolonen A, Mattila S, Hohtola A 2007 Biosynthesis of hyperforin and adhyperforin from amino acid precursors in shoot cultures of Hypericum perforatum. Phytochemistry 68: 1038-1045.

Karsten U, Barrow KD, King RJ 1993 Floridoside, L-isofloridoside, and D-isofloridoside in the red alga Porphyra columbina. Seasonal and osmotic effects. Plant Physiol. 103: 485-491.

Karsten U, Michalik D, Michalik M, West JA 2005 A new unusual low molecular weight carbohydrate in the red algal genus Hypoglossum (Delesseriaceae, Ceramiales) and its possible function as an osmolyte. Planta 222: 319-326.

Kastanos EK, Woldman YY, Appling DR 1997 Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae. Biochemistry 36: 14956-14964.

Katul GG, Ellsworth DS, Lai CT 2000 Modelling assimilation and intercellular CO2 from measured conductance: a synthesis of approaches. Plant Cell Environ. 23: 1313-1328.

Katz J, Lee WNP, Wals PA, Bergner EA 1989 Studies of glycogen synthesis and the Krebs cycle by mass isotopomer analysis with [U-13C]glucose in rats. J. Biol. Chem. 264: 12994-13004.

Katz J, Wals P, Lee WNP 1993 Isotopomer studies of gluconeogenesis and the Krebs cycle with 13C-labeled lactate. J. Biol. Chem. 268: 25509-25521.

Katz J, Wals PA, Lee WNP 1991 Determination of pathways of glycogen synthesis and the dilution of the three-carbon pool with [U-13C]glucose. Proc. Natl. Acad. Sci. U.S.A. 88: 2103-2107.

Katz-Brull R, Seger D, Rivenson-Segal D, Rushkin E, Degani H 2002 Metabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether-phospholipid synthesis. Cancer Res. 62: 1966-1970.

Keitel C, Adams MA, Holst T, Matzarakis A, Mayer H, Rennenberg H, Gessler A 2003 Carbon and oxygen isotope composition of organic compounds in the phloem sap provides a short-term measure for stomatal conductance of European beech (Fagus sylvatica L.). Plant Cell Environ. 26: 1157-1168.

Keitel C, Matzarakis A, Rennenberg H, Gessler A 2006 Carbon isotopic composition and oxygen isotopic enrichment in phloem and total leaf organic matter of European beech (Fagus sylvatica L.) along a climate gradient. Plant Cell Environ. 29: 1492-1507.

Keniry MA 2003 A comparison of the association of spermine with duplex and quadruplex DNA by NMR. FEBS Lett. 542: 153-158.

Ketchum RE, Rithner CD, Qiu D, Kim YS, Williams RM, Croteau RB 2003 Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures. Phytochemistry 62: 901-909.

Kets EP, Galinski EA, de Wit M, de Bont JA, Heipieper HJ 1996 Mannitol, a novel bacterial compatible solute in Pseudomonas putida S12. J. Bacteriol. 178: 6665-6670.

Kiefer P, Nicolas C, Letisse F, Portais JC 2007 Determination of carbon labeling distribution of intracellular metabolites from single fragment ions by ion chromatography tandem mass spectrometry. Anal. Biochem. 360: 182-188.

King RW, Ben-Tal Y 2001 A florigenic effect of sucrose in Fuchsia hybrida is blocked by gibberellin-induced assimilate competition. Plant Physiol. 125: 488-496.

King RW, Junttila O, Mander LN, Beck EJ 2004 Gibberellin structure and function: biological activity and competitive inhibition of gibberellin 2- and 3-oxidases. Physiol. Plant. 120: 287-297.

Klapa MI, Aon JC, Stephanopoulos G 2003 Systematic quantification of complex metabolic flux networks using stable isotopes and mass spectrometry. Eur. J. Biochem. 270: 3525-3542.

Klapa MI, Park SM, Sinskey AJ, Stephanopoulos G 1999 Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory. Biotechnol. Bioeng. 62: 375-391.

Kleijn RJ, Geertman JM, Nfor BK, Ras C, Schipper D, Pronk JT, Heijnen JJ, van Maris AJ, van Winden WA 2007 Metabolic flux analysis of a glycerol-overproducing Saccharomyces cerevisiae strain based on GC-MS, LC-MS and NMR-derived (13)C-labelling data. FEMS Yeast Res. 7: 216-231.

Kleijn RJ, van Winden WA, Ras C, van Gulik WM, Schipper D, Heijnen JJ 2006 13C-Labeled gluconate tracing as a direct and accurate method for determining the pentose phosphate pathway split ratio in Penicillium chrysogenum. Appl. Environ. Microbiol. 72: 4743-4754.

Kleijn RJ, van Winden WA, van Gulik WM, Heijnen JJ 2005 Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence. FEBS J. 272: 4970-4982.

Klumpp K, Schaufele R, Lotscher M, Lattanzi FA, Feneis W, Schnyder H 2005 C-isotope composition of CO2 respired by shoots and roots: fractionation during dark respiration?. Plant Cell Environ. 28: 241-250.

Kobayashi M, Gaskin P, Spray CR, Suzuki Y, Phinney BO, MacMillan J 1993 Metabolism and biological activity of gibberellin A4 in vegetative shoots of Zea mays, Oryza sativa, and Arabidopsis thaliana. Plant Physiol. 102: 379-386.

Kokoeva MV, Storch KF, Klein C, Oesterhelt D 2002 A novel mode of sensory transduction in archaea: binding protein-mediated chemotaxis towards osmoprotectants and amino acids. EMBO J. 21: 2312-2322.

Koranda M, Kerschbaum S, Wanek W, Zechmeister H, Richter A 2007 Physiological responses of bryophytes Thuidium tamariscinum and Hylocomium splendens to increased nitrogen deposition. Ann. Bot. (Lond.) 99: 161-169.

Kosegarten H, Kalinowski HO, Mengel K 1995 Long-term C-13 labeling of starch and sucrose during the course of amyloplast development in intact suspension cultured storage cells of potato (Solanum tuberosum). J. Plant Physiol. 146: 405-410.

Kouchi H 1982 Direct analysis of 13C abundance in plant carbohydrates by gas chromatography-mass spectrometry. J. Chromatogr. 241: 305-323.

Krisa S, Teguo PW, Decendit A, Deffieux G, Vercauteren J, Merillon JM 1999 Production of 13C-labelled anthocyanins by Vitis vinifera cell suspension cultures. Phytochemistry 51: 651-656.

Kromer JO, Sorgenfrei O, Klopprogge K, Heinzle E, Wittmann C 2004 In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome. J. Bacteriol. 186: 1769-1784.

Krook J, Vreugdenhil D, Dijkema C, van der Plas LHW 1998 Sucrose and starch metabolism in carrot (Daucus carota L.) cell suspensions analysed by C-13 labelling: indications for a cytosol and a plastid-localized oxidative pentose phosphate pathway. J. Exp. Bot. 49: 1917-1924.

Kruger NJ, von Schaewen A 2003 The oxidative pentose phosphate pathway: structure and organisation. Curr. Opin. Plant Biol. 6: 236-246.

Kuchel PW, Philp DJ 2007 Isotopomer subspaces as indicators of metabolic-pathway structure. J. Theor. Biol. Jul 5 [Epub ahead of print].

Kunnecke B, Seelig J 1991 Glycogen-metabolism as detected by in vivo and in vitro C-13 NMR spectroscopy using [1,2-C-2(13)]glucose as substrate. Biochim. Biophys. Acta 1095: 103-113.

Lacointe A, Deleens E, Ameglio T, Saint-Joanis B, Lelarge C, Vandame M, Song GC, Daudet FA 2004 Testing the branch autonomy theory: a C-13/C-14 double-labelling experiment on differentially shaded branches. Plant Cell Environ. 27: 1159-1168.

Lai MC, Yang DR, Chuang MJ 1999 Regulatory factors associated with synthesis of the osmolyte glycine betaine in the halophilic Methanoarchaeon Methanohalophilus portucalensis. Appl. Environ. Microbiol. 65: 828-833.

Lammers PJ, Jun J, Abubaker J, Arreola R, Gopalan A, Bago B, Hernandez-Sebastia C, Allen JW, Douds DD, Pfeffer PE, Shachar-Hill Y 2001 The glyoxylate cycle in an arbuscular mycorrhizal fungus. Carbon flux and gene expression. Plant Physiol. 127: 1287-1298.

Lamplot Z, Sebela M, Malon M, Lenobel R, Lemr K, Havlis J, Pec P, Qiao C, Sayre LM 2004 1,5-Diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases. Eur. J. Biochem. 271: 4696-4708.

Lapadatescu C, Ginies C, Le Quere JL, Bonnarme P 2000 Novel scheme for biosynthesis of aryl metabolites from L-phenylalanine in the fungus Bjerkandera adusta. Appl. Environ. Microbiol. 66: 1517-1522.

Lapidot A, Haber S 2001 Effect of endogenous beta-hydroxybutyrate on glucose metabolism in the diabetic rabbit brain: a (13)C-magnetic resonance spectroscopy study of [U-(13)C]glucose metabolites. J. Neurosci. Res. 64: 207-216.

Lardizabal KD, Metz JG, Sakamoto T, Hutton WC, Pollard MR, Lassner MW 2000 Purification of a jojoba embryo wax synthase, cloning of its cDNA, and production of high levels of wax in seeds of transgenic Arabidopsis. Plant Physiol. 122: 645-656.

Laskar DD, Jourdes M, Patten AM, Helms GL, Davin LB, Lewis NG 2006 The Arabidopsis cinnamoyl CoA reductase irx4 mutant has a delayed but coherent (normal) program of lignification. Plant J. 48: 674-686.

