Definitions

Definitions:

P1 = Specific activity of exogenously supplied precursor, P (nCi.nmol^-1)

P2 = Initial pool size of exogenously supplied precursor (nmol.gfw^-1)

TS = Total time of the simulation (min)

k = A variable that determines the rate of uptake of the exogenously supplied precursor, A8 = P2.k; as the pool of P2 declines, the rate of uptake of P2 declines proportionately.

F1 = Specific activity of endogenous unlabeled precursor of pool A (nCi.nmol^-1)

A1 = Initial specific activity of metabolic of pool A (nCi.nmol^-1)

A2 = Initial pool size of metabolic pool of A (nmol.gfw^-1)

A3 = Rate of synthesis of metabolic pool of A from unlabeled precursor (nmol.min^-1.gfw^-1)

A4 = Rate of exchange between metabolic and storage pools of A (nmol.min^-1.gfw^-1)

A5 = Initial specific activity of storage of pool A (nCi.nmol^-1)

A6 = Initial pool size of storage pool of A (nmol.gfw^-1)

A7 = Rate of utilization of metabolic pool of A in "other" reactions (nmol.min^-1.gfw^-1)

B1 = Initial specific activity of metabolic of pool B (nCi.nmol^-1)

B2 = Initial pool size of metabolic pool of B (nmol.gfw^-1)

B3 = Rate of synthesis of metabolic pool of B (nmol.min^-1.gfw^-1)

B4 = Rate of exchange between metabolic and storage pools of B (nmol.min^-1.gfw^-1)

B5 = Initial specific activity of storage of pool B (nCi.nmol^-1)

B6 = Initial pool size of storage pool of B (nmol.gfw^-1)

B7 = Rate of utilization of metabolic pool of B in "other" reactions (nmol.min^-1.gfw^-1)

C1 = Initial specific activity of metabolic of pool C (nCi.nmol^-1)

C2 = Initial pool size of metabolic pool of C (nmol.gfw^-1)

C3 = Rate of synthesis of metabolic pool of C (nmol.min^-1.gfw^-1)

C4 = Rate of exchange between metabolic and storage pools of C (nmol.min^-1.gfw^-1)

C5 = Initial specific activity of storage of pool C (nCi.nmol^-1)

C6 = Initial pool size of storage pool of C (nmol.gfw^-1)

C7 = Rate of utilization of metabolic pool of C in "other" reactions (nmol.min^-1.gfw^-1)

D1 = Initial specific activity of metabolic of pool D (nCi.nmol^-1)

D2 = Initial pool size of metabolic pool of D (nmol.gfw^-1)

D3 = Rate of synthesis of metabolic pool of D (nmol.min^-1.gfw^-1)

D4 = Rate of exchange between metabolic and storage pools of D (nmol.min^-1.gfw^-1)

D5 = Initial specific activity of storage of pool D (nCi.nmol^-1)

D6 = Initial pool size of storage pool of D (nmol.gfw^-1)

D7 = Rate of utilization of metabolic pool of D in "other" reactions (nmol.min^-1.gfw^-1)

E1 = Initial specific activity of metabolic of pool E (nCi.nmol^-1)

E2 = Initial pool size of metabolic pool of E (nmol.gfw^-1)

E3 = Rate of synthesis of metabolic pool of E (nmol.min^-1.gfw^-1)

E4 = Rate of exchange between metabolic and storage pools of E (nmol.min^-1.gfw^-1)

E5 = Initial specific activity of storage of pool E (nCi.nmol^-1)

E6 = Initial pool size of storage pool of E (nmol.gfw^-1)

E7 = Rate of utilization of metabolic pool of E in "other" reactions (nmol.min^-1.gfw^-1)

gfw = g fresh weight