David E. Salt Professor Ph.D. E-mail: CV

PULSe - Interdisciplinary Life Science Training Group

Area of Interest: Understanding the mechanisms that regulate the ionome, or elemental composition, of plants. To achieve this we couple high-throughput elemental profiling, using Inductively Coupled Plasma Mass Spectrometry (ICP-MS), with bioinformatics (www.purdue.edu/dp/ionomics), genomics and genetics (forward, reverse and natural variation). We apply this system in both genetic model species (yeast, Arabidopsis and rice) and “wild” plants (Astragalus, Thlaspi and Pteris), in order to uncover the genes and gene networks that regulate the ionome, along with the selective forces that shape this regulation.

 

Recent publication (Last 5-years)

 

Total publications as of Dec 2007 = 70

Total citations = 3,269

Average citation per publication = 51.89

Highest cited publication = 479

 

Freeman JL, Salt DE (2007) The metal tolerance profile of Thlaspi goesingense is mimicked in Arabidopsis thaliana heterologously expressing serine acetyl-transferase. BMC Plant Biology 7:63. http://www.biomedcentral.com/content/pdf/1471-2229-7-63.pdf.

 

Callahan DL, Kolev SD, O'Hair RA, Salt DE, Baker AJ (2007) Relationships of nicotianamine and other amino acids with nickel, zinc and iron in Thlaspi hyperaccumulators. New Phytologist 176 836-848.

 

Peters JL, Dufner-Beattie J, Xu W, Geiser J, Lahner B, Salt DE, Andrews GK (2007) Targeting of the mouse Slc39a2 (Zip2) gene reveals highly cell-specific patterns of expression, and unique functions in zinc, iron, and calcium homeostasis. Genesis 45: 339-352.

 

Muthukumar B, Yakubov B, Salt DE (2007) Transcriptional activation and localization of expression of Brassica juncea putative metal transport protein BjMTP1. BMC Plant Biology 7: 32. http://www.biomedcentral.com/content/pdf/1471-2229-7-32.pdf.

 

Borevitz JO, Hazen SP, Michael TP, Morris GP, Baxter IR, Hu TT, Chen H, Werner JD, Nordborg M, Salt DE, Kay SA, Chory J, Weigel D, Jones JD, Ecker JR (2007) Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana. PNAS 104: 12057-12062. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1914337&blobtype=pdf.

 

Baxter I, Ouzzani M, Orcun S, Kennedy B, Jandhyala SS, Salt DE (2007) Purdue Ionomics Information Management System (PIIMS): An integrated functional genomics platform. Plant Physiology 143: 600-611. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1803751&blobtype=pdf.

 

Lee J, Nam J, Park HC, Na G, Miura K, Jin JB, Yoo CY, Baek D, Kim DH, Jeong JC, Kim D, Lee SY, Salt DE, Mengiste T, Gong Q, Ma S, Bohnert HJ, Kwak SS, Bressan RA, Hasegawa PM, Yun DJ (2007) Salicylic acid-mediated innate immunity in Arabidopsis is regulated by SIZ1 SUMO E3 ligase. Plant Journal 49: 79-90.

 

Ellis DR, Gumaelius L, Indriolo E, Pickering IJ, Banks JA, Salt DE (2006) Isolation and characterization of a unique arsenate reductase from the arsenic hyperaccumulating fern Pteris vittata. Plant Physiology 141:1544-1554. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1533930&blobtype=pdf.

 

Yoo CY, Miura K, Jin JB, Lee J, Park HC, Salt DE, Yun DJ, Bressan RA, Hasegawa PM (2006) SIZ1 SUMO E3 Ligase Facilitates Basal Thermotolerance in Arabidopsis Independent of Salicylic Acid. Plant Physiology 143 1548-1558. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1676064&blobtype=pdf.

 

Waters BM, Chu HH, Didonato RJ, Roberts LA, Eisley RB, Lahner B, Salt DE, Walker EL (2006) Mutations in Arabidopsis yellow stripe-like1 and yellow stripe-like3 reveal their roles in metal ion homeostasis and loading of metal ions in seeds. Plant Physiology 141: 1446-1458. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1533956&blobtype=pdf.

 

Pickering IJ, Gumaelius L, Harris HH, Prince RC, Hirsch G, Banks JA, Salt DE, George GN (2006) Localizing the biochemical transformations of arsenate in a hyperaccumulating fern. Environmental Science and Technology 40: 5010-5014.

 

Rus A, Baxter I, Muthukumar B, Gustin J, Lahner B, Yakubova E and Salt DE (2006) Natural variants of AtHKT1 enhance Na⁺ accumulation in two wild populations of Arabidopsis. PLoS Genetics 2(12): e210. doi:10.1371/journal.pgen.0020210

 

Peer WA, Mahmoudian M, Freeman JL, Lahner B, Richards EL, Reeves RD, Murphy AS, Salt DE (2006) Identifying model hyperaccumulating plants II: Germplasm analysis of 27 Brassicaceae accessions from a wide geographic area. New Phytologist 172: 248-260.