Lattanzi FA, Schnyder H, Thornton B 2005 The sources of carbon and nitrogen supplying leaf growth. Assessment of the role of stores with compartmental models. Plant Physiol. 137: 383-395.

Le Lay P, Isaure MP, Sarry JE, Kuhn L, Fayard B, Le Bail JL, Bastien O, Garin J, Roby C, Bourguignon J 2006 Metabolomic, proteomic and biophysical analyses of Arabidopsis thaliana cells exposed to a caesium stress. Influence of potassium supply. Biochimie 88: 1533-1547.

Leech AP, Boetzel R, McDonald C, Shrive AK, Moore GR, Coggins JR, Sawyer L, Kleanthous C 1998 Re-evaluating the role of His-143 in the mechanism of type I dehydroquinase from Escherichia coli using two-dimensional 1H,13C NMR. J. Biol. Chem. 273: 9602-9607.

Li M, Ho PY, Yao S, Shimizu K 2006 Effect of lpdA gene knockout on the metabolism in Escherichia coli based on enzyme activities, intracellular metabolite concentrations and metabolic flux analysis by (13)C-labeling experiments. J. Biotechnol. 122: 254-266.

Li P, Takei R, Takahashi K, Nabeta K 2007 Biosynthesis of theobroxide and its related compounds, metabolites of Lasiodiplodia theobromae. Phytochemistry 68: 819-823.

Li R, Moore M, King J 2003 Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana. Plant Cell Physiol. 44: 233-241.

Li T, Rosazza JP 1998 NMR identification of an acyl-adenylate intermediate in the aryl-aldehyde oxidoreductase catalyzed reaction. J. Biol. Chem. 273: 34230-34233.

Liguzinski P, Korzeniewski B 2006 Metabolic control over the oxygen consumption flux in intact skeletal muscle: in silico studies. Am. J. Physiol. Cell. Physiol. 291: C1213-C1224.

Liu H, Reynolds KA 2001 Precursor supply for polyketide biosynthesis: the role of crotonyl-CoA reductase. Metab. Eng. 3: 40-48.

Llic N, Normanly J, Cohen JD 1996 Quantification of free plus conjugated indoleacetic acid in Arabidopsis requires correction for the nonenzymatic conversion of indolic nitriles. Plant Physiol. 111: 781-788.

Logan TM, Zhong P, Lynn DG 1992 Metabolic thermotolerance: magnetic resonance detected protection of glutamate synthase. Biochemistry 31: 7256-7263.

London RE 1988 C-13 labeling in studies of metabolic regulation. Prog. Nucl. Mag. Res. Spectrom. 20: 337-383.

London RE, Allen DL, Gabel SA, DeRose EF 1999 Carbon-13 nuclear magnetic resonance study of metabolism of propionate by Escherichia coli. J. Bacteriol. 181: 3562-3570.

Loreto F, Ciccioli P, Brancaleoni E, Cecinato A, Frattoni M, Sharkey TD 1996 Different sources of reduced carbon contribute to form three classes of terpenoid emitted by Quercus ilex L. leaves. Proc. Natl. Acad. Sci. U.S.A. 93: 9966-9969.

Loreto F, Ciccioli P, Brancaleoni E, Frattoni M, Delfine S 2000 Incomplete 13C labelling of a-pinene content of Quercus ilex leaves and appearance of unlabelled C in a-pinene emission in the dark. Plant Cell Environ. 23: 229-234.

Loreto F, Ciccioli P, Cecinato A, Brancaleoni E, Frattoni M, Fabozzi C, Tricoli D 1996 Evidence of the photosynthetic origin of monoterpenes emitted by Quercus ilex L. leaves by 13C labeling. Plant Physiol. 110: 1317-1322.

Loreto F, Delfine S, Di Marco G 1999 Estimation of photorespiratory carbon dioxide recycling during photosynthesis. Aust. J. Plant Physiol. 26: 733-736.

Loreto F, Harley PC, Di Marco G, Sharkey TD 1992 Estimation of mesophyll conductance to CO(2) flux by three different methods. Plant Physiol. 98: 1437-1443.

Loreto F, Pinelli P, Brancaleoni E, Ciccioli P 2004 13C labeling reveals chloroplastic and extrachloroplastic pools of dimethylallyl pyrophosphate and their contribution to isoprene formation. Plant Physiol. 135: 1903-1907.

Loreto F, Velikova V, Di Marco G 2001 Respiration in the light measured by (CO2)-C12 emission in (CO2)-C13 atmosphere in maize leaves. Aust. J. Plant Physiol. 28: 1103-1108.

Lu D, Mulder H, Zhao P, Burgess SC, Jensen MV, Kamzolova S, Newgard CB, Sherry AD 2002 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proc. Natl. Acad. Sci. U.S.A. 99: 2708-2713.

Lu F, Ralph J 2003 Non-degradative dissolution and acetylation of ball-milled plant cell walls: high-resolution solution-state NMR. Plant J. 35: 535-544.

Lu W, Zhao B, Feng D, Yang S 2004 Cloning and characterization of the Halobacillus trueperi betH gene, encoding the transport system for the compatible solute glycine betaine. FEMS Microbiol. Lett. 235: 393-399.

Lu WD, Chi ZM, Su CD 2006 Identification of glycine betaine as compatible solute in Synechococcus sp. WH8102 and characterization of its N-methyltransferase genes involved in betaine synthesis. Arch. Microbiol. 186: 495-506.

Lubken T, Schmidt J, Porzel A, Arnold N, Wessjohann L 2004 Hygrophorones A-G: fungicidal cyclopentenones from Hygrophorus species (Basidiomycetes). Phytochemistry 65: 1061-1071.

Ma JF, Nomoto K 1994 Incorporation of label from 13C-, 2H-, and 15N-labeled methionine molecules during the biosynthesis of 2'-deoxymugineic acid in roots of wheat. Plant Physiol. 105: 607-610.

Ma JF, Nomoto K 1993 Two related biosynthetic pathways of mugineic acids in gramineous plants. Plant Physiol. 102: 373-378.

Maaheimo H, Fiaux J, Cakar ZP, Bailey JE, Sauer U, Szyperski T 2001 Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional C-13 labeling of common amino acids. Eur. J. Biochem. 268: 2464-2479.

MacCoss MJ, Fukagawa NK, Matthews DE 1999 Measurement of homocysteine concentrations and stable isotope tracer enrichments in human plasma. Anal. Chem. 71: 4527-4533.

Macfarlane C, Adams MA, White DA 2004 Productivity, carbon isotope discrimination and leaf traits of trees of Eucalyptus globulus Labill. in relation to water availability. Plant Cell Environ. 27: 1515-1524.

MacMillan J, Ward DA, Phillips AL, Sanchez-Beltran MJ, Gaskin P, Lange T, Hedden P 1997 Gibberellin biosynthesis from gibberellin A12-aldehyde in endosperm and embryos of Marah macrocarpus. Plant Physiol. 113: 1369-1377.

Mahmood U, Kaul VK, Acharya R 2004 Volatile constituents of Capillipedium parviflorum. Phytochemistry 65: 2163-2166.

Mahmoud AA, Ahmed AA 2006 alpha-Pinene-type monoterpenes and other constituents from Artemisia suksdorfii. Phytochemistry 67: 2103-2109.

Mahmoud M, Gentil E, Robins RJ 2004 Natural-abundance isotope ratio mass spectrometry as a means of evaluating carbon redistribution during glucose-citrate cofermentation by Lactococcus lactis. Eur. J. Biochem. 271: 4392-4400.

Majumdar A, Sonawat HM 1998 A two-dimensional 1H detected 13C NMR investigation of pyruvate metabolism in Halobacterium salinarium. J. Biochem. (Tokyo) 123: 115-119.

Makino M, Motegi T, Fujimoto Y 2004 Tirucallane-type triterpenes from Juliania adstringens. Phytochemistry 65: 891-896.

Malloy CR, Sherry AD, Jeffrey FMH 1988 Evaluation of carbon flux and substrate selection through alternate pathways involving the citric acid cycle of the heart by C-13 NMR spectroscopy. J. Biol. Chem. 263: 6964-6971.

Mambu L, Grellier P, Florent L, Joyeau R, Ramanitrahasimbola D, Rasoanaivo P, Frappier F 2006 Clerodane and labdane diterpenoids from Nuxia sphaerocephala. Phytochemistry 67: 444-451.

Mancuso A, Sharfstein ST, Tucker SN, Clark DS, Blanch HW 1994 Examination of primary metabolic pathways in a murine hybridoma with C-13 nuclear magnetic resonance spectroscopy. Biotechnol. Bioeng. 44: 563-585.

Manz B, Muller K, Kucera B, Volke F, Leubner-Metzger G 2005 Water uptake and distribution in germinating tobacco seeds investigated in vivo by nuclear magnetic resonance imaging. Plant Physiol. 138: 1538-1551.

Markham KR 1996 Novel anthocyanins produced in petals of genetically transformed lisianthus. Phytochemistry 42: 1035-1038.

Markova M, Peneff C, Hewlins MJ, Schirmer T, John RA 2005 Determinants of substrate specificity in omega-aminotransferases. J. Biol. Chem. 280: 36409-36416.

Martin F, Boiffin V, Pfeffer PE 1998 Carbohydrate and amino acid metabolism in the Eucalyptus globulus-pisolithus tinctorius ectomycorrhiza during glucose utilization. Plant Physiol. 118: 627-635.

Martin G, Chauvin MF, Baverel G 1997 Model applicable to NMR studies for calculating flux rates in five cycles involved in glutamate metabolism. J. Biol. Chem. 272: 4717-428.

Martinez M, Cuskelly GJ, Williamson J, Toth JP, Gregory JF 2000 Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. J. Nutr. 130: 1115-1123.

Martini S, Ricci M, Bonechi C, Trabalzini L, Santucci A, Rossi C 2004 In vivo 13C-NMR and modelling study of metabolic yield response to ethanol stress in a wild-type strain of Saccharomyces cerevisiae. FEBS Lett. 564: 63-68.

Marx A, Eikmanns BJ, Sahm H, de Graaf AA, Eggeling L 1999 Response of the central metabolism in Corynebacterium glutamicum to the use of an NADH-dependent glutamate dehydrogenase. Metab. Eng. 1: 35-48.

Mason GF, Petersen KF, de Graaf RA, Shulman GI, Rothman DL 2007 Measurements of the anaplerotic rate in the human cerebral cortex using (13)C magnetic resonance spectroscopy and [1-(13)C] and [2-(13)C] glucose. J. Neurochem. 100: 73-86.

Mason GF, Rothman DL 2004 Basic principles of metabolic modeling of NMR (13)C isotopic turnover to determine rates of brain metabolism in vivo. Metab. Eng. 6: 75-84.

Mason RP, Sanders JK, Crawford A, Hunter BK 1986 Formaldehyde metabolism by Escherichia coli. Detection by in vivo 13C NMR spectroscopy of S-(hydroxymethyl)glutathione as a transient intracellular intermediate. Biochemistry 25: 4504-4507.

Masse G, Belt ST, Rowland SJ 2004 Biosynthesis of unusual monocyclic alkenes by the diatom Rhizosolenia setigera (Brightwell). Phytochemistry 65: 1101-1106.

Massou S, Nicolas C, Letisse F, Portais JC 2007 Application of 2D-TOCSY NMR to the measurement of specific 13C-enrichments in complex mixtures of 13C-labeled metabolites. Metab. Eng. 9: 252-257.

Matheron C, Delort AM, Gaudet G, Liptaj T, Forano E 1999 Interactions between carbon and nitrogen metabolism in Fibrobacter succinogenes S85: a 1H and 13C nuclear magnetic resonance and enzymatic study. Appl. Environ. Microbiol. 65: 1941-1948.

Mayer SM, Gawlita E, Avissar YJ, Anderson VE, Beale SI 1993 Intermolecular nitrogen transfer in the enzymic conversion of glutamate to d-aminolevulinic acid by extracts of Chlorella vulgaris. Plant Physiol. 101: 1029-1038.

McCaskill D, Croteau R 1999 Isopentenyl diphosphate is the terminal product of the deoxyxylulose-5-phosphate pathway for terpenoid biosynthesis in plants. Tetrahedron Lett. 40: 653-656.

McDowell LM, Klug CA, Beusen DD, Schaefer J 1996 Ligand geometry of the ternary complex of 5-enolpyruvylshikimate-3-phosphate synthase from rotational-echo double-resonance NMR. Biochemistry 35: 5395-5403.

McDowell N, Brooks JR, Fitzgerald SA, Bond BJ 2003 Carbon isotope discrimination and growth response of old Pinus ponderosa trees to stand density reductions. Plant Cell Environ. 26: 631-644.

Meikle AJ, Chudek JA, Reed RH, Gadd GM 1991 Natural abundance C-13 nuclear magnetic resonance spectroscopic analysis of acyclic polyol and trehalose accumulation by several yeast species in response to salt stress. FEMS Microbiol. Lett. 82: 163-167.

Meinzer FC, Woodruff DR, Shaw DC 2004 Integrated responses of hydraulic architecture, water and carbon relations of western hemlock to dwarf mistletoe infection. Plant Cell Environ. 27: 937-946.

Mesnard F, Marty D, Gillet-Manceau F, Fliniaux MA, Monti JP 1999 Glutamine synthetase activity in Solanaceous cell suspensions accumulating alkaloids or not. 13C NMR and enzymatic assay. C. R. Acad. Sci. III 322: 743-748.

Mesnard F, Ratcliffe RG 2005 NMR analysis of plant nitrogen metabolism. Photosynth. Res. 83: 163-180.

Mesnard F, Roscher A, Garlick AP, Girard S, Baguet E, Arroo RR, Lebreton J, Robins RJ, Ratcliffe G 2002 Evidence for the involvement of tetrahydrofolate in the demethylation of nicotine by Nicotiana plumbaginifolia cell-suspension cultures. Planta 214: 911-919.

Messana I, Misiti F, el-Sherbini S, Giardina B, Castagnola M 1999 Quantitative determination of the main glucose metabolic fluxes in human erythrocytes by 13C- and 1H-MR spectroscopy. J. Biochem. Biophys. Methods 39: 63-84.

Meurice G, Bondon A, Deborde C, Boyaval P 2001 Determination of metabolic fluxes during glucose catabolism in Propionibacterium freudenreichii subsp. shermanii. Meded. Rijksuniv. Gent. Fak. Landbouwkd. Toegep. Biol. Wet. 66: 219-225.

Miccheli A, Tomassini A, Puccetti C, Valerio M, Peluso G, Tuccillo F, Calvani M, Manetti C, Conti F 2006 Metabolic profiling by 13C-NMR spectroscopy: [1,2-13C2]glucose reveals a heterogeneous metabolism in human leukemia T cells. Biochimie 88: 437-448.

Miller AE, Bowman WD 2002 Variation in nitrogen-15 natural abundance and nitrogen uptake traits among co-occurring alpine species: do species partition by nitrogen form?. Oecologia 130: 609-616.

Moller R, McDonald AG, Walter C, Harris PJ 2003 Cell differentiation, secondary cell-wall formation and transformation of callus tissue of Pinus radiata D. Don. Planta 217: 736-747.

Mollney M, Wiechert W, Kownatzki D, de Graaf AA 1999 Bidirectional reaction steps in metabolic networks: IV. Optimal design of isotopomer labeling experiments. Biotechnol. Bioeng. 66: 86-103.

Monti A, Brugnoli E, Scartazza A, Amaducci MT 2006 The effect of transient and continuous drought on yield, photosynthesis and carbon isotope discrimination in sugar beet (Beta vulgaris L.). J. Exp. Bot. 57: 1253-1262.

Morris PG, McIntyre DJO, Coxon R, Bachelard HS, Moriarty KT, Greenhaff PL, MacDonald IA 1994 Nuclear magnetic resonance spectroscopy as a tool to study carbohydrate metabolism. Proc. Nutr. Soc. 53: 335-343.

Morvan-Bertrand A, Pavis N, Boucaud J, Prud'Homme M-P 1999 Partitioning of reserve and newly assimilated carbon in roots and leaf tissues of Lolium perenne during regrowth after defoliation: assessment by 13C steady-state labelling and carbohydrate analysis. Plant Cell Environ. 22: 1097-1108.

Mouillon JM, Aubert S, Bourguignon J, Gout E, Douce R, Rebeille F 1999 Glycine and serine catabolism in non-photosynthetic higher plant cells: their role in C1 metabolism. Plant J. 20: 197-205.

Muller A, Hillebrand H, Weiler EW 1998 Indole-3-acetic acid is synthesized from L-tryptophan in roots of Arabidopsis thaliana. Planta 206: 362-369.

Mulquiney PJ, Bubb WA, Kuchel PW 1999 Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations in vivo kinetic characterization of 2,3-bisphosphoglycerate synthase/phosphatase using C-13 and P-31 NMR. Biochem. J. 342: 567-580.

Muzitano MF, Tinoco LW, Guette C, Kaiser CR, Rossi-Bergmann B, Costa SS 2006 The antileishmanial activity assessment of unusual flavonoids from Kalanchoe pinnata. Phytochemistry 67: 2071-2077.

Myers RW, Abeles RH 1990 Conversion of 5-S-methyl-5-thio-D-ribose to methionine in Klebsiella pneumoniae. Stable isotope incorporation studies of the terminal enzymatic reactions in the pathway. J. Biol. Chem. 265: 16913-16921.

Myers RW, Wray JW, Fish S, Abeles RH 1993 Purification and characterization of an enzyme involved in oxidative carbon-carbon bond cleavage reactions in the methionine salvage pathway of Klebsiella pneumoniae. J. Biol. Chem. 268: 24785-24791.

Nagata S, Wang YQ, Oshima A, Zhang L, Miyake H, Sasaki H, Ishida A 2007 Efficient cyclic system to yield ectoine using Brevibacterium sp. JCM 6894 subjected to osmotic downshock. Biotechnol. Bioeng. Aug 15 [Epub ahead of print].

Nakano H, Nakajima E, Hiradate S, Fujii Y, Yamada K, Shigemori H, Hasegawa K 2004 Growth inhibitory alkaloids from mesquite (Prosopis juliflora (Sw.) DC.) leaves. Phytochemistry 65: 587-591.

Nanchen A, Fuhrer T, Sauer U 2006 Determination of metabolic flux ratios from 13C-experiments and gas chromatography-mass spectrometry data: protocol and principles. Methods Mol. Biol. 358: 177-198.

Nasini G, Arnone A, Assante G, Bava A, Moricca S, Ragazzi A 2004 Secondary mould metabolites of Cladosporium tenuissimum, a hyperparasite of rust fungi. Phytochemistry 65: 2107-2111.

Nau-Wagner G, Boch J, Le Good JA, Bremer E 1999 High-affinity transport of choline-O-sulfate and its use as a compatible solute in Bacillus subtilis. Appl. Environ. Microbiol. 65: 560-568.

Naylor S, Mason RP, Sanders JK, Williams DH, Moneti G 1988 Formaldehyde adducts of glutathione. Structure elucidation by two-dimensional n.m.r. spectroscopy and fast-atom-bombardment tandem mass spectrometry. Biochem. J. 249: 573-579.

Neese RA, Hellerstein MK 1995 Calculations for gluconeogenesis by mass isotopomer distribution analysis. J. Biol. Chem. 270: 14464-14466.