 

Rampey RA, Woodward AW, Hobbs BN, Tierney NP, Lahner B, Salt DE, and Bartel B (2006) An Arabidopsis basic helix-loop-helix leucine zipper protein modulates metal homeostasis and auxin conjugate responsiveness. Genetics 174 1841-1857. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1698629&blobtype=pdf.

 

Freeman JL, Persans MW, Nieman K, Salt DE (2005) Nickel and cobalt resistance engineered in Escherichia coli by over-expression of serine acetyltransferase from the nickel hyperaccumulating plants Thlaspi goesingense. Applied and Environmental Microbiology 71: 8627-8633. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1317400&blobtype=pdf.

 

Sors TG, Ellis DR, Salt DE (2005) Selenium uptake, translocation, assimilation and metabolite fate in plants. Photosynthesis Research 86: 373-389.

 

Cheng NH, Pittman JK, Shigaki T, Lachmansingh J, Leclere S, Lahner B, Salt DE, Hirschi KD (2005) Functional association of Arabidopsis CAX1 and CAX3 is required for normal growth and ion homeostasis. Plant Physiology. 138: 2048-2060. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1183394&blobtype=pdf.

 

Sors TG, Ellis DR, Na GN, Lahner B, Lee S, Leustek T, Pickering IJ, Salt DE (2005) Analysis of sulfur and selenium assimilation in Astragalus plants with varying capacities to accumulate selenium. Plant Journal 42: 785-797.

 

Freeman JL, Garcia D, Kim D, Hopf A, Salt DE (2005) Constitutively elevated salicylic acid signals glutathione mediated nickel tolerance in Thlaspi nickel hyperaccumulators. Plant Physiology 137:1082-1091. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1065408&blobtype=pdf.

 

Salt DE (2004) Update on ionomics. Plant Physiology 136: 2451-2456. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=523312&blobtype=pdf.

 

Gumaelius L, Lahner B, Salt DE, Banks JA (2004). Arsenic hyperaccumulation in gametophytes of Pteris vittata: A new model system for analysis of arsenic hyperaccumulation. Plant Physiology 136: 3198-3208. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=523379&blobtype=pdf.

 

Lahner B, Salt DE (2004). Mapping links between the genome and ionome in plants. In Plant Nutritional Genomics. Martin Broadley & Philip White (eds), Blackwell Publishing / CRC Press.

 

Freeman JL, Persans MW, Nieman K, Albrecht C, Peer W, Pickering IJ, Salt DE (2004). Increased glutathione biosynthesis plays a role in nickel hyper tolerance in Thlaspi nickel hyperaccumulators. Plant Cell 16: 2176-2191. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=519206&blobtype=pdf.

 

Kim D, Gustin JL, Persans MW, Baek D, Yun D-J, Salt DE (2004). The plant CDF family member TgMTP1 from the Ni/Zn hyperaccumulator Thlaspi goesingense acts to enhance efflux of Zn at the plasma membrane when expressed in Saccharomyces cerevisiae. Plant Journal 39: 237-251.

 

Whiting SN, Reeves RD, Richards D, Johnson MS, Cooke JA, Malaisse F, Paton A, Smith JAC, Chaney RL, Ginocchio R, Jaffre T, Johns R, McIntyre T, Purvis OW, Salt DE, Schat H, Zhao FJ, Baker AJM (2004) Research priorities for conservation of metallophyte biodiversity and their potential for restoration and site remediation. Restoration Ecology 12: 106-116.

 

Ellis DR, Sors TG, Brunk DG, Albrecht C, Orser C, Lahner B, Woods KV, Harris HH, Pickering IJ, Salt DE (2004). Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase. BMC Plant Biology 4. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=343276&blobtype=pdf.

 

Ticconi C, Delatorre C, Lahner B, Salt DE, Abel S (2004) Arabidopsis pdr2 reveals a phosphate-sensitive checkpoint in root development. Plant Journal 37:801-814.

 

Lahner B, Gong J, Mahmoudian M, Smith EL, Abid KB, Rogers EE, Guerinot ML, Harper JF, Ward JM, McIntyre L, Schroeder JI, Salt DE (2003) Genomic scale profiling of nutrient and trace elements in Arabidopsis thaliana. Nature Biotechnology, 21: 1215-1221.

 

Peer WA, Mamoudian M, Lahner B, Reeves RD, Murphy AS, Salt DE (2003) Identifying model metal hyperaccumulating plants: germplasm analysis of 20 Brassicaceae accessions from a wide geographical area. New Phytologist, 159: 421-430.

 

Pickering IJ, Hirsch G, Prince RC, Yu EY, Salt DE, George GN (2003) Imaging of selenium in plants using tapered metal capillary optics. Journal of Synchrotron Radiation 10: 289-290.

 

Pickering IJ, Wright C, Bubner B, Ellis D, Persans MW, Yu EY, George GN, Prince RC, Salt DE (2003) Chemical form and distribution of selenium and sulfur in the selenium hyperaccumulator Astragalus bisulcatus. Plant Physiology 131: 1460-1467. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=166905&blobtype=pdf.

 

Ellis DR, Salt DE (2003) Plants, selenium and human health. Current Opinions In Plant Biology 6:273-279.