Neese RA, Schwarz J-M, Faix D, Turner S, Letscher A, Vu D, Hellerstein MK 1995 Gluconeogenesis and intrahepatic triose phosphate flux in response to fasting or substrate loads. J. Biol. Chem. 270: 14452-14463.

Neves AR, Ramos A, Nunes MC, Kleerebezem M, Hugenholtz J, de Vos WM, Almeida J, Santos H 1999 In vivo nuclear magnetic resonance studies of glycolytic kinetics in Lactococcus lactis. Biotechnol. Bioeng. 64: 200-212.

Nibeilliu ME, Malthouse JP 2004 The stereospecificity and catalytic efficiency of the tryptophan synthase-catalysed exchange of the alpha-protons of amino acids. Biochem. J. 381: 847-852.

Nielsen TH, Christophersen C, Anthoni U, Sorensen J 1999 Viscosinamide, a new cyclic depsipeptide with surfactant and antifungal properties produced by Pseudomonas fluorescens DR54. J. Appl. Microbiol. 87: 80-90.

Nishimura T, Mori Y, Furukawa T, Kadota A, Koshiba T 2006 Red light causes a reduction in IAA levels at the apical tip by inhibiting de novo biosynthesis from tryptophan in maize coleoptiles. Planta 224: 1427-1435.

Nissim I, Daikhin Y, Nissim I, Luhovyy B, Horyn O, Wehrli SL, Yudkoff M 2006 Agmatine stimulates hepatic fatty acid oxidation: a possible mechanism for up-regulation of ureagenesis. J. Biol. Chem. 281: 8486-8496.

Nobuyasu H, Liu S, Adu-Gyamfi JJ, Mohapatra PK, Fujita K 2003 Variation in the export of C-13 and N-15 from soybean leaf: the effects of nitrogen application and sink removal. Plant Soil 253: 331-339.

Nogues I, Brilli F, Loreto F 2006 Dimethylallyl diphosphate and geranyl diphosphate pools of plant species characterized by different isoprenoid emissions. Plant Physiol. 141: 721-730.

Nogues S, Tcherkez G, Cornic G, Ghashghaie J 2004 Respiratory carbon metabolism following illumination in intact French bean leaves using 13C/12C isotope labeling. Plant Physiol. 136: 3245-3254.

Nogues S, Tcherkez G, Streb P, Pardo A, Baptist F, Bligny R, Ghashghaie J, Cornic G 2006 Respiratory carbon metabolism in the high mountain plant species Ranunculus glacialis. J. Exp. Bot. 57: 3837-3845.

Noh K, Wiechert W 2006 Experimental design principles for isotopically in stationary 13C labeling experiments. Biotechnol. Bioeng. 94: 234-251.

Nordin A, Schmidt IK, Shaver GR 2004 Nitrogen uptake by arctic soil microbes and plants in relation to soil nitrogen supply. Ecology 85: 955-962.

Noronha SB, Yeh HJ, Spande TF, Shiloach J 2000 Investigation of the TCA cycle and the glyoxylate shunt in Escherichia coli BL21 and JM109 using 13C-NMR/MS. Biotechnol. Bioeng. 68: 316-327.

Norton RS, MacKay MA, Borowitzka LJ 1982 The physical state of osmoregulatory solutes in unicellular algae. A natural-abundance carbon-13 nuclear-magnetic-resonance relaxation study. Biochem. J. 202: 699-706.

Novak K, Cherubini P, Saurer M, Fuhrer J, Skelly JM, Krauchi N, Schaub M 2007 Ozone air pollution effects on tree-ring growth, delta(13)C, visible foliar injury and leaf gas exchange in three ozone-sensitive woody plant species. Tree Physiol. 27: 941-949.

Ocheltree TW, Marshall JD 2004 Apparent respiratory discrimination is correlated with growth rate in the shoot apex of sunflower (Helianthus annuus). J. Exp. Bot. 55: 2599-2605.

Okawa S, Makino A, Mae T 2003 Effect of irradiance on the partitioning of assimilated carbon during the early phase of grain filling in rice. Ann. Bot. (Lond.) 92: 357-364.

Okinaka Y, Mimori K, Takeo K, Kitamura S, Takeuchi Y, Yamaoka N, Yoshikawa M 1995 A structural model for the mechanisms of elicitor release from fungal cell walls by plant beta-1,3-endoglucanase. Plant Physiol. 109: 839-845.

Olsson PA, Van Aarle IM, Allaway WG, Ashford AE, Rouhier H 2002 Phosphorus effects on metabolic processes in monoxenic arbuscular mycorrhiza cultures. Plant Physiol. 130: 1162-1171.

Opitz S, Schneider B 2003 Oxidative biosynthesis of phenylbenzoisochromenones from phenylphenalenones. Phytochemistry 62: 307-312.

Page JE, Hause G, Raschke M, Gao W, Schmidt J, Zenk MH, Kutchan TM 2004 Functional analysis of the final steps of the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway to isoprenoids in plants using virus-induced gene silencing. Plant Physiol. 134: 1401-1413.

Pagot Y, Belin JM, Husson F, Spinnler HE 2007 Metabolism of phenylalanine and biosynthesis of styrene in Penicillium camemberti. J. Dairy Res. 74: 180-185.

Paiva AA, Tilton RF Jr, Crooks GP, Huang LQ, Anderson KS 1997 Detection and identification of transient enzyme intermediates using rapid mixing, pulsed-flow electrospray mass spectrometry. Biochemistry 36: 15472-15476.

Panagiotou G, Christakopoulos P, Grotkjaer T, Olsson L 2006 Engineering of the redox imbalance of Fusarium oxysporum enables anaerobic growth on xylose. Metab. Eng. 8: 474-482.

Park SM, Klapa MI, Sinskey AJ, Stephanopoulos G 1999 Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications. Biotechnol. Bioeng. 62: 392-401.

Park SM, Shaw-Reid C, Sinskey AJ, Stephanopoulos G 1997 Elucidation of anaplerotic pathways in Corynebacterium glutamicum via 13C-NMR spectroscopy and GC-MS. Appl. Microbiol. Biotechnol. 47: 430-440.

Park YI, Buszko ML, Gander JE 1999 Glycine betaine: reserve form of choline in Penicillium fellutanum in low-sulfate medium. Appl. Environ. Microbiol. 65: 1340-1342.

Paseshnichenko VA 1998 A new alternative non-mevalonate pathway for isoprenoid biosynthesis in eubacteria and plants. Biochemistry (Mosc.) 63: 139-148.

Pasternack LB, Laude DA Jr, Appling DR 1994 Whole-cell detection by 13C NMR of metabolic flux through the C1-tetrahydrofolate synthase/serine hydroxymethyltransferase enzyme system and effect of antifolate exposure in Saccharomyces cerevisiae. Biochemistry 33: 7166-7173.

Pasternack LB, Laude DA Jr, Appling DR 1994 13C NMR analysis of intercompartmental flow of one-carbon units into choline and purines in Saccharomyces cerevisiae. Biochemistry 33: 74-82.

Pasternack LB, Laude DA Jr, Appling DR 1992 13C NMR detection of folate-mediated serine and glycine synthesis in vivo in Saccharomyces cerevisiae. Biochemistry 31: 8713-8719.

Pasternack LB, Littlepage LE, Laude DA Jr, Appling DR 1996 13C NMR analysis of the use of alternative donors to the tetrahydrofolate-dependent one-carbon pools in Saccharomyces cerevisiae. Arch. Biochem. Biophys. 326: 158-165.

Patel RN 1998 Tour de paclitaxel: biocatalysis for semisynthesis. Annu. Rev. Microbiol. 52: 361-395.

Paterson E, Thornton B, Midwood AJ, Sim A 2005 Defoliation alters the relative contributions of recent and non-recent assimilate to root exudation from Festuca rubra. Plant Cell Environ. 28: 1525-1533.

Pedersen H, Christensen B, Hjort C, Nielsen J 2000 Construction and characterization of an oxalic acid nonproducing strain of Aspergillus niger. Metab. Eng. 2: 34-41.

Peleg Z, Fahima T, Abbo S, Krugman T, Nevo E, Yakir D, Saranga Y 2005 Genetic diversity for drought resistance in wild emmer wheat and its ecogeographical associations. Plant Cell Environ. 28: 176-191.

Pelton JG, Kustu S, Wemmer DE 1999 Solution structure of the DNA-binding domain of NtrC with three alanine substitutions. J. Mol. Biol. 292: 1095-1110.

Perrin RM, Wigge PA 2002 Physiology and metabolism: Web alert. Curr. Opin. Plant Biol. 5: 189-190.

Peters-Wendisch PG, Wendisch VF, de Graaf AA, Eikmanns BJ, Sahm H 1996 C3-carboxylation as an anaplerotic reaction in phosphoenolpyruvate carboxylase-deficient Corynebacterium glutamicum. Arch. Microbiol. 165: 387-396.

Petersen S, de Graaf AA, Eggeling L, Mollney M, Wiechert W, Sahm H 2000 In vivo quantification of parallel and bidirectional fluxes in the anaplerosis of Corynebacterium glutamicum. J. Biol. Chem. 275: 35932-35941.

Petersen S, Mack C, De Graaf AA, Riedel C, Eikmanns BJ, Sahm H 2001 Metabolic consequences of altered phosphoenolpyruvate carboxykinase activity in Corynebacterium glutamicum reveal anaplerotic regulation mechanisms in vivo. Metab. Eng. 3: 344-361.

Peuke AD, Gessler A, Rennenberg H 2006 The effect of drought on C and N stable isotopes in different fractions of leaves, stems and roots of sensitive and tolerant beech ecotypes. Plant Cell Environ. 29: 823-835.

Pfeffer PE, Douds Jr DD, Becard G, Shachar-Hill Y 1999 Carbon uptake and the metabolism and transport of lipids in an arbuscular mycorrhiza. Plant Physiol. 120: 587-598.

Pfeffer PE, Shachar-Hill Y, Tu SI, Brauer D 2004 Measurement of intracellular pH in maize root tissue with alpha-methyl fluorinated alanines and in-vivo F-19 NMR spectroscopy. Physiol. Plant. 122: 373-379.

Pfefferle W, Mockel B, Bathe B, Marx A 2003 Biotechnological manufacture of lysine. Adv. Biochem. Eng. Biotechnol. 79: 59-112.

Phalakornkule C, Fry B, Zhu T, Kopesel R, Ataai MM, Domach MM 2000 13C NMR evidence for pyruvate kinase flux attenuation underlying suppressed acid formation in Bacillus subtilis. Biotechnol. Prog. 16: 169-175.

Phalakornkule C, Lee S, Zhu T, Koepsel R, Ataai MM, Grossmann IE, Domach MM 2001 A MILP-based flux alternative generation and NMR experimental design strategy for metabolic engineering. Metab. Eng. 3: 124-137.

Picon-Cochard C, Coll L, Balandier P 2006 The role of below-ground competition during early stages of secondary succession: the case of 3-year-old Scots pine (Pinus sylvestris L.) seedlings in an abandoned grassland. Oecologia 148: 373-383.

Pierik AJ, Roseboom W, Happe RP, Bagley KA, Albracht SP 1999 Carbon monoxide and cyanide as intrinsic ligands to iron in the active site of [NiFe]-hydrogenases. NiFe(CN)2CO, biology's way to activate H2. J. Biol. Chem. 274: 3331-3337.

Pinelli P, Loreto F 2003 12CO2 emission from different metabolic pathways measured in illuminated and darkened C3 and C4 leaves at low, atmospheric and elevated CO2 concentration. J. Exp. Bot. 54: 1761-1769.

Pines O, Shemesh S, Battat E, Goldberg I 1997 Overexpression of cytosolic malate dehydrogenase (MDH2) causes overproduction of specific organic acids in Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 48: 248-255.

Pitson SM, Mendz GL, Srinivasan S, Hazell SL 1999 The tricarboxylic acid cycle of Helicobacter pylori. Eur. J. Biochem. 260: 258-267.

Poeaknapo C, Fisinger U, Zenk MH, Schmidt J 2004 Evaluation of the mass spectrometric fragmentation of codeine and morphine after 13C-isotope biosynthetic labeling. Phytochemistry 65: 1413-1420.

Pollard M, Ohlrogge J 1999 Testing models of fatty acid transfer and lipid synthesis in spinach leaf using in vivo oxygen-18 labeling. Plant Physiol. 121: 1217-1226.

Prabhu V, Chatson KB, Abrams GD, King J 1996 13C nuclear magnetic resonance detection of interactions of serine hydroxymethyltransferase with C1-tetrahydrofolate synthase and glycine decarboxylase complex activities in Arabidopsis. Plant Physiol. 112: 207-216.

Prabhu V, Chatson KB, Lui H, Abrams GD, King J 1998 Effects of sulfanilamide and methotrexate on 13C fluxes through the glycine decarboxylase/serine hydroxymethyltransferase enzyme system in Arabidopsis. Plant Physiol. 116: 137-144.

Prater JL, Mortazavi B, Chanton JP 2006 Diurnal variation of the delta C-13 of pine needle respired CO2 evolved in darkness. Plant Cell Environ. 29: 202-211.

Previs SF, Des Rosiers C, Beylot M, David F, Brunengraber H 1996 Assay of the 13C and 2H mass isotopomer distribution of phosphoenolpyruvate by gas chromatography/mass spectrometry. J. Mass Spectrom. 31: 643-648.

Previs SF, Hallowell PT, Neimanis KD, David F, Brunengraber H 1998 Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis. Heterogeneity of glucose labeling in incubated hepatocytes. J. Biol. Chem. 273: 16853-16859.

Proteau PJ 1998 Biosynthesis of phytol in the cyanobacterium Synechocystis sp. UTEX 2470: utilization of the non-mevalonate pathway. J. Nat. Prod. 61: 841-843.

Puccetti C, Aureli T, Manetti C, Conti F 2002 13C-NMR isotopomer distribution analysis: a method for measuring metabolic fluxes in condensation biosynthesis. NMR Biomed. 15: 404-415.

Rae C, Moussa Cel-H, Griffin JL, Bubb WA, Wallis T, Balcar VJ 2005 Group I and II metabotropic glutamate receptors alter brain cortical metabolic and glutamate/glutamine cycle activity: a 13C NMR spectroscopy and metabolomic study. J. Neurochem. 92: 405-416.

Rager MN, Binet MR, Bouvet OM 1999 31P and 13C nuclear magnetic resonance studies of metabolic pathways in Pasteurella multocida characterization of a new mannitol-producing metabolic pathway. Eur. J. Biochem. 263: 695-701.

Rager MN, Binet MR, Ionescu G, Bouvet OM 2000 31P-NMR and 13C-NMR studies of mannose metabolism in Plesiomonas shigelloides. Toxic effect of mannose on growth. Eur. J. Biochem. 267: 5136-5141.

Ralph J, Akiyama T, Kim H, Lu F, Schatz PF, Marita JM, Ralph SA, Srinivasa Reddy MS, Chen F, Dixon RA 2006 Effects of coumarate 3-hydroxylase down-regulation on lignin structure. J. Biol. Chem. 281: 8843-8853.

Ratcliffe RG 1994 In vivo NMR studies of higher plants and algae. Adv. Bot. Res. 20: 43-123.

Raveh E, Cohen S, Raz T, Yakir D, Grava A, Goldschmidt EE 2003 Increased growth of young citrus trees under reduced radiation load in a semi-arid climate. J. Exp. Bot. 54: 365-373.

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S 2006 Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses. Proc. Natl. Acad. Sci. U.S.A. 103: 15687-15692.

Reed RH, Wright PJ, Chudek JA, Hunter G 1995 Turnover of hexitols in the marine macroalga Himanthalia elongata (Phaeophyta, Fucales). Eur. J. Phycol. 30: 169-177.

Reeds PJ, Berthold HK, Boza JJ, Burrin DG, Jahoor F, Jaksic T, Klein PD, Keshen T, Miller R, Stoll B, Wykes LJ 1997 Integration of amino acid and carbon intermediary metabolism: studies with uniformly labeled tracers and mass isotopomer analysis. Eur. J. Pediatr. 156: S50-S58.

Regev R, Peri I, Gilboa H, Avi-Dor Y 1990 13C NMR study of the interrelation between synthesis and uptake of compatible solutes in two moderately halophilic eubacteria. Bacterium Ba1and Vibro costicola. Arch. Biochem. Biophys. 278: 106-112.

Remy A, Boers RB, Egorova-Zachernyuk T, Gast P, Lugtenburg J, Gerwert K 2003 Does different orientation of the methoxy groups of ubiquinone-10 in the reaction centre of Rhodobacter sphaeroides cause different binding at QA and QB? Eur. J. Biochem. 270: 3603-3609.

Renard CM, Jarvis MC 1999 A cross-polarization, magic-angle-spinning, 13C-nuclear-magnetic-resonance study of polysaccharides in sugar beet cell walls. Plant Physiol. 119: 1315-1322.

Reo NV, Adinehzadeh M, Foy BD 2002 Kinetic analyses of liver phosphatidylcholine and phosphatidylethanolamine biosynthesis using 13C NMR spectroscopy. Biochim. Biophys. Acta 1580: 171-188.

Rhodes D, McNeil SD, Nuccio ML, Hanson AD 2004 Metabolic engineering and flux analysis of glycine betaine synthesis in plants: progress and prospects. In (BN Kholodenko, HV Westerhoff, eds.) "Metabolic Engineering in the Post Genomic Era", Horizon Bioscience, Wymondham, Norfolk, U.K., pp. 409-434.

Ribnicky DM, Shulaev V, Raskin I 1998 Intermediates of salicylic acid biosynthesis in tobacco. Plant Physiol. 118: 565-572.

Richman A, Swanson A, Humphrey T, Chapman R, McGarvey B, Pocs R, Brandle J 2005 Functional genomics uncovers three glucosyltransferases involved in the synthesis of the major sweet glucosides of Stevia rebaudiana. Plant J. 41: 56-67.

Rieder C, Eisenreich W, O'Brien J, Richter G, Gotze E, Boyle P, Blanchard S, Bacher A, Simon H 1998 Rearrangement reactions in the biosynthesis of molybdopterin--an NMR study with multiply 13C/15N labelled precursors. Eur. J. Biochem. 255: 24-36.

Riget F, Moller P, Dietz R, Nielsen TG, Asmund G, Strand J, Larsen MM, Hobson KA 2007 Transfer of mercury in the marine food web of West Greenland. J. Environ. Monit. 9: 877-883.

Rijhwani SK, Ho CH, Shanks JV 1999 In vivo 31P and multilabel 13C NMR measurements for evaluation of plant metabolic pathways. Metab. Eng. 1: 12-25.

Rinehart KL, Potgieter M, Wright DA 1982 Use of D-[(C6)-C-13]-labeled glucose together with C-13-depleted glucose and homonuclear C-13 decoupling to identify the labeling pattern by this precursor of the M-C7N unit of geldanamycin. J. Am. Chem. Soc. 104: 2649-2652.

Rishavy MA, Cleland WW 2000 13C and 15N kinetic isotope effects on the reaction of aspartate aminotransferase and the tyrosine-225 to phenylalanine mutant. Biochemistry 39: 7546-7551.

Rober M, Geider K, Muller-Rober B, Willmitzer L 1996 Synthesis of fructans in tubers of transgenic starch-deficient potato plants does not result in an increased allocation of carbohydrates. Planta 199: 528-536.

Robert H, Le Marrec C, Blanco C, Jebbar M 2000 Glycine betaine, carnitine, and choline enhance salinity tolerance and prevent the accumulation of sodium to a level inhibiting growth of Tetragenococcus halophila. Appl. Environ. Microbiol. 66: 509-517.

Roberts JKM, Hooks MA, Miaullis AP, Edwards S, Webster C 1992 Contribution of malate and amino acid metabolism to cytoplasmic pH regulation in hypoxic maize root tips studied using nuclear magnetic resonance spectroscopy. Plant Physiol. 98: 480-487.

Roberts MF, Lai MC, Gunsalus RP 1992 Biosynthetic pathways of the osmolytes N epsilon-acetyl-beta-lysine, beta-glutamine, and betaine in Methanohalophilus strain FDF1 suggested by nuclear magnetic resonance analyses. J. Bacteriol. 174: 6688-6693.

Robertson DE, Noll D, Roberts MF 1992 Free amino acid dynamics in marine methanogens. beta-Amino acids as compatible solutes. J. Biol. Chem. 267: 14893-14901.

Robertson DE, Noll D, Roberts MF, Menaia JA, Boone DR 1990 Detection of the osmoregulator betaine in methanogens. Appl. Environ. Microbiol. 56: 563-565.

Robertson MD, Livesey G, Mathers JC 2002 Quantitative kinetics of glucose appearance and disposal following a 13C-labelled starch-rich meal: comparison of male and female subjects. Br. J. Nutr. 87: 569-577.

Robinson SA, Slade AP, Fox GG, Phillips R, Ratcliffe RG, Stewart GR 1991 The role of glutamate dehydrogenase in plant nitrogen metabolism. Plant Physiol. 95: 509-516.

Roden M, Shulman GI 1999 Applications of NMR spectroscopy to study muscle glycogen metabolism in man. Annu. Rev. Med. 50: 277-290.

Roeder SB, Master BS, Stewart CJ. 1975 13C NMR or coenzyme A and its constituent moieties. Physiol. Chem. Phys. 7: 115-123.

Roessner-Tunali U, Liu J, Leisse A, Balbo I, Perez-Melis A, Willmitzer L, Fernie AR 2004 Kinetics of labelling of organic and amino acids in potato tubers by gas chromatography-mass spectrometry following incubation in C labelled isotopes. Plant J. 39: 668-679.

Roje S, Chan SY, Kaplan F, Raymond RK, Horne DW, Appling DR, Hanson AD 2002 Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo. J. Biol. Chem. 277: 4056-4061.

Rolletschek H, Koch K, Wobus U, Borisjuk L 2005 Positional cues for the starch/lipid balance in maize kernels and resource partitioning to the embryo. Plant J. 42: 69-83.

Rontein D, Dieuaide-Noubhani M, Dufourc EJ, Raymond P, Rolin D 2002 The metabolic architecture of plant cells: stability of central metabolism and flexibility of anabolic pathways during the growth cycle of tomato cells. J. Biol. Chem. 277: 43948-43960.

Roosens NH, Willem R, Li Y, Verbruggen I, Biesemans M, Jacobs M 1999 Proline metabolism in the wild-type and in a salt-tolerant mutant of Nicotiana plumbaginifolia studied by 13C-nuclear magnetic resonance imaging. Plant Physiol. 121: 1281-1290.

Roseboom W, Blokesch M, Bock A, Albracht SP 2005 The biosynthetic routes for carbon monoxide and cyanide in the Ni-Fe active site of hydrogenases are different. FEBS Lett. 579: 469-472.

Ross BD, Kingsley PB, Benyoseph O 1994 Measurement of pentose phosphate pathway activity in a single incubation with [1,6-C-13(2),6,6-H-2(2)]glucose. Biochem. J. 302: 31-38.

Rost B, Richter KU, Riebesell U, Hansen PJ 2006 Inorganic carbon acquisition in red tide dinoflagellates. Plant Cell Environ. 29: 810-822.

Running JA, Burlingame RP, Berry A 2003 The pathway of L-ascorbic acid biosynthesis in the colourless microalga Prototheca moriformis. J. Exp. Bot. 54: 1841-1849.

Sahm H, Eggeling L, de Graaf AA 2000 Pathway analysis and metabolic engineering in Corynebacterium glutamicum. Biol. Chem. 381: 899-910.

Saranga Y, Jiang CX, Wright RJ, Yakir D, Paterson AH 2004 Genetic dissection of cotton physiological responses to arid conditions and their inter-relationships with productivity. Plant Cell Environ. 27: 263-277.

Sauer U 2006 Metabolic networks in motion: 13C-based flux analysis. Mol. Syst. Biol. 2: 62.

Sauer U, Hatzimanikatis V, Bailey JE, Hochuli M, Szyperski T, Wuthrich K 1997 Metabolic fluxes in riboflavin-producing Bacillus subtilis. Nat. Biotechnol. 15: 448-452.

Sauer U, Lasko DR, Fiaux J, Hochuli M, Glaser R, Szyperski T, Wuthrich K, Bailey JE 1999 Metabolic flux ratio analysis of genetic and environmental modulations of Escherichia coli central carbon metabolism. J. Bacteriol. 181: 6679-6688.

Schaefer J, Kier LD, Stejskal EO 1980 Characterization of photorespiration in intact leaves using C-13 dioxide labeling. Plant Physiol. 65: 254-259.

Schafer S, Gotz M, Eisenreich W, Bacher A, Fuchs G 1989 13C-NMR study of autotrophic CO2 fixation in Thermoproteus neutrophilus. Eur. J. Biochem. 184: 151-156.

Schmidt HL, Werner RA, Eisenreich W, Fuganti C, Fronza G, Remaud G, Robins RJ 2006 The prediction of isotopic patterns in phenylpropanoids from their precursors and the mechanism of the NIH-shift: basis of the isotopic characteristics of natural aromatic compounds. Phytochemistry 67: 1094-1103.

Schmidt J, Boettcher C, Kuhnt C, Kutchan TM, Zenk MH 2007 Poppy alkaloid profiling by electrospray tandem mass spectrometry and electrospray FT-ICR mass spectrometry after [ring-(13)C(6)]-tyramine feeding. Phytochemistry 68: 189-202.

Schmidt K, Carlsen M, Nielsen J, Villadsen J 1997 Modeling isotopomer distributions in biochemical networks using isotopomer mapping matrices. Biotechnol. Bioeng. 55: 831-840.

Schmidt K, Marx A, de Graaf AA, Wiechert W, Sahm H, Nielsen J, Villadsen J 1998 13C tracer experiments and metabolite balancing for metabolic flux analysis: comparing two approaches. Biotechnol. Bioeng. 58: 254-257.

Schmidt K, Nielsen J, Villadsen J 1999 Quantitative analysis of metabolic fluxes in Escherichia coli, using two-dimensional NMR spectroscopy and complete isotopomer models. J. Biotechnol. 71: 175-189.

Schmidt K, Norregaard LC, Pedersen B, Meissner A, Duus JO, Nielsen JO, Villadsen J 1999 Quantification of intracellular metabolic fluxes from fractional enrichment and 13C-13C coupling constraints on the isotopomer distribution in labeled biomass components. Metab. Eng. 1: 166-179.

Schmidt RC, Muller A, Hain R, Bartling D, Weiler EW 1996 Transgenic tobacco plants expressing the Arabidopsis thaliana nitrilase II enzyme. Plant J. 9: 683-691.

Schneider B 1997 In vivo nuclear magnetic resonance spectroscopy of low molecular weight compounds in plant cells. Planta 203: 1-8.

Schnitzler JP, Graus M, Kreuzwieser J, Heizmann U, Rennenberg H, Wisthaler A, Hansel A 2004 Contribution of different carbon sources to isoprene biosynthesis in poplar leaves. Plant Physiol. 135: 152-160.

Schnyder H, de Visser R 1999 Fluxes of reserve-derived and currently assimilated carbon and nitrogen in perennial ryegrass recovering from defoliation. The regrowing tiller and its component functionally distinct zones. Plant Physiol. 119: 1423-1436.

Schnyder H, Schaufele R, Lotscher M, Gebbing T 2003 Disentangling CO2 fluxes: direct measurements of mesocosm-scale natural abundance (CO2)-C-13/(CO2)-C-12 gas exchange, C-13 discrimination, and labelling of CO2 exchange flux components in controlled environments. Plant Cell Environ. 26: 1863-1874.

Schrader MC, Eskey CJ, Simplaceanu V, Ho C 1993 A carbon-13 nuclear magnetic resonance investigation of the metabolic fluxes associated with glucose metabolism in human erythrocytes. Biochim. Biophys. Acta 1182: 162-178.

Schuster S 2001 Flux determination by isotopomer balancing - a successful application of theory to experiment. Trends Biotechnol. 19: 85.

Schwender J, Ohlrogge JB 2002 Probing in vivo metabolism by stable isotope labeling of storage lipids and proteins in developing Brassica napus embryos. Plant Physiol. 130: 347-361.

Schwender J, Ohlrogge JB, Shachar-Hill Y 2003 A flux model of glycolysis and the oxidative pentosephosphate pathway in developing Brassica napus embryos. J. Biol. Chem. 278: 29442-29453.

Schwender J, Seemann M, Lichtenthaler HK, Rohmer M 1996 Biosynthesis of isoprenoids (carotenoids, sterols, prenyl side-chains of chlorophylls and plastoquinone) via a novel pyruvate/glyceraldehyde 3-phosphate non-mevalonate pathway in the green alga Scenedesmus obliquus. Biochem. J. 316: 73-80.

Schwender J, Shachar-Hill Y, Ohlrogge JB 2006 Mitochondrial metabolism in developing embryos of Brassica napus. J. Biol. Chem. 281: 34040-34047.

Schwender J, Zeidler J, Groner R, Muller C, Focke M, Braun S, Lichtenthaler FW, Lichtenthaler HK 1997 Incorporation of 1-deoxy-D-xylulose into isoprene and phytol by higher plants and algae. FEBS Lett. 414: 129-134.

Seidel V, Windhovel J, Eaton G, Alfermann AW, Arroo RR, Medarde M, Petersen M, Woolley JG 2002 Biosynthesis of podophyllotoxin in Linum album cell cultures. Planta 215: 1031-1039.

Selivanov VA, Marin S, Lee PW, Cascante M 2006 Software for dynamic analysis of tracer-based metabolomic data: estimation of metabolic fluxes and their statistical analysis. Bioinformatics 22: 2806-2812.

Shaheen R, Hood-Nowotny RC 2005 Carbon isotope discrimination: potential for screening salinity tolerance in rice at the seedling stage using hydroponics. Plant Breed. 124: 220-224.

Shanks JV 2001 In situ NMR systems. Curr. Issues Mol. Biol. 3: 15-26.

Sharkey TD, Loreto F, Delwiche CF, Treichel IW 1991 Fractionation of carbon isotopes during biogenesis of atmospheric isoprene. Plant Physiol. 97: 463-466.

Shekhtman A, Ghose R, Goger M, Cowburn D 2002 NMR structure determination and investigation using a reduced proton (REDPRO) labeling strategy for proteins. FEBS Lett. 524: 177-182.

Shen J, Petersen KF, Behar KL, Brown P, Nixon TW, Mason GF, Petroff OA, Shulman GI, Shulman RG, Rothman DL 1999 Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proc. Natl. Acad. Sci. U.S.A. 96: 8235-8240.

Shen ZW, Fisinger U, Poulev A, Eisenreich W, Werner I, Pleiner E, Bacher A, Zenk MH 2001 Tracer studies with C-13-labeled carbohydrates in cultured plant cells. Retrobiosynthetic analysis of chelidonic acid biosynthesis. Phytochemistry 57: 33-42.

Sherry AD, Jeffrey FM, Malloy CR 2004 Analytical solutions for (13)C isotopomer analysis of complex metabolic conditions: substrate oxidation, multiple pyruvate cycles, and gluconeogenesis. Metab. Eng. 6: 12-24.

Shimizu H 2002 Metabolic engineering--integrating methodologies of molecular breeding and bioprocess systems engineering. J. Biosci. Bioeng. 94: 563-573.

Shulman RG, Rothman DL 2001 13C NMR of intermediary metabolism: implications for systemic physiology. Annu. Rev. Physiol. 63: 15-48.

Shuttleworth WA, Evans JN 1994 Site-directed mutagenesis and NMR studies of histidine-385 mutants of 5-enolpyruvylshikimate-3-phosphate synthase. Biochemistry 33: 7062-7068.

Sibson NR, Mason GF, Shen J, Cline GW, Herskovits AZ, Wall JE, Behar KL, Rothman DL, Shulman RG 2001 In vivo 13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during. J. Neurochem. 76: 975-989.

Siebert M, Severin K, Heide L 1994 Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase. Microbiology 140: 897-904.

Siebert M, Sommer S, Li SM, Wang ZX, Severin K, Heide L 1996 Genetic engineering of plant secondary metabolism. Accumulation of 4-hydroxybenzoate glucosides as a result of the expression of the bacterial ubiC gene in tobacco. Plant Physiol. 112: 811-819.

Simpson NE, Han Z, Berendzen KM, Sweeney CA, Oca-Cossio JA, Constantinidis I, Stacpoole PW 2006 Magnetic resonance spectroscopic investigation of mitochondrial fuel metabolism and energetics in cultured human fibroblasts: effects of pyruvate dehydrogenase complex deficiency and dichloroacetate. Mol. Genet. Metab. 89: 97-105.

Sims AP, Folkes BF, Cavill AP, Parsley KR 1990 A new method for measuring 13-carbon abundance in tracer experiments. Plant Cell Environ. 13: 857-869.

Sitbon F, Astot C, Edlund A, Crozier A, Sandberg G 2000 The relative importance of tryptophan-dependent and tryptophan-independent biosynthesis of indole-3-acetic acid in tobacco during vegetative growth. Planta 211: 715-721.

Smith AM, Ratcliffe RG, Sweetlove LJ 2004 Activation and function of mitochondrial uncoupling protein in plants. J. Biol. Chem. 279: 51944-51952.

Smith EC, Williamson EM, Wareham N, Kaatz GW, Gibbons S 2007 Antibacterials and modulators of bacterial resistance from the immature cones of Chamaecyparis lawsoniana. Phytochemistry 68: 210-217.

Smith GM, Pettigrew GW 1980 Identification of N,N-dimethylproline as the N-terminal blocking group of Crithidia oncopelti cytochrome c557. Eur. J. Biochem. 110: 123-130.

Smith LT, Smith GM, Madkour MA 1990 Osmoregulation in Agrobacterium tumefaciens: accumulation of a novel disaccharide is controlled by osmotic strength and glycine betaine. J. Bacteriol. 172: 6849-6855.

So AK, John-McKay M, Espie GS 2002 Characterization of a mutant lacking carboxysomal carbonic anhydrase from the cyanobacterium Synechocystis PCC6803. Planta 214: 456-467.

Sommer S, Kohle A, Yazaki K, Shimomura K, Bechthold A, Heide L 1999 Genetic engineering of shikonin biosynthesis hairy root cultures of Lithospermum erythrorhizon transformed with the bacterial ubiC gene. Plant Mol. Biol. 39: 683-693.

Sonntag K, Schwinde J, de Graaf AA, Marx A, Eikmanns BJ, Wiechert W, Sahm H 1995 13C NMR studies of the fluxes in the central metabolism of Corynebacterium glutamicum during growth and overproduction of amino acids in batch cultures. Appl. Microbiol. Biotechnol. 44: 489-495.

Spiteller P, Steglich W 2001 Biosynthesis of 2-aminobenzaldehyde in flowers of Robinia pseudoacacia and Philadelphus coronarius. Phytochemistry 57: 361-363.

Sriram G, Fulton DB, Iyer VV, Peterson JM, Zhou R, Westgate ME, Spalding MH, Shanks JV 2004 Quantification of compartmented metabolic fluxes in developing soybean embryos by employing biosynthetically directed fractional 13C labeling, two-dimensional [13C, 1H] nuclear magnetic resonance, and comprehensive isotopomer balancing. Plant Physiol. 136: 3043-3057.

Sriram G, Gonzalez-Rivera O, Shanks JV 2006 Determination of biomass composition of Catharanthus roseus hairy roots for metabolic flux analysis. Biotechnol. Prog. 22: 1659-1663.

Sriram G, Shanks JV 2004 Improvements in metabolic flux analysis using carbon bond labeling experiments: bondomer balancing and Boolean function mapping. Metab. Eng. 6: 116-132.

Stabler SP, Allen RH 2004 Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry. Clin. Chem. 50: 365-372.

Staddon PL, Ostle N, Dawson LA, Fitter AH 2003 The speed of soil carbon throughput in an upland grassland is increased by liming. J. Exp. Bot. 54: 1461-1469.

Stam F, Smulders YM, van Guldener C, Jakobs C, Stehouwer CD, de Meer K 2005 Folic acid treatment increases homocysteine remethylation and methionine transmethylation in healthy subjects. Clin. Sci. (Lond.) 108: 449-456.

Stam F, van Guldener C, ter Wee PM, Kulik W, Smith DE, Jakobs C, Stehouwer CD, de Meer K 2004 Homocysteine clearance and methylation flux rates in health and end-stage renal disease: association with S-adenosylhomocysteine. Am. J. Physiol. Renal Physiol. 287: F215-F223.

Stintzing FC, Conrad J, Klaiber I, Beifuss U, Carle R 2004 Structural investigations on betacyanin pigments by LC NMR and 2D NMR spectroscopy. Phytochemistry 65: 415-422.

Stoker PW, O'Leary MH, Boehlein SK, Schuster SM, Richards NG 1996 Probing the mechanism of nitrogen transfer in Escherichia coli asparagine synthetase by using heavy atom isotope effects. Biochemistry 35: 3024-3030.

Stover P, Schirch V 1992 Synthesis of (6S)-5-formyltetrahydropteroyl-polyglutamates and interconversion to other reduced pteroylpolyglutamate derivatives. Anal. Biochem. 202: 82-88.

Struys EA, Jansen EE, de Meer K, Jakobs C 2000 Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry. Clin. Chem. 46: 1650-1656.

Studelska DR, McDowell LM, Espe MP, Klug CA, Schaefer J 1997 Slowed enzymatic turnover allows characterization of intermediates by solid-state NMR. Biochemistry 36: 15555-15560.

Sundberg B, Tuominen H, Little C 1994 Effects of the indole-3-acetic acid (IAA) transport inhibitors N-1-naphthylphthalamic acid and morphactin on endogenous IAA dynamics in relation to compression wood formation in 1-year-old Pinus sylvestris (L.) shoots. Plant Physiol. 106: 469-476.

Suthers PF, Burgard AP, Dasika MS, Nowroozi F, Van Dien S, Keasling JD, Maranas CD 2007 Metabolic flux elucidation for large-scale models using (13)C labeled isotopes. Metab. Eng. May 29 [Epub ahead of print].

Suzuki Y, Amano T, Shioi Y 2006 Characterization and cloning of the chlorophyll-degrading enzyme pheophorbidase from cotyledons of radish (Raphanus sativus L.). Plant Physiol. 140: 716-725.

Szyperski T 1998 13C-NMR, MS and metabolic flux balancing in biotechnology research. Q. Rev. Biophys. 31: 41-106.

Szyperski T 1995 Biosynthetically directed fractional 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism. Eur. J. Biochem. 232: 433-448.

Szyperski T, Glaser RW, Hochuli M, Fiaux J, Sauer U, Bailey JE, Wuthrich K 1999 Bioreaction network topology and metabolic flux ratio analysis by biosynthetic fractional 13C labeling and two-dimensional NMR spectroscopy. Metab. Eng. 1: 189-197.

Takeda K, Sato S, Kobayashi H, Kanaitsuka Y, Ueno M, Kinoshita T, Tazaki H, Fujimori T 1994 The anthocyanin responsible for purplish blue flower colour of Aconitum chinense. Phytochemistry 36: 613-616.

Talibart R, Jebbar M, Gouesbet G, Himdi-Kabbab S, Wroblewski H, Blanco C, Bernard T 1994 Osmoadaptation in rhizobia: ectoine-induced salt tolerance. J. Bacteriol. 176: 5210-5217.

Tang Y, Pingitore F, Mukhopadhyay A, Phan R, Hazen TC, Keasling JD 2007 Pathway confirmation and flux analysis of central metabolic pathways in Desulfovibrio vulgaris Hildenborough using GC-MS and FT-ICR mass spectrometry. J. Bacteriol. 189: 940-949.

Tang YJ, Hwang JS, Wemmer DE, Keasling JD 2007 The Shewanella oneidensis MR-1 fluxome under various oxygen conditions. Appl. Environ. Microbiol. 73: 718-729.

Tavernier P, Besson I, Portais JC, Courtois J, Courtois B, Barbotin JN 1998 In vivo 13C-NMR studies of polymer synthesis in Rhizobium meliloti M5N1 strain. Biotechnol. Bioeng. 58: 250-253.

Taylor AM, Brooks JR, Lachenbruch B, Morrell JJ 2007 Radial patterns of carbon isotopes in the xylem extractives and cellulose of Douglas-fir. Tree Physiol. 27: 921-927.

Tcherkez G, Cornic G, Bligny R, Gout E, Ghashghaie J 2005 In vivo respiratory metabolism of illuminated leaves. Plant Physiol. 138: 1596-1606.

Tcherkez G, Hodges M 2007 How stable isotopes may help to elucidate primary nitrogen metabolism and its interaction with (photo)respiration in C3 leaves. J. Exp. Bot. Jul 23 [Epub ahead of print].

Tcherkez G, Nogues S, Bleton J, Cornic G, Badeck F, Ghashghaie J 2003 Metabolic origin of carbon isotope composition of leaf dark-respired CO2 in french bean. Plant Physiol. 131: 237-244.

Tel-Or E, Spath S, Packer L, Mehlhorn RJ 1986 Carbon-13 NMR studies of salt shock-induced carbohydrate turnover in the marine cyanobacterium Agmenellum quadruplicatum. Plant Physiol. 82: 646-652.

Temraz A, El Gindi OD, Kadry HA, De Tommasi N, Braca A 2006 Steroidal saponins from the aerial parts of Tribulus alatus Del. Phytochemistry 67: 1011-1018.

Terada K, Suwa K, Takeyama S, Honda C, Kamisako W 1996 Biosynthesis of the acetylenic compounds in cultured cells of Asparagus officinalis from D- and 13C-labelled phenylalanines. Biol. Pharm. Bull. 19: 748-751.

Terahara N, Callebaut A, Ohba R, Nagata T, Ohnishi-Kameyama M, Suzuki M 1996 Triacylated anthocyanins from Ajuga reptans flowers and cell cultures. Phytochemistry 42: 199-203.

Terskikh VV, Feurtado JA, Borchardt S, Giblin M, Abrams SR, Kermode AR 2005 In vivo 13C NMR metabolite profiling: potential for understanding and assessing conifer seed quality. J. Exp. Bot. 56: 2253-2265.

Textor S, Wendisch VF, de Graaf AA, Muller U, Linder MI, Linder D, Buckel W 1997 Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria. Arch. Microbiol. 168: 428-436.

Thompson AJ, Andrews J, Mulholland BJ, McKee JM, Hilton HW, Horridge JS, Farquhar GD, Smeeton RC, Smillie IR, Black CR, Taylor IB 2007 Overproduction of abscisic acid in tomato increases transpiration efficiency and root hydraulic conductivity and influences leaf expansion. Plant Physiol. 143: 1905-1917.

Thornton B, Paterson E, Midwood AJ, Sim A, Pratt SM 2004 Contribution of current carbon assimilation in supplying root exudates of Lolium perenne measured using steady-state C labelling. Physiol. Plant. 120: 434-441.

Thykaer J, Christensen B, Nielsen J 2002 Metabolic network analysis of an adipoyl-7-ADCA-producing strain of Penicillium chrysogenum: elucidation of adipate degradation. Metab. Eng. 4: 151-158.

Townsend JH, Davis SR, Mackey AD, Gregory JF 2004 Folate deprivation reduces homocysteine remethylation in a human intestinal epithelial cell culture model: role of serine in one-carbon donation. Am. J. Physiol. Gastroint. Liver Physiol. 286: G588-G595.

Tran-Dinh S, Beganton F, Nguyen TT, Bouet F, Herve M 1996 Mathematical model for evaluating the Krebs cycle flux with non-constant glutamate-pool size by 13C-NMR spectroscopy. Evidence for the existence of two types of Krebs cycles in cells. Eur. J. Biochem. 242: 220-227.

Tran-Dinh S, Hoerter JA, Mateo P, Gyppaz F, Herve M 1998 13C-NMR spectroscopic evaluation of the citric acid cycle flux in conditions of high aspartate transaminase activity in glucose-perfused rat hearts. Biochimie 80: 1013-1024.

Trotter PJ, Adamson AL, Ghrist AC, Rowe L, Scott LR, Sherman MP, Stites NC, Sun Y, Tawiah-Boateng MA, Tibbetts AS, Wadington MC, West AC 2005 Mitochondrial transporters involved in oleic acid utilization and glutamate metabolism in yeast. Arch. Biochem. Biophys. 442: 21-32.

Turner SM, Linfoot PA, Neese RA, Hellerstein MK 2005 Sources of plasma glucose and liver glycogen in fasted ob/ob mice. Acta Diabetol. 42: 187-193.

Ueno D, Ma JF, Iwashita T, Zhao FJ, McGrath SP 2005 Identification of the form of Cd in the leaves of a superior Cd-accumulating ecotype of Thlaspi caerulescens using 113Cd-NMR. Planta 221: 928-936.

van der Hoeven RS, Steffens JC 2000 Biosynthesis and elongation of short- and medium-chain-length fatty acids. Plant Physiol. 122: 275-282.

Van Dien SJ, Strovas T, Lidstrom ME 2003 Quantification of central metabolic fluxes in the facultative methylotroph methylobacterium extorquens AM1 using 13C-label tracing and mass spectrometry. Biotechnol. Bioeng. 84: 45-55.

van Dijk TH, van der Sluijs FH, Wiegman CH, Baller JF, Gustafson LA, Burger HJ, Herling AW, Kuipers F, Meijer AJ, Reijngoud DJ 2001 Acute inhibition of hepatic glucose-6-phosphatase does not affect gluconeogenesis but directs gluconeogenic flux toward glycogen in fasted rats. A pharmacological study with the chlorogenic acid derivative S4048. J. Biol. Chem. 276: 25727-25735.

van Doorn WG, Sinz A, Tomassen MM 2004 Daffodil flowers delay senescence in cut Iris flowers. Phytochemistry 65: 571-577.

van Winden W, Schipper D, Verheijen P, Heijnen J 2001 Innovations in generation and analysis of 2D [13C,1H] COSY NMR spectra for metabolic flux analysis purposes. Metab. Eng. 3: 322-343.

van Winden W, Verheijen P, Heijnen S 2001 Possible pitfalls of flux calculations based on 13C-labeling. Metab. Eng. 3: 151-162.

Van Winden WA, Heijnen JJ, Verheijen PJ 2002 Cumulative bondomers: A new concept in flux analysis from 2D [13C,1H] COSY NMR data. Biotechnol. Bioeng. 80: 731-745.

van Winden WA, Heijnen JJ, Verheijen PJ, Grievink J 2001 A priori analysis of metabolic flux identifiability from 13C-labeling data. Biotechnol. Bioeng. 74: 505-516.

van Winden WA, van Dam JC, Ras C, Kleijn RJ, Vinke JL, van Gulik WM, Heijnen JJ 2005 Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of (13)C-labeled primary metabolites. FEMS Yeast Res. 5: 559-568.

Van Winden WA, Van Gulik WM, Schipper D, Verheijen PJ, Krabben P, Vinke JL, Heijnen JJ 2003 Metabolic flux and metabolic network analysis of Penicillium chrysogenum using 2D [13C, 1H] COSY NMR measurements and cumulative bondomer simulation. Biotechnol. Bioeng. 83: 75-92.

van Winden WA, Wittmann C, Heinzle E, Heijnen JJ 2002 Correcting mass isotopomer distributions for naturally occurring isotopes. Biotechnol. Bioeng. 80: 477-479.

Van Zijl PC, Davis D, Eleff SM, Moonen CT, Parker RJ, Strong JM 1997 Determination of cerebral glucose transport and metabolic kinetics by dynamic MR spectroscopy. Am. J. Physiol. 273: E1216-E1227.

Varner J, Ramkrishna D 1999 Mathematical models of metabolic pathways. Curr. Opin. Biotechnol. 10: 146-150.

Vercoutere B, Durozard D, Baverel G, Martin G 2004 Complexity of glutamine metabolism in kidney tubules from fed and fasted rats. Biochem. J. 378: 485-495.

Verheyden A, Helle G, Schleser GH, Dehairs F, Beeckman H, Koedam N 2004 Annual cyclicity in high-resolution stable carbon and oxygen isotope ratios in the wood of the mangrove tree Rhizophora mucronata. Plant Cell Environ. 27: 1525-1536.

